perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-2-12-18perinatology-1965Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSМитохондриальная динамика и значение ее нарушений в развитии детских болезней. Часть II. Кардиологические и эндокринологические аспектыMitochondrial dynamics and the significance of its disturbances in the development of childhood diseases. Part II. Cardiological and endocrinological aspectshttps://orcid.org/0000-0002-0552-6939СухоруковВ. С.SukhorukovV. S.

Сухоруков Владимир Сергеевич - д.м.н., проф., зав. лабораторией нейроморфологии Института мозга ; проф. кафедры гистологии, эмбриологии и цитологии

117997 Москва, ул. Островитянова, д. 1

Moscow

sukhorukov@neurology.ruhttps://orcid.org/0000-0002-8999-9986БараничТ. И.BaranichT. I.

Баранич Татьяна Ивановна - к.м.н., ст. науч. сотр. лаборатории нейроморфологии Института мозга ; доц. кафедры гистологии, эмбриологии и цитологии

117997 Москва, ул. Островитянова, д. 1

Moscow

https://orcid.org/0000-0001-7112-2556ЕгороваА. В.EgorovaA. V.

Егорова Анна Валериевна - к.м.н., науч. сотр. лаборатории нейроморфологии Института мозга; доц. кафедры гистологии, эмбриологии и цитологии

117997 Москва, ул. Островитянова, д. 1

Moscow

https://orcid.org/0009-0000-2413-0262ФедороваЕ. Н.FedorovaE. N.

Федорова Евгения Николаевна - лаборант-исследователь лаборатории нейроморфологии Института мозга; ассистент кафедры гистологии, эмбриологии и цитологии

117997 Москва, ул. Островитянова, д. 1

Moscow

https://orcid.org/0009-0000-2413-0262СкворцоваК. А.SkvortsovaK. A.

Скворцова Кристина Андреевна - лаборант лаборатории нейроморфологии Института мозга; студентка

117997 Москва, ул. Островитянова, д. 1

Moscow

ХарламовД. А.KharlamovD. A.

Харламов Дмитрий Алексеевич - к.м.н., вед. науч. сотр.

119620 Москва, ул. Авиаторов, д. 38

Moscow

https://orcid.org/0000-0002-4653-9867КрапивкинА. И.KrapivkinA. I.

Крапивкин Алексей Игоревич - д.м.н., дир.;  проф. кафедры госпитальной педиатрии им. академика В.А. Таболина педиатрического факультета

117997 Москва, ул. Островитянова, д. 1

119620 Москва, ул. Авиаторов, д. 38

Moscow

ФГБНУ «Научный центр неврологии»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияResearch Center of Neurology; Pirogov Russian National Research Medical UniversityRussian FederationГБУЗ «Научно-практический центр специализированной медицинской помощи детям им. В.Ф. Войно-Ясенецкого»РоссияVoino-Yasenetsky Scientific and Practical Center for Specialized Medical Care for ChildrenRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ГБУЗ «Научно-практический центр специализированной медицинской помощи детям им. В.Ф. Войно-Ясенецкого»РоссияPirogov Russian National Research Medical University; Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care for ChildrenRussian Federation2024080520246921218Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1965

Динамика митохондриальных преобразований в клетке вызывает в последние годы все больший интерес как представителей фундаментальной науки, так и исследователей в области прикладной медицины. Растет число наблюдений, доказывающих важное регуляторное влияние митохондриальной динамики на разнообразные физиологические и патологические процессы во многих, если не во всех органных и тканевых структурах. Представляются все более значимыми перспективы изучения особенностей и регуляторов этих процессов для понимания патогенеза заболеваний, разработки их новых биомаркеров, а также технологий лечения. Цель настоящей статьи — обзор полученных в отношении митохондриальной динамики фактов, которые, с точки зрения авторов, заслуживают внимания педиатров. Объем соответствующей информации оказался слишком широк, чтобы уместиться в рамках одной статьи, что заставило разделить ее на несколько последовательных публикаций. Во второй части приведены сведения о роли нарушений митохондриальной динамики в патогенезе сердечно-сосудистых и эндокринных заболеваний у детей.

In recent years, the dynamics of mitochondrial transformations in cells have been of more concern to both representatives of basic science and researchers in the field of applied medicine. A growing number of observations demonstrate the important regulatory influence of mitochondrial dynamics on a variety of physiological and pathological processes in many, if not all, organ and tissue structures. The prospects for studying the features and regulators of these processes for understanding the pathogenesis of diseases, developing their new biomarkers, as well as treatment technologies seem increasingly significant. The purpose of this article is to review the facts obtained regarding mitochondrial dynamics, which, from the authors’ point of view, deserve the attention of pediatricians. The volume of relevant information turned out to be too extensive to fit into one article, which forced it to be divided into several successive publications. The second part provides information about the role of mitochondrial dynamics disturbances in the pathogenesis of cardiovascular and endocrine diseases in children.

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The authors declare that there are no conflicts of interest present.