perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2020-65-3-61-77perinatology-1151Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРеспираторные события во время сна у детей первого года жизни и их референтные величиныRespiratory events in sleeping infants of the first year of life and their reference valuesКельмансонИ. А.KelmansonI. A.

Кельмансон Игорь Александрович – д.м.н., проф. кафедры детских болезней лечебного факультета; проф. кафедры клинической психологии

197341 Санкт-Петербург, ул. Аккуратова, д. 2

iakelmanson@hotmail.comИнститут медицинского образования ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России; Санкт-Петербургский государственный институт психологии и социальной работыРоссияInstitute for Medical Education of the Almazov National Medical Research Centre; St. Petersburg State Institute for Psychology and Social WorkRussian Federation2020070720206536177Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20202020Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1151

Приводятся референтные величины важнейших респираторных событий, фиксируемых во время сна по данным полисомнографического обследования 2073 детей первого года жизни. Референтные величины разработаны в соответствии с принятым LMS (лямбда-мю-сигма) алгоритмом сглаживания показателей, максимально приближающего расчетные значения к фактическим данным. Представлены центильные кривые и табличные значения референтных величин индексов, максимальной продолжительности и плотности различных видов апноэ, периодического дыхания, показателей сатурации и индексов десатурации в отдельные фазы сна у детей в возрасте от 1 до 52 нед. Приведенные референтные показатели сопоставляются с имеющимися данными литературы.

The authors present the reference values of the major respiratory events based on polysomnographic evaluation of 2,073 sleeping infants of the first year of life. These reference values were developed in accordance with the adopted LMS (lambda-mu-sigma) algorithm aimed at smoothing and maximal approximation of the calculated values to the real ones. The article describes the centile curves and centile tables of the respiratory events indices, maximal lengths and densities of the different types of apneas, periodic breathing, oxygen saturation and de-saturation indices at different sleep stages of the 1-to-52-week-old infants. The reference values are compared with available literature data.

