perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2023-68-5-22-29perinatology-1870Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSСовременные представления о клебсиеллезной инфекции у детейCurrent insight into klebsiella infection in childrenНиколаеваИ. В.NikolaevaI. V.

Николаева Ирина Венидиктовна — д.м.н., проф., зав. кафедрой инфекционных болезней  

420012 Казань, ул. Бутлерова, д. 49

Kazan

irinanicolaeva@mail.ruhttps://orcid.org/0000-0001-9651-2307СеменоваД. Р.SemenovaD. R.

Семенова Дина Рашидовна — к.м.н., зав. боксированным отделением №14 

420110 Казань, пр. Победы, д. 83, кор. 2

Kazan

https://orcid.org/0000-0002-4389-4775ШайхиеваГ. С.ShaikhievaG. S.

Шайхиева Гульнара Сиреневна — к.м.н., зав. боксированным отделением №15 

420110 Казань, пр. Победы, д. 83, кор. 2

Kazan

ФГБОУ ВО «Казанский государственный медицинской университет» МЗ РФРоссияKazan State Medical University of the Ministry of Health of RussiaRussian FederationГАУЗ «Республиканская клиническая инфекционная больница им. профессора А.Ф. Агафонова» Минздрава Республики ТатарстанРоссияRepublican Clinical Hospital of Infectious DiseasesRussian Federation2023141120236852229Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20232023Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1870

Klebsiella pneumoniae — значимый возбудитель внутрибольничных и внебольничных инфекций у детей. Актуальность клебсиеллезной инфекции возросла в последние годы в связи с распространением полирезистентных и гипервирулентных штаммов, способных вызывать инвазивные формы инфекции (сепсис, менингит, абсцесс печени и др.). Штаммы Kl. pneumoniae, продуцирующие β-лактамазы расширенного спектра действия, а также карбапенемрезистентные штаммы служат причиной внутрибольничных вспышек с высокой летальностью. Выбор антибактериальных препаратов для лечения инвазивных форм инфекции ограничен и зависит от спектра чувствительности к противомикробным препаратам циркулирующих в стационаре клинических изолятов клебсиелл и возраста ребенка. В связи с высокой частотой продукции β-лактамаз расширенного спектра карбапенемы являются препаратами выбора в эмпирической терапии инвазивных форм инфекции.

Klebsiella pneumoniae is an important causative agent of nosocomial and community-acquired infections in children. The relevance of Klebsiella infection has increased in recent years due to the spread of multiresistant and hypervirulent strains that can cause invasive forms of infection (sepsis, meningitis, liver abscess, etc.). Strains of Kl. pneumoniae, producing extended-spectrum β-lactamase (ESBL), as well as carbapenem-resistant strains, are the cause of nosocomial outbreaks with high mortality. The choice of antibacterial drugs for the treatment of invasive forms of infection is limited and depends on the spectrum of sensitivity to antimicrobial drugs of Klebsiella clinical isolates circulating in the hospital and the age of the child. Due to the high rate of ESBL production, carbapenems are the drugs of choice in the empirical therapy of invasive forms of infection.

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The authors declare that there are no conflicts of interest present.