perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2021-66-1-31-38perinatology-1335Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSБиологическая роль зонулина и эффективность его использования в качестве биомаркера синдрома повышенной кишечной проницаемостиBiological role of zonulin: a biomarker of increased intestinal permeability syndromehttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinA. I.

Хавкин Анатолий Ильич – доктор медицинских наук, профессор, главный научный сотрудник отдела гастроэнтерологии 

125412 Москва, ул. Талдомская, д. 2

Moscow

gastropedclin@gmail.comhttps://orcid.org/0000-0002-4516-4194БогдановаН. М.BogdanovaN. M.

Богданова Наталья Михайловна – кандидат медицинских наук, доцент кафедры пропедевтики детских болезней с курсом общего ухода за детьми

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaV. P.

Новикова Валерия Павловна – доктор медицинских наук, профессор, зав. кафедрой пропедевтики детских болезней с курсом общего ухода за детьми, зав. лабораторией медико-социальных проблем в педиатрии 

Санкт-Петербург

Saint Petersburg

ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияVeltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical UniversityRussian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation2021290320216613138Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20212021Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1335

Изменение рациона, а также широкий спектр патологических состояний, обусловленных инфекционным агентом, аллергическим или аутоиммунным воспалительным процессом, влияют на биологические ритмы пищеварительного тракта, что оказывает негативное действие на кишечную микробиоту и приводит к повышению проницаемости слизистой оболочки кишечника. Измененная микробиота потенцирует воспаление и способствует возникновению патологического «замкнутого круга». Фактором, модулирующим плотность межклеточных соединений, является белок зонулин. В обзоре представлены данные о биологической роли зонулина, возможностях коррекции при нарушении его синтеза с помощью функциональных продуктов для детского питания.

.Both changes in diet and pathological conditions caused by an infectious agent, allergic or autoimmune inflammatory process, affect the biological rhythms of the digestive tract, which negatively affects the intestinal microbiota and increases the permeability of the intestinal mucosa. The altered microbiota potentiates inflammation and causes a “vicious circle”. The zonulin protein is the agent that modulates the density of intercellular connections. The review presents data on the biological role of zonulin, correction of its synthesis violation with the help of functional products for baby food.

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The authors declare that there are no conflicts of interest present.