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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">perinatology</journal-id><journal-title-group><journal-title xml:lang="ru">Российский вестник перинатологии и педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-4065</issn><issn pub-type="epub">2500-2228</issn><publisher><publisher-name>Ltd. “The National Academy of Pediatric Science and Innovation”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21508/1027-4065-2022-67-3-61-65</article-id><article-id custom-type="elpub" pub-id-type="custom">perinatology-1653</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Васкуло-эндетелиальный фактор роста в грудном молоке</article-title><trans-title-group xml:lang="en"><trans-title>Vascular endothelial growth factor in breast milk</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3011-4247</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дементьева</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dementieva</surname><given-names>Yu. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дементьева Юлия Назымовна — ст. преподаватель кафедры педиатрии</p><p>432017 Ульяновск, ул. Л. Толстого, д. 42</p></bio><bio xml:lang="en"><p>Ulyanovsk</p></bio><email xlink:type="simple">basyrovayu@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6589-3354</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черданцев</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherdantsev</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черданцев Александр Петрович — д.м.н., доц., проф. кафедры педиатрии</p><p>432017 Ульяновск, ул. Л. Толстого, д. 42</p></bio><bio xml:lang="en"><p>Ulyanovsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5475-7031</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгова</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgova</surname><given-names>D. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Долгова Динара Ришатовна — к.б.н., доц., дир. Научно-исследовательского медико-биологического центра </p><p>432017 Ульяновск, ул. Л. Толстого, д. 42</p></bio><bio xml:lang="en"><p>Ulyanovsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3246-6078</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стенюшкина</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stenyushkina</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стенюшкина Мария Анатольевна — асс. кафедры педиатрии </p><p>432017 Ульяновск, ул. Л. Толстого, д. 42</p></bio><bio xml:lang="en"><p>Ulyanovsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0937-313X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бахтогаримов</surname><given-names>И. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakhtogarimov</surname><given-names>I. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бахтогаримов Ильдар Рамильевич — аспирант 1-го года обучения</p><p>119991 Москва, ул. Вавилова, д. 32</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Епифанова</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Epifanova</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Епифанова Елена Геннадьевна — студент V курса медицинского факультета </p><p>432017 Ульяновск, ул. Л. Толстого, д. 42</p></bio><bio xml:lang="en"><p>Ulyanovsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ульяновский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ulyanovsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Engelhardt Institute of Molecular Biology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>09</day><month>08</month><year>2022</year></pub-date><volume>67</volume><issue>3</issue><fpage>61</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ltd. “The National Academy of Pediatric Science and Innovation”, 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><copyright-holder xml:lang="en">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><license xlink:href="https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.ped-perinatology.ru/jour/article/view/1653">https://www.ped-perinatology.ru/jour/article/view/1653</self-uri><abstract><p>Фактор роста эндотелия сосудов — одно из звеньев ангиогенеза; проявляет различную активность в грудном молоке при изменениях условий его хранения.</p><sec><title>Цель исследования</title><p>Цель исследования. Оценка концентрации фактора роста эндотелия сосудов (VEGF) в грудном молоке и периферической крови у женщин с различным состоянием здоровья в динамике лактации; оценка влияния физических факторов на активность данного показателя.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 96 кормящих женщин. Образцы грудного молока и периферической крови для проведения лабораторной части исследования брали на 3–5-е сутки после родов, затем через 1, 3 и 6 мес лактации. Для оценки влияния физических факторов на уровень VEGF в грудном молоке использовали разные режимы температурного воздействия: заморозку и длительное (до 6 мес) хранение, нагрев в СВЧ-печи до температуры 60 °С.</p></sec><sec><title>Заключение</title><p>Заключение. Показано, что уровень VEGF в молоке не меняется в пробах, полученных от женщин с различным уровнем здоровья во время беременности и лактации. Консервация молока при низкой температуре влияет на снижение концентрации данного белка более чем в 4 раза. Быстрое нагревание проб методом СВЧ-воздействия (до температуры 60 °С) приводит к частичной инактивации белка.</p></sec></abstract><trans-abstract xml:lang="en"><p>Vascular endothelial growth factor is a consequence of angiogenesis links, while at the same time it exhibits different activity under changes in breast milk storage conditions.</p><sec><title>Purpose</title><p>Purpose. To study the vascular endothelial growth factor (vascular endothelial growth factor, VEGF) in breast milk and peripheral blood in women with different states of health in the dynamics of lactation, to assess the effect of physical exposure on this indicator.</p></sec><sec><title>Material and methods</title><p>Material and methods. 96 lactating women were enrolled in the study. The sampling of breast milk and peripheral blood for the laboratory part of the study was carried out 3–5 days after birth, then after 1, 3, and 6 months of lactation. To assess the influence of physical factors on the level of VEGF in breast milk, different modes of temperature exposure were used: freezing and long-term (up to 6 months) storage, heating in a microwave oven up to +60°C.</p></sec><sec><title>Conclusion</title><p>Conclusion. It has been shown that the VEGF level does not change in samples obtained from women with different states of health during pregnancy and lactation. Preservation of milk at a low temperature affects the reduction of this protein by more than 4 times. Rapid heating of samples by microwave exposure (up to +60°C) leads to partial inactivation of the protein.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>грудное молоко</kwd><kwd>VEGF</kwd><kwd>иммунитет</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>breast milk</kwd><kwd>VEGF</kwd><kwd>immunity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Castillo-Castaneàda P.C., Garciàa-Gonzaàlez A., BencomoAlvarez A.E., Barros-Nuneàz P., Gaxiola-Robles R., Celina Meàndez-Rodri àguez L., Zenteno-Savi àn T. Micronutrient Content and Antioxidant Enzyme Activities in Human Breast Milk. J Trace Elem Med Biol 2019; 51: 36–41. 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