младенцыполисомнографияреферентные величиныцентильные кривыеinfantspolysomnographyreference valuescentile curvesReferencesBrockmann P.E., Poets A., Poets C.F. Reference values for respiratory events in overnight polygraphy from infants aged 1 and 3 months. Sleep med 2013; 14(12): 1323–1327. DOI: 10.1016/j.sleep.2013.07.016Brockmann P.E., Poets A., Poets C.F. Reference values for respiratory events in overnight polygraphy from infants aged 1 and 3 months. Sleep med 2013; 14(12): 1323–1327. DOI: 10.1016/j.sleep.2013.07.016Scholle S., Wiater A., Scholle H.C. Normative values of polysomnographic parameters in childhood and adolescence: cardiorespiratory parameters. Sleep med 2011; 12 (10): 988–996. DOI: 10.1016/j.sleep.2011.05.006Scholle S., Wiater A., Scholle H.C. Normative values of polysomnographic parameters in childhood and adolescence: cardiorespiratory parameters. Sleep med 2011; 12 (10): 988–996. DOI: 10.1016/j.sleep.2011.05.006Schlüter B., Buschatz D., Trowitzsch E. Polysomnographic reference curves for the first and second year of life. Somnologie 2001; 5 (1): 3–16.Schlüter B., Buschatz D., Trowitzsch E. Polysomnographic reference curves for the first and second year of life. Somnologie 2001; 5 (1): 3–16.Daftary A.S., Jalou H.E., Shively L., Slaven J.E., Davis S.D. Polysomnography reference values in healthy newborns. J Clin Sleep Med 2019; 15(3): 437–443. DOI: 10.5664/jcsm.7670Daftary A.S., Jalou H.E., Shively L., Slaven J.E., Davis S.D. Polysomnography reference values in healthy newborns. J Clin Sleep Med 2019; 15(3): 437–443. DOI: 10.5664/jcsm.7670Hunt C.E., Corwin M.J., Lister G., Weese‐Mayer D.E., Ward S.L.D., Tinsley L.R. et al. Precursors of cardiorespiratory events in infants detected by home memory monitor. Pediatr pulmonol 2008; 43 (1): 87–98. DOI: 10.1002/ppul.20745Hunt C.E., Corwin M.J., Lister G., Weese‐Mayer D.E., Ward S.L.D., Tinsley L.R. et al. Precursors of cardiorespiratory events in infants detected by home memory monitor. Pediatr pulmonol 2008; 43 (1): 87–98. DOI: 10.1002/ppul.20745Kahn A., Groswasser J., Franco P., Kelmanson I., Kato I., Dan B. et al. Breathing during sleep in infancy. Sleep and breathing in children: a developmental approach. New York, 2000; 405–422.Kahn A., Groswasser J., Franco P., Kelmanson I., Kato I., Dan B. et al. Breathing during sleep in infancy. Sleep and breathing in children: a developmental approach. New York, 2000; 405–422.Kelmanson I.A., Groswasser J., Franco P., Kahn A. Sighs during sleep in future victims of sudden infant deaths. Sleep Hypnosis 2003; 5(2): 83–88.Kelmanson I.A., Groswasser J., Franco P., Kahn A. Sighs during sleep in future victims of sudden infant deaths. Sleep Hypnosis 2003; 5(2): 83–88.Berry R.B., Budhiraja R., Gottlieb D.J., Gozal D., Iber C., Kapur V.K. et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. J Сlin Sleep Med 2012; 8 (5): 597–619. DOI: 10.5664/jcsm.2172Berry R.B., Budhiraja R., Gottlieb D.J., Gozal D., Iber C., Kapur V.K. et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. J Сlin Sleep Med 2012; 8 (5): 597–619. DOI: 10.5664/jcsm.2172Razi N.M., DeLauter M., Pandit P.B. Periodic breathing and oxygen saturation in preterm infants at discharge. J Perinatol 2002; 22(6): 442–444.Razi N.M., DeLauter M., Pandit P.B. Periodic breathing and oxygen saturation in preterm infants at discharge. J Perinatol 2002; 22(6): 442–444.Richards J., Alexander J., Shinebourne E., De Swiet M., Wilson A., Southall D. Sequential 22-hour profiles of breathing patterns and heart rate in 110 full-term infants during their first 6 months of life. Pediatrics 1984; 74(5): 763–777.Richards J., Alexander J., Shinebourne E., De Swiet M., Wilson A., Southall D. Sequential 22-hour profiles of breathing patterns and heart rate in 110 full-term infants during their first 6 months of life. Pediatrics 1984; 74(5): 763–777.Curzi-Dascalova L., Peirano P., Christova E. Respiratory Characteristics During Sleep in Healthy Small-for-Gestational Age. Pediatrics 1996; 97(4): 554–559.Curzi-Dascalova L., Peirano P., Christova E. Respiratory Characteristics During Sleep in Healthy Small-for-Gestational Age. Pediatrics 1996; 97(4): 554–559.Horemuzova E., Katz‐Salamon M., Milerad J. Breathing patterns, oxygen and carbon dioxide levels in sleeping healthy infants during the first nine months after birth. Acta Paediatr 2000; 89(11): 1284–1289.Horemuzova E., Katz‐Salamon M., Milerad J. Breathing patterns, oxygen and carbon dioxide levels in sleeping healthy infants during the first nine months after birth. Acta Paediatr 2000; 89(11): 1284–1289.Kato I., Franco P., Groswasser J., Kelmanson I., Togari H., Kahn A. Frequency of obstructive and mixed sleep apneas in 1,023 infants. Sleep 2000; 23(4): 487–492.Kato I., Franco P., Groswasser J., Kelmanson I., Togari H., Kahn A. Frequency of obstructive and mixed sleep apneas in 1,023 infants. Sleep 2000; 23(4): 487–492.Guilleminault