perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2023-68-3-117-123perinatology-1834Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУFOR THE PRACTITIONERПищевая аллергия и анафилаксия на грецкий орехFood allergy and anaphylaxis to walnuthttps://orcid.org/0000-0002-6137-6138ИвановА. А.IvanovA. A.

Иванов Артем Александрович - врач-педиатр педиатрического соматического отделения

119049 Москва, 4-й Добрынинский переулок, дом 1/9

Moscow

IvanovAA32@zdrav.mos.ruhttps://orcid.org/0000-0001-8792-2670ЕсаковаН. В.EsakovaN. V.

Есакова Наталья Владиславовна - к.м.н., ст. науч. сотр. отдела аллергологии и клинической иммунологии

125412 Москва, ул. Талдомская, д. 2

Moscow

https://orcid.org/0000-0002-4514-8469ЗиминС. Б.ZiminS. B.

Зимин Сергей Борисович - врач-педиатр, зав. педиатрическим соматическим отдел

119049 Москва, 4-й Добрынинский переулок, дом 1/9

Moscow

https://orcid.org/0000-0001-8272-3648ГоревВ. В.GorevV. V.

Горев Валерий Викторович - к.м.н., гл. врач

119049 Москва, 4-й Добрынинский переулок, дом 1/9

Moscow

https://orcid.org/0000-0001-5039-8473ПампураА. Н.PampuraA. N.

Пампура Александр Николаевич - д.м.н., зав. отделом аллергологии и клинической иммунологии; врач–аллерголог-иммунолог педиатрического соматического отделения

119049 Москва, 4-й Добрынинский переулок, дом 1/9

125412 Москва, ул. Талдомская, д. 2

Moscow

ГБУЗ «Морозовская детская городская клиническая больница ДЗМ»РоссияMorozov Children’s City HospitalRussian FederationОСП «Научно-исследовательский клинический институт педиатрии и детской хирургии им. академика Ю.Е. Вельтищева» (Институт Вельтищева) ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияVeltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical UniversityRussian FederationГБУЗ «Морозовская детская городская клиническая больница ДЗМ»; ОСП «Научно-исследовательский клинический институт педиатрии и детской хирургии им. академика Ю.Е. Вельтищева» (Институт Вельтищева) ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияMorozov Children’s City Hospital; Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical UniversityRussian Federation202315072023683117123Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20232023Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1834

Среди большого разнообразия орехов грецкий орех представляется аллергеном, заслуживающим особого внимания в контексте острых аллергических реакций, ввиду их тяжести/системности, низкой индуцирующей пороговой дозы триггера и минимальной вероятности развития толерантности. Вместе с тем общее потребление грецкого ореха неуклонно растет, при этом данные об удельной доле рассматриваемого аллергена как триггера анафилаксии незаслуженно занижены ввиду его часто «скрытого» присутствия в продуктах питания и сложностей верификации триггера. В настоящей статье представлены эпидемиологические аспекты пищевой аллергии к грецкому ореху, приведены современные данные о молекулярной характеристике и свойствах различных белков аллергена, их клинической значимости для развития анафилаксии. Статья дополнена разбором двух клинических случаев пищевой анафилаксии к грецкому ореху из собственной клинической практики.

Among the wide variety of tree nuts, walnut is an allergen that deserves special attention in the context of acute allergic reactions, due to their severity, low inducing trigger dose, and minimal likelihood of developing tolerance. The overall consumption of walnut has been steadily increasing, while the importance of this allergen as a trigger for anaphylaxis is underestimated due to its often “hidden” presence in foods and the difficulty of trigger verification. This article presents the epidemiological aspects of walnut food allergy, provides current data on the molecular characteristics and properties of various allergen proteins, and their clinical significance for the development of anaphylaxis. The article is supplemented with two clinical cases of food anaphylaxis to walnuts from own clinical practice.

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The authors declare that there are no conflicts of interest present.