perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2020-65-4-41-46perinatology-1199Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSРоль кишечной микрофлоры в патогенезе вторичной гипероксалурии у детейIntestinal micro biota and its role in the pathogenesis of secondary hyperoxaluria in childrenhttps://orcid.org/0000-0002-8070-5785ОбуховаА. Н.ObukhovaA. N.

Обухова Анна Николаевна — аспирант кафедры госпитальной педиатрии.

603950 Нижний Новгород, пл. Минина и Пожарского, д. 10/1

obukhovaanna@mail.ruhttps://orcid.org/0000-0002-8531-3174ХалецкаяО. В.KhaletskayaO. V.

Халецкая Ольга Владимировна — доктор медицинских наук, профессор, заведующий кафедрой госпитальной педиатрии.

603950 Нижний Новгород, пл. Минина и Пожарского, д. 10/1

https://orcid.org/0000-0002-5961-9794ТушЕ. В.TushE. V.

Туш Елена Валерьевна — кандидат медицинских наук, доцент кафедры госпитальной педиатрии.

603950 Нижний Новгород, пл. Минина и Пожарского, д. 10/1

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава РоссииРоссияPrivolzhsky Research Medical UniversityRussian Federation2020230920206544146Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20202020Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1199Цель исследования

Цель исследования. Изложение современных данных о роли кишечной микрофлоры в развитии вторичной гипероксалурии у детей.

Материал и метод

Материал и метод. Критический анализ данных литературы с обобщением имеющихся в настоящее время результатов оригинальных исследований по вкладу микрофлоры кишечника Oxalobacter formigenes, бактерий рода Bifidobacterium и Lactobacillus в предупреждение развития и снижение клинических проявлений вторичной гипероксалурии.

Результаты

Результаты. Представлен обзор современного состояния знаний о факторах риска развития и патогенезе вторичной гипероксалурии. В обзоре рассматривается вклад кишечной микробиоты в предупреждение вторичной гипероксалурии.

Выводы

Выводы. Изучение вклада кишечной микробиоты (в первую очередь O. formigenes, бактерий рода Bifidobacterium и Lactobacillus) в предупреждение вторичной гипероксалурии поможет рационализировать тактику ведения пациентов и разработать новые подходы к профилактике вторичной гипероксалурии.

Objective

Objective. To present modern data on the role of intestinal micro flora in the development of secondary hyperoxaluria in children.

Material and method

Material and method. To analyze literature data and generalize the available results of original studies on intestinal micro flora Oxalobacterformigenes, Bifidobacterium and Lactobacillus bacteria and their role in the prevention and reduction of clinical manifestations of secondary hyperoxaluria.

Results

Results. The authors have presented the current data on the risk factors for the development and pathogenesis of secondary hyperoxaluria. They have described the intestinal micro biota and its role in prevention of secondary hyperoxaluria.

Conclusions

Conclusions. The study of the intestinal micro biota (especially O. formigenes, Bifidobacterium and Lactobacillus bacteria) and its role in the prevention of secondary hyperoxaluria will help to rationalize the management of patients and to develop new approaches to the prevention of secondary hyperoxaluria.

