perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2022-67-2-142-152perinatology-1631Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУFOR THE PRACTITIONERCOVID-19: уроки педиатрической науки и практикиCOVID-19: Lessons from pediatric science and practiceХаритоноваЛ. А.KharitonovaL. A.

Харитонова Любовь Алексеевна — д.м.н., проф., зав. кафедрой педиатрии с инфекционными болезнями у детей факультета дополнительного профессионального образования

117997 Москва, ул. Островитянова, д. 1

Moscow

ГригорьевК. И.GrigorievK. I.

Григорьев Константин Иванович — д.м.н., проф. кафедры педиатрии с инфекционными заболеваниями у детей факультета дополнительного профессионального образования

117997 Москва, ул. Островитянова, д. 1

Moscow

k-i-grigoryev@yandex.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияPirogov Russian National Research Medical UniversityRussian Federation202211062022672142152Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20222022Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1631

Пандемия новой тяжелой инфекции, объявленная Всемирной организацией здравоохранения в прошлом году, продолжает развиваться. В  определенной степени эпидемия затронула детское население; дети не  оставались вне распространения COVID-19, причем это касается даже новорожденных. В  лекции представлены сводные данные о  результатах клинических наблюдений в Тушинской детской городской клинической больнице Москвы и из научных источников. Новое заболевание  — действительно новое. Это касается его патогенеза, диагностики, тактики лечения с  использованием современных лекарственных средств. Педиатры впервые столкнулись с невероятной ситуацией, когда взрослые болеют тяжелее, чем дети. Отмечено, что, в  связи с  ограниченным сроком и  количеством наблюдений, все рекомендации, существующие на данном этапе, носят временный характер и, без сомнения, подлежат уточнению. Большая часть информации, касающаяся воздействия COVID-19 на ребенка, находится в стадии клинических исследований и на пути к внедрению в педиатрическую практику.

The pandemic of a new severe infection, announced by the World Health Organization last year, is still spreading. To a certain extent, the epidemic has affected the pediatric population. Children have not been left out of the spread of COVID-19, and this applies even to newborns. The lecture presents summary data on the results of clinical observations both in the Tushino Children’s City Clinical Hospital in Moscow and scientific sources. A new disease is really new. This applies to its pathogenesis, diagnosis, treatment tactics with the use of modern medicines. For the first time, pediatricians are faced with the incredible situation where adults are more severely affected than children. It was noted that due to the limited period and scarce observations, all recommendations existing at this stage are temporary and undoubtedly subject to clarification. Most information regarding the impact of COVID-19 on a child is in clinical trials and is en route to be introduced into pediatric practice.

