perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-2-34-41perinatology-1968Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSЭпидемиология ротавирусной инфекции: эволюция возбудителя и успехи вакцинацииEpidemiology of rotavirus infection: the evolution of the pathogen and the success of vaccinationhttps://orcid.org/0000-0001-6335-0487ГорбуновС. Г.GorbunovS. G.

Горбунов Сергей Георгиевич - д.м.н., проф. кафедры детских инфекционных болезней; гл. науч. сотр. отдела детских инфекционных заболеваний

125445 Москва, ул. Смольная, д. 38

Moscow

gsgsg70@mail.ruhttps://orcid.org/0000-0001-7257-8731ЧебуркинА. А.CheburkinA. A.

Чебуркин Андрей Андреевич - д.м.н., проф. кафедры детских инфекционных болезней

125445 Москва, ул. Смольная, д. 38

Moscow

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ГБУЗ Московской области «Научно-исследовательский клинический институт детства Минздрава Московской области»РоссияRussian Medical Academy of Continuing Professional Education; Research Clinical Institute of Childhood of the Moscow RegionRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Professional EducationRussian Federation2024080520246923441Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1968

В обзоре представлены данные о распространении различных генотипов ротавируса и его изменчивости в мире и в России, которые происходят как в силу естественных причин, так и под влиянием вакцинации против ротавирусной инфекции, а также о трансформации клинико-эпидемиологических особенностей течения этого заболевания у детей в результате происходящих мутаций возбудителя.

The review presents data on the spread of various rotavirus genotypes and its variability in the world and in Russia, which occur both due to natural causes and under the influence of vaccination against rotavirus infection, as well as on the transformation of clinical and epidemiological features of the course of this disease in children as a result of the pathogen mutations.

детиротавирусная инфекциягенотипштаммвакцинацияchildrenrotavirus infectiongenotypestrainvaccinationReferencesCrawford S.E., Ramani S., Tate J.E., Parashar U.D., Svensson L., Hagbom M. et al. Rotavirus infection. Nat Rev Dis Primers 2017; 3: 17083. DOI: 10.1038/nrdp.2017.83Crawford S.E., Ramani S., Tate J.E., Parashar U.D., Svensson L., Hagbom M. et al. Rotavirus infection. Nat Rev Dis Primers 2017; 3: 17083. DOI: 10.1038/nrdp.2017.83Gomez-Rial J., Sanchez-Batan S., Rivero-Calle I., Pardo-Seco J., Martinon-Martinez J.M., Salas A., Martinon-Torres F. Rotavirus infection beyond the gut. Infect Drug Resist 2019; 12: 55–64. DOI: 10.2147/IDR.S186404Gomez-Rial J., Sanchez-Batan S., Rivero-Calle I., Pardo-Seco J., Martinon-Martinez J.M., Salas A., Martinon-Torres F. Rotavirus infection beyond the gut. Infect Drug Resist 2019; 12: 55–64. DOI: 10.2147/IDR.S186404Dian Z., Sun Y., Zhang G., Xu Y., Fan X., Yang X. et al. Rotavirus-related systemic diseases: clinical manifestation, evidence and pathogenesis. Crit Rev Microboil 2021; 47(5): 580–595. DOI: 10.1080/1040841X.2021.1907738Dian Z., Sun Y., Zhang G., Xu Y., Fan X., Yang X. et al. Rotavirus-related systemic diseases: clinical manifestation, evidence and pathogenesis. Crit Rev Microboil 2021; 47(5): 580–595. DOI: 10.1080/1040841X.2021.1907738Ardura-Garcia C., Kreis C., Rakic M., Jaboyedoff M., Mallet M.C., Low N., Kuehni C.E. Rotavirus disease and health care utilisation among children under 5 years of age in highly developed countries: a systematic review and meta-analysis. Vaccine 2021; 39(22): 2917–2928. DOI: 10.1016/j.vaccine. 2021.04.039Ardura-Garcia C., Kreis C., Rakic M., Jaboyedoff M., Mallet M.C., Low N., Kuehni C.E. Rotavirus disease and health care utilisation among children under 5 years of age in highly developed countries: a systematic review and meta-analysis. Vaccine 2021; 39(22): 2917–2928. DOI: 10.1016/j.vaccine. 2021.04.039Gower C.M., Stowe J., Andrews N.J., Dunning J., Ramsay M.E., Ladhani S.N. Sustaines declines in age group-specific rotavirus infection and acute gastroenteritis in vaccinated and unvaccinated individuals during the 5 years since rotavirus vaccine introduction in England. Clin Infect Dis 2022; 74(3): 437–445. DOI: 10.1093/cid/ciab460Gower C.M., Stowe J., Andrews N.J., Dunning J., Ramsay M.E., Ladhani S.N. Sustaines declines in age group-specific rotavirus infection and acute gastroenteritis in vaccinated and unvaccinated individuals during the 5 years since rotavirus vaccine introduction in England. Clin Infect Dis 2022; 74(3): 437–445. DOI: 10.1093/cid/ciab460Olsson-Åkefeldt S., Rotzén-Östlund M., Hammas B., Eriksson M., Bennