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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">perinatology</journal-id><journal-title-group><journal-title xml:lang="ru">Российский вестник перинатологии и педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-4065</issn><issn pub-type="epub">2500-2228</issn><publisher><publisher-name>Ltd. “The National Academy of Pediatric Science and Innovation”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21508/1027-4065-2019-64-6-119-125</article-id><article-id custom-type="elpub" pub-id-type="custom">perinatology-1030</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FOR THE PRACTITIONER</subject></subj-group></article-categories><title-group><article-title>Кисломолочные продукты: от истории к современности</article-title><trans-title-group xml:lang="en"><trans-title>Fermented milk products: from history to the present</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1228-443X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бельмер</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belmer</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бельмер Сергей Викторович – д.м.н., проф. кафедры госпитальной педиатрии №2</p><p>117513 Москва, Ленинский проспект, д. 117</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>16</day><month>01</month><year>2020</year></pub-date><volume>64</volume><issue>6</issue><fpage>119</fpage><lpage>125</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ltd. “The National Academy of Pediatric Science and Innovation”, 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><copyright-holder xml:lang="en">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><license xlink:href="https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.ped-perinatology.ru/jour/article/view/1030">https://www.ped-perinatology.ru/jour/article/view/1030</self-uri><abstract><p>С древнейших времен люди знают о пользе для здоровья кисломолочных продуктов. Эти продукты получают путем молочно-кислого брожения с использованием различных микроорганизмов, но в первую очередь представителей Lactobacillus. Число разновидностей кисломолочных продуктов велико. Наиболее известны йогурт, кефир, простокваша, ряженка, сметана. Йогурт производится с использованием закваски, включающей Streptococcus thermophilus и Lactobacillus bulgaricus. Показаны многочисленные положительные эффекты йогуртов, в частности антибактериальный эффект в отношении многих патогенных микроорганизмов. Йогурт, как и другие кисломолочные продукты, имеет сниженное по сравнению с цельным молоком содержание лактозы, что позволяет употреблять этот продукт лицам с лактазной недостаточностью. Кроме того, белок кисломолочных продуктов в большей степени доступен ферментам желудочно-кишечного тракта и легче усваивается. Показан также гипохолестеринемический эффект йогуртов. Кисломолочные продукты, включая йогурт, рекомендуются для детского питания. В частности, показана эффективность питьевого йогурта, обогащенного пре- и пробиотиками, как здоровым детям, так и детям с функциональными нарушениями желудочно-кишечного тракта, нарушениями кишечного микробиоценоза, часто и длительно болеющим, а также в остром периоде ОРВИ и на этапе реконвалесценции. Таким образом, идеи о значении кисломолочных продуктов для здоровья и долголетия, высказанные более 100 лет назад, получили твердое научное обоснование и исследования в этом направлении продолжаются.