<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">perinatology</journal-id><journal-title-group><journal-title xml:lang="ru">Российский вестник перинатологии и педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-4065</issn><issn pub-type="epub">2500-2228</issn><publisher><publisher-name>Ltd. “The National Academy of Pediatric Science and Innovation”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21508/1027-4065-2021-66-6-17-22</article-id><article-id custom-type="elpub" pub-id-type="custom">perinatology-1524</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Бронхиальная обструкция у детей дошкольного возраста</article-title><trans-title-group xml:lang="en"><trans-title>Bronchial obstruction in pre-school children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1796-2711</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марковская</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Markovskaya</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марковская Анжелика Игоревна – асп. кафедры педиатрии</p><p>672000 Чита, ул. Горького, д. 39 А</p></bio><bio xml:lang="en"><p>Chita</p></bio><email xlink:type="simple">anzhelika_petrova_1992@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9670-9211</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапова</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapova</surname><given-names>N. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Потапова Наталья Леонидовна – к.м.н., зав. кафедрой поликлинической педиатрии</p><p>672000 Чита, ул. Горького, д. 39 А</p></bio><bio xml:lang="en"><p>Chita</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8771-5230</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаймоленко</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaymolenko</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаймоленко Инесса Никандровна – д.м.н., проф., зав. кафедрой педиатрии</p><p>672000 Чита, ул. Горького, д. 39 А</p></bio><bio xml:lang="en"><p>Chita</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0740-1718</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мизерницкий</surname><given-names>Ю. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Mizernitskiy</surname><given-names>Yu. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мизерницкий Юрий Леонидович – д.м.н., проф., зав. отделом хронических воспалительных и аллергических болезней легких, засл. работник здравоохранения РФ</p><p>125412 Москва, ул. Талдомская, д. 2</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chita State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>18</day><month>01</month><year>2022</year></pub-date><volume>66</volume><issue>6</issue><fpage>17</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ltd. “The National Academy of Pediatric Science and Innovation”, 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><copyright-holder xml:lang="en">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><license xlink:href="https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.ped-perinatology.ru/jour/article/view/1524">https://www.ped-perinatology.ru/jour/article/view/1524</self-uri><abstract><p>На основе данных зарубежной и отечественной литературы представлены подходы к определению фенотипов бронхообструктивного синдрома у детей дошкольного возраста. Приведены данные об основных зарубежных исследованиях, посвященных изучению особенностей течения бронхообструктивного синдрома в зависимости от возраста и клинического исхода. Обсуждаются факторы риска, предрасполагающие к его рецидивирующему течению, инструменты прогноза реализации в бронхиальную астму и выбор стратегии терапии в зависимости от фенотипа.</p></abstract><trans-abstract xml:lang="en"><p>Based on the analysis of foreign and domestic literature, the authors present the approaches to determining the phenotypes of bronchial obstructive syndrome in preschool children. They outline the data on the main foreign studies devoted to the peculiarities of the bronchial obstruction syndrome course depending on age and clinical outcome. They discuss the risk factors leading to the recurrent course of bronchial obstruction, tools for predicting bronchial asthma, and the choice of phenotype-dependent therapy strategy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>бронхообструктивный синдром</kwd><kwd>свистящее дыхание</kwd><kwd>дошкольный возраст</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>bronchoobstructive syndrome</kwd><kwd>wheezing</kwd><kwd>preschool age</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Marques G., Wendt A., Wehrmeister F.C. Temporal evolution of and factors associated with asthma and wheezing in schoolchildren in Brazil. Jornal Brasileiro de Pneumologia 2019; 45(3): e20180138. DOI: 10.1590/1806-3713/e20180138</mixed-citation><mixed-citation xml:lang="en">Marques G., Wendt A., Wehrmeister F.C. Temporal evolution of and factors associated with asthma and wheezing in schoolchildren in Brazil. Jornal Brasileiro de Pneumologia 2019; 45(3): e20180138. DOI: 10.1590/1806-3713/e20180138</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kere M., Melén E. Special Considerations in Preschool Age. Severe Asthma in Children and Adolescents 2019; 19–46. DOI:10.1007/978-3-030-27431-3_2</mixed-citation><mixed-citation xml:lang="en">Kere M., Melén E. Special Considerations in Preschool Age. Severe Asthma in Children and Adolescents 2019; 19–46. DOI:10.1007/978-3-030-27431-3_2</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kaiser S.V., Huynh T., Bacharier L.B., Rosenthal J.L., Bakel L.A., Parkin P.C. et al. Preventing exacerbations in preschoolers with recurrent wheeze: a meta-analysis. Pediatrics 2016; 137(6): e20154496. DOI: 10.1542/peds.2015-4496</mixed-citation><mixed-citation xml:lang="en">Kaiser S.V., Huynh T., Bacharier L.B., Rosenthal J.L., Bakel L.A., Parkin P.C. et al. Preventing exacerbations in preschoolers with recurrent wheeze: a meta-analysis. Pediatrics 2016; 137(6): e20154496. DOI: 10.1542/peds.2015-4496</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bacharier L.B., Guilbert T.W. Preschool Wheezing Phenotypes Exhibit Heterogeneity in Disease Expression and Prognosis. Ann Am Thorac Soc 2019; 16 (7): 820–822. DOI: 10.1513/AnnalsATS.201903-234ED</mixed-citation><mixed-citation xml:lang="en">Bacharier L.B., Guilbert T.W. Preschool Wheezing Phenotypes Exhibit Heterogeneity in Disease Expression and Prognosis. Ann Am Thorac Soc 2019; 16 (7): 820–822. DOI: 10.1513/AnnalsATS.201903-234ED</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kabra S.K., Kumar A. A young child with persistent respiratory symptoms: Think beyond asthma. Journal of Postgraduate Medicine 2017; 63(2): 81–83. DOI: 10.4103/jpgm.JPGM_92_17</mixed-citation><mixed-citation xml:lang="en">Kabra S.K., Kumar A. A young child with persistent respiratory symptoms: Think beyond asthma. Journal of Postgraduate Medicine 2017; 63(2): 81–83. DOI: 10.4103/jpgm.JPGM_92_17</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Usemann J., Xu B., Delgado-Eckert E., Korten I., Anagnostopoulou P., Gorlanova O. et al. Dynamics of respiratory symptoms during infancy and associations with wheezing at school age. ERJ Open Res 2018; 4(4): 00037-2018. DOI: 10.1183/23120541.00037-2018</mixed-citation><mixed-citation xml:lang="en">Usemann J., Xu B., Delgado-Eckert E., Korten I., Anagnostopoulou P., Gorlanova O. et al. Dynamics of respiratory symptoms during infancy and associations with wheezing at school age. ERJ Open Res 2018; 4(4): 00037-2018. DOI: 10.1183/23120541.00037-2018</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kwong C.G., Bacharier L.B. Phenotypes of wheezing and asthma in preschool children. Curr Opin Allergy Clin Immunol 2019; 19(2): 148–153. DOI: 10.1097/ACI.0000000000000516</mixed-citation><mixed-citation xml:lang="en">Kwong C.G., Bacharier L.B. Phenotypes of wheezing and asthma in preschool children. Curr Opin Allergy Clin Immunol 2019; 19(2): 148–153. DOI: 10.1097/ACI.0000000000000516</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Иванова Н.А. Рецидивирующая обструкция бронхов и бронхиальная астма у детей первых пяти лет жизни. Российский вестник перинатологии и педиатрии 2016; 61: (5): 64–69. DOI: 10.21508/1027-4065-2016-61-5-64-69</mixed-citation><mixed-citation xml:lang="en">Ivanova N.A. Recurrent bronchial obstruction and asthma in children during the first five years of life. Rossiyskiy vestnik perinatologii i pediatrii 2016; 61(5): 64–69 (in Russ.) DOI: 10.21508/1027-4065-2016-61-5-64-69</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Huang S., Garshick E., Weschler L.B., Hong C., Li J., Li L. et al. Home environmental and lifestyle factors associated with asthma, rhinitis and wheeze in children in Beijing, China. Environ Pollut 2020; 256: 113426. DOI: 10.1016/j.envpol.2019.113426</mixed-citation><mixed-citation xml:lang="en">Huang S., Garshick E., Weschler L.B., Hong C., Li J., Li L. et al. Home environmental and lifestyle factors associated with asthma, rhinitis and wheeze in children in Beijing, China. Environ Pollut 2020; 256: 113426. DOI: 10.1016/j.envpol.2019.113426</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez F.D., Wright A.L., Taussig L.M., Holberg C.J., Halonen M., Morgan W.J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332(3):133–138. DOI: 10.1056/NEJM199501193320301</mixed-citation><mixed-citation xml:lang="en">Martinez F.D., Wright A.L., Taussig L.M., Holberg C.J., Halonen M., Morgan W.J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995; 332(3):133–138. DOI: 10.1056/NEJM199501193320301</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Castro-Rodríguez J.A., Holberg C.J., Wright A.L., Martinez F.D A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162(4Pt1): 1403–1406. DOI: 10.1164/ajrccm.162.4.9912111</mixed-citation><mixed-citation xml:lang="en">Castro-Rodríguez J.A., Holberg C.J., Wright A.L., Martinez F.D A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162(4Pt1): 1403–1406. DOI: 10.1164/ajrccm.162.4.9912111</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Brand P.L., Baraldi E., Bisgaard H., Boner A.L., Castro-Rodriguez J.A., Custovic A. et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. European Respiratory Journal 2008; 32(4): 1096–1110. DOI: 10.1183/09031936.00002108</mixed-citation><mixed-citation xml:lang="en">Brand P.L., Baraldi E., Bisgaard H., Boner A.L., Castro-Rodriguez J.A., Custovic A. et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. European Respiratory Journal 2008; 32(4): 1096–1110. DOI: 10.1183/09031936.00002108</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Paul S.P., Bhatt J.M. Preschool wheeze is not asthma: a clinical dilemma. Indian J Pediatr 2014; 81(11): 1193–1195. DOI: 10.1007/s12098-014-1500-x</mixed-citation><mixed-citation xml:lang="en">Paul S.P., Bhatt J.M. Preschool wheeze is not asthma: a clinical dilemma. Indian J Pediatr 2014; 81(11): 1193–1195. DOI: 10.1007/s12098-014-1500-x</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Oksel C., Granell R., Mahmoud O., Custovic A., Henderson A.J. Causes of variability in latent phenotypes of childhood wheeze. J Allergy Clin Immunol 2019; 143(5): 1783–1790. e11. DOI: 10.1016/j.jaci.2018.10.059</mixed-citation><mixed-citation xml:lang="en">Oksel C., Granell R., Mahmoud O., Custovic A., Henderson A.J. Causes of variability in latent phenotypes of childhood wheeze. J Allergy Clin Immunol 2019; 143(5): 1783–1790. e11. DOI: 10.1016/j.jaci.2018.10.059</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Spycher B.D., Cochrane C., Granell R., Sterne J.C., Silverman M., Pedersen E. et al. Temporal stability of multitrigger and episodic viral wheeze in early childhood. Eur Respir J 2017; 50(5): pii: 1700014. DOI: 10.1183/13993003.00014-2017</mixed-citation><mixed-citation xml:lang="en">Spycher B.D., Cochrane C., Granell R., Sterne J.C., Silverman M., Pedersen E. et al. Temporal stability of multitrigger and episodic viral wheeze in early childhood. Eur Respir J 2017; 50(5): pii: 1700014. DOI: 10.1183/13993003.00014-2017</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Raaymakers M.J.A., Brand P.L.P., Landstra A.M., Brouwer M.L., Balemans W.A.F., Niers L.E.M. et al. Episodic viral wheeze and multiple-trigger wheeze in preschool children are neither distinct nor constant patterns. A prospective multicenter cohort study in secondary care. Pediatr Pulmonol 2019; 54(9): 1439–1446. DOI: 10.1002/ppul.24411</mixed-citation><mixed-citation xml:lang="en">Raaymakers M.J.A., Brand P.L.P., Landstra A.M., Brouwer M.L., Balemans W.A.F., Niers L.E.M. et al. Episodic viral wheeze and multiple-trigger wheeze in preschool children are neither distinct nor constant patterns. A prospective multicenter cohort study in secondary care. Pediatr Pulmonol 2019; 54(9): 1439–1446. DOI: 10.1002/ppul.24411</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Van Wonderen K.E., Geskus R.B., van Aalderen W.M., Mohrs J., Bindels P.J., van der Mark L.B., Ter Riet G. Stability and predictiveness of multiple trigger and episodic viral wheeze in preschoolers. Clin Exp Allergy 2016; 46(6): 837–847. DOI: 10.1111/cea.12660</mixed-citation><mixed-citation xml:lang="en">Van Wonderen K.E., Geskus R.B., van Aalderen W.M., Mohrs J., Bindels P.J., van der Mark L.B., Ter Riet G. Stability and predictiveness of multiple trigger and episodic viral wheeze in preschoolers. Clin Exp Allergy 2016; 46(6): 837–847. DOI: 10.1111/cea.12660</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Jartti T., Bønnelykke K., Elenius V., Feleszko W. Role of viruses in asthma. Semin Immunopathol 2020; 42(1): 61–74. DOI: 10.1007/s00281-020-00781-5</mixed-citation><mixed-citation xml:lang="en">Jartti T., Bønnelykke K., Elenius V., Feleszko W. Role of viruses in asthma. Semin Immunopathol 2020; 42(1): 61–74. DOI: 10.1007/s00281-020-00781-5</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bergroth E., Aakula M., Elenius V., Remes S., Piippo-Savolainen E., Korppi M. et al. Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma. J Allergy Clin Immunol Pract 2020; 8(2): 588–595.e4. DOI: 10.1016/j.jaip.2019.08.043</mixed-citation><mixed-citation xml:lang="en">Bergroth E., Aakula M., Elenius V., Remes S., Piippo-Savolainen E., Korppi M. et al. Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma. J Allergy Clin Immunol Pract 2020; 8(2): 588–595.e4. DOI: 10.1016/j.jaip.2019.08.043</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Schultz A., Brand P.L. Episodic viral wheeze and multiple trigger wheeze in preschool children: a useful distinction for clinicians? Paediatr Respir Rev 2011; 12(3): 160–164. DOI: 10.1016/j.prrv.2011.01.008</mixed-citation><mixed-citation xml:lang="en">Schultz A., Brand P.L. Episodic viral wheeze and multiple trigger wheeze in preschool children: a useful distinction for clinicians? Paediatr Respir Rev 2011; 12(3): 160–164. DOI: 10.1016/j.prrv.2011.01.008</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Caudri D. Multi-trigger and viral wheeze: describing symptoms or defining diseases? Eur Respir J 2017; 50(5): pii: 1701283. DOI: 10.1183/13993003.01283-2017</mixed-citation><mixed-citation xml:lang="en">Caudri D. Multi-trigger and viral wheeze: describing symptoms or defining diseases? Eur Respir J 2017; 50(5): pii: 1701283. DOI: 10.1183/13993003.01283-2017</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ma H., Li Y., Tang L., Peng X., Jiang L., Wan J. et al. Impact of childhood wheezing on lung function in adulthood: A meta-analysis. PLoS One 2018; 13(2): e0192390. DOI: 10.1371/journal.pone.0192390</mixed-citation><mixed-citation xml:lang="en">Ma H., Li Y., Tang L., Peng X., Jiang L., Wan J. et al. Impact of childhood wheezing on lung function in adulthood: A meta-analysis. PLoS One 2018; 13(2): e0192390. DOI: 10.1371/journal.pone.0192390</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Bonato M., Tiné M., Bazzan E., Biondini D., Saetta M., Baraldo S. Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing. J Clin Med 2019; 8(8): pii: E1180. DOI: 10.3390/jcm8081180</mixed-citation><mixed-citation xml:lang="en">Bonato M., Tiné M., Bazzan E., Biondini D., Saetta M., Baraldo S. Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing. J Clin Med 2019; 8(8): pii: E1180. DOI: 10.3390/jcm8081180</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Granell R., Henderson A.J., Sterne J.A. Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: A population-based birth cohort. J Allergy Clin Immunol 2016; 138(4): 1060-1070.e11. DOI: 10.1016/j.jaci.2016.01.046</mixed-citation><mixed-citation xml:lang="en">Granell R., Henderson A.J., Sterne J.A. Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: A population-based birth cohort. J Allergy Clin Immunol 2016; 138(4): 1060-1070.e11. DOI: 10.1016/j.jaci.2016.01.046</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Oksel C., Granell R., Haider S., Fontanella S., Simpson A., Turner S. et al. Distinguishing Wheezing Phenotypes from Infancy to Adolescence. A Pooled Analysis of Five Birth Cohorts. AnnAmThoracSoc 2019; 16(7): 868–876. DOI: 10.1513/AnnalsATS.201811-837OC</mixed-citation><mixed-citation xml:lang="en">Oksel C., Granell R., Haider S., Fontanella S., Simpson A., Turner S. et al. Distinguishing Wheezing Phenotypes from Infancy to Adolescence. A Pooled Analysis of Five Birth Cohorts. AnnAmThoracSoc 2019; 16(7): 868–876. DOI: 10.1513/AnnalsATS.201811-837OC</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Савенкова Н.Д., Джумагазиев А.А., Безрукова Д.А. Клинико-прогностическое значение фенотипов бронхообструктивного синдрома для развития бронхиальной астмы у детей. Астраханский медицинский журнал 2019; 14(2): 51–59. DOI: 10.17021/2019.14.2.51.59</mixed-citation><mixed-citation xml:lang="en">Savenkova N.D., Dzhumagaziev A.A., Bezrukova D.A. Сlinical and prognostic significance of wheezing phenotypes for the development of bronchial asthma in children. Astrahanskij medicinskij zhurnal 2019; 14(2): 51–59. (in Russ.) DOI: 10.17021/2019.14.2.51.59</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Геппе Н.А., Иванова Н.А., Камаев А.В., Колосова Н.Г., Кондюрина Е.Г., Малахов А.Б. и др. Бронхиальная обструкция на фоне острой респираторной инфекции у детей дошкольного возраста: диагностика, дифференциальная диагностика, терапия, профилактика. Москва: МедКом-Про, 2019; 78 с.</mixed-citation><mixed-citation xml:lang="en">Geppe N.A., Ivanova N.A., Kamaev A.V., Kolosova N.G., Kondjurina E.G., Malahov A.B. et al. Bronchial obstruction on the background of acute respiratory infection in preschool children: diagnosis, differential diagnosis, therapy, prevention. Moscow: MedKom-Pro, 2019; 78 p. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sordillo J.E., Coull B.A., Rifas-Shiman S.L., Wu A.C., Lutz S.M., Hivert M.F. et al. Characterization of longitudinal wheeze phenotypes from infancy to adolescence in Project Viva, a prebirth cohort study. J Allergy Clin Immunol 2020; 145(2): 716–719.e8. DOI: 10.1016/j.jaci.2019.10.026</mixed-citation><mixed-citation xml:lang="en">Sordillo J.E., Coull B.A., Rifas-Shiman S.L., Wu A.C., Lutz S.M., Hivert M.F. et al. Characterization of longitudinal wheeze phenotypes from infancy to adolescence in Project Viva, a prebirth cohort study. J Allergy Clin Immunol 2020; 145(2): 716–719.e8. DOI: 10.1016/j.jaci.2019.10.026</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Oo S., Le Souëf P. The wheezing child: an algorithm. Aust Fam Physician 2015; 44(6): 360–364</mixed-citation><mixed-citation xml:lang="en">Oo S., Le Souëf P. The wheezing child: an algorithm. Aust Fam Physician 2015; 44(6): 360–364</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Li H.F., Yan L.P., Wang K., Li X.T., Liu H.X., Tan W. Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis. Respir Res 2019; 20(1): 38. DOI: 10.1186/s12931-019-1006-1</mixed-citation><mixed-citation xml:lang="en">Li H.F., Yan L.P., Wang K., Li X.T., Liu H.X., Tan W. Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis. Respir Res 2019; 20(1): 38. DOI: 10.1186/s12931-019-1006-1</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Nwokoro C., Grigg J. Preschool wheeze, genes and treatment. Paediatr Respir Rev 2018; 28: 47–54. DOI: 10.1016/j.prrv.2017.11.003</mixed-citation><mixed-citation xml:lang="en">Nwokoro C., Grigg J. Preschool wheeze, genes and treatment. Paediatr Respir Rev 2018; 28: 47–54. DOI: 10.1016/j.prrv.2017.11.003</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Селиверстова Е.Н., Башкина О.А., Стройкова Т.Р., Сергиенко Д.Ф., Аверина И.А. Ассоциация полиморфизма гена СС16 с факторами риска формирования бронхообструктивного синдрома у детей. Вестник Российского университета дружбы народов. Серия: Медицина 2018; 22(2): 183–190. DOI: 10.22363/2313-0245-2018-22-2-183-190</mixed-citation><mixed-citation xml:lang="en">Seliverstova E.N., Bashkina O.A., Stroikova T.R., Sergienko D.F., Averina I.A. Association of СС16 polymorphism with risk factors of formation of broncho-obstructive syndrome in children. Vestnik Rossiiskogo universiteta druzhby narodov. Seriya: Meditsina 2018; 22(2): 183–190 (in Russ.)]. DOI: 10.22363/2313-0245-2018-22-2-183-190</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Петрова А.И., Гаймоленко И.Н. Факторы риска развития острой бронхиальной обструкции у детей дошкольного возраста. Забайкальский медицинский вестник 2019; 1: 70–75.</mixed-citation><mixed-citation xml:lang="en">Petrova A.I., Gaymolenko I.N. Risk factors for acute bronchial obstruction in preschool children. Zabaikal’skii meditsinskii vestnik 2019; 1: 70–75. (in Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Johansson H., Norlander K., Malinovschi A. Increased prevalence of exercise-induced airway symptoms – A five-year follow-up from adolescence to young adulthood. Respir Med 2019; 154: 76–81. DOI: 10.1016/j.rmed.2019.06.011</mixed-citation><mixed-citation xml:lang="en">Johansson H., Norlander K., Malinovschi A. Increased prevalence of exercise-induced airway symptoms – A five-year follow-up from adolescence to young adulthood. Respir Med 2019; 154: 76–81. DOI: 10.1016/j.rmed.2019.06.011</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Guo J., Zhu W., Wang H., Holt P.G., Zhang G., Liu C. Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study. Allergy Asthma Clin Immunol 2019; 15: 38. DOI: 10.1186/s13223-019-0351-4</mixed-citation><mixed-citation xml:lang="en">Guo J., Zhu W., Wang H., Holt P.G., Zhang G., Liu C. Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study. Allergy Asthma Clin Immunol 2019; 15: 38. DOI: 10.1186/s13223-019-0351-4</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Bao Y., Chen Z., Liu E., Xiang L., Zhao D., Hong J. Risk Factors in Preschool Children for Predicting Asthma During the Preschool Age and the Early School Age: a Systematic Review and Meta-Analysis. Curr Allergy Asthma Rep 2017; 17(12): 85. DOI: 10.1007/s11882-017-0753-7</mixed-citation><mixed-citation xml:lang="en">Bao Y., Chen Z., Liu E., Xiang L., Zhao D., Hong J. Risk Factors in Preschool Children for Predicting Asthma During the Preschool Age and the Early School Age: a Systematic Review and Meta-Analysis. Curr Allergy Asthma Rep 2017; 17(12): 85. DOI: 10.1007/s11882-017-0753-7</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Shen S.Y., Xiao W.Q., Lu J.H., Yuan M.Y., He J.R., Xia H.M. et al. Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis. BMC Pulm Med 2018; 18(1):120. DOI: 10.1186/s12890-018-0679-4</mixed-citation><mixed-citation xml:lang="en">Shen S.Y., Xiao W.Q., Lu J.H., Yuan M.Y., He J.R., Xia H.M. et al. Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis. BMC Pulm Med 2018; 18(1):120. DOI: 10.1186/s12890-018-0679-4</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">AbdelKader A.M., Nassar M.F. Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait. East Mediterr Health J 2019; 25(3): 197–204. DOI: 10.26719/emhj.18.031</mixed-citation><mixed-citation xml:lang="en">AbdelKader A.M., Nassar M.F. Serum 25-hydroxyvitamin D status and wheezing in pre-school children, Kuwait. East Mediterr Health J 2019; 25(3): 197–204. DOI: 10.26719/emhj.18.031</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kotecha S.J., Watkins W.J., Lowe J., Granell R., Henderson A.J., Kotecha S. Comparison of the Associations of Early-Life Factors on Wheezing Phenotypes in Preterm-Born Children and Term-Born Children. Am J Epidemiol 2019; 188(3): 527–536. DOI: 10.1093/aje/kwy268</mixed-citation><mixed-citation xml:lang="en">Kotecha S.J., Watkins W.J., Lowe J., Granell R., Henderson A.J., Kotecha S. Comparison of the Associations of Early-Life Factors on Wheezing Phenotypes in Preterm-Born Children and Term-Born Children. Am J Epidemiol 