perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”perinatology-188Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSМеханизмы развития и тяжесть синдрома анемии при хронической болезни почек у детейMechanisms for development of anemia and its severity in children with chronic kidney diseaseЛысоваЕ. В.LysovaE. V.

асп. кафедры факультетской педиатрии

СавенковаН. Д.SavenkovaN. D.

д.м.н., проф., зав. кафедрой факультетской педиатрии

ГБОУ ВПО «Санкт-Петербургский государственный педиатрический медицинский университет»РоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation2015140320166033136Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20162016Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/188

В обзоре литературы обобщены современные сведения о причинах и механизмах развития синдрома анемии при хронической болезни почек у детей. Продемонстрирована связь между тяжестью анемии и состоянием обмена железа, уровнем гепсидина, дефицитом эритропоэтина, изменением уровня HIF-1 и HIF-2 на разных стадиях хронической болезни почек у детей. Приведены данные о значении HIF-1α в стимуляции эритропоэза на ранних стадиях хронической болезни почек. По результатам исследований показано снижение уровня HIF-1α на поздних стадиях заболевания. 

The literature review summarizes current information on the causes of and mechanisms for the development of anemia in children with chronic kidney disease. It demonstrates the relationship between the severity of anemia and iron metabolism, hepcidin, erythropoietin deficiency, and changes in the levels of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in different stages of chronic kidney disease in children. There are data on the value of HIF-1α in stimulating erythropoiesis in the early stages of chronic kidney disease. The studies have shown a reduction in HIF-1α in the later stages of this disease. 

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The authors declare that there are no conflicts of interest present.