</p></abstract><trans-abstract xml:lang="en"><p>Since antiquity people have known about the health benefits of fermented milk products. These products are obtained by lactic acid fermentation using various microorganisms, but primarily Lactobacillus spp. The number of varieties of fermented milk products is large. The most famous are yogurt, kefir, lapper milk, baked yogurt, sour cream. Yogurt is made using sourdough including Streptococcus thermophilus and Lactobacillus bulgaricus. Numerous positive effects of yoghurts are shown, including the antibacterial effect against many pathogenic microorganisms. Yogurt, like other fermented milk products, have a reduced lactose content compared to whole milk, which allows people with lactase deficiency to consume this product. In addition, the protein of fermented milk products is more accessible to enzymes of the gastrointestinal tract and is easier to digest. The hypocholesterolemic effect of yogurt is also shown. Fermented milk products, including yogurt, are recommended for baby food. In particular, the efficacy of drinking yogurt enriched with prebiotics and probiotics is shown for both healthy children and children with functional disorders of the gastrointestinal tract, disorders of the intestinal microflora, whose who is sick often and long, as well as in the acute period of acute respiratory viral infections and at the convalescence stage. Thus, the ideas about the importance of fermented milk products for health and longevity, expressed more than 100 years ago, today have a solid scientific basis and research in this direction continues.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>молоко</kwd><kwd>кисломолочные продукты</kwd><kwd>йогурт</kwd><kwd>молочнокислые бактерии</kwd><kwd>лактобациллы</kwd><kwd>пробиотики</kwd><kwd>кишечная микрофлора</kwd><kwd>функциональные желудочно-кишечные расстройства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>milk</kwd><kwd>fermented milk products</kwd><kwd>yogurt</kwd><kwd>lactic acid bacteria</kwd><kwd>lactobacilli</kwd><kwd>probiotics</kwd><kwd>intestinal microflora</kwd><kwd>functional gastrointestinal disorders</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Swithinbank H., Newman G. Bacteriology of Milk. Editors E. P. Dutton &amp; Co. New York, NY: 1903; 599.</mixed-citation><mixed-citation xml:lang="en">Swithinbank H., Newman G. Bacteriology of Milk. Editors E. P. Dutton &amp; Co. New York, NY: 1903; 599.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Van Slyke L.L., Hart E.B. Chemical changes in the souring of milk and their relations to cottage cheese. Bulletin (New York Agricultural Experiment Station) 1904; 245–260(245): 46.</mixed-citation><mixed-citation xml:lang="en">Van Slyke L.L., Hart E.B. Chemical changes in the souring of milk and their relations to cottage cheese. Bulletin (New York Agricultural Experiment Station) 1904; 245–260(245): 46.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Manchester K.L. Louis Pasteur, fermentation, and a rival. S Afr J Sci 2007; 103: 377–380.</mixed-citation><mixed-citation xml:lang="en">Manchester K.L. Louis Pasteur, fermentation, and a rival. S Afr J Sci 2007; 103: 377–380.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lister J. On the lactic fermentation, and its bearings on pathology. Trans Pathol Soc Lond 1878; 29: 425–467.</mixed-citation><mixed-citation xml:lang="en">Lister J. On the lactic fermentation, and its bearings on pathology. Trans Pathol Soc Lond 1878; 29: 425–467.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lister J. Further contribution to the natural history of bacteria and the germ theory of fermentative changes. J Cell Sci 1873; s2–13: 380–408.</mixed-citation><mixed-citation xml:lang="en">Lister J. Further contribution to the natural history of bacteria and the germ theory of fermentative changes. J Cell Sci 1873; s2–13: 380–408.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Orla-Jensen S. The Lactic Acid Bacteria. Mémoires de L’Académie Royale des Sciences et des Lettres de Danemark, Copenhagen, Denmark: 1919.</mixed-citation><mixed-citation xml:lang="en">Orla-Jensen S. The Lactic Acid Bacteria. Mémoires de L’Académie Royale des Sciences et des Lettres de Danemark, Copenhagen, Denmark: 1919.