perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2022-67-5-163-169perinatology-1718Research ArticleК XVIII РОССИЙСКОМУ КОНГРЕССУ «ПЕДИАТРИЯ И ДЕТСКАЯ ХИРУРГИЯ В ПРИВОЛЖСКОМ ФЕДЕРАЛЬНОМ ОКРУГЕ». ОРИГИНАЛЬНЫЕ СТАТЬИКонцентрация серотонина в крови у детей при COVID-19Blood serotonin concentration in children with COVID-19https://orcid.org/0000-0003-3676-2130ХуснутдиноваЛ. Р.KhusnutdinovaL. R.

асп. кафедры госпитальной педиатрии,

420012 Казань, ул. Бутлерова, д. 49

Kazan

husnutdinova-lil@mail.ruhttps://orcid.org/0000-0002-6662-3548СадыковаД. И.SadykovaD. I.

д.м.н., зав. кафедрой госпитальной педиатрии, 

420012 Казань, ул. Бутлерова, д. 49

Kazan

https://orcid.org/0000-0002-4686-1231НигматуллинаР. Р.NigmatullinaR. R.

д.б.н., проф. кафедры нормальной физиологии,

420012 Казань, ул. Бутлерова, д. 49

Kazan

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииРоссияKazan State Medical UniversityRussian Federation202220112022675163169Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20222022Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1718

При COVID-19 имеется риск развития тромботических осложнений. Серотонин известен как медиатор, играющий важную роль в патогенезе тромбообразования.

Цель

Цель. Изучить уровень серотонина и его метаболита в крови у детей при COVID-19.

Материал и методы

Материал и методы. В исследовании участвовали 72 ребенка в возрасте от 3 до 17 лет. Из них 43 пациента (средний возраст 11,2±4,8 года) с диагнозом «новая коронавирусная инфекция COVID-19» без сопутствующей патологии составили основную группу, 29 здоровых детей (средний возраст 11,8±3,8 года) — контрольную группу. Концентрацию серотонина и его метаболита 5-гидроксииндолуксусной кислоты (5-ГИУК) в крови определяли при помощи метода высокоэффективной жидкостной хроматографии с электрохимическим детектированием. Для определения степени тяжести поражения легких использовали данные компьютерной томографии.

Результаты

Результаты. В нашем исследовании при COVID-19 у детей в возрасте от 3 до 17 лет уровень серотонина и его метаболита значительно выше по сравнению с контролем. Концентрация серотонина в плазме крови в основной группе в 20–30 раз выше по сравнению с одновозрастным контролем. Соотношение 5-гидроксииндолуксусная кислота/серотонин у детей с COVID-19 значительно ниже, чем в контрольной группе. При сравнении уровня серотонина и 5-ГИУК у детей с COVID-19 в зависимости от степени поражения легких не выявлено статистически значимых различий.

Заключение

Заключение. Уровень серотонина и его метаболита в крови у детей с COVID-19 статистически значимо повышается, что может быть связано с гиперактивацией тромбоцитов при инфекции SARS-CoV2 и риском повышенного тромбообразования. 

COVID-19 has a risk of thrombotic complications. Serotonin plays an important role in pathogenesis of thrombosis.

Purpose

Purpose. To evaluate level of serotonin and its metabolite in the blood of children with COVID-19.

Methods

Methods. This study included 72 children aged 3 to 17 years. Of these, 43 patients (mean age 11.2 ± 4.8 years) diagnosed with COVID-19 without comorbidities made up the study group, 29 healthy children (mean age 11.8 ± 3.8 years) — the control group. Concentration of serotonin and its metabolite (5-HIAA) in the blood was determined using high performance liquid chromatography with electrochemical detection. Computed tomography data were used to determine severity of lung damage.

Results

Results. In our study children with COVID-19 aged 3 to 17 years had significantly higher serotonin and its metabolite levels compared to the control group. Concentration of serotonin in plasma in main group was 20–30 times higher than in the same-age control. The 5-HIAA/serotonin ratio in children with COVID-19 is significantly lower than in the control group. Levels of serotonin and 5-HIAA in children with COVID-19 depending on the severity of CT-scan lung damage showed no significant differences.

Conclusion

Conclusion. Serotonin and its metabolite levels in plasma of children with COVID-19 is significantly increased. It may be related to platelet hyperactivation in SARS-CoV-2 infection and increased risk of thrombosis, which requires further research. 

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The authors declare that there are no conflicts of interest present.