C., Ariagno R., Korobkin R., Nagel L., Baldwin R., Coons S. et al. Mixed and obstructive sleep apnea and near miss for sudden infant death syndrome: 2. Comparison of near miss and normal control infants by age. Pediatrics 1979; 64(6): 882–891.Guilleminault C., Ariagno R., Korobkin R., Nagel L., Baldwin R., Coons S. et al. Mixed and obstructive sleep apnea and near miss for sudden infant death syndrome: 2. Comparison of near miss and normal control infants by age. Pediatrics 1979; 64(6): 882–891.Hoppenbrouwers T., Hodgman J.E., Cabal L. Obstructive apnea, associated patterns of movement, heart rate, and oxygenation in infants at low and increased risk for SIDS. Pediatr Pulmonol 1993; 15(1): 1–12.Hoppenbrouwers T., Hodgman J.E., Cabal L. Obstructive apnea, associated patterns of movement, heart rate, and oxygenation in infants at low and increased risk for SIDS. Pediatr Pulmonol 1993; 15(1): 1–12.Montgomery-Downs H.E., O’Brien L.M., Gulliver T.E., Gozal D. Polysomnographic characteristics in normal preschool and early school-aged children. Pediatrics 2006; 117(3): 741–753. DOI: 10.1542/peds.2005-1067Montgomery-Downs H.E., O’Brien L.M., Gulliver T.E., Gozal D. Polysomnographic characteristics in normal preschool and early school-aged children. Pediatrics 2006; 117(3): 741–753. DOI: 10.1542/peds.2005-1067Marcus C.L., Omlin K.J., Basinki D.J., Bailey S.L., Rachal A.B., Von Pechmann W.S. et al. Normal polysomnographic values for children. Am Rev Respir Dis 1992; 146(5): 1235–1239.Marcus C.L., Omlin K.J., Basinki D.J., Bailey S.L., Rachal A.B., Von Pechmann W.S. et al. Normal polysomnographic values for children. Am Rev Respir Dis 1992; 146(5): 1235–1239.Uliel S., Tauman R., Greenfeld M., Sivan Y. Normal polysomnographic respiratory values in children and adolescents. Chest 2004; 125(3): 872–878.Uliel S., Tauman R., Greenfeld M., Sivan Y. Normal polysomnographic respiratory values in children and adolescents. Chest 2004; 125(3): 872–878.Ng D.K., Chan C.-H. A review of normal values of infant sleep polysomnography. Pediatr Neonatol 2013; 54(2): 82–87. DOI: 10.1016/j.pedneo.2012.11.011Ng D.K., Chan C.-H. A review of normal values of infant sleep polysomnography. Pediatr Neonatol 2013; 54(2): 82–87. DOI: 10.1016/j.pedneo.2012.11.011Mitchell R.B. Adenotonsillectomy for obstructive sleep apnea in children: outcome evaluated by pre‐and postoperative polysomnography. Laryngoscope 2007; 117(10): 1844–1854. DOI: 10.1097/MLG.0b013e318123ee56Mitchell R.B. Adenotonsillectomy for obstructive sleep apnea in children: outcome evaluated by pre‐and postoperative polysomnography. Laryngoscope 2007; 117(10): 1844–1854. DOI: 10.1097/MLG.0b013e318123ee56Kelly D.H., Riordan L., Smith M.J. Apnea and periodic breathing in healthy full‐term infants, 12–18 months of age. Pediatr Pulmonol 1992; 13(3): 169–171.Kelly D.H., Riordan L., Smith M.J. Apnea and periodic breathing in healthy full‐term infants, 12–18 months of age. Pediatr Pulmonol 1992; 13(3): 169–171.Thoppil C., Belan M., Cowen C., Mathew O. Behavioral arousal in newborn infants and its association with termination of apnea. J Appl Physiol 1991; 70(6): 2479–2484.Thoppil C., Belan M., Cowen C., Mathew O. Behavioral arousal in newborn infants and its association with termination of apnea. J Appl Physiol 1991; 70(6): 2479–2484.Hunt C.E., Corwin M.J., Lister G., Weese-Mayer D.E., Neuman M.R., Tinsley L. et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. J Pediatr 1999; 135(5): 580–586.Hunt C.E., Corwin M.J., Lister G., Weese-Mayer D.E., Neuman M.R., Tinsley L. et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. J Pediatr 1999; 135(5): 580–586.Poets C., Stebbens V., Southall D. Arterial oxygen saturation and breathing movements during the first year of life. J Dev Physiol 1991; 15(6): 341–345.Poets C., Stebbens V., Southall D. Arterial oxygen saturation and breathing movements during the first year of life. J Dev Physiol 1991; 15(6): 341–345.Poets C.F., Southall D.P. Patterns of oxygenation during periodic breathing in preterm infants. Early Hum Develop 1991; 26(1): 1–12.Poets C.F., Southall D.P. Patterns of oxygenation during periodic breathing in preterm infants. Early Hum Develop 1991; 26(1): 1–12.O’Brien L., Stebbens V., Poets C., Heycock E., Southall D. Oxygen saturation during the first 24 hours of life. Arch Dis Child Fetal Neonatal Ed 2000; 83(1): F35–F38.O’Brien L., Stebbens V., Poets C., Heycock E., Southall D. Oxygen saturation during the first 24 hours of life. Arch Dis Child Fetal Neonatal Ed 2000; 83(1): F35–F38.Poets C., Stebbens V., Lang J., O’Brien L., Southall D., Boon A. Arterial oxygen saturation in healthy term neonates. Eur J Pediatr 1996; 155(3): 219–223.Poets C., Stebbens V., Lang J., O’Brien L., Southall D., Boon A. Arterial oxygen saturation in healthy term neonates. Eur J Pediatr 1996; 155(3): 219–223.

The authors declare that there are no conflicts of interest present.