perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2022-67-4-143-150perinatology-1687Research ArticleОБМЕН ОПЫТОМSHARING EXPERIENCESЧастота врожденных пороков сердца у новорожденных: десятилетний опыт одной клиникиFrequency of congenital heart diseases in newborn: ten years’ single clinic experiencehttps://orcid.org/0000-0003-0513-9012СоколовА. А.SokolovA. A.

д.м.н., проф., рук. лаборатории ультразвуковых и функциональных методов исследований Научно-исследовательского института кардиологии, 

634012 Томск, ул. Киевская, д. 111 А

Tomsk

https://orcid.org/0000-0001-7500-3589МарцинкевичГ. И.MartsinkevichG. I.

к.м.н., зав. отделением ультразвуковой и функциональной диагностики Научно-исследовательского института кардиологии, 

634012 Томск, ул. Киевская, д. 111 А

Tomsk

https://orcid.org/0000-0002-6531-7223СморгонА. И.SmorgonA. V.

мл. науч. сотр. лаборатории ультразвуковых и функциональных методов исследований Научно-исследовательского института кардиологии,

634012 Томск, ул. Киевская, д. 111 А

Tomsk

a.v.smorgon@gmail.comФБГНУ «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияTomsk National Research Medical Center of the Russian Academy of SciencesRussian Federation202222092022674143150Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20222022Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1687

Врожденные пороки сердца встречаются в популяции с частотой 8 на 1000 живорожденных. Информация о распростраренности различных врожденных пороков сердца у новорожденных в связи с широким внедрением пренатальной ультразвуковой диагностики и повышением ее точности позволяет планировать беременность и тактику ведения новорожденных с критическими пороками сердца. Целью настоящего исследования было ретроспективное изучение частоты различия различных врожденных пороков сердца по данным эхокардиографического исследования среди новорожденных в рамках опыта одной клиники за период с 2009 по 2019 г. В клинике НИИ кардиологии эхокардиографические исследования выполнены у 34 298 детей в возрасте от 1 дня до 17 лет, средний возраст составил 3,68 года, медианный 2,0 года. Новорожденные из них составляли 4,6% (n=1607). Проанализированы результаты эхокардиографических исследований у 1607 новорожденных в возрасте от 1 до 27 дней. У 247 (15,3%) обследуемых врожденных пороков не выявлено, у 1360 новорожденных имелись различные врожденные пороки сердца. Установлено, что наиболее часто встречающимися пороками у новорожденных были дефекты межжелудочковой перегородки (37%), более 60% из  них составили клинически незначимые мелкие мышечные дефекты. Показано, что частота вычвления врожденных пороков сердца у новорожденных со сложной пренатальной диагностикой (коарктация аорты, двойное отхождение сосудов) увеличилась в последние годы. Определялось снижение частоты развития дефекта атриовентрикулярной перегородки в течение последних 5 лет. Возможности кардиохирургии новорожденных в конкретной клинике влияли на структуру выявления отдельных врожденных пороков сердца вследствие пренатального планирования беременности и хирургической тактики. 

Congenital heart disease occurs in the population with a frequency of 8 per 1000 live births. Information on the incidence of various congenital heart defects in newborns in connection with the widespread introduction of prenatal ultrasound diagnostics and an increase in its accuracy allows for planning pregnancy and management of newborns with critical heart defects. The aim of this study wasto retrospectively study the incidence of various congenital heart defects according to echocardiographic studies among newborns in the framework of the experience of one clinic over the period from 2009 to 2019. In the clinic of the Science Research Institute of Cardiology, echocardiographic studies were performed in 34298 children aged 1 day to 17 years, the average age was 3.68 years, the median 2.0 years. The newborns accounted for 4.6% of them (n = 1607). The results of echocardiographic studies were analyzed in 1607 newborns aged from 1 to 27 days. In 247 (15.3%) of the examined no congenital defects were detected, 1360 newborns had various congenital heart diseases. It was found that the most common anomaly in  newborns were interventricular septal defects (37%), more than 60% of all interventricular septal defects were clinically insignificant small muscle defects. It has been shown that the incidence of congenital heart defects in newborns with complex prenatal diagnosis (coarctation of the aorta, double outlet right ventricle) has increased in recent years. A decrease in the incidence of atrioventricular septal defect was observed over the past five years. The possibilities of neonatal cardiac surgery in a particular clinic influenced the structure of the occurrence of individual congenital heart disease due to prenatal pregnancy planning and surgical tactics. 

