perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-2-5-11perinatology-1964Research ArticleПЕРЕДОВАЯEDITORIALЭпилептогенез и нейровоспалениеEpileptogenesis and neuroinflammationhttps://orcid.org/0000-0002-0625-1404СоколовП. Л.SokolovP. L.

Соколов Павел Леонидович - д.м.н., вед. науч. сотр.

119620 Москва, ул. Авиаторов, д. 38

Moscow

npc@npcmed.ruhttps://orcid.org/0000-0002-4653-9867КрапивкинА. И.KrapivkinA. I.

Крапивкин Алексей Игоревич - д.м.н., дир.

119620 Москва, ул. Авиаторов, д. 38

Moscow

ГБУЗ «Научно-практический центр специализированной медицинской помощи детям им. В.Ф. Войно-Ясенецкого» ДЗМРоссияVoino-Yasenetsky Scientific and Practical Center for Specialized Medical Care for ChildrenRussian Federation202407052024692511Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1964

Прогресс в терапии эпилепсии в последнее время определяется разработкой и применением новых противосудорожных средств, поиском новых альтернативных методов коррекции эпилептических приступов. Актуальной остается проблема фармакорезистентности. Представлен анализ информации о нейровоспалении как патофизиологическом феномене и его возможной роли в эпилептогенезе, а также перспективах воздействия на патологический процесс посредством вли- яния на элементы патогенеза. Приведены общие данные об эпилептогенезе, роли нейровоспаления в его формировании, об основных клеточных и гуморальных эффекторах нейровоспалительного процесса и перспективах формирования новых терапевтических подходов.

Progress in the treatment of epilepsy in recent years has been determined mainly by the development and use of new anticonvulsants, as well as the search for new alternative methods for reducing epileptic seizures. The issue of pharmacoresistance remains relevant. This paper presents an analysis of information about neuroinflammation as a pathophysiological phenomenon, its possible role in epileptogenesis and the prospects for influencing the pathological process in epilepsy by influencing its elements. General data on epileptogenesis, the role of neuroinflammation in its formation and maintenance, the main cellular and humoral effectors of the neuroinflammatory process and the prospects for the development of new therapeutic approaches are presented.

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The authors declare that there are no conflicts of interest present.