perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2020-65-6-122-128perinatology-1300Research ArticleОБМЕН ОПЫТОМSHARING EXPERIENCESТрудности диагностики и лечения болезни Кавасаки у детейDifficulties in Kawasaki Disease Diagnosis and Treatment in Childrenhttps://orcid.org/0000-0002-9025-9141ДобровановА. Е.DobrovanovA. E.

Доброванов Александр Евгеньевич – к.м.н., врач-педиатр и сотрудник кафедры педиатрии; сотрудник Университета здоровья и социальных наук Святой Елизаветы

85107, Братислава, ул. Антолская, д. 11

Oleksandr Dobrovanov - MBA – Masterof Business Administration

Bratislava

Vinnytsya

https://orcid.org/0000-0001-6067-681XДмитриевД.DmytrievD.

Дмитриев Дмитрий Валерьевич – д.м.н., проф. кафедры хирургии №1 с курсом анестезиологии и интенсивной терапии; рук. Центра лечения боли, зав. отделением анестезиологии и реанимации 

21018, Винница, ул. Пирогова, д. 56 

Dmytro Dmytriiev

Vinnytsya

https://orcid.org/0000-0001-7892-0243ДмитриеваЕ. Ю.DmytrievaK. Yu.

Дмитриева Екатерина Юрьевна (Dmytriieva Kateryna) – врач ультразвуковой диагностики высшей квалификационной категории, доц.

21018, Винница, ул. Пирогова, д. 56

Dmytriieva Kateryna

Vinnytsya

ГуштявоваЛ.HustavovaL.

Lucia Hustavova - PhD

Клиника детей и подростков А. Гетлика Словацкого медицинского университета и университетской больницы; Университет здоровья и социальных наук Святой Елизаветы; Винницкий национальный медицинский университет им. Н.И. ПироговаСловакияA. Getlik Clinic for Children and Adolescents, Slovak Medical University and University Hospital; St. Elizabeth University of Health and Social Sciences; National Pirogov Memorial Medical UniversitySlovakiaВинницкий национальный медицинский университет им. Н.И. Пирогова; Отделение анестезиологии, реанимации и лечения боли Винницкого областного эндокринологического центраУкраинаNational Pirogov Memorial Medical University; Department of Anesthesiology, Intensive Care Unit and Pain Medicine, Vinnytsya Regional Clinical Endocrinology CenterUkraineВинницкий национальный медицинский университет им. Н.И. ПироговаУкраинаNational Pirogov Memorial Medical UniversityUkraineСловацкий медицинский университет, хирургическая клиника №1 лечебного факультета Словацкого медицинского университета и Детского госпиталя в БратиславеСловакияSlovak Medical University, 1st Department of Surgery, Faculty of Medicine, SMU and UNB, Children's HospitalSlovakia202021012021656122128Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20212021Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1300

Болезнь Кавасаки – острый васкулит, характерный для детского возраста, поражающий артерии среднего калибра и приводящий к развитию аневризм коронарных артерий примерно у 25% нелеченых пациентов. Это заболевание служит одной из причин приобретенных заболеваний сердца у детей в экономически развитых странах. Причина болезни Кавасаки остается неизвестной. Статья основана на текущих рекомендациях и клиническом случае, особое внимание обращено на необходимость ранней диагностики и адекватного лечения, так как только ранняя диагностика и своевременное лечение пациентов с этим заболеванием предотвращают повреждение коронарных артерий.

The Kawasaki disease is the acute vasculitis specific to the childhood that affects the medium-sized arteries and causes the coronary aneurysms in about 25% of the patients untreated. This disease is one of the causes of the heart diseases acquired in the children in the economically developed countries. The cause of the Kawasaki disease remains unknown. The Article is based on the current guidelines and clinical case, with special focus on the necessity of the early diagnosis and proper treatment, since only early diagnosis and timely treatment of the patients with this disease prevent the damage of the coronary arteries.

детиболезнь Кавасакихолестазаневризмакоронарные артериивнутривенные иммуноглобулиныацетилсалициловая кислотаchildrenKawasaki diseasecholestasiscoronary arteryaneurysmsintravenous immunoglobulinsacetylsalicylic acidReferencesMajerova L., Olejnik P., Vrsanska V. Diagnosis and treatment of Kawasaki disease in children and its coronary complications. Pediatr Prax 2018; 19(5): 224–228.Majerova L., Olejnik P., Vrsanska V. Diagnosis and treatment of Kawasaki disease in children and its coronary complications. Pediatr Prax 2018; 19(5): 224–228.McCrindle B.W., Rowley A.H., Newburger J.W., Burns A.F., Bolger M.G., Annette L.B. et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals from the American Heart Association [online]. Circulation 2017; 135: e927–e999. DOI: 10.1161/CIR.0000000000000484McCrindle B.W., Rowley A.H., Newburger J.W., Burns A.F., Bolger M.G., Annette L.B. et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals from the American Heart Association [online]. Circulation 2017; 135: e927–e999. DOI: 10.1161/CIR.0000000000000484Геппе Н.А., Подчерняева Н.С., Лыскина Г.А. Руководство по детской ревматологии. М.: ГЭОТАР-Медиа, 2011; 720. [Geppe N.A., Podchernjaeva N.S., Lyskina G.A. Guidelines for Pediatric Rheumatology. Moscow: GEOTAR-Media, 2011; 720. (in Russ.)]Геппе Н.А., Подчерняева Н.С., Лыскина Г.А. Руководство по детской ревматологии. М.: ГЭОТАР-Медиа, 2011; 720. [Geppe N.A., Podchernjaeva N.S., Lyskina G.A. Guidelines for Pediatric Rheumatology. Moscow: GEOTAR-Media, 2011; 720. (in Russ.)]Lyskina G.A., Shirinskaya O.G. Clinical manifestation, diagnostics and treatment of Kawasaki disease: known data and unsolved questions. Voprosy sovremennoi pediatrii (Current Pediatrics) 2013; 12(1): 63–73.Lyskina G.A., Shirinskaya O.G. Clinical manifestation, diagnostics and treatment of Kawasaki disease: known data and unsolved questions. Voprosy sovremennoi pediatrii (Current Pediatrics) 2013; 12(1): 63–73.Baker A.L., Lu M., Minich L.L., Atz A.M., Klein G.L., Korsin R. et al. Associated symptoms in the ten days before diagnosis of Kawasaki disease. J Pediatr 2009; 154: 592–595.Baker A.L., Lu M., Minich L.L., Atz A.M., Klein G.L., Korsin R. et al. Associated symptoms in the ten days before diagnosis of Kawasaki disease. J Pediatr 2009; 154: 592–595.Verdoni L., Mazza A., Gervasoni A., Martelli L., Ruggeri M., Ciuffreda M. et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 2020; 395(10239): 1771–1778. DOI: https://doi.org/10.1016/S0140-6736(20)31103-XVerdoni L., Mazza A., Gervasoni A., Martelli L., Ruggeri M., Ciuffreda M. et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 2020; 395(10239): 1771–1778. DOI: https://doi.org/10.1016/S0140-6736(20)31103-XScheinfeld N.S., Jones E.L., Ogershok P.R., Parrillo S.J. Kawasaki disease [online]. Diseases Conditions. 2017; https://emedicine.medscape.com/article/965367-overview#a5Scheinfeld N.S., Jones E.L., Ogershok P.R., Parrillo S.J. Kawasaki disease [online]. Diseases Conditions. 