детивторичная гипероксалуриямикрофлора кишечникаOxalobacter formigenesLactobacillusBifidobacteriumchildrensecondary hyperoxaluriaintestinal micro floraOxalobacter formigenesLactobacillusBifidobacteriumReferencesДлин В.В., Османов И.М. Дисметаболическая нефропатия с оксалатно-кальциевой кристаллурией. Эффективная фармакотерапия. Педиатрия 2013; 42: 8-17.Dlin V.V., Osmanov I.M. Dysmetabolic nephropathy with oxalate-calcium crystalluria. Effektivnaya farmakoterapiya. Pediatriya 2013; 42: 8-17. (in Russ.)Борисова Т.П. Гипероксалурия и оксалатно-кальциевая кристаллурия: механизмы развития и возможности коррекции. Мгжнародний журнал пед1атри, акушерства та гшекологп Травень 2016; 9: (3): 51-57.Borisova T.P. Hyperoxaluria and oxalate-calcium crystalluria: mechanisms of development and possibilities of correction. Mezhdunarod-nyy zhurnal pediatrii, akusherstva i ginekologii maya 2016; 9: (3): 51-57. (in Russ.)Степаненко В.М. Клинико-лабораторная характеристика обменной нефропатии у детей. Курортная медицина 2017; 3: 150-157.Stepanenko V.M. Clinical and laboratory characteristics of metabolic nephropathy in children. Kurort-naya meditsina 2017; 3:150-157. (in Russ.)Лойманн Э., Цыгин А.Н., Саркисян А.А. Детская нефрология: практическое руководство. Москва: Литтерра, 2010; 370.Loymann E., Tsygin A.N., Sarkisyan A.A. Pediatric Nephrology: a practical handbook. Moscow: Litterra, 2010; 370. (in Russ.)Аверьянова Н.И., Балуева Л.Г., Иванова Н.В., Рудави-на Т.И. Нарушения обмена щавелевой кислоты у детей. Современные проблемы науки и образования 2015; 3: 174-179.Aver’yanova N.I., Baluyeva L.G., Ivanova N.V., Rudavina T.I. Oxalic acid metabolism disorders in children. Sovremennyye problemy nauki i obrazovaniya 2015; 3: 174179. (in Russ.)Tekgal S., Dogan H.S., Erdem E., Hoebeke P., Kocvara R, Ni-jman J.M. et al. Guidelines on Paediatric Urology. European Society for Paediatric Urology, 2016; 136. http://uroweb.org/ Ссылка активна на 10.12.2018.Tekgal S., Dogan H.S., Erdem E., Hoebeke P., Kocvara R, Ni-jman J.M. et al. Guidelines on Paediatric Urology. European Society for Paediatric Urology, 2016; 136. http://uroweb.org/ Ссылка активна на 10.12.2018.Юрьева Э.А., Длин В.В., Кудин М.В., Новикова Н.Н., Воздвиженская Е.С., Харабадзе М.Н. и др. Обменные нефропатии у детей: причины развития, клинико-лабораторные проявления. Российский вестник перинатологии и педиатрии 2016; 61(2): 28-34.Yur’yeva E.A., Dlin V.V., Kudin M.V., Novikova N.N., Vozdvizhenskaya E.S., Khar-abadze M.N. et al. Metabolic nephropathies in children: causes of development, clinical and laboratory manifestations. Rossiyskiy vestnik perinatologii i pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2016; 61(2): 28-34. (in Russ.)Prezioso D., Strazzullo P., Lotti T, Bianchi G., Borghi L., Cai-one P. et al. Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group. Arch Ital Urol Androl 2016; 88(1): 76. DOI: 10.4081/aiua.2016.1.76.Prezioso D., Strazzullo P., Lotti T, Bianchi G., Borghi L., Cai-one P. et al. Dietary treatment of urinary risk factors for renal stone formation. A review of CLU Working Group. Arch Ital Urol Androl 2016; 88(1): 76. DOI: 10.4081/aiua.2016.1.76.Беляева И.А., Бомбардирова Е.П., Турти Т.В., Ми-тиш М.Д., Потехина Т.