perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2020-65-1-22-29perinatology-1053Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSМетаболические маркеры и окислительный стресс в патогенезе ожирения у детейMetabolic markers and oxidative stress in children’s obesity pathogenesishttps://orcid.org/0000-0003-1820-299XПовароваО. В.PovarovaO. V.

Поварова Оксана Викторовна – к.м.н., ст. науч. сотр. кафедры фармакологии факультета фундаментальной медицины

Москва, Ломоносовский проспект, д. 27, корп. 1

Moscow

oxpovarova@gmail.comhttps://orcid.org/0000-0002-7106-3338ГородецкаяЕ. А.GorodetskayaE. A.

Городецкая Евгения Ароновна – к.б.н., доц. кафедры фармакологии факультета фундаментальной медицины 

Москва, Ломоносовский проспект, д. 27, корп. 1

Moscow

https://orcid.org/0000-0003-0068-2788КалениковаЕ. И.KalenikovaE. I.

Каленикова Елена Игоревна – проф., д.фарм.н., зав. кафедрой фармацевтической химии, фармакогнозии и организации фармацевтического дела факультета фундаментальной медицины 

 Москва, Ломоносовский проспект, д. 27, корп. 1

Moscow

https://orcid.org/0000-0001-8942-4851МедведевО. С.MedvedevO. S.

Медведев Олег Стефанович – д.м.н., проф., зав. кафедрой фармакологии факультета фундаментальной медицины 

Москва, Ломоносовский проспект, д. 27, корп. 1

Moscow

ФГБОУ «Московский государственный университет имени М.В. Ломоносова»РоссияLomonosov Moscow State UniversityRussian Federation2020050320206512229Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20202020Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1053

В обзоре представлен современный взгляд на ожирение как хронический воспалительный процесс в жировой ткани. Ожирение сопровождается изменениями в липидном, белковом, углеводном, минеральном обмене и нарушением гормональной функции жировой ткани как эндо- и паракринного органа. В настоящее время продолжается поиск биохимических маркеров метаболических нарушений при ожирении. Сопряженные с ожирением факторы (гипергликемия, повышенный уровень липидов, инсулинорезистентность, хроническое воспаление, гиперлептинемия, дисфункция эндотелия, нарушение дыхательной функции митохондрий, дефицит минералов и микроэлементов) формируют и усиливают окислительный стресс, что делает его неотъемлемой составляющей патогенеза ожирения и возможных осложнений. С учетом важной роли коэнзима Q10 в антиоксидантной защите тканей обсуждается вопрос взаимосвязи ожирения, а также метаболических нарушений с эндогенным уровнем коэнзима Q10 и возможность использования этого соединения для фармакологической коррекции.

The article presents a modern view of obesity as a chronic inflammation of adipose tissue. Obesity is accompanied by metabolic changes in lipid, protein, carbohydrate, mineral metabolism and disorders in the hormonal function of adipose tissue as an endo- and paracrine organ. At the moment, there are searched the biochemical markers of metabolic disorders of obesity. The obesity-related factors (hyperglycemia, increased lipid levels, insulin resistance, chronic inflammation, hyperleptinemia, endothelial dysfunction, impaired respiratory function of mitochondria, minerals and microelements deficiency) form and increase oxidative stress making it an integral component of the pathogenesis of obesity and possible complications. Given the important role of Q10 coenzyme in antioxidant tissue protection, the authors discuss the relationship of obesity and metabolic disorders to the endogenous levels of Q10 coenzyme and its possible use for pharmacological correction.

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The authors declare that there are no conflicts of interest present.