perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2020-65-2-28-33perinatology-1104Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSРотавирусная инфекция и иммунитет: дискуссионные вопросы клинико-иммунологических исследованийRotavirus infection and immunity: discussion issues of clinical and immunological studieshttps://orcid.org/0000-0001-6335-0487ГорбуновС. Г.GorbunovS. G.

Горбунов Сергей Георгиевич – д.м.н., проф.кафедры детских инфекционных болезней Российской медицинской академии непрерывного профессионального образования

123995 Москва, ул. Баррикадная, д. 2/1

gsgsg70@mail.ruhttps://orcid.org/0000-0002-0895-6707МазанковаЛ. Н.MazankovaL. N.

Мазанкова Людмила Николаевна – д.м.н., проф., зав. кафедрой детских инфекционных болезней Российской медицинской академии непрерывного профессионального образования

123995 Москва, ул. Баррикадная, д. 2/1

 

ОськинА. HOs’kinA. N.

Оськин Александр Николаевич – асп. кафедры детских инфекционных болезней Российской медицинской академии непрерывного профессионального образования

123995 Москва, ул. Баррикадная, д. 2/1

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Professional EducationRussian Federation2020130520206522833Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20202020Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1104

В обзоре представлены данные литературы, касающиеся механизмов иммунного ответа при ротавирусной инфекции. Отмечается ведущая роль факторов врожденного иммунитета в защите организма от ротавируса. Показано, что как клеточное, так и гуморальное звенья иммунной системы имеют большое значение в патогенезе ротавирусной инфекции. В основе протективного эффекта лежит активация системы интерферона и других цитокинов, а также TLR – врожденного иммунного рецептора для двуспиральной РНК ротавируса. Отражены также возрастные аспекты иммунного ответа, которые обусловливают более высокую восприимчивость к ротавирусу в неонатальный период и уменьшают ее с возрастом.

The article reflects the literature data on the immune response mechanisms to rotavirus infection. The authors note that innate immunity factors play the leading role in protecting the organism from rotavirus. They demonstrate that both cellular and humoral components of the immune system are important in the pathogenesis of rotavirus infection. The protective effect is based on the activation of interferon and other cytokines, as well as TLR – innate immune receptor for double-stranded rotavirus RNA. The authors also describe the age-related aspects of the immune response, which cause a higher susceptibility to rotavirus in the neonatal period and its reduction with age.

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The authors declare that there are no conflicts of interest present.