В. Кишечная микробиота у недоношенных детей - современное состояние проблемы. Педиатрическая фармакология 2015; 12(3): 296-303.Belyayeva I.A., Bombardirova Ye.P., Turti T.V., Mitish M.D., Potekhina T.V. Intestinal microbiota in preterm infants -current state of the problem. Pediatricheskaya farmakologiya 2015; 12(3): 296-303. (in Russ.)Макарова С.Г., Намазова-Баранова Л.С. Кишечная микробиота и использование пробиотиков в практике педиатра. Что нового? Педиатрическая фармакология 2015; 12(1): 38-45.Makarova S.G., Namazova-Baranova L.S. Intestinal microbiota and the use of probiotics in pediatrician’s practice. What’s new? Pediatricheskaya farmakologiya 2015; 12(1): 38-45. (in Russ.)Holscher H.D. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes 2017; 8(2): 172-184. DOI: 10.1080/19490976.2017.1290756Holscher H.D. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes 2017; 8(2): 172-184. DOI: 10.1080/19490976.2017.1290756Singh R.K., Chang H-W, Yan D., Lee K.M., Ucmak D., Wong K. et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med 2017; 15(1): 73-90. DOI: 10.1186/s12967-017-1175-ySingh R.K., Chang H-W, Yan D., Lee K.M., Ucmak D., Wong K. et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med 2017; 15(1): 73-90. DOI: 10.1186/s12967-017-1175-yYang A.L., Kashyap P.C. A clinical primer of the role of gut microbiome in health and disease. Trop Gastroenterol 2015; 36(1): 1-13.Yang A.L., Kashyap P.C. A clinical primer of the role of gut microbiome in health and disease. Trop Gastroenterol 2015; 36(1): 1-13.Milani C., Duranti S., Bottacini F., Casey E., Turroni F., Ma-hony J. et al. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev 2017; 81(4): 1-67. DOI: 10.1128/MMBR.00036-17Milani C., Duranti S., Bottacini F., Casey E., Turroni F., Ma-hony J. et al. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev 2017; 81(4): 1-67. DOI: 10.1128/MMBR.00036-17Ардатская М.Д., Бельмер С.В., Добрица В.П., Захаренко С.М., Лазебник Л.Б., Минушкин О.Н. и др. Дисбиоз (дисбактериоз) кишечника: современное состояние проблемы, комплексная диагностика и лечебная коррекция. Экспериментальная и клиническая гастроэнтерология 2015; 5: (117):13—50.Ardatskaya M.D., Bel’mer S.V., Dobrit-sa V.P., Zakharenko S.M., Lazebnik L.B., Minushkin O.N. et al. Intestinal dysbiosis: current state of the problem, complex diagnostics and therapeutic correction. Eksperimental’naya i klinicheskaya gastroyenterologiya 2015; 5: (117):13—50. (in Russ.)Власов В.В., Мошкин М.П. Микробный «орган» человека. Наука из первых рук 2014; 1(55): 32-35.Vlasov V.V., Moshkin M.P. Microbial «organ» of the human. Nauka iz per-vykh ruk 2014; 1(55): 32-35. (in Russ.)Siener R., Bangen U., Sidhu H, Honow R., Von Unruh G., Hesse A. The role of Oxalobacter formigenes colonization in calcium oxalate stone disease. Kidney Int 2013; 83(6): 1144-1149. DOI: 10.1038/ki.2013.104.Siener R., Bangen U., Sidhu H, Honow R., Von Unruh G., Hesse A. The role of Oxalobacter formigenes colonization in calcium oxalate stone disease. Kidney Int 2013; 83(6): 1144-1149. DOI: 10.1038/ki.2013.104.Torzewska A. Oxalobacter formigenes-characteristics and role in development of calcium oxalate urolithiasis. Postepy Hig Med Dosw 2013; 27: 1144-1153.Torzewska A. Oxalobacter formigenes-characteristics and role in development of calcium oxalate urolithiasis. Postepy Hig Med Dosw 2013; 27: 1144-1153.