детиCOVID-19SARS-CoV-2«красная» зонаchildrenCOVID-19SARS-CoV-2«red» zoneReferencesHoffmann M., Kleine-Weber H., Schroeder S., Kruger N., Herrler T., Erichsen S. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020; 181: 271–280. DOI: 10,1016/j.cell.2020.02.052Hoffmann M., Kleine-Weber H., Schroeder S., Kruger N., Herrler T., Erichsen S. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020; 181: 271–280. DOI: 10,1016/j.cell.2020.02.052Synowiec A., Szczepanski A., Barreto-Duran E., Lie L.K., Pyrc K. Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2): a systemic infection. Clin Microbiol Rev 2021; 34: e00133–20. DOI: 10,1128/CMR.00133–20Synowiec A., Szczepanski A., Barreto-Duran E., Lie L.K., Pyrc K. Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2): a systemic infection. Clin Microbiol Rev 2021; 34: e00133–20. DOI: 10,1128/CMR.00133–20Logunov D.Y., Dolzhikova I.V., Shcheblyakov D.V., Tukhvatulin A.I., Zubkova O.V., Dzharullaeva A.S. et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet 2021; 397(10275): 671–681. DOI: 10,1016/S0140–6736(21)00234–8Logunov D.Y., Dolzhikova I.V., Shcheblyakov D.V., Tukhvatulin A.I., Zubkova O.V., Dzharullaeva A.S. et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet 2021; 397(10275): 671–681. DOI: 10,1016/S0140–6736(21)00234–8Song Z., Xu Y., Bao L., Zhang L., Yu P., Qu Y. From SARS to MERS, thrusting coronaviruses into the spotlight. Viruses 2019; 11(1): 59. DOI: 10,3390/v11010059Song Z., Xu Y., Bao L., Zhang L., Yu P., Qu Y. From SARS to MERS, thrusting coronaviruses into the spotlight. Viruses 2019; 11(1): 59. DOI: 10,3390/v11010059Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y. Сlinical features of patients infected with the new coronavirus 2019 in Wuhan, China. The Lancet 2020; 395: 497–506Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y. Сlinical features of patients infected with the new coronavirus 2019 in Wuhan, China. The Lancet 2020; 395: 497–506Mallapaty S. Why does the coronavirus spread so easily between people? Nature 2020; 579: 183. DOI: 10,1038/d41586–020–00660-xMallapaty S. Why does the coronavirus spread so easily between people? Nature 2020; 579: 183. DOI: 10,1038/d41586–020–00660-xРумянцев А.Г. Коронавирусная инфекция COVID-19. Научные вызовы и возможные пути лечения и профилактики заболевания. Российский журнал детской гематологии и онкологии 2020; 7(3): 47–53. DOI: 10,21682/2311–1267–2020–7–3–47–53Rumyantsev A.G. Coronavirus infection COVID-19. Scientific challenges and possible ways of treatment and prevention of the disease. Rossiyskiy zhurnal detskoy gematologii i onkologii 2020; 7(3): 47–53. (in Russ.) DOI: 10,21682/2311–1267–2020–7–3–47–53Аксенова А.Ю. Фактор Фон Виллебранда и повреждение эндотелия: возможная связь с COVID-19. Экологическая генетика. 2020; 18(2): 135–138. DOI: 10,17816/ecogen33973Aksenova A.Yu. Von Willebrand factor and endothelial damage: a possible link to COVID-19. Ecological genetics. 2020; 18(2): 135–138. (in Russ.) DOI: 10,17816/ecogen33973Liu J., Li S., Liu J., Liang B., Wang X., Wang H. et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine 2020; 55: 102763. DOI: 10,1016/j.ebiom.2020,102763Liu J., Li S., Liu J., Liang B., Wang X., Wang H. et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBio- Medicine 2020; 55: 102763. DOI: 10,1016/j.ebiom.2020,102763Feldstein L.R., Rose E.B., Horwitz S.M., Collins J.P., Newhams M.M., Son M.B.F. et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med 2020; 383(4): 334–346. DOI: 10,1056/NEJMoa2021680Feldstein L.R., Rose E.B., Horwitz S.M., Collins J.P., Newhams M.M., Son M.B.F. et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med 2020; 383(4): 334–346. DOI: 10,1056/NEJMoa2021680Liang W., Feng Z., Rao S., Xiao C., Xue X., Lin Z. et al. Diarrhea may be underestimated: the missing link in the new coronavirus 2019. Gut 2020; 69: 1141–1143. DOI: 10,1136/gutjnl-2020–320832Liang W., Feng Z., Rao S., Xiao C., Xue X., Lin Z. et al. Diarrhea may be underestimated: the missing link in the new coronavirus 2019. Gut 2020; 69: 1141–1143. DOI: 10,1136/gutjnl-2020–320832Salvatore S., Marinoni M., Agosti М. Additional Concerns Regarding Children With Coronavirus Disease 2019. JAMA Pediatr 2020; 174(12): 1217–1218. DOI: 10,1001/jamapediatrics.2020,2922Salvatore S., Marinoni M., Agosti М. Additional Concerns Regarding Children With Coronavirus Disease 2019. JAMA Pediatr 2020; 174(12): 1217–1218. DOI: 10,1001/jamapediatrics.2020,2922Levin M. Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic. N Engl J Med 2020; 383(4): 393–395. DOI: 10,1056/NEJMe2023158Levin M. Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic. N Engl J Med 2020; 383(4): 393–395. DOI: 10,1056/NEJMe2023158Onouchi Y. The genetics of Kawasaki disease. Int J Rheum Dis 2018; 21: 26–30. DOI: 10,1111/1756–185X.13218Onouchi Y. The genetics of Kawasaki disease. Int J Rheum Dis 2018; 21: 26–30. DOI: 10,1111/1756–185X.13218Намазова-Баранова Л.С. Коронавирусная инфекция (COVID-19) у детей. Педиатрическая фармакология 2020; 17 (3): 162–168. DOI:10,15690/pf.v17i3,2121)Namazova-Baranova L.S. Coronavirus infection (COVID-19) in children. Pediatricheskaya farmakologiya 2020; 17 (3): 162–168. (in Russ.) DOI:10,15690/pf.v17i3,2121)Lassandro G., Palladino V., Amoruso A., Palmieri V.V., Russo G., Giordano P. Children in Coronaviruses Wonderland: What Clinicians Need to Know. Mediterr J Hematol Infect Dis 2020; 12(1): e2020042. DOI: 10,4084/MJHID.2020,042Lassandro G., Palladino V., Amoruso A., Palmieri V.V., Russo G., Giordano P. Children in Coronaviruses Wonderland: What Clinicians Need to Know. Mediterr J Hematol Infect Dis 2020; 12(1): e2020042. DOI: 10,4084/MJHID.2020,042Zou L., Ruan F., Huang M., Liang L., Huang H., Hong Z. et al. Sars-Cov-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 2020; 382 (12): 1177–1179. DOI: 10,1056/NEJMc2001737Zou L., Ruan F., Huang M., Liang L., Huang H., Hong Z. et al. Sars-Cov-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 2020; 382 (12): 1177–1179. DOI: 10,1056/NEJMc2001737an Doremalen N., Bushmaker T., Morris D.H., Holbrook M.G., Gamble A., Williamson B.N., Tamin A. et al. Aerosol and surface stability of Sars-Cov-2 as compared with Sars-Cov-1. N Engl J Med 2020; 382(16): 1564–1567. DOI: 10,1056/NEJMc2004973an Doremalen N., Bushmaker T., Morris D.H., Holbrook M.G., Gamble A., Williamson B.N., Tamin A. et al. Aerosol and surface stability of Sars-Cov-2 as compared with Sars-Cov-1. N Engl J Med 2020; 382(16): 1564–1567. DOI: 10,1056/NEJMc2004973Намазова-Баранова Л.С., Баранов А.А. COVID-19 и дети. Пульмонология 2020; 30(5): 609–628. DOI: 10,18093/0869–0189–2020–30–5–609–628Namazova-Baranova L.S., Baranov A.A. COVID-19 and children. Pulmonologiya 2020; 30(5): 609–628. (in Russ.) DOI: 10,18093/0869–0189–2020–30–5–609–628Jiehao C., Jin X., Daojiong L., Zhi Y., Lei X., Zhenghai Q. et al. A case series of children with 2019 novel coronavirus infection: Clinical and epidemiological features. Clin Infect Dis 2020; 71(6): 1547–1551. DOI: 10,1093/cid/ciaa198Jiehao C., Jin X., Daojiong L., Zhi Y., Lei X., Zhenghai Q. et al. A case series of children with 2019 novel coronavirus infection: Clinical and epidemiological features. Clin Infect Dis 2020; 71(6): 1547–1551. DOI: 10,1093/cid/ciaa198Donà D., Minotti C., Costenaro P., Da Dalt L., Giaquinto C. Fecal-Oral Transmission of SARS-CoV-2 In Children: is it Time to Change Our Approach? Pediatr Infect Dis J 2020; 39 (7): e133–e134. DOI: 10,1097/INF.0000000000002704Donà D., Minotti C., Costenaro P., Da Dalt L., Giaquinto C. Fecal-Oral Transmission of SARS-CoV-2 In Children: is it Time to Change Our Approach? Pediatr Infect Dis J 2020; 39 (7): e133–e134. DOI: 10,1097/INF.0000000000002704Горелов А.