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Schellhaass S.M., Morris H.A. Rheological and scanning electron microscopic examination of skim milk gels obtained by fermenting with ropy and non-ropy strains of lactic acid bacteria. Food Microstruct 1985; 4: 279–287.</mixed-citation><mixed-citation xml:lang="en">Schellhaass S.M., Morris H.A. Rheological and scanning electron microscopic examination of skim milk gels obtained by fermenting with ropy and non-ropy strains of lactic acid bacteria. Food Microstruct 1985; 4: 279–287.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kulp W.L., Rettger L.F. Comparative study of Lactobacillus acidophilus and Lactobacillus bulgaricus. J Bacteriol 1924; 9: 357–395.</mixed-citation><mixed-citation xml:lang="en">Kulp W.L., Rettger L.F. Comparative study of Lactobacillus acidophilus and Lactobacillus bulgaricus. J Bacteriol 1924; 9: 357–395.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Мечников И.И. Этюды оптимизма. Москва: Наука, 1988; 155.</mixed-citation><mixed-citation xml:lang="en">Mechnikov I.I. Etudes of optimism. Moscow: Nauka, 1988; 155 (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Holzapfel W.H., Haberer P., Geisen R., Björkroth J., Schillinger U. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am J Clin Nutr 2001; 73(suppl): 365S–373S.</mixed-citation><mixed-citation xml:lang="en">Holzapfel W.H., Haberer P., Geisen R., Björkroth J., Schillinger U. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am J Clin Nutr 2001; 73(suppl): 365S–373S.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Holzapfel W.H., Haberer P., Snel J., Schillinger U., Huis in’t Veld J.H. Overview of gut flora and probiotics. Int J Food Microbiol 1998; 41: 85–101. DOI: 10.1016/s0168-1605(98)00044-0</mixed-citation><mixed-citation xml:lang="en">Holzapfel W.H., Haberer P., Snel J., Schillinger U., Huis in’t Veld J.H. Overview of gut flora and probiotics. Int J Food Microbiol 1998; 41: 85–101. DOI: 10.1016/s0168-1605(98)00044-0</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Orla-Jensen S. Dairy Bacteriology. Editor P.S. Arup. Philadelphia. Blakiston’s Son &amp; Co, 1921; 180.</mixed-citation><mixed-citation xml:lang="en">Orla-Jensen S. Dairy Bacteriology. Editor P.S. Arup. Philadelphia. Blakiston’s Son &amp; Co, 1921; 180.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pette J.W., Lolkema H. Yoghurt. 1. Symbiosis and antibiosis in mixed cultures of Lactobacillus bulgaricus and Streptococcus thermophilus. Nederlandsch Melken Zuiveltijdschrift 1950; 4: 197–208.</mixed-citation><mixed-citation xml:lang="en">Pette J.W., Lolkema H. Yoghurt. 1. Symbiosis and antibiosis in mixed cultures of Lactobacillus bulgaricus and Streptococcus thermophilus. Nederlandsch Melken Zuiveltijdschrift 1950; 4: 197–208.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jankov J., Stoyanov I.V. Study on the thermophilic lactobacilli in milk for yoghurt production. Conference Proceedings XVII International Dairy Congress, Section F5. Munich, Germany 1966; 677–680.</mixed-citation><mixed-citation xml:lang="en">Jankov J., Stoyanov I.V. Study on the thermophilic lactobacilli in milk for yoghurt production. Conference Proceedings XVII International Dairy Congress, Section F5. Munich, Germany 1966; 677–680.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pette J. W., Kooy J.S. Bacteriophages in yoghurt. Nederlandsch Melken Zuiveltijdschrift 1952; 6: 233–241.</mixed-citation><mixed-citation xml:lang="en">Pette J. W., Kooy J.S. Bacteriophages in yoghurt. Nederlandsch Melken Zuiveltijdschrift 1952; 6: 233–241.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mocquot G., Hurel C. The selection and use of some microorganisms for the manufacture of fermented and acidified milk products. J Soc Dairy Technol 1970; 23: 130–146.</mixed-citation><mixed-citation xml:lang="en">Mocquot G., Hurel C. The selection and use of some microorganisms for the manufacture of fermented and acidified milk products. J Soc Dairy Technol 1970; 23: 130–146.