Дорофеев А.Э., Руденко Н.Н., Деркач И.А., Чечула Ю.В. Заболевания кишечника и почки. Гастроэнтерология 2015; 3: (57): 101-105.Dorofeyev A.E., Rudenko N.N., Der-kach I.A., Chechula Yu.V. Diseases of the intestines and kidneys. Gastroenterologiya 2015; 3: (57): 101-105. (in Russ.)Allison M.J., Dawson K.A., Mayberry W.R., Foss J.G. Oxalo-bacter formigenes gen. nov., sp. nov.: oxalate-degrading anaerobes that inhabit the gastrointestinal tract. Arch Microbiol 1985; 141: 1-7.Allison M.J., Dawson K.A., Mayberry W.R., Foss J.G. Oxalo-bacter formigenes gen. nov., sp. nov.: oxalate-degrading anaerobes that inhabit the gastrointestinal tract. Arch Microbiol 1985; 141: 1-7.Dawson K.A., Allison K.A., Hartman P.A. Isolation and some characteristics of anaerobic oxalate-degrading bacteria from the rumen. Appl Environ Microbiol 1980; 40(4): 833-839.Dawson K.A., Allison K.A., Hartman P.A. Isolation and some characteristics of anaerobic oxalate-degrading bacteria from the rumen. Appl Environ Microbiol 1980; 40(4): 833-839.Knight J., Deora R., Assimos D.G., Holmes R.P. The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease. Urolithiasis 2013; 41(3): 187-196.Knight J., Deora R., Assimos D.G., Holmes R.P. The genetic composition of Oxalobacter formigenes and its relationship to colonization and calcium oxalate stone disease. Urolithiasis 2013; 41(3): 187-196.Mehta M., Nazzal L. The role of the microbiome in kidney stone formation. Int J Surg 2016; 36: 607-612. DOI: 10.1016/j.ijsu.2016.11.024Mehta M., Nazzal L. The role of the microbiome in kidney stone formation. Int J Surg 2016; 36: 607-612. DOI: 10.1016/j.ijsu.2016.11.024Miller A.W., Oakeson K.F., Dale C., Dearing M.D. Microbial community transplant results in increased and long-term oxalate degradation. Microb Ecol 2016; 72(2): 470-478. DOI: 10.1007/s00248-016-0800-2.Miller A.W., Oakeson K.F., Dale C., Dearing M.D. Microbial community transplant results in increased and long-term oxalate degradation. Microb Ecol 2016; 72(2): 470-478. DOI: 10.1007/s00248-016-0800-2.Шестаев А.Ю., Паронников М.В., Протощак В.В., Бабкин П.А., Гулько А.М. Метаболизм оксалата и роль Ox-alobacter formigenes в развитии мочекаменной болезни. Экспериментальная и клиническая урология 2013; 2: 68-73.Shestayev A.Yu., Paronnikov M.V., Protoshchak V.V., Babkin P.A., Gul’ko A.M. Oxalate metabolism and the role of Oxalobacter formigenes in the development of urolithiasis. Eksperimental’naya i klinicheskaya urologiya 2013; 2: 68-73. (in Russ.)Herve V., Junier T., Bindschedler S., Verrecchia E., Junier P. Diversity and ecology of oxalotrophic bacteria. World J Microbiol Biotechnol 2016; 32(2): 28-36. DOI: 10.1007/s11274-015-1982-3Herve V., Junier T., Bindschedler S., Verrecchia E., Junier P. Diversity and ecology of oxalotrophic bacteria. World J Microbiol Biotechnol 2016; 32(2): 28-36. DOI: 10.1007/s11274-015-1982-3Peck A.B., Canales B.K., Nguyen C.Q. Oxalate-degrading microorganisms or oxalate-degrading enzymes: which is the future therapy for enzymatic dissolution of calcium-oxalate uroliths in recurrent stone disease? Urolithiasis 