В., Николаева С.В., Акимкин В.Г. Новая коронавирусная инфекция COVID-19: особенности течения у детей в Российской Федерации. Педиатрия им. Г.Н. Сперанского 2020; 99(6): 57–62.Gorelov A.V., Nikolaeva S.V., Akimkin V.G. New coronavirus infection COVID-19: features of the course in children in the Russian Federation. Pediatriya. Zhurnal of Speranskyi 2020; 99 (6): 57–62. (in Russ.)Мескина Е.Р. Предварительный клинико-эпидемиологический анализ первых 1000 случаев COVID-19 у детей в Московской области. Журнал микробиологии, эпидемиологии и иммунобиологии 2020; 97(3): 202–215. DOI: 10,36233/0372–9311–2020–97–3–2Meskina E.R. Preliminary clinical and epidemiological analysis of the first 1000 cases of COVID-19 in children in the Moscow region. Zhurnal mikrobiologii, epidemiologii i immunobiologii 2020; 97(3): 202–215. (in Russ.) DOI: 10,36233/0372–9311–2020–97–3–2De Rose D.U., Piersigilli F., Ronchetti M.P., Santisi А., Bersani Il., Dotta A. et al. Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far. Italian J Pediatr 2020; 46: 56–64. DOI: 10,1186/s13052–020–0820-xDe Rose D.U., Piersigilli F., Ronchetti M.P., Santisi А., Bersani Il., Dotta A. et al. Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far. Italian J Pediatr 2020; 46: 56–64. DOI: 10,1186/s13052–020–0820-xZhou F., Yu T., Du R., Fan G., Liu Y., Liu Z. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229): 1054–1062. DOI: 10,1016/S0140–6736(20)30566–3Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229): 1054–1062. DOI: 10,1016/S0140–6736(20)30566–3Временные методические рекомендации профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Версия 8 (03.09.2020). Минздрав РФ, 2020: 220. https://стопкоронавирус.рф/ai/doc/1213/attach/vmr_COVID-19_V14_27–12–2021.pdf/ Ссылка активна на 28.02.2022.Interim guidelines for the prevention, diagnosis and treatment of novel coronavirus infection (COVID-19). Version 8 (03.09.2020). Ministry of Health of the Russian Federation, 2020: 220. (in Russ.) https://стопкоронавирус.рф/ai/doc/1213/attach/vmr_COVID-19_V14_27–12–2021.pdf/ Ссылка активна на 28.02.2022.Zhu H., Wang L., Fang C., Peng S., Zhang L., Chang G. et al. Clinical analysis of 10 neonates born to mothers with 2019nCoV pneumonia. Transl Pediatr 2020; 9(1): 51–60. DOI: 10,21037/tp.2020.02.06Zhu H., Wang L., Fang C., Peng S., Zhang L., Chang G. et al. Clinical analysis of 10 neonates born to mothers with 2019- nCoV pneumonia. Transl Pediatr 2020; 9(1): 51–60. DOI: 10,21037/tp.2020.02.06Пиманов С.И., Дикарева Е.А. Гастроэнтерологические проявления COVID-19: первые обобщения. Клинический разбор в общей медицине 2020; 1: 6–13. DOI: 10,47407/kr2020,1.1,00001Pimanov S.I., Dikareva E.A. Gastroenterological manifestations of COVID-19: first generalizations. Klinicheskiy razbor v obshchey meditsine 2020; 1: 6–13. (in Russ.) DOI: 10,47407/kr2020,1.1,00001Фурман Е.Г. Коронавирусная инфекция COVID-19 и дети. Педиатрия им. Г.Н. Сперанского 2020; 99(3): 245–251.Furman E.G. Coronavirus infection COVID-19 and children. Pediatriya. Zhurnal of Speranskyi 2020; 99(3): 245–251. (in Russ.)Гоми Р., Асгари Н., Хаджихейдари А., Эстеки Р., Байбанаки Ф., Насиринасаб Ф. Пандемия COVID-19: систематический обзор современных данных. Инфекция и иммунитет 2020; 10(4): 655–663. DOI: 10,15789/2220–7619-TCP-1508Gomi R., Asgari N., Hajiheidari A., Esteki R., Baybanaki F., Nasirinasab F. The COVID-19 pandemic: a systematic review of current evidence. Infektsiya i immunitet 2020; 10(4): 655–663. (in Russ.) DOI: 10,15789/2220–7619-TCP-1508Каледа М.И., Никишина И.