perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2021-66-5-150-156perinatology-1495Research ArticleК XVIII РОССИЙСКОМУ КОНГРЕССУ «ПЕДИАТРИЯ И ДЕТСКАЯ ХИРУРГИЯ В ПРИВОЛЖСКОМ ФЕДЕРАЛЬНОМ ОКРУГЕ». ОБЗОРЫ ЛИТЕРАТУРЫПервичный склерозирующий холангит при воспалительных заболеваниях кишечника у детейPrimary schlerosing cholangitis in children with inflammatory bowel diseasehttps://orcid.org/0000-0002-2957-680XКамаловаА. А.KamalovaA. A.

Камалова Аэлита Асхатовна – д.м.н., проф. кафедры госпитальной педиатрии; врач диагностического отделения

420012 Казань, ул. Бутлерова, д. 49

15 420011 Казань, Оренбургский тракт, д. 140

Kazan

aelitakamalova@gmail.comhttps://orcid.org/0000-0002-1835-5649ГайфутдиноваА. Р.GaifutdinovaA. R.

Гайфутдинова Алия Ринатовна – асп. кафедры госпитальной педиатрии; врач-диетолог

420012 Казань, ул. Бутлерова, д. 49

15 420011 Казань, Оренбургский тракт, д. 140

Kazan

https://orcid.org/0000-0003-3261-9986МаловА. А.MalovA. A.

Малов Алексей Анатольевич – к.м.н., асс. кафедры онкологии с курсом лучевой диагностики и лучевой терапии;  врач-рентгенолог отделения лучевой диагностики

420012 Казань, ул. Бутлерова, д. 49

15 420011 Казань, Оренбургский тракт, д. 140

Kazan

https://orcid.org/0000-0001-6426-4484СафинаЭ. Р.SafinaE. R.

Сафина Эльнара Равиловна – асп. кафедры госпитальной педиатрии

420012 Казань, ул. Бутлерова, д. 49

Kazan

https://orcid.org/0000-0002-7761-3046НизамоваР. А.NizamovaR. A.

Низамова Раиля Альбертовна – врач-педиатр, гастроэнтеролог, зав. диагностическим отделением

15 420011 Казань, Оренбургский тракт, д. 140

Kazan

https://orcid.org/0000-0003-0254-9497БасановаЛ. И.BasanovaL. I.

Басанова Лилия Игоревна – зам. гл. врача по медицинской части

15 420011 Казань, Оренбургский тракт, д. 140

Kazan

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России; ГАУЗ «Детская республиканская клиническая больница» Минздрава Республики ТатарстанРоссияKazan State Medical University; Children’s Republican Clinical Hospital of Tatarstan RepublicRussian FederationФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииРоссияKazan State Medical UniversityRussian FederationГАУЗ «Детская республиканская клиническая больница» Минздрава Республики ТатарстанРоссияChildren’s Republican Clinical Hospital of Tatarstan RepublicRussian Federation202109122021665150156Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20212021Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1495

Представлен обзор современных данных о клинических особенностях, современных методах диагностики и стратегиях терапии при первичном склерозирующем холангите у детей с воспалительными заболеваниями кишечника. Первичный склерозирующий холангит может протекать бессимптомно в течение долгого времени, в дальнейшем приобретая прогрессирующий характер с формированием цирроза печени. Заболевание относится к важным факторам риска развития холангиокарциномы. В статье представлен диагностический алгоритм при повышении уровня трансаминаз в сыворотке крови у детей с воспалительными заболеваниями кишечника, при этом особое внимание уделено различным вариантам гепатобилиарной патологии, в том числе первичному склерозирующему холангиту. Широкое внедрение педиатрической шкалы SCOPE (Sclerosing Cholangitis Outcomes in PEdiatrics index) позволит своевременно диагностировать и назначить лечение пациенту уже на ранней стадии заболевания, что может улучшить прогноз заболевания.

The article provides an overview of current data on clinical features, modern diagnostic methods and therapeutic strategies for primary sclerosing cholangitis in children with inflammatory bowel disease. Primary sclerosing cholangitis can be asymptomatic for a long time, acquiring a progressive character with liver cirrhosis. The disease is one of the most important risk factors for the development of cholangiocarcinoma. The article presents a diagnostic algorithm for increased transaminases in the serum of the children with inflammatory bowel disease, with an emphasis on various variants of hepatobiliary pathology including primary sclerosing cholangitis. The widespread application of the pediatric scale SCOPE (Sclerosing Cholangitis Outcomes in Pediatrics index) will allow us to timely diagnose and prescribe treatment for a patient with primary sclerosing cholangitis at an early stage improving the prognosis of the disease.

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The authors declare that there are no conflicts of interest present.