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cerning J., Bouillanne C., Desmazeaud M.J., Landon M. Isolation and characterization of exocellular polysaccharide produced by Lactobacillus bulgaricus. Biotechnol Lett 1986; 8: 625–628.</mixed-citation><mixed-citation xml:lang="en">Cerning J., Bouillanne C., Desmazeaud M.J., Landon M. Isolation and characterization of exocellular polysaccharide produced by Lactobacillus bulgaricus. Biotechnol Lett 1986; 8: 625–628.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cerning J., Bouillanne C., Desmazeaud M.J., Landon M. Exocellular polysaccharide production by Streptococcus thermophilus. Biotechnol Lett 1988; 10: 255–260.</mixed-citation><mixed-citation xml:lang="en">Cerning J., Bouillanne C., Desmazeaud M.J., Landon M. Exocellular polysaccharide production by Streptococcus thermophilus. Biotechnol Lett 1988; 10: 255–260.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">O’Connor E.B., Barrett E., Fitzgerald G., Hill C., Stanton C., Ross R.P. Production of vitamins, exopolysaccharides and bacteriocins by probiotic bacteria. Probiotic Dairy Products. Editor A.Y. Tamime. Oxford, UK. Blackwell Publishing Ltd., 2005; 167–194.</mixed-citation><mixed-citation xml:lang="en">O’Connor E.B., Barrett E., Fitzgerald G., Hill C., Stanton C., Ross R.P. Production of vitamins, exopolysaccharides and bacteriocins by probiotic bacteria. Probiotic Dairy Products. Editor A.Y. Tamime. Oxford, UK. Blackwell Publishing Ltd., 2005; 167–194.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pette J.W., Lolkema H. Yoghurt. 3. Acid production and aroma formation in yoghurt. Nederlandsch Melken Zuiveltijdschrift 1950; 4: 261–273.</mixed-citation><mixed-citation xml:lang="en">Pette J.W., Lolkema H. Yoghurt. 3. Acid production and aroma formation in yoghurt. Nederlandsch Melken Zuiveltijdschrift 1950; 4: 261–273.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dan T., Wang D., Jin R. L., Zhang H.P., Zhou T.T., Sun T.S. Characterization of volatile compounds in fermented milk using solid-phase microextraction methods coupled with gas chromatography-mass spectrometry. J Dairy Sci 2017; 100: 2488–2500. DOI: 10.3168/jds.2016-11528</mixed-citation><mixed-citation xml:lang="en">Dan T., Wang D., Jin R. L., Zhang H.P., Zhou T.T., Sun T.S. Characterization of volatile compounds in fermented milk using solid-phase microextraction methods coupled with gas chromatography-mass spectrometry. J Dairy Sci 2017; 100: 2488–2500. DOI: 10.3168/jds.2016-11528</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rašić J., Milanović Z. Influence of Str. Diacetilactisculture on the flavour of yoghurt. Conference Proceedings XVII International Dairy Congress, Section F5, Munich, Germany 1966; 637–642.</mixed-citation><mixed-citation xml:lang="en">Rašić J., Milanović Z. Influence of Str. Diacetilactisculture on the flavour of yoghurt. Conference Proceedings XVII International Dairy Congress, Section F5, Munich, Germany 1966; 637–642.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lawrence R.L., Perry G.A. Process for improving the flavor of cultured milk products and the resulting product. Corn Products Company, assignee. US Pat. No. 3,022,176. 1962.</mixed-citation><mixed-citation xml:lang="en">Lawrence R.L., Perry G.A. Process for improving the flavor of cultured milk products and the resulting product. Corn Products Company, assignee. US Pat. No. 3,022,176. 1962.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lilly D.M., Stillwell R.H. Probiotics: Growth-promoting factors produced by microorganisms. Science 1965; 147: 747–748.</mixed-citation><mixed-citation xml:lang="en">Lilly D.M., Stillwell R.H. Probiotics: Growth-promoting factors produced by microorganisms. Science 1965; 147: 747–748.