2016; 44(1): 45-50. DOI: 10.1007/s00240-015-0845-6Peck A.B., Canales B.K., Nguyen C.Q. Oxalate-degrading microorganisms or oxalate-degrading enzymes: which is the future therapy for enzymatic dissolution of calcium-oxalate uroliths in recurrent stone disease? Urolithiasis 2016; 44(1): 45-50. DOI: 10.1007/s00240-015-0845-6Whittamore J., Hatch M. The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man. Urolithiasis 2017; 45(1): 89-108. DOI: 10.1007/s00240-016-0952-zWhittamore J., Hatch M. The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man. Urolithiasis 2017; 45(1): 89-108. DOI: 10.1007/s00240-016-0952-zPeBenito A., Nazzal L., Wang C., Li H., Noya-Alarcon O., Contreras M. et al. Comparative prevalence of Oxalobacter formigenes in three human populations. Sci Rep 2019; 9(1): 574. DOI: 10.1038/s41598-018-36670-zPeBenito A., Nazzal L., Wang C., Li H., Noya-Alarcon O., Contreras M. et al. Comparative prevalence of Oxalobacter formigenes in three human populations. Sci Rep 2019; 9(1): 574. DOI: 10.1038/s41598-018-36670-zArvans D., Jung Y.C., Antonopoulos D., Koval J., Granja I., Bashir M. et al. Oxalobacter formigenes - derived bioactive factors stimulate oxalate transport by intestinal epithelial cells. J Am Soc Nephrol 2017; 28(3): 876-887. DOI: 10.1681/ASN.2016020132Arvans D., Jung Y.C., Antonopoulos D., Koval J., Granja I., Bashir M. et al. Oxalobacter formigenes - derived bioactive factors stimulate oxalate transport by intestinal epithelial cells. J Am Soc Nephrol 2017; 28(3): 876-887. DOI: 10.1681/ASN.2016020132Krawczyk B., Kur J., Stojowska-Swedrzynska K., Spibida M. Principles and applications of ligation mediated PCR methods for DNA-based typing of microbial organisms. Acta Bio-chim Pol 2016; 63(1): 39-52. DOI: 10.18388/abp.2015_1192Krawczyk B., Kur J., Stojowska-Swedrzynska K., Spibida M. Principles and applications of ligation mediated PCR methods for DNA-based typing of microbial organisms. Acta Bio-chim Pol 2016; 63(1): 39-52. DOI: 10.18388/abp.2015_1192Assimos D. Sensitivity of human strains of Oxalobacter for-migenes to commonly prescribed antibiotics. J Urol 2013; 189(1): 171-172. DOI: 10.1016/j.juro.2012.09.124Assimos D. Sensitivity of human strains of Oxalobacter for-migenes to commonly prescribed antibiotics. J Urol 2013; 189(1): 171-172. DOI: 10.1016/j.juro.2012.09.124Mehta M., Goldfarb D., Nazzal L. The role of the microbiome in kidney stone formation. Int J Surg 2016; 36: 607-612. DOI: 10.1016/j.ijsu.2016.11.024Mehta M., Goldfarb D., Nazzal L. The role of the microbiome in kidney stone formation. Int J Surg 2016; 36: 607-612. DOI: 10.1016/j.ijsu.2016.11.024Sadaf H., Raza S., Hassan S. Role of gut microbiota against calcium oxalate. Microb Pathog 2017; 109: 287-291. DOI: 10.1016/j.micpath.2017.06.009Sadaf H., Raza S., Hassan S. Role of gut microbiota against calcium oxalate. Microb Pathog 2017; 109: 287-291. DOI: 10.1016/j.micpath.2017.06.009Goldstein E.J., Tyrrell K.L. Citron D.M. Lactobacillus species: taxonomic complexity and controversial susceptibilities. Clin Infect Dis 2015; 60: 98-107. DOI: 10.1093/cid/civ072Goldstein E.J., Tyrrell K.L. Citron D.M. Lactobacillus species: taxonomic complexity and controversial susceptibilities. Clin Infect Dis 2015; 60: 98-107. DOI: 10.1093/cid/civ072Bull M., Plummer S., Marchesi J., Mahenthiralingam E. The life history of Lactobacillus acidophilus as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success. FEMS Microbiol Lett 2013; 349(2): 77-87. DOI: 10.1111/1574-6968.12293Bull M., Plummer S., Marchesi J., Mahenthiralingam E. The life history of Lactobacillus acidophilus as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success. FEMS Microbiol Lett 2013; 349(2): 77-87. DOI: 10.1111/1574-6968.12293Zhao C., Yang H., Zhu X., Li Y., Wang N., Han S. et al. Oxalate-degrading enzyme recombined lactic acid bacteria strains reduce hyperoxaluria. Urology 2018; 113: 253.e1-253.e7. DOI: 10.1016/j.urology.2017.11.038Zhao C., Yang H., Zhu X., Li Y., Wang N., Han S. et al. Oxalate-degrading enzyme recombined lactic acid bacteria strains reduce hyperoxaluria. Urology 2018; 113: 253.e1-253.e7. DOI: 10.1016/j.urology.2017.11.038Di Cerbo A., Palmieri B., Aponte M., Morales-Medina J.C. Lannitti T. Mechanisms and therapeutic effectiveness of lactobacilli. J Clin Pathol 2016; 69(3): 187-203. DOI: 10.1136/jclinpath-2015-202976Di Cerbo A., Palmieri B., Aponte M., Morales-Medina J.C. Lannitti T. Mechanisms and therapeutic effectiveness of lactobacilli. J Clin Pathol 2016; 69(3): 187-203. DOI: 10.1136/jclinpath-2015-202976Sasikumar P., Gomathi S., Anbazhagan K., Abhishek A., Paul E., Vasudevan V. et al. Recombinant Lactobacillus plantarum expressing and secreting heterologous oxalate decarboxylase prevents renal calcium oxalate stone deposition in experimental rats. J Biomed Sci 2014; 30: 86-99. DOI: 10.1186/s12929-014-0086-ySasikumar P., Gomathi S., Anbazhagan K., Abhishek A., Paul E., Vasudevan V. et al. Recombinant Lactobacillus plantarum expressing and secreting heterologous oxalate decarboxylase prevents renal calcium oxalate stone deposition in experimental rats. J Biomed Sci 2014; 30: 86-99. DOI: 10.1186/s12929-014-0086-yPaul E., Albert A., Ponnusamy S., Srishti R.M., Amalraj G.V., Selvi M.S. et al. Designer probiotic Lactobacillus plantarum expressing oxalate decarboxylase developed using group II in-tron degrades intestinal oxalate in hyperoxaluric rats. Microbiol Res 2018; 215: 65-75.Paul E., Albert A., Ponnusamy S., Srishti R.M., Amalraj G.V., Selvi M.S. et al. Designer probiotic Lactobacillus plantarum expressing oxalate decarboxylase developed using group II in-tron degrades intestinal oxalate in hyperoxaluric rats. Microbiol Res 2018; 215: 65-75.Anbazhagan K., Sasikumar P., Sivasamy G., Palaniswamy H. In vitro degradation of oxalate by recombinant Lactobacillus plan-tarum expressing heterologous oxalate decarboxylase. J Appl Microbiol 2013; 115(3): 880-887. DOI: 10.1111/jam.12269Anbazhagan K., Sasikumar P., Sivasamy G., Palaniswamy H. In vitro degradation of oxalate by recombinant Lactobacillus plan-tarum expressing heterologous oxalate decarboxylase. J Appl Microbiol 2013; 115(3): 880-887. DOI: 10.1111/jam.12269Sasikumar P., Gomathi S., Anbazhagan K., Selvam G.S. Secretion of biologically active heterologous oxalate decarboxylase (OxdC) in Lactobacillus plantarum WCFS1 using homologous signal peptides. Biomed Res Int 2013; 1—9. DOI: 10.1155/2013/280432Sasikumar P., Gomathi