perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”perinatology-151Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSИммуннообусловленные эпилепсии у детейImmune-mediated epilepsies in childrenБелоусоваЕ. Д.BelousovaE. D.

д.м.н., проф., зав. отделом психоневрологии и эпилептологии Научно-исследовательского клинического института педиатрии

ЯблонскаяМ. И.YablonskayaM. I.

к.м.н., стн.с. отдела психоневрологии и наследственных заболеваний с нарушением психики того же учреждения

ТагироваМ. К.TagirovaM. K.

н.с. того же учреждения 125412 Москва, ул. Талдомская, д. 2

КуликоваС. Л.KulikovaS. L.

к.м.н., в.н.с. Республиканского научно-практического центра неврологии и нейрохирургии

ЛихачевС. А.LikhachevS. A.

д.м.н., проф., рук. неврологического отдела того же учреждения

ОСП «Научно-исследовательский клинический институт педиатрии» ГБОУ ВПО РНИМУ им. Н.Н. Пирогова Минздрава России, МоскваРоссияResearch Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, MoscowRussian FederationРеспубликанский научно-практический центр неврологии и нейрохирургии, Минск, БеларусьРоссияRepublican Research-and-Practical Center of Neurology and Neurosurgery, Minsk, BelarusRussian Federation2015130320166052632Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20162016Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/151

Представлен обзор современной литературы, посвященной иммуннообусловленным эпилепсиям у детей. Описываются клиника, лабораторная диагностика и лечение аутоиммунных энцефалитов (лимбического и с антителами к NMDA-рецепто-рам), энцефалопатии Хашимото, опсоклонус-миоклонус-синдрома и синдрома Расмуссена, а также группы острых энцефалопатии с имуннообусловленным эпилептическим статусом (FIRES-, DESK-, HHE- синдром). Приводится клинический случай энцефалопатии Хашимото. Подчеркивается тесная взаимосвязь эпилепсии и воспаления, в том числе формирование аутоиммунного процесса в результате повторных эпилептических приступов.

The paper reviews the current literature on immune-mediated pediatric epilepsies. It describes the clinical picture, laboratory diagnosis, and treatment of autoimmune encephalitides (limbic encephalitis and anti-NMDA-receptor antibody encephalitis), Hashimoto's encephalopathy, opsoclonus-myoclonus-syndrome, and Rasmussen's syndrome, as well as groups of acute encephalopathies with immune-mediated status epilepticus (FIRES-, DESK-, HHE- syndrome). A clinical case of Hashimoto's encephalopathy is described. Emphasis is laid on a close relationship between epilepsy and inflammation, including the development of an autoimmune process due to recurrent epileptic seizures.

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The authors declare that there are no conflicts of interest present.