2017; https://emedicine.medscape.com/article/965367-overview#a5Gedalia A. Kawasaki disease: 40 years after the original report [online]. Curr Rheumatol Rep 2007; 9(4): 336–341. DOI: 10.1007/s11926-007-0053-7Gedalia A. Kawasaki disease: 40 years after the original report [online]. Curr Rheumatol Rep 2007; 9(4): 336–341. DOI: 10.1007/s11926-007-0053-7Newburger J.W., Takahashi M., Gerber M.A., Lloyd Y.T., Jane C.B., Stanford T. et al. Diagnosis, treatment, and longterm management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004; 110: 2747–2771. DOI: 10.1161/01.CIR.0000145143.19711.78Newburger J.W., Takahashi M., Gerber M.A., Lloyd Y.T., Jane C.B., Stanford T. et al. Diagnosis, treatment, and longterm management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004; 110: 2747–2771. DOI: 10.1161/01.CIR.0000145143.19711.78Lin K.H., Chang S.S., Yu C.W., Lin S.C., Liu S.C., Chao H.I. et al. Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: A systematic review and meta-analysis [online]. BMJ Open 2015; 5: 1. DOI: 10.1136/bmjopen-2014-006703Lin K.H., Chang S.S., Yu C.W., Lin S.C., Liu S.C., Chao H.I. et al. Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: A systematic review and meta-analysis [online]. BMJ Open 2015; 5: 1. DOI: 10.1136/bmjopen-2014-006703Margossian R., Lu M., Minich L.L., Bradley T.J., Cohen M.S., Li J.S., et al. Pediatric Heart Network Investigators. Predictors of coronary artery visualization in Kawasaki disease. J Am Soc Echocardiogr 2011; 24: 53–59. DOI: 10.1016/j.echo.2010.10.015Margossian R., Lu M., Minich L.L., Bradley T.J., Cohen M.S., Li J.S., et al. Pediatric Heart Network Investigators. Predictors of coronary artery visualization in Kawasaki disease. J Am Soc Echocardiogr 2011; 24: 53–59. DOI: 10.1016/j.echo.2010.10.015Olejnik P., Boruta P., Glezlova A., Bordacova L., Masura J. The first experiences with the high-resolution multi-slice CT-angiography in pediatric cardiology in Slovakia. Bratisl Med J 2008; 109(5): 220–223Olejnik P., Boruta P., Glezlova A., Bordacova L., Masura J. The first experiences with the high-resolution multi-slice CT-angiography in pediatric cardiology in Slovakia. Bratisl Med J 2008; 109(5): 220–223Kardos M., Olejnik P., Culen M., Masura J. Indication criteria for cardiac CT and MRI in patients with congenital heart defects. Kardiol Prax 2013; 11(4): 185–189.Kardos M., Olejnik P., Culen M., Masura J. Indication criteria for cardiac CT and MRI in patients with congenital heart defects. Kardiol Prax 2013; 11(4): 185–189.Olejnik P., Berecova Z., Boruta P., Masura J. Selected chapters from pediatric cardiology: MRI in pediatric cardiology [online]. 1st edition. Bratislava: Univerzita Komenskeho, 2015; 177.Olejnik P., Berecova Z., Boruta P., Masura J. Selected chapters from pediatric cardiology: MRI in pediatric cardiology [online]. 1st edition. Bratislava: Univerzita Komenskeho, 2015; 177.http://www.fmed.uniba.sk/fileadmin/lf/sluzby/akademicka_kniznica/PDF/Elektronicke_knihy_LF_UK/MRI_v_detskej_kardiologii.pdfhttp://www.fmed.uniba.sk/fileadmin/lf/sluzby/akademicka_kniznica/PDF/Elektronicke_knihy_LF_UK/MRI_v_detskej_kardiologii.pdfOlejnik P., Berecova Z., Boruta P., Masura J. Selected chapters from pediatric cardiology: CT-angiography in pediatric cardiology [online].1st edition. Bratislava: Univerzita Komenskeho, 2012; 156.Olejnik P., Berecova Z., Boruta P., Masura J. Selected chapters from pediatric cardiology: CT-angiography in pediatric cardiology [online].1st edition. Bratislava: Univerzita Komenskeho, 2012; 156.https://www.fmed.uniba.sk/fileadmin/lf/sluzby/akademicka_kniznica/PDF/Elektronicke_knihy_LF_UK/CT_-_angiografia_v_detskej_kardiologii.pdfhttps://www.fmed.uniba.sk/fileadmin/lf/sluzby/akademicka_kniznica/PDF/Elektronicke_knihy_LF_UK/CT_-_angiografia_v_detskej_kardiologii.pdfХарченко Г.