2019; 188(3): 527–536. DOI: 10.1093/aje/kwy268</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ernest E., Wainstock T., Sheiner E., Segal I., Landau D., Walfisch A. Apgar score and long-term respiratory morbidity of the offspring: a population-based cohort study with up to 18 years of follow-up. Eur J Pediatr 2019; 178(3): 403–411. DOI: 10.1007/s00431-018-03311-6</mixed-citation><mixed-citation xml:lang="en">Ernest E., Wainstock T., Sheiner E., Segal I., Landau D., Walfisch A. Apgar score and long-term respiratory morbidity of the offspring: a population-based cohort study with up to 18 years of follow-up. Eur J Pediatr 2019; 178(3): 403–411. DOI: 10.1007/s00431-018-03311-6</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Hammar K.S., Hedlin G., Söderhäll C. Rhinovirus and preschool wheeze. Pediatr Allergy Immunol 2017; 28(6): 513–520. DOI: 10.1111/pai.12740</mixed-citation><mixed-citation xml:lang="en">Hammar K.S., Hedlin G., Söderhäll C. Rhinovirus and preschool wheeze. Pediatr Allergy Immunol 2017; 28(6): 513–520. DOI: 10.1111/pai.12740</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Rubner F.J., Jackson D.J., Evans M.D., Gangnon R.E., Tisler C.J., Pappas T.E. et al. Early life rhinovirus wheezing, allergic sensitization and asthma risk at adolescence. J Allergy Clin Immunol 2017; 139(2): 501–507. DOI: 10.1016/j.jaci.2016.03.049</mixed-citation><mixed-citation xml:lang="en">Rubner F.J., Jackson D.J., Evans M.D., Gangnon R.E., Tisler C.J., Pappas T.E. et al. Early life rhinovirus wheezing, allergic sensitization and asthma risk at adolescence. J Allergy Clin Immunol 2017; 139(2): 501–507. DOI: 10.1016/j.jaci.2016.03.049</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">De Jong C.C.M., Pedersen E.S., Goutaki M., Trachsel D., Barben J., Kuehni C.E. Do clinical investigations predict long-term wheeze? A follow-up of pediatric respiratory out-patients. Pediatr Pulmonol 2019; 54(8): 1156–1161. DOI: 10.1002/ppul.24347</mixed-citation><mixed-citation xml:lang="en">De Jong C.C.M., Pedersen E.S., Goutaki M., Trachsel D., Barben J., Kuehni C.E. Do clinical investigations predict long-term wheeze? A follow-up of pediatric respiratory out-patients. Pediatr Pulmonol 2019; 54(8): 1156–1161. DOI: 10.1002/ppul.24347</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Beigelman A., Rosas-Salazar C., Harter T.V. Childhood Asthma: Is it All About Bacteria and not About Viruses? A Pro/ Con Debate. J Allergy Clin Immunol Pract 2018; 6(3): 719–725. DOI: 10.1016/j.jaip.2017.11.020</mixed-citation><mixed-citation xml:lang="en">Beigelman A., Rosas-Salazar C., Harter T.V. Childhood Asthma: Is it All About Bacteria and not About Viruses? A Pro/ Con Debate. J Allergy Clin Immunol Pract 2018; 6(3): 719–725. DOI: 10.1016/j.jaip.2017.11.020</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kwong C.G., Bacharier L.B. Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children. Curr Allergy Asthma Rep 2017; 17:(5): 34. DOI: 10.1007/s11882-017-0701-6</mixed-citation><mixed-citation xml:lang="en">Kwong C.G., Bacharier L.B. Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children. Curr Allergy Asthma Rep 2017; 17:(5): 34. DOI: 10.1007/s11882-017-0701-6</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Castro-Rodriguez J.A., Cifuentes L., Martinez F.D. Predicting Asthma Using Clinical Indexes. Front Pediatr 2019; 7: 320. DOI: 10.3389/fped.2019.00320</mixed-citation><mixed-citation xml:lang="en">Castro-Rodriguez J.A., Cifuentes L., Martinez F.D. Predicting Asthma Using Clinical Indexes. Front Pediatr 2019; 7: 320. DOI: 10.3389/fped.2019.00320</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Mark L.B., van Wonderen K.E., Mohrs J., van Aalderen W.M., ter Riet G., Bindels P.J. Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score. Prim Care Respir J 2014; 23:(1): 52–59. DOI: 10.4104/pcrj.2014.00003</mixed-citation><mixed-citation xml:lang="en">Van der Mark L.B., van Wonderen K.E., Mohrs J., van Aalderen W.M., ter Riet G., Bindels P.J. Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score. Prim Care Respir J 2014; 23:(1): 52–59. DOI: 10.4104/pcrj.2014.00003</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Pescatore A.M., Dogaru C.M, Duembgen L., Silverman M., Gaillard E.A. Spycher B.D. et al. A simple asthma prediction tool for preschool children with wheeze or cough. J AllergyClin Immunol 2014; 133(1): 111–118. DOI: 10.1016/j.jaci.2014.06.002</mixed-citation><mixed-citation xml:lang="en">Pescatore A.M., Dogaru C.M, Duembgen L., Silverman M., Gaillard E.A. Spycher B.D. et al. A simple asthma prediction tool for preschool children with wheeze or cough. J AllergyClin Immunol 2014; 133(1): 111–118. DOI: 10.1016/j.jaci.2014.06.002</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Фурман Е.Г., Грымова Н.Н., Санакоева Л.П., Крылова О.А., Мазунина Е.С. Оценка риска развития бронхиальной астмы у детей раннего возраста с помощью опросника «Asthma Prediction Tool». Российский вестник перинатологии и педиатрии 2018; 63(1): 34–39. DOI: 10.21508/1027-4065-2018-63-1-34-39.</mixed-citation><mixed-citation xml:lang="en">Furman E.G., Grymova N.N., Sanakoeva L.P., Krylova O.A., Mazunina E.S. Risk assessment for the bronchial asthma development in infants using a russian-language version of questionnaire «Asthma Prediction Tool». Rossiyskiy vestnik perinatologii i pediatrii 2018; 63(1): 34–39. (In Russ.) DOI: 10.21508/1027–4065–2018–63–1–34–39</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Castro-Rodriguez J.A., Rodriguez-Martinez C.E., Ducharme F.M. Daily inhaled corticosteroids or montelukast for preschoolers with asthma or recurrent wheezing: A systematic review. Pediatr Pulmonol 2018; 53(12): 1670–1677. DOI: 10.1002/ppul.24176</mixed-citation><mixed-citation xml:lang="en">Castro-Rodriguez J.A., Rodriguez-Martinez C.E., Ducharme F.M. Daily inhaled corticosteroids or montelukast for preschoolers with asthma or recurrent wheezing: A systematic review. Pediatr Pulmonol 2018; 53(12): 1670–1677. DOI: 10.1002/ppul.24176</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Shamrani A., Bagais K., Alenazi A., Alqwaiee M., Al-Harbi A.S. Wheezing in children: Approaches to diagnosis and management. Int J Pediatr Adolesc Med 2019; 6(2): 68–73. DOI: 10.1016/j.ijpam.2019.02.003</mixed-citation><mixed-citation xml:lang="en">Al-Shamrani A., Bagais K., Alenazi A., Alqwaiee M., Al-Harbi A.S. Wheezing in children: Approaches to diagnosis and management. Int J Pediatr Adolesc Med 2019; 6(2): 68–73. DOI: 10.1016/j.ijpam.2019.02.003</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Harding T.W., Driscoll C., Hensey C.C. Strategies for treatment of pre-schoolers with episodic viral wheeze. J Paediatr Child Health 2017; 53(12): 1241. DOI: 10.1111/jpc.13798</mixed-citation><mixed-citation xml:lang="en">Harding T.W., Driscoll C., Hensey C.C. Strategies for treatment of pre-schoolers with episodic viral wheeze. J Paediatr Child Health 2017; 53(12): 1241. DOI: 10.1111/jpc.13798</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Kaiser S.V., Huynh T., Bacharier L.B., Rosenthal J.L., Bakel L.A., Parkin P.C. et al. Preventing Exacerbations in preschoolers with recurrent wheeze: ameta-analysis. Pediatrics 2016; 137(6): pii: e20154496. DOI: 10.1542/peds.2015-4496</mixed-citation><mixed-citation xml:lang="en">Kaiser S.V., Huynh T., Bacharier L.B., Rosenthal J.L., Bakel L.A., Parkin P.C. et al. Preventing Exacerbations in preschoolers with recurrent wheeze: ameta-analysis. Pediatrics 2016; 137(6): pii: e20154496. DOI: 10.1542/peds.2015-4496</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Foster S.J., Cooper M.N., Oosterhof S., Borland M.L. Oral prednisolone in preschool children with virus-associated wheeze: a prospective, randomized, double-blind, placebo-controlled trial. Lancet Respir Med 2018; 6(2): 97–106. DOI: 10.1016/S2213-2600(18)30008-0</mixed-citation><mixed-citation xml:lang="en">Foster S.J., Cooper M.N., Oosterhof S., Borland M.L. Oral prednisolone in preschool children with virus-associated wheeze: a prospective, randomized, double-blind, placebo-controlled trial. Lancet Respir Med 2018; 6(2): 97–106. DOI: 10.1016/S2213-2600(18)30008-0</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
