perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-1-25-33perinatology-1935Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSМитохондриальная динамика и значение ее нарушений в развитии детских болезней. Часть I. Физиологические и неврологические аспектыMitochondrial dynamics and the significance of its disturbances in the development of childhood diseases. Part I. Physiological and neurological aspectshttps://orcid.org/0000-0002-0552-6939СухоруковВ. С.SukhorukovV. S.

Владимир Сергеевич Сухоруков, д. м. н., проф., зав. лабораторией, проф.

Институт мозга

лаборатория нейроморфологии

кафедра гистологии, эмбриологии и цитологии

117997

ул. Островитянова, д. 1

Москва

Moscow

https://orcid.org/0000-0002-8999-9986БараничТ. И.BaranichT. I.

Татьяна Ивановна Баранич, к. м. н., ст. науч. сотр.

Институт мозга

лаборатория нейроморфологии

117997

ул. Островитянова, д. 1

Москва

Moscow

https://orcid.org/0000-0001-7112-2556ЕгороваА. В.EgorovaA. V.

Анна Валериевна Егорова, к. м. н., науч. сотр.

Институт мозга

лаборатория нейроморфологии

117997

ул. Островитянова, д. 1

Москва

Moscow

https://orcid.org/0009-0000-2413-0262ФедороваЕ. Н.FedorovaE. N.

Евгения Николаевна Федорова, лаборант-исследователь

Институт мозга

лаборатория нейроморфологии

117997

ул. Островитянова, д. 1

Москва

Moscow

https://orcid.org/0009-0000-2413-0262СкворцоваК. А.SkvortsovaK. A.

Кристина Андреевна Скворцова, лаборант, студентка

Институт мозга

лаборатория нейроморфологии

117997

ул. Островитянова, д. 1

Москва

Moscow

https://orcid.org/0009-0007-5533-084XХарламовД. А.KharlamovD. A.

Дмитрий Алексеевич Харламов, к. м. н., вед. науч. сотр.

119620

ул. Авиаторов, д. 38

Москва

Moscow

https://orcid.org/0000-0002-4653-9867КрапивкинА. И.KrapivkinA. I.

Алексей Игоревич Крапивкин, д. м. н., дир. центра, проф.

педиатрический факультет

кафедра госпитальной педиатрии им. академика В. А. Таболина

117997

ул. Островитянова, д. 1

Москва

Moscow

krapivkin@list.ruФГБНУ «Научный центр неврологии»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияResearch Center of Neurology; Pirogov Russian National Research Medical UniversityRussian FederationГБУЗ «Научно-практический центр специализированной медицинской помощи детям им. В.Ф. Войно-Ясенецкого»РоссияVoino-Yasenetsky Scientific and Practical Center for Specialized Medical Care for ChildrenRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ГБУЗ «Научно-практический центр специализированной медицинской помощи детям им. В.Ф. Войно-Ясенецкого»РоссияPirogov Russian National Research Medical University; Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care for ChildrenRussian Federation2024070320246912533Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1935

   Динамика митохондриальных преобразований в клетке вызывает в последние годы все больший интерес как представителей фундаментальной науки, так и исследователей в области прикладной медицины. Растет число наблюдений, доказывающих важное регуляторное влияние митохондриальной динамики на разнообразные физиологические и патологические процессы во многих, если не во всех, органных и тканевых структурах. Представляются все более важными перспективы изучения особенностей и регуляторов этих процессов для понимания патогенеза заболеваний, разработки их новых биомаркеров, а также технологий лечения.

   Цель настоящей статьи — обзор полученных в отношении митохондриальной динамики фактов, которые с точки зрения авторов заслуживают внимания педиатров.

   Объем соответствующей информации оказался слишком широк, чтобы уместиться в рамках одной статьи, что заставило разделить ее на несколько последовательных публикаций. В части I приведены сведения об основных процессах, включенных в понятие «митохондриальная динамика», о значении поддержания баланса последней для онтогенеза и тканевого гомеостаза, а также данные о ее нарушениях при болезнях нервной системы у детей.

   In recent years, the dynamics of mitochondrial transformations in cells have been of more concern to both representatives of basic science and researchers in the field of applied medicine. A growing number of observations demonstrate the important regulatory influence of mitochondrial dynamics on a variety of physiological and pathological processes in many, if not all, organ and tissue structures. The prospects for studying the features and regulators of these processes for understanding the pathogenesis of diseases, developing their new biomarkers, as well as treatment technologies seem increasingly significant.

   The purpose of this article is to review the facts obtained regarding mitochondrial dynamics, which, from the authors’ point of view, deserve the attention of pediatricians.

   The volume of relevant information turned out to be too extensive to fit into one article, which forced it to be divided into several successive publications. The first part provides information about the main processes included in the concept of “mitochondrial dynamics,” the importance of maintaining the balance of the latter for ontogenesis and tissue homeostasis, as well as data on its disturbances in diseases of the nervous system in children.

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The authors declare that there are no conflicts of interest present.