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">FAO/WHO. 2002. Guidelines for the evaluation of probiotics in food. www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf</mixed-citation><mixed-citation xml:lang="en">FAO/WHO. 2002. Guidelines for the evaluation of probiotics in food. www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Vasiljevic T., Shah N.P. Probiotics – from Metchnikoff to bioactives. Int Dairy J 2008; 18: 714–728.</mixed-citation><mixed-citation xml:lang="en">Vasiljevic T., Shah N.P. Probiotics – from Metchnikoff to bioactives. Int Dairy J 2008; 18: 714–728.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Allen S.J., Martinez E.G., Gregorio G.V., Dans L.F. Probiotics for treating acute infectious diarrhoea. Cochrane Data base Syst Rev 2010; (11): CD003048. DOI: 10.1002/14651858.CD003048.pub3</mixed-citation><mixed-citation xml:lang="en">Allen S.J., Martinez E.G., Gregorio G.V., Dans L.F. Probiotics for treating acute infectious diarrhoea. Cochrane Data base Syst Rev 2010; (11): CD003048. DOI: 10.1002/14651858.CD003048.pub3</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hume M.E. Historic perspective: Prebiotics, probiotics, and other alternatives to antibiotics. Poult Sci 2011; 90: 2663–2669. DOI: 10.3382/ps.2010-01030</mixed-citation><mixed-citation xml:lang="en">Hume M.E. Historic perspective: Prebiotics, probiotics, and other alternatives to antibiotics. Poult Sci 2011; 90: 2663–2669. DOI: 10.3382/ps.2010-01030</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Jagielski V.A. Improvement in dietetic compounds from milk. US Pat. No. 117,889. 1871.</mixed-citation><mixed-citation xml:lang="en">Jagielski V.A. Improvement in dietetic compounds from milk. US Pat. No. 117,889. 1871.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Rotch T.M., Kendall A.I. A preparatory study of the bacillus acidophilus in regard to its possible therapeutic use. Am J Dis Child 1911; II(1): 30–38. DOI: 10.1001/archpedi.1911.04100070037004</mixed-citation><mixed-citation xml:lang="en">Rotch T.M., Kendall A.I. A preparatory study of the bacillus acidophilus in regard to its possible therapeutic use. Am J Dis Child 1911; II(1): 30–38. DOI: 10.1001/archpedi.1911.04100070037004</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Marriott W.M. The artificial feeding of athreptic infants. JAMA 1919; 73(16): 1173–1177. DOI: 10.1001/jama.1919.02610420001001</mixed-citation><mixed-citation xml:lang="en">Marriott W.M. The artificial feeding of athreptic infants. JAMA 1919; 73(16): 1173–1177. DOI: 10.1001/jama.1919.02610420001001</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Marriott W.M., Davidson L.T. Acidified whole milk as a routine infant food. J Am Med Assoc 1923; 81: 2007–2009</mixed-citation><mixed-citation xml:lang="en">Marriott W.M., Davidson L.T. Acidified whole milk as a routine infant food. J Am Med Assoc 1923; 81: 2007–2009</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Halpern G.M., Vruwink K.G., van de Water J., Keen C.L., Gershwin M.E. Influence of long-term yogurt consumption in young adults. Int J Immunother 1991; 7: 205–210.</mixed-citation><mixed-citation xml:lang="en">Halpern G.M., Vruwink K.G., van de Water J., Keen C.L., Gershwin M.E. Influence of long-term yogurt consumption in young adults. Int J Immunother 1991; 7: 205–210.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gearing A.J.H., Wadhwa M., Perris A.D. Interleukin 2 stimulates T cell proliferation using a calcium flux. Immunol Lett 1985; 10: 297–302.</mixed-citation><mixed-citation xml:lang="en">Gearing A.J.H., Wadhwa M., Perris A.D. Interleukin 2 stimulates T cell proliferation using a calcium flux. Immunol Lett 1985; 10: 297–302.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Gately M.K., Martz E. Early steps in specific tumor lysis by sensitized mouse T lymphocytes. J Immunol 1979; 122: 482–489.