perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2021-66-6-134-141perinatology-1543Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУFOR THE PRACTITIONERГемолитико-уремический синдром, ассоциированный со Streptococcus pneumoniaeHemolytic uremic syndrome associated with Streptococcus pneumoniaehttps://orcid.org/0000-0001-5860-856XБайкоС. В.BaikoS. V.

Байко Сергей Валерьевич – д.м.н., проф. 1-й кафедры детских болезней

220020 Минск, ул. Нарочанская, д. 17

Minsk

СтрельченяЕ. С.StrelcheniaE. S.

Стрельченя Екатерина Сергеевна – врач отделения анестезиологии и реанимации №2

220018 Минск, ул. Якубовского, д. 53

Minsk

РеутС. У.ReutS. U.

Реут Светлана Устиновна – зав. отделением анестезиологии и реанимации №2

220018 Минск, ул. Якубовского, д. 53

Minsk

УО «Белорусский государственный медицинский университет»БеларусьBelarusian State Medical UniversityBelarusУЗ «Городская детская инфекционная клиническая больница»БеларусьCity Children’s Infectious Clinical HospitalBelarus202120012022666134141Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20222022Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1543

Гемолитико-уремический синдром, ассоциированный со Streptococcus pneumoniae – редкое заболевание, которое встречается в 5–10% от всех случаев гемолитико-уремических синдромов в детском возрасте. Пневмонии и менингиты относятся к основным заболеваниям, которые могут осложняться St. pneumoniae-ассоциированным гемолитико-уремическим синдромом. Широкое внедрение в клиническую практику полимеразной цепной реакции позволило увеличить частоту выявления данной патологии. В статье представлены эпидемиология, клиническая картина, особенности патогенеза, диагностика и лечение St. pneumoniae-ассоциированного гемолитико-уремического синдрома. Описаны 3 клинических случая данного синдрома у детей с пневмониями. У 2 пациентов пневмония протекала с деструкцией легочной ткани, эмпиемой плевры, бактериемией и тяжелой почечной недостаточностью, при которой требовалась терапия, замещающая функцию почек, методом гемофильтрации. Исходы гемолитико-уремического синдрома, ассоциированного со St. pneumoniae, хуже, чем при типичном гемолитико-уремическом синдроме, и связаны с тяжестью основного заболевания (пневмонии, менингита).

Hemolytic uremic syndrome associated with Streptococcus pneumoniae is a rare disease that occurs in 5-10% of all cases of hemolytic uremic syndromes in childhood. Pneumonia and meningitis are among the main diseases that can be complicated by St. pneumoniae-associated hemolytic uremic syndrome. The widespread introduction of polymerase chain reaction into clinical practice has increased the frequency of detection of this pathology. The article presents the epidemiology, clinical picture, features of pathogenesis, diagnosis and treatment of St. pneumoniae-associated hemolytic uremic syndrome. The authors described 3 clinical cases of this syndrome in children with pneumonia. In 2 patients, pneumonia proceeded with destruction of lung tissue, pleural empyema, bacteremia, and severe renal failure, which required hemofiltration therapy to replace renal function. Outcomes of hemolytic uremic syndrome associated with St. pneumoniae is worse than in typical hemolytic uremic syndrome, and is associated with the severity of the underlying disease (pneumonia, meningitis).

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The authors declare that there are no conflicts of interest present.