П., Федоров Е.С., Насонов Е.Л. Коронавирусная болезнь 2019 (COVID-19) у детей: уроки педиатрической ревматологии. Научно-практическая ревматология. 2020; 58(5): 469–479. DOI: 10,47360/1995–4484–2020–469–479Kaleda M.I., Nikishina I.P., Fedorov E.S., Nasonov E.L. Coronavirus Disease 2019 (COVID-19) in Children: Lessons from Pediatric Rheumatology. Nauchno-prakticheskaya revmatologiya 2020; 58 (5): 469–479. (in Russ.) DOI: 10,47360/1995–4484–2020–469–479Whittaker E., Bamford A., Kenny J., Kaforou M., Joneset C.E., Shah P. et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 2020; 324(3): 259–269. DOI: 10,1001/jama.2020,10369Whittaker E., Bamford A., Kenny J., Kaforou M., Joneset C.E., Shah P. et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 2020; 324(3): 259–269. DOI: 10,1001/jama.2020,10369Belhadjer Z., Méot M., Bajolle F., Khraichet D., Legendre A., Abakka S. et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation 2020; 142(5): 429–436. DOI: 10,1161/CIRCULATIONAHA.120,048360Belhadjer Z., Méot M., Bajolle F., Khraichet D., Legendre A., Abakka S. et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation 2020; 142(5): 429–436. DOI: 10,1161/CIRCULATIONAHA.120,048360Multisystem Inflammatory Syndrome in Children (MIS-C). Centers for Disease Control and Prevention [internet]. https://www.cdc.gov/mis-c/hcp/ Ссылка активна на 25.02.2022Multisystem Inflammatory Syndrome in Children (MIS-C). Centers for Disease Control and Prevention [internet]. https://www.cdc.gov/mis-c/hcp/ Ссылка активна на 25.02.2022Azkur Ah. K., Akdis M., Azkur D., Sokolowska М., van de Veen W., Brüggen M.-Ch., еt al. Immune response to SARSCoV-2 and mechanisms of immunopathological changes in COVID-19. Allergy 2020; 75(7): 1564–1581. DOI: 10,1111/all.14364Azkur Ah. K., Akdis M., Azkur D., Sokolowska М., van de Veen W., Brüggen M.-Ch., еt al. Immune response to SARSCoV- 2 and mechanisms of immunopathological changes in COVID-19. Allergy 2020; 75(7): 1564–1581. DOI: 10,1111/all.14364Deeks J.J., Dinnes J., Takwoingi Y., Davenport C., Spijker R., Taylor-Phillips S. et al. Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Database Syst Rev 2020; 6(6): CD013652. DOI: 10,1002/14651858.CD013652Deeks J.J., Dinnes J., Takwoingi Y., Davenport C., Spijker R., Taylor-Phillips S. et al. Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Database Syst Rev 2020; 6(6): CD013652. DOI: 10,1002/14651858.CD013652Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020:1–10. DOI: 10,1016/S0140–6736(20)30183–5Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020:1–10. DOI: 10,1016/S0140–6736(20)30183–5Заплатников А.Л., Османов И.М., Горев В.В., Дмитриев А.В., Миронова А.К., Дементьев А.А. и др. Новая коронавирусная инфекция COVID-19 в практике неонатолога и педиатра. Рос вестн перинатол и педиатр 2020; 65(3): 71–17. DOI: 10,21508/1027–4065–2020–65–3–11–17Zaplatnikov A.L., Osmanov I.M., Gorev V.V., Dmitriev A.V., Mironova A.K., Dementyev A.A. et al. New coronavirus infection COVID-19 in the practice of a neonatologist and pediatrician. Rossiyskiy vestnik perinatologii i pediatrii 2020; 65(3): 11–17. (in Russ.) DOI: 10,21508/1027–4065–2020–65–3–11–17Пилат Т.Л., Радыш И.В., Суровцев В.В., Коростелева М.М., Ханферьян Р.А. Возможности специализированной диетической коррекции нарушений желудочно-кишечного тракта у больных с вирусной инфекцией СOVID-19. Лечащий врач 2020; 8: 11–18.Pilat T.L., Radysh I.V., Surovtsev V.V., Korosteleva M.M., Khanferyan R.A. Possibilities of specialized dietary correction of disorders of the gastrointestinal tract in patients with COVID-19 viral infection. Lechashchiy vrach 2020; 8: 11– 18. (in Russ.)