детиврожденные пороки сердцаэхокардиографияноворожденныераспространенностьchildrencongenital heart diseaseechocardiographynewbornsprevalenceReferencesEgbe A., Uppu S., Stroustrup A., Lee S., Ho D., Srivastav S. Incidences and sociodemographics of specific congenital heart diseases in the United States of America: an evaluation of hospital discharge diagnoses. Pediatr Cardiol 2014; 35(6): 975-982. DOI: 10.1007/s00246-014-0884-8Egbe A., Uppu S., Stroustrup A., Lee S., Ho D., Srivastav S. Incidences and sociodemographics of specific congenital heart diseases in the United States of America: an evaluation of hospital discharge diagnoses. Pediatr Cardiol 2014; 35(6): 975-982. DOI: 10.1007/s00246-014-0884-8Titus M.J., Moodley J. Advances in fetal genetic diagnosis and therapy: ethical issues and appropriate technology in cost-restrained countries. Best Pract Res Clin Obstet Gynae Col 2012; 26(5): 531-540. DOI: 10.1016/j.bpobgyn.2012.06.004. Epub 2012 Jul 31.Titus M.J., Moodley J. Advances in fetal genetic diagnosis and therapy: ethical issues and appropriate technology in cost-restrained countries. Best Pract Res Clin Obstet Gynae Col 2012; 26(5): 531-540. DOI: 10.1016/j.bpobgyn.2012.06.004. Epub 2012 Jul 31.Gottschalk I., Abel J.S., Menzel T., Herberg U., Breuer J., Gembruch U. et al. Prenatal diagnosis, associated findings and postnatal outcome of fetuses with double outlet right ventricle (DORV) in a single center. J Perinat Med 2019; 47(3): 354- 364. DOI: 10.1515/jpm-2018-0316Gottschalk I., Abel J.S., Menzel T., Herberg U., Breuer J., Gembruch U. et al. Prenatal diagnosis, associated findings and postnatal outcome of fetuses with double outlet right ventricle (DORV) in a single center. J Perinat Med 2019; 47(3): 354- 364. DOI: 10.1515/jpm-2018-0316Lopez L., Colan S.D., Frommelt P.C., Ensing G.J., Kendall K., Younoszai A.K. et al. Recommendations for Quantification Methods During the Performance of a Pediatric Echocardiogram: A Report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr 2010; 23: 465-495. DOI: 10.1016/j.echo.2010.03.019Lopez L., Colan S.D., Frommelt P.C., Ensing G.J., Kendall K., Younoszai A.K. et al. Recommendations for Quantification Methods During the Performance of a Pediatric Echocardiogram: A Report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr 2010; 23: 465-495. DOI: 10.1016/j.echo.2010.03.019Chanda S.L., Singh N., Shukla D.K. Incidence of congenital heart disease. Indian J Pediatr 2001; 68: 507-510. DOI: 10.1007/BF02723241Chanda S.L., Singh N., Shukla D.K. Incidence of congenital heart disease. Indian J Pediatr 2001; 68: 507-510. DOI: 10.1007/BF02723241Bharucha T., Hlavacek A.M., Spicer D.E., Theocharis P., Anderson R.H. How should we diagnose and differentiate hearts with double-outlet right ventricle? Cardiol Young 2017; 27(1): 1-15. DOI: 10.1017/S1047951116001190Bharucha T., Hlavacek A.M., Spicer D.E., Theocharis P., Anderson R.H. How should we diagnose and differentiate hearts with double-outlet right ventricle? Cardiol Young 2017; 27(1): 1-15. DOI: 10.1017/S1047951116001190Quartermain M.D., Hill K.D., Goldberg D.J., Jacobs J.P., Jacobs M.L., Pasquali S.K. et al. Prenatal Diagnosis Influences Preoperative Status in Neonates with Congenital Heart Disease: An Analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database. Pediatr Cardiol 2019; 40(3): 489-496. DOI: 10.1007/s00246-018-1995-4Quartermain M.D., Hill K.D., Goldberg D.J., Jacobs J.P., Jacobs M.L., Pasquali S.K. et al. Prenatal Diagnosis Influences Preoperative Status in Neonates with Congenital Heart Disease: An Analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database. Pediatr Cardiol 2019; 40(3): 489-496. DOI: 10.1007/s00246-018-1995-4Jacobs J.P. The science of