</mixed-citation><mixed-citation xml:lang="en">Gately M.K., Martz E. Early steps in specific tumor lysis by sensitized mouse T lymphocytes. J Immunol 1979; 122: 482–489.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Goulet J., Saucier L., Moineau S. Stimulation of the non-specific immune response of mice by fermented milks. In: National Yogurt Association, ed. Yogurt: nutritional and health properties. McLean, VA: Kirby Lithographics, 1989; 187–200.</mixed-citation><mixed-citation xml:lang="en">Goulet J., Saucier L., Moineau S. Stimulation of the non-specific immune response of mice by fermented milks. In: National Yogurt Association, ed. Yogurt: nutritional and health properties. McLean, VA: Kirby Lithographics, 1989; 187–200.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Perdigon G., Nader de Macias M.E., Alvarez S., Oliver G., Pesce de Ruiz Holgado A.A. Systemic augmentation of the immune response in mice by feeding fermented milks with Lactobacillus casei and Lactobacillus acidophilus. Immunology 1988; 63: 17–23.</mixed-citation><mixed-citation xml:lang="en">Perdigon G., Nader de Macias M.E., Alvarez S., Oliver G., Pesce de Ruiz Holgado A.A. Systemic augmentation of the immune response in mice by feeding fermented milks with Lactobacillus casei and Lactobacillus acidophilus. Immunology 1988; 63: 17–23.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sato K., Saito H., Tomioka H. Enhancement of host resistance against Listeria infection by Lactobacillus casei: activation of liver macrophages and peritoneal macrophages by Lactobacillus casei. Microbiol Immunol 1988; 32:689–98. DOI: 10.1111/j.1348-0421.1988.tb01430.x</mixed-citation><mixed-citation xml:lang="en">Sato K., Saito H., Tomioka H. Enhancement of host resistance against Listeria infection by Lactobacillus casei: activation of liver macrophages and peritoneal macrophages by Lactobacillus casei. Microbiol Immunol 1988; 32:689–98. DOI: 10.1111/j.1348-0421.1988.tb01430.x</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Perdigon G., Nader de Macias M.E., Alvarez S., Oliver G., Pesce de Ruiz Holgado A.A. Enhancement of immune response in mice fed with Streptococcus thermophilus and Lactobacillus acidophilus. J Dairy Sci 1987; 70: 919–926. DOI: 10.3168/jds.S0022-0302(87)80095-4</mixed-citation><mixed-citation xml:lang="en">Perdigon G., Nader de Macias M.E., Alvarez S., Oliver G., Pesce de Ruiz Holgado A.A. Enhancement of immune response in mice fed with Streptococcus thermophilus and Lactobacillus acidophilus. J Dairy Sci 1987; 70: 919–926. DOI: 10.3168/jds.S0022-0302(87)80095-4</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Kitazawa H., Mataumura K., Itoh T., Yamauchi T. Interferon induction in murine peritoneal macrophage by stimulation with Lactobacillus acidophilus. Microbiol Immunol 1992; 36: 311–315. DOI: 10.1111/j.1348-0421.1992.tb01668.x</mixed-citation><mixed-citation xml:lang="en">Kitazawa H., Mataumura K., Itoh T., Yamauchi T. Interferon induction in murine peritoneal macrophage by stimulation with Lactobacillus acidophilus. Microbiol Immunol 1992; 36: 311–315. DOI: 10.1111/j.1348-0421.1992.tb01668.x</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kumura H., Tanoue Y., Tsukahara M., Tanaka T., Shimazaki K. Screening of dairy yeast strains for probiotics applications. J Dairy Sci 2004; 87: 4050–4056. DOI: 10.3168/jds.S0022-0302(04)73546-8</mixed-citation><mixed-citation xml:lang="en">Kumura H., Tanoue Y., Tsukahara M., Tanaka T., Shimazaki K. Screening of dairy yeast strains for probiotics applications. J Dairy Sci 2004; 87: 4050–4056. DOI: 10.3168/jds.S0022-0302(04)73546-8</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Figler M., Mózsik G., Schaffer B., Gasztonyi B., Ács P., Szili B. et al. Effect of special Hungarian probiotic kefir on faecal microflora. World J Gastroenterol 2006; 12(7): 1129–1132. DOI: 10.3748/wjg.v12.i7.1129</mixed-citation><mixed-citation xml:lang="en">Figler M., Mózsik G., Schaffer B., Gasztonyi B., Ács P., Szili B. et al. Effect of special Hungarian probiotic kefir on faecal microflora. World J Gastroenterol 2006; 12(7): 1129–1132. DOI: 10.3748/wjg.v12.i7.1129</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Thoreux K., Schmucker D.L. Kefir Milk Enhances Intestinal Immunity in Young but Not Old Rats. J Nutr 2001; 131: 807–812.