Сао В., Wang Y., Wen D., Liu W., Wang J., Fan G. et al. A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19. N Engl J Med 2020; 382(19): 1787–1799. DOI: 10,1056/NEJMoa2001282Сао В., Wang Y., Wen D., Liu W., Wang J., Fan G. et al. A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19. N Engl J Med 2020; 382(19): 1787–1799. DOI: 10,1056/NEJMoa2001282Мелехина Е.В., Горелов А.В., Музыка А.Д. Клинические особенности течения COVID-19 у детей различных возрастных групп. Обзор литературы к началу апреля 2020 года. Вопросы практической педиатрии 2020; 15(2): 7–20. DOI:10,20953/1817–7646–2020–2–7–20Melekhina E.V., Gorelov A.V., Music A.D. Clinical features of the course of COVID-19 in children of different age groups. Literature review by early April 2020. Voprosy prakticheskoy pediatrii 2020; 15(2): 7–20. (in Russ.) DOI:10,20953/1817–7646–2020–2–7–20Геппе Н.А., Афанасьева О.И., Заплатников А.Л., Кондюрина Е.Г. Коронавирусная инфекция у детей. Вопросы практической педиатрии 2020; 15(5): 73–86. DOI: 10,20953/1817–7646–2020–5–73–86Geppe N.A., Afanasyeva O.I., Zaplatnikov A.L., Kondyurina E.G. Coronavirus infection in children. Voprosy prakticheskoy pediatrii 2020; 15(5): 73–86. (in Russ.) DOI: 10,20953/1817–7646–2020–5–73–86Götzinger F., Santiago-García B., Noguera-Julián A., Lanaspa M., Lancella L., Carducci F.I.C. et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health 2020; 4: 653–661. DOI: 10,1016/S2352–4642(20)30177–2Götzinger F., Santiago-García B., Noguera-Julián A., Lanaspa M., Lancella L., Carducci F.I.C. et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health 2020; 4: 653–661. DOI: 10,1016/S2352–4642(20)30177–2Groß S., Jahn Ch. Cushman S., Bär Ch., Thum Th. SARSCoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications. J Mol Cel Cardiol 2020; 144: 47–53. DOI: 10,1016/j.yjmcc.2020.04.031Groß S., Jahn Ch. Cushman S., Bär Ch., Thum Th. SARSCoV- 2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications. J Mol Cel Cardiol 2020; 144: 47–53. DOI: 10,1016/j.yjmcc.2020.04.031Diez J.-M., Romero C., Gajardo R. Currently available intravenous immunoglobulin (GamunexR-C and Flebogamma R DIF) contains antibodies reacting against SARS-CoV-2 antigens. BioRxiv 2020: 029017. DOI: 10,1101/2020.04.07,029017Diez J.-M., Romero C., Gajardo R. Currently available intravenous immunoglobulin (GamunexR-C and Flebogamma R DIF) contains antibodies reacting against SARS-CoV-2 antigens. BioRxiv 2020: 029017. DOI: 10,1101/2020.04.07,029017Климов Ю.А., Тихонов С.В., Лалабекова М.В., Батышева Т.Т., Аксенова Е.И., Быкова О.В. и др. Медицинская реабилитация детей, перенесших COVID-19, в режиме дистанционного дневного стационара с использованием цифровых технологий: временное методическое руководство №71. М.: Департамент здравоохранения г. Москвы, 2020: 40.Klimov Yu.A., Tikhonov S.V., Lalabekova M.V., Batysheva T.T., Aksenova E.I., Bykova O.V. et al. Medical rehabilitation of children who have undergone COVID-19 in the mode of a remote day hospital using digital technologies: temporary methodological guide No. 71. M.: Moscow Department of Health, 2020: 40. (in Russ.)Министерство здравоохранения Российской Федерации. Методические рекомендации: Особенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (COVID-19) у детей. Версия 2 (03.07.2020). https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/050/914/original/03062020_дети_COVID-19_v2.pdf/ Ссылка активна на 25.02.2022.Ministry of Health of the Russian Federation. Methodical recommendations: Features of clinical manifestations and treatment of a disease caused by a new coronavirus infection (COVID-19) in children. Version 2 (07/03/2020). (in Russ.) https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/050/914/original/03062020_дети_COVID-19_v2.pdf/ Ссылка активна на 25.02.2022.

The authors declare that there are no conflicts of interest present.