perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2021-66-3-27-33perinatology-1402Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSРоль иммунной системы в развитии и прогрессировании вирусного повреждения миокардаImmune system in development and progression of viral myocardial damagehttps://orcid.org/0000-0003-4979-9733ХегайИ. М.KhegaiI. M.

Хегай Ирина Михайловна – асп. кафедры госпитальной педиатрии им. В.А. Таболина

117997 Москва, ул. Островитянова, д. 1

Moscow

Im.kabu@gmail.comhttps://orcid.org/0000-0001-9627-2833ТрунинаИ. И.TruninaI. I.

Трунина Инна Игоревна – д.м.н., проф. кафедры госпитальной педиатрии им. В.А. Таболина, зав. отделением кардиологии, гл. внештатный детский специалист-кардиолог Департамента здравоохранения Москвы

117997 Москва, ул. Островитянова, д. 1

Moscow

https://orcid.org/0000-0002-6607-3793ЧеботареваТ. А.ChebotarevaT. A.

Чеботарева Татьяна Александровна – д.м.н., проф. кафедры детских инфекционных болезней

123242 Москва, Баррикадная ул. 2/1, стр. 1

Moscow

https://orcid.org/0000-0001-8505-6190ХодикянГ. К.KhodikyanG. K.

Ходикян Гита Карапетовна – ст. преподаватель Института общественных наук

119571 Москва, проспект Вернадского, д. 82

Moscow

https://orcid.org/0000-0002-9567-6761ШумиловП. В.ShumilovP. V.

Шумилов Петр Валентинович – д.м.н., проф., зав. каф. госпитальной педиатрии им. В.А. Таболина

117997 Москва, ул. Островитянова, д. 1 

Moscow

ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияPirogov Russian National Research Medical UniversityRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ГБУЗ «Детская городская клиническая больница им. З.А. Башляевой» ДЗМРоссияPirogov Russian National Research Medical University; Bashlyaeva Children’s Municipal Clinical HospitalRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Professional EducationRussian FederationРоссийская академия народного хозяйства и государственной службы при Президенте Российский ФедерацииРоссияRussian Presidential Academy of National Economy and Public AdministrationRussian Federation2021290620216632733Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20212021Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1402

В обзоре представлены сведения о роли иммунной системы в развитии и прогрессировании кардиальной патологии, вызванной вирусной инфекцией. Показана роль лимфоцитов (Т-хелперов-17 – Th17) в персистенции вируса в ткани миокарда. Приведены сведения о повышении уровня интерлейкина-17A, основного цитокина Th17 у пациентов с дилатационной кардиомиопатией, что доказывает роль этих клеток в прогрессировании кардиальной патологии. Обсуждается роль T-регуляторных (Treg) лимфоцитов при воспалительном поражении сердца.

This review demonstrates the role of the immune system in the development and progression of cardiac pathology caused by viral infection. The authors describe the role of lymphocytes (T- helper-17–Th17) in the viral persistence in myocardial tissue. They provide the information on increased level of interleukin-17A, the main Th17 cytokine in patients with dilated cardiomyopathy, which proves role of these cells in the progression of cardiac pathology. They discuss the role of T regulatory (Treg) lymphocytes in inflammatory heart disease.

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The authors declare that there are no conflicts of interest present.