</mixed-citation><mixed-citation xml:lang="en">Thoreux K., Schmucker D.L. Kefir Milk Enhances Intestinal Immunity in Young but Not Old Rats. J Nutr 2001; 131: 807–812.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Lopitz-Otsoa F., Remenleria A., Elguezabal N., Garaizar J. Kefir: a symbiotic yeasts-bacteria community with alleged healthy capabilities. Rev Iberoam Micol 2006; 23: 67–74.</mixed-citation><mixed-citation xml:lang="en">Lopitz-Otsoa F., Remenleria A., Elguezabal N., Garaizar J. Kefir: a symbiotic yeasts-bacteria community with alleged healthy capabilities. Rev Iberoam Micol 2006; 23: 67–74.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Bayless T.M., Huang S.-S. Inadequate intestinal digestion of lactose. Am J Clin Nutr 1969; 22: 250–256.</mixed-citation><mixed-citation xml:lang="en">Bayless T.M., Huang S.-S. Inadequate intestinal digestion of lactose. Am J Clin Nutr 1969; 22: 250–256.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Goodenough E.R., Kleyn D.H. Influence of viable yogurt microflora on digestion of lactose by the rat. J Dairy Sci 1976; 59: 601–606.</mixed-citation><mixed-citation xml:lang="en">Goodenough E.R., Kleyn D.H. Influence of viable yogurt microflora on digestion of lactose by the rat. J Dairy Sci 1976; 59: 601–606.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H.S., Gilliland S.E. Lactobacillus acidophilus as a dietary adjunct for milk to aid lactose digestion in humans. J Dairy Sci 1983; 66: 959–966.</mixed-citation><mixed-citation xml:lang="en">Kim H.S., Gilliland S.E. Lactobacillus acidophilus as a dietary adjunct for milk to aid lactose digestion in humans. J Dairy Sci 1983; 66: 959–966.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Kolars J.C., Levitt M.D., Aouji M., Savaiano D.A. Yogurt – An autodigesting source of lactose. N Engl J Med 1984; 310: 1–3.</mixed-citation><mixed-citation xml:lang="en">Kolars J.C., Levitt M.D., Aouji M., Savaiano D.A. Yogurt – An autodigesting source of lactose. N Engl J Med 1984; 310: 1–3.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Oppenheim J.J., Togawa A., Chedid L., Mizel S. Components of microbacteria and muramyl dipeptide with adjuvant activity induced lymphocyte activating factor. Cell Immunol 1980; 50: 71–81.</mixed-citation><mixed-citation xml:lang="en">Oppenheim J.J., Togawa A., Chedid L., Mizel S. Components of microbacteria and muramyl dipeptide with adjuvant activity induced lymphocyte activating factor. Cell Immunol 1980; 50: 71–81.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Forster K.A. The vitamin content of the sour milk products, yoghurt, kefir and saya. Biochem Z 1931; 236: 276–297.</mixed-citation><mixed-citation xml:lang="en">Forster K.A. The vitamin content of the sour milk products, yoghurt, kefir and saya. Biochem Z 1931; 236: 276–297.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Tufano M.A., Cipollaro de l’Ero G., Ianniello R., Galdiero M., Galdiero F. Protein A and other surface components of Staphylococcus aureus stimulate production of IL-1 alpha, IL-4, IL-6, TNF and IFN-gamma. Eur Cytokine Netw 1991; 2(5): 361–366.</mixed-citation><mixed-citation xml:lang="en">Tufano M.A., Cipollaro de l’Ero G., Ianniello R., Galdiero M., Galdiero F. Protein A and other surface components of Staphylococcus aureus stimulate production of IL-1 alpha, IL-4, IL-6, TNF and IFN-gamma. Eur Cytokine Netw 1991; 2(5): 361–366.