А., Кимирилова Г.О. Клинико-эпидемиологическая характеристика кори в Астраханской области в период 2013–2019 гг. Российский вестник перинатологии и педиатрии 2020; 65(1): 86–93. [Kharchenko G.A., Kimirilova O.G. Clinical and epidemiological characteristics of measles in the Astrakhan region in 2013–2019. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2020; 65(1): 86–93. (in Russ).] DOI: 10.21508/1027-4065-2020-65-1-86-93Харченко Г.А., Кимирилова Г.О. Клинико-эпидемиологическая характеристика кори в Астраханской области в период 2013–2019 гг. Российский вестник перинатологии и педиатрии 2020; 65(1): 86–93. [Kharchenko G.A., Kimirilova O.G. Clinical and epidemiological characteristics of measles in the Astrakhan region in 2013–2019. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 2020; 65(1): 86–93. (in Russ).] DOI: 10.21508/1027-4065-2020-65-1-86-93Mori M., Miyamae T., Imagawa T., Katakura S., Kimura K., Yokota S. Meta-analysis of the results of intravenous gamma globulin treatment of coronary artery lesions in Kawasaki disease. Mod Rheumatol 2004; 14: 361–366. DOI: 10.1007/s10165-004-0324-3Mori M., Miyamae T., Imagawa T., Katakura S., Kimura K., Yokota S. Meta-analysis of the results of intravenous gamma globulin treatment of coronary artery lesions in Kawasaki disease. Mod Rheumatol 2004; 14: 361–366. DOI: 10.1007/s10165-004-0324-3Oates-Whitehead R.M., Baumer J.H., Haines L., Love S., Maconochie I.K., Gupta A., et al. Intravenous immunoglobulin for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev 2003; 4: CD004000. DOI: 10.1002/14651858.CD004000Oates-Whitehead R.M., Baumer J.H., Haines L., Love S., Maconochie I.K., Gupta A., et al. Intravenous immunoglobulin for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev 2003; 4: CD004000. DOI: 10.1002/14651858.CD004000Dobrovanov O., Kralinsky K., Kovalchuk VP. Etiological agents of urinary infections and microbial resistance: retrospective study. Lek Obzor (Bratislava) 2019; 68(7): 186–190.Dobrovanov O., Kralinsky K., Kovalchuk VP. Etiological agents of urinary infections and microbial resistance: retrospective study. Lek Obzor (Bratislava) 2019; 68(7): 186–190.Kralinsky K., Kmecova L., Dobrovanov O. Nová éra antimikrobiálnej terapie. Abstrakty prednášok. 50. celoslovenská pediatrická konferencia s medzinárodnou účasťou Galandové dni. Pediatria (Bratislava) 2018; S3/13: 12–13.Kralinsky K., Kmecova L., Dobrovanov O. Nová éra antimikrobiálnej terapie. Abstrakty prednášok. 50. celoslovenská pediatrická konferencia s medzinárodnou účasťou Galandové dni. Pediatria (Bratislava) 2018; S3/13: 12–13.Dobrovanov O., Kralinsky K., Krcmery V. Start of the respiratory infection season and initial antibiotic therapy. Pediatria (Bratislava) 2018; 13(5): 245–250.Dobrovanov O., Kralinsky K., Krcmery V. Start of the respiratory infection season and initial antibiotic therapy. Pediatria (Bratislava) 2018; 13(5): 245–250.

The authors declare that there are no conflicts of interest present.