perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2023-68-4-61-XXperinatology-1849Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВлияние физических нагрузок на окислительно-восстановительный статус детей с корригированными врожденными пороками сердцаThe effect of the physical exercise on the redox status of chil- dren with repaired congenital heart diseaseshttps://orcid.org/0000-0002-7999-8656ДубоваяА. В.DubovayaA. V.

Анна Валериевна Дубовая, д. м. н., проф., зав. кафедрой

кафедра педиатрии № 3

283003

пр. Ильича, д. 16

Донецк

Donetsk

dubovaya_anna@mail.ruhttps://orcid.org/0000-0001-6729-3248УсенкоН. А.UsenkoN. A.

Надежда Алексеевна Усенко, асс.

кафедра педиатрии № 3

283003

пр. Ильича, д. 16

Донецк

Donetsk

https://orcid.org/0000-0002-3082-5447БордюговаЕ. В.BordyugovaE. V.

Елена Вячеславовна Бордюгова, доц.

кафедра педиатрии № 3

283003

пр. Ильича, д. 16

Донецк

Donetsk

ФГБОУ ВО «Донецкий государственный медицинский университет им. М. Горького» Минздрава РоссииРоссияM. Gorky Donetsk State Medical UniversityRussian Federation2023060920236846165Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20232023Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1849   Цель исследования

   Цель исследования. Оценка влияния программы физической реабилитации с включением препарата убидекаренон на окислительно-восстановительный статус у детей с корригированными врожденными пороками сердца.

   Материалы и методы

   Материалы и методы. Изучено состояние маркеров свободно-радикального окисления (лактата, пирувата, отношения лактата к пирувату) и антиоксидантной системы (каталазы, восстановленного глутатиона в эритроцитах и глутатионпероксидазы) у 84 детей, из них 48 детей с корригированными врожденными пороками сердца и 36 здоровых сверстников. Основную группу составили 28 пациентов, которые в течение года выполняли программу реабилитации с применением физических нагрузок в сочетании с приемом препарата убидекаренон, группу сравнения — 20 детей, получавшие только убидекаренон.

   Результаты

   Результаты. После выполнения программы реабилитации у детей как основной группы, так и группы сравнения отмечались достоверное (р < 0,05) снижение уровня лактата, отношения лактата к пирувату и повышение уровня каталазы и восстановленного глутатиона в эритроцитах. Группа детей, выполнявших физические упражнения, имела достоверное меньшие, чем пациенты из группы сравнения, уровни маркеров свободно-радикального окисления и более высокую активность ферментов антиоксидантной системы.

   Выводы

   Выводы. У детей с корригированными врожденными пороками сердца выявлены нарушения в процессах свободно-радикального окисления и антиоксидантной системы. Применение убидекаренона снижает окислительный стресс и повышает антиоксидантную защиту у детей с корригированными врожденными пороками сердца. Включение физических нагрузок в программу реабилитации детей с корригированными пороками сердца улучшает окислительно-восстановительный статус и повышает эффективность реабилитационных мероприятий.

   Purpose

   Purpose. Evaluation of the impact of the physical rehabilitation program with the inclusion of ubidecarenone on the redox status in children with repaired congenital heart diseases.

   Material and methods

   Material and methods. Markers of free radical oxidation (lactate, pyruvate, lactate-to-pyruvate ratio) and antioxidant system (catalase, reduced glutathione and glutathione peroxidase) were studied in 84 children, including 48 children with repaired congenital heart diseases and 36 healthy peers. The main group consisted of 28 patients who performed a rehabilitation program using physical activity in combination with taking ubidecarenone for a year, the comparison group consisted of 20 children who received only ubidecarenone.

   Results

   Results. After the rehabilitation program was completed, both the main group and the comparison group had a significant (p < 0.05) decrease in lactate levels, the ratio of lactate to pyruvate, and an increase in catalase and reduced RBC glutathione. The group of children who performed physical exercises had significantly lower levels of markers of free radical oxidation and higher values of markers of the antioxidant system than the patients from the comparison group.

   Conclusion

   Conclusion. There are free radical oxidation and the antioxidant system impairments in children with repaired congenital heart diseases. The use of ubidecarenone reduces oxidative stress and increases antioxidant protection in children with repaired congenital heart diseases. The inclusion of physical activity in the rehabilitation program for children with repaired congenital heart diseases improves the redox status and increases the effectiveness of rehabilitation.

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The authors declare that there are no conflicts of interest present.