S., Anbazhagan K., Selvam G.S. Secretion of biologically active heterologous oxalate decarboxylase (OxdC) in Lactobacillus plantarum WCFS1 using homologous signal peptides. Biomed Res Int 2013; 1—9. DOI: 10.1155/2013/280432Gomathi G., Sasikumar P., Anbazhagan K., Sasikumar S., Ka-vitha M., Selvi M.S. Screening of indigenous oxalate degrading lactic acid bacteria from human faeces and South Indian fermented foods: assessment of probiotic potential. Sci World J 2014; 4: 1-11. DOI: 10.1155/2014/648059Gomathi G., Sasikumar P., Anbazhagan K., Sasikumar S., Ka-vitha M., Selvi M.S. Screening of indigenous oxalate degrading lactic acid bacteria from human faeces and South Indian fermented foods: assessment of probiotic potential. Sci World J 2014; 4: 1-11. DOI: 10.1155/2014/648059Murru N., Blaiotta G., Peruzy M.F., Santonicola S., Mercogli-ano R., Aponte M. Screening of oxalate degrading lactic acid bacteria of food origin. Ital J Food Saf 2017; 6(2): 61-64. DOI: 10.4081/ijfs.2017.6345Murru N., Blaiotta G., Peruzy M.F., Santonicola S., Mercogli-ano R., Aponte M. Screening of oxalate degrading lactic acid bacteria of food origin. Ital J Food Saf 2017; 6(2): 61-64. DOI: 10.4081/ijfs.2017.6345Sanders M.E. Probiotics and microbiota composition. BMC Med 2016; 14(1): 82-84. DOI: 10.1186/s12916-016-0629-z.Sanders M.E. Probiotics and microbiota composition. BMC Med 2016; 14(1): 82-84. DOI: 10.1186/s12916-016-0629-z.Mogna L., Pane M., Nicola S., Raiteri E. Screening of different probiotic strains for their in vitro ability to metabolise oxalates: any prospective use in humans? J Clin Gastroenterol 2014; 48: 91-95. DOI: 10.1097/MCG.0000000000000228Mogna L., Pane M., Nicola S., Raiteri E. Screening of different probiotic strains for their in vitro ability to metabolise oxalates: any prospective use in humans? J Clin Gastroenterol 2014; 48: 91-95. DOI: 10.1097/MCG.0000000000000228Fontana L., Bermudez-Brito M., Plasa-Diaz J., Munoz.-Quez.a-da S., Gil A. Sources, isolation, characterisation and evaluation of probiotics. Br J Nutr 2013; 109: 35-50. DOI: 10.1017/S0007114512004011Fontana L., Bermudez-Brito M., Plasa-Diaz J., Munoz.-Quez.a-da S., Gil A. Sources, isolation, characterisation and evaluation of probiotics. Br J Nutr 2013; 109: 35-50. DOI: 10.1017/S0007114512004011Esaiassen E., Hjerde E., Cavanagh J.P., Simonsen G.S., Klin-genberrg C. et al. Bifidobacterium bacteremia: clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol 2017; 55(7): 2234-2248. DOI: 10.1128/JCM.00150-17Esaiassen E., Hjerde E., Cavanagh J.P., Simonsen G.S., Klin-genberrg C. et al. Bifidobacterium bacteremia: clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol 2017; 55(7): 2234-2248. DOI: 10.1128/JCM.00150-17Klimesova K., Whittamore J., Hatch M. Bifidobacterium an-imalis subsp. lactis decreases urinary oxalate excretion in a mouse model of primary hyperoxaluria. Urolithiasis 2015; 43(2): 107-117. DOI: 10.1007/s00240-014-0728-2Klimesova K., Whittamore J., Hatch M. Bifidobacterium an-imalis subsp. lactis decreases urinary oxalate excretion in a mouse model of primary hyperoxaluria. Urolithiasis 2015; 43(2): 107-117. DOI: 10.1007/s00240-014-0728-2

The authors declare that there are no conflicts of interest present.