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Goulet J., Saucier L., Moineau S. Stimulation of the non-specific immune response of mice by fermented milks. In: National Yogurt Association, ed. Yogurt: nutritional and health properties. McLean, VA: Kirby Lithographics, 1989: 187–200.</mixed-citation><mixed-citation xml:lang="en">Goulet J., Saucier L., Moineau S. Stimulation of the non-specific immune response of mice by fermented milks. In: National Yogurt Association, ed. Yogurt: nutritional and health properties. McLean, VA: Kirby Lithographics, 1989: 187–200.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Mann G. V., Spoerry A. Studies of a surfactant and cholesteremia in the Maasai. Am J Clin Nutr 1974; 27: 464–469.</mixed-citation><mixed-citation xml:lang="en">Mann G. V., Spoerry A. Studies of a surfactant and cholesteremia in the Maasai. Am J Clin Nutr 1974; 27: 464–469.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Mann G.V. A factor in yogurt which lowers cholesteremia in man. Atherosclerosis 1977; 26: 335–340.</mixed-citation><mixed-citation xml:lang="en">Mann G.V. A factor in yogurt which lowers cholesteremia in man. Atherosclerosis 1977; 26: 335–340.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Ejtahed H.S., Mohtadi-Nia J., Homayouni-Rad A., Niafar M., Asghari-Jafarabadi M., Mofid V. et al. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci 2011; 94: 3288–3294. DOI: 10.3168/jds.2010-4128</mixed-citation><mixed-citation xml:lang="en">Ejtahed H.S., Mohtadi-Nia J., Homayouni-Rad A., Niafar M., Asghari-Jafarabadi M., Mofid V. et al. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci 2011; 94: 3288–3294. DOI: 10.3168/jds.2010-4128</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Sayon-Orea C., Martínez-González M.A., Ruiz-Canela M., Bes-Rastrollo M. Associations between yogurt consumption and weight gain and risk of obesity and metabolic syndrome: A systematic review. Adv Nutr 2017; 8: 146S–154S. DOI: 10.3945/an.115.011536</mixed-citation><mixed-citation xml:lang="en">Sayon-Orea C., Martínez-González M.A., Ruiz-Canela M., Bes-Rastrollo M. Associations between yogurt consumption and weight gain and risk of obesity and metabolic syndrome: A systematic review. Adv Nutr 2017; 8: 146S–154S. DOI: 10.3945/an.115.011536</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy G.V., Friend B.A., Shahani K.M., Farmer R.E. Antitumor activity of yogurt components. J Food Prot 1983; 46: 8–11.</mixed-citation><mixed-citation xml:lang="en">Reddy G.V., Friend B.A., Shahani K.M., Farmer R.E. Antitumor activity of yogurt components. J Food Prot 1983; 46: 8–11.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Ayebo A.D., Shahani K.M., Dam R. Antitumor component(s) of yogurt: Fractionation. J Dairy Sci 1981; 64: 2318–2323.</mixed-citation><mixed-citation xml:lang="en">Ayebo A.D., Shahani K.M., Dam R. Antitumor component(s) of yogurt: Fractionation. J Dairy Sci 1981; 64: 2318–2323.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Хавкин А.И., Федотова О.Б., Волынец Г.В., Кошкарова Ю.А., Пенкина Н.А., Комарова О.Н. Результаты проспективного сравнительного открытого рандомизированного исследования по изучению эффективности йогурта, обогащенного пребиотиками и пробиотиками, у детей раннего возраста, перенесших острую респираторную инфекцию. Вопросы детской диетологии 2019; 17(1): 29–37. DOI: 10.20953/1727-5784-2019-1-29-37</mixed-citation><mixed-citation xml:lang="en">Khavkin А.I., Fedotova O.B., Volynets G.V., Koshkarova Yu.A., Penkina N.A., Komarova O.N. The results of a prospective comparative open-label randomised study of the effectiveness of a probioticand prebiotic-fortified yogurt in small children after an acute respiratory infection. Voprosy detskoi dietologii (Pediatric Nutrition) 2019; 17(1): 29–37. DOI: 10.20953/1727-5784-2019-1-29-37 (in Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