assessing the outcomes and improving the quality of the congenital and paediatric cardiac care Curr Opin Cardiol 2015; 30(1): 100-11. DOI: 10.1097/HCO.0000000000000133Jacobs J.P. The science of assessing the outcomes and improving the quality of the congenital and paediatric cardiac care Curr Opin Cardiol 2015; 30(1): 100-11. DOI: 10.1097/HCO.0000000000000133Fatema N.N., Chowdhury R.B., Chowdhury L. Incidence of congenital heart disease among hospital live births in a tertiary hospital of Bangladesh. Cadiovasc J 2008; 1: 14-20. DOI: 10.3329/cardio.v1i1.8199Fatema N.N., Chowdhury R.B., Chowdhury L. Incidence of congenital heart disease among hospital live births in a tertiary hospital of Bangladesh. Cadiovasc J 2008; 1: 14-20. DOI: 10.3329/cardio.v1i1.8199Hoffman J.I., Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 1890-1900. DOI: 10.1016/s0735-1097(02)01886-7Hoffman J.I., Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 1890-1900. DOI: 10.1016/s0735-1097(02)01886-7Li J.J., Liu Y., Xie S.Y., Zhao G.D., Dai T., Chen H. et al. Newborn screening for congenital heart disease using echocardiography and follow-up at high altitude in China. Int J Cardiol 2019; 274: 106-112. DOI: 10.1016/j.ijcard.2018.08.102Li J.J., Liu Y., Xie S.Y., Zhao G.D., Dai T., Chen H. et al. Newborn screening for congenital heart disease using echocardiography and follow-up at high altitude in China. Int J Cardiol 2019; 274: 106-112. DOI: 10.1016/j.ijcard.2018.08.102Wu M.H., Chen H.C., Lu C.W., Wang J.K., Huang S.C., Huang S.K. Prevalence of congenital heart disease at live birth in Taiwan. J Pediatr 2010; 156(5): 782-785. DOI: 10.1016/j.jpeds.2009.11.062Wu M.H., Chen H.C., Lu C.W., Wang J.K., Huang S.C., Huang S.K. Prevalence of congenital heart disease at live birth in Taiwan. J Pediatr 2010; 156(5): 782-785. DOI: 10.1016/j.jpeds.2009.11.062Linde D., Konings E.M., Slager M.A., Witsenburg M., Helbing W.A., Johanna J. et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol 2011; 58(21): 2241-2247. DOI: 10.1016/j.jacc.2011.08.025Linde D., Konings E.M., Slager M.A., Witsenburg M., Helbing W.A., Johanna J. et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol 2011; 58(21): 2241-2247. DOI: 10.1016/j.jacc.2011.08.025Zhao Q.M., Niu C., Liu F., Wu L., Ma X.J., Huang G.Y. Spontaneous Closure Rates of Ventricular Septal Defects (6,750 Consecutive Neonates). Am J Cardiol 2019; 124(4): 613-617. DOI: 10.1016/j.amjcard.2019.05.022 15.Zhao Q.M., Niu C., Liu F., Wu L., Ma X.J., Huang G.Y. Spontaneous Closure Rates of Ventricular Septal Defects (6,750 Consecutive Neonates). Am J Cardiol 2019; 124(4): 613-617. DOI: 10.1016/j.amjcard.2019.05.022 15.Miyake T., Shinohara T., Nakamura Y., Fukuda T., Tasato H., Toyohara K. et al. Spontaneous closure of ventricular septal defects followed up from˂3 months of age. Pediatr Int 2004; 46(2): 135–140. DOI: 10.1046/j.1442–200x.2004.01858. xMiyake T., Shinohara T., Nakamura Y., Fukuda T., Tasato H., Toyohara K. et al. Spontaneous closure of ventricular septal defects followed up from˂3 months of age. Pediatr Int 2004; 46(2): 135–140. DOI: 10.1046/j.1442–200x.2004.01858. xVaidya R., Wilson D., Paris Y., Madore L., Singh R. Use of acetaminophen for patent ductus arteriosus treatment: a single center experience. J Matern Fetal Neonatal Med 2020; 33(16): 2723–2729. DOI: 10.1080/14767058.2018.1559810Vaidya R., Wilson D., Paris Y., Madore L., Singh R. Use of acetaminophen for patent ductus arteriosus treatment: a single center experience. J Matern Fetal Neonatal Med 2020; 33(16): 2723–2729. DOI: 10.1080/14767058.2018.1559810McGrath R.L., McGuinness G.A., Way G.L., Wolfe R.R., Nora J.J., Simmons M.A. The silent ductus arteriosus. J Pediatr 1978; 93(1): 110–113. DOI: 10.1016/s0022– 