perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2022-67-1-14-20perinatology-1573Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSСовременные аспекты противосудорожной фармакотерапии у новорожденныхModern aspects of anticonvulsant pharmacotherapy in newbornshttps://orcid.org/0000-0001-6958-6423ПерфильевВ. Ю.Perfil’evV. Yu.

Перфильев Вячеслав Юрьевич — к.м.н., доц. кафедры фармакологии, врач–клинический фармаколог клиник

Томск

Tomsk

p.v.yu@mail.ruhttps://orcid.org/0000-0003-4035-8341МирошниченкоА. Г.MiroshnichenkoA. G.

Мирошниченко Александр Геннадьевич — д.м.н., проф. кафедры фармакологии 

Томск

Tomsk

https://orcid.org/0000-0002-2133-665XЖелевВ. А.ZhelevV. A.

Желев Виктор Александрович — д.м.н., проф., зав. кафедрой госпитальной педиатрии 

Томск

Tomsk

https://orcid.org/0000-0001-9500-5776ДевальдЭ. В.DevaldE. V.

Девальд Эдуард Владимирович — асс. кафедры госпитальной педиатрии

634050 Томск, Московский тракт, д. 2 

Tomsk

ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава РоссииРоссияSiberian State Medical UniversityRussian Federation2022080420226711420Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20222022Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1573

Надлежащее лечение судорог у новорожденных важно для снижения частоты долгосрочных неврологических нарушений. Ни одно из используемых в настоящее время лекарственных средств для лечения судорог у новорожденных не имеет достаточной доказательной базы, чтобы можно было бы однозначно судить о его эффективности. Отсутствуют результаты крупных исследований, позволяющих принять решение о выборе противосудорожного препарата для стартовой терапии и альтернативы в случае неэффективности препарата выбора. В обзоре обобщены данные об эффективности противосудорожных препаратов различных фармакологических групп, рассмотрены их преимущества, недостатки и возможные механизмы вариабельности эффективности при применении у новорожденных. Проанализированы подходы к оценке длительности применения противосудорожных препаратов. Обсуждены проблемы и перспективы клинических исследований с целью повышения эффективности и безопасности противосудорожной терапии у новорожденных.

Proper treatment of neonatal seizures is crucial for reducing long-term neurological disorders. None of the currently used drugs to treat neonatal seizures has sufficient evidentiary base to make an unambiguous conclusion about its effectiveness. There are no results of large-scale studies that allow choosing an anticonvulsant drug for starting therapy and an alternative to it, in case the drug of choice is ineffective. The review summarizes the data on the effectiveness of anticonvulsants of different pharmacologic classes and considers their benefits, drawbacks, and possible mechanisms of variability in effectiveness when used in newborns. The review also analyzes approaches to the duration of the anticonvulsant therapy and discusses the problems and prospects of clinical trials for increasing the effectiveness and safety of anticonvulsant therapy in newborns.

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The authors declare that there are no conflicts of interest present.