perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2020-65-3-160-168perinatology-1165Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУFOR THE PRACTITIONERПерспективы использования ферментированных молочных продуктов у детей с первичной гиполактазией взрослого типаProspects of fermented milk products in children with primary hypolactasia of the adult typehttps://orcid.org/0000-0002-4516-4194БогдановаН. М.BogdanovaN. M.

Богданова Наталья Михайловна – к.м.н., доц. кафедры пропедевтики детских болезней

194100 Санкт-Петербург, ул. Литовская, д. 2

natasha.bogdanov@mail.ruhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.

Хавкин Анатолий Ильич – д.м.н., проф., гл. науч. сотр. отдела гастроэнтерологии

125412 Москва, ул. Талдомская, д. 2

https://orcid.org/0000-0002-6980-8046КолобоваО. Л.KolobovaO. L.

Колобова Оксана Леонидовна – к.м.н., доц. кафедры госпитальной педиатрии

194100 Санкт-Петербург, ул. Литовская, д. 2

ФГБОУ ВО Санкт-Петербургский государственный педиатрический медицинский университет Минздрава РоссииРоссияSt. Petersburg State Pediatric Medical UniversityRussian FederationОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБАУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияVeltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical UniversityRussian Federation202008072020653160168Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20202020Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1165

Лактоза (β-галактозил-1,4 глюкоза) – молочный сахар, основной дисахарид грудного молока человека и молока млекопитающих. Кишечная дисахаридаза – лактаза – катализирует гидролиз лактозы. Биологическую функцию фермента контролирует ген лактазы LCT. Возрастная генетически обусловленная особенность экспрессии дисахарида, эпигенетические факторы и естественный отбор индивидуумов с сохраняющейся толерантностью к молочному сахару на протяжении всей жизни разделили популяцию человека по гену LCT на два фенотипа: лактазаперсистентный (устойчивый к лактозе, lactase persistent) и лактазанеустойчивый (lactase non-persistent). Существуют противоречивые данные, что последний вариант фенотипа ассоциирован с низкой абсорбцией кальция и развитием остеопороза. Показано, что регулярное употребление ферментированных пробиотических молочных продуктов лицами с фенотипом lactase non-persistence обеспечивает накопление пиковой минерализации костной ткани и профилактику остеопороза.

Lactose (β-galactosyl-1,4 glucose) is milk sugar, the main disaccharide of human and other mammalian breast milk. Lactase is intestinal disaccharidase that catalyzes the lactose hydrolysis. The lactase gene LCT controls biological function of the enzyme. The age-related genetically determined feature of disaccharide expression, epigenetic factors, and natural selection with persistent tolerance to milk sugar throughout lifetime has divided the human population according to the LCT gene into two phenotypes: lactase persistent and lactase non-persistent. There is conflicting evidence that the latter phenotype is associated with low calcium absorption and the development of osteoporosis. The regular use of fermented probiotic dairy products by individuals with the lactase non-persistence phenotype ensures the accumulation of peak bone mineralization and prevents osteoporosis.

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The authors declare that there are no conflicts of interest present.