3476(78)80617–9McGrath R.L., McGuinness G.A., Way G.L., Wolfe R.R., Nora J.J., Simmons M.A. The silent ductus arteriosus. J Pediatr 1978; 93(1): 110–113. DOI: 10.1016/s0022– 3476(78)80617–9Hussain S., Sabir M., Afzal M., Asghar I. Incidence of congenital heart disease among neonates in a neonatal unit of a tertiary care hospital. J Pak Med Assoc 2014; 64(2): 175–178Hussain S., Sabir M., Afzal M., Asghar I. Incidence of congenital heart disease among neonates in a neonatal unit of a tertiary care hospital. J Pak Med Assoc 2014; 64(2): 175–178Saxena A., Mehta A., Sharma M., Salhan S., Kalaivani M., Ramakrishnan S. et al. Birth prevalence of congenital heart disease: A cross-sectional observational study from North India. Ann Pediatr Cardiol 2016; 9(3): 205–209. DOI: 10.4103/0974–2069.189122Saxena A., Mehta A., Sharma M., Salhan S., Kalaivani M., Ramakrishnan S. et al. Birth prevalence of congenital heart disease: A cross-sectional observational study from North India. Ann Pediatr Cardiol 2016; 9(3): 205–209. DOI: 10.4103/0974–2069.189122Tanner K., Sabrine N., Wren C. Cardiovascular malformations among preterm infants. Pediatrics 2005; 116(6): e833–8. DOI: 10.1542/peds.2005–0397Tanner K., Sabrine N., Wren C. Cardiovascular malformations among preterm infants. Pediatrics 2005; 116(6): e833–8. DOI: 10.1542/peds.2005–0397Kenny D., Hares D., Uzun O. Ventricular non-compaction in the setting of double-outlet right ventricle (tetralogy of Fallot type) with doubly committed subarterial ventricular septal defect. Heart 2007; 93(5): 647. DOI: 10.1136/hrt.2006.090480Kenny D., Hares D., Uzun O. Ventricular non-compaction in the setting of double-outlet right ventricle (tetralogy of Fallot type) with doubly committed subarterial ventricular septal defect. Heart 2007; 93(5): 647. DOI: 10.1136/hrt.2006.090480Беспалова Е.Д., Тюменева А.И., Синьковская Е.С., Суратова О.Г. Пренатальная ультразвуковая диагностика сложных врожденных пороков сердца. Бюллетень НЦССХ им. А.Н. Бакулева РАМН «Сердечно-сосудистые заболевания» 2003; 4(11): 321.Bespalova E.D., Tyumeneva A.I., Sinkovskaya E.S., Suratova O.G. Prenatal ultrasound diagnosis of complex congenital heart defects. Bjulleten’ NCSSH im. A.N. Bakuleva RAMN «Serdechno-sosudistye zabolevanija» 2003; 4(11): 321. (in Russ.)Шаповал Л.А., Куркевич А.К. Роль фетальной эхокардиографии в составлении прогноза для плода с полной атриовентрикулярной коммуникацией. Современная педиатрия 2019; 2(98): 12-17.Shapoval L.A., Kurkevich A.K. The role of fetal echocardiography in predicting a fetus with complete atrioventricular communication. Sovremennaja pediatrija 2019; 2(98): 12-17. (in Russ.)Adriaanse B.M., Uittenbogaard L.B., Tromp C.H.N., Schaefer S.S., Heymans M.W., van Vugt J.M. et al. Prenatal examination of the area and morphology of the atrioventricular valves using four-dimensional ultrasound in normal and abnormal hearts Prenat Diagn 2015; 35(8): 741-747. DOI: 10.1002/pd.4569Adriaanse B.M., Uittenbogaard L.B., Tromp C.H.N., Schaefer S.S., Heymans M.W., van Vugt J.M. et al. Prenatal examination of the area and morphology of the atrioventricular valves using four-dimensional ultrasound in normal and abnormal hearts Prenat Diagn 2015; 35(8): 741-747. DOI: 10.1002/pd.4569Calkoen E., Adriaanse B., Haak M., Bartelings M., Kolesnik A., Niszczota C. How Normal is a ‘Normal’ Heart in Fetuses and Infants with Down Syndrome? Fetal Diagn Ther 2016; 39(1): 13-20. DOI: 10.1159/000381710Calkoen E., Adriaanse B., Haak M., Bartelings M., Kolesnik A., Niszczota C. How Normal is a ‘Normal’ Heart in Fetuses and Infants with Down Syndrome? Fetal Diagn Ther 2016; 39(1): 13-20. DOI: 10.1159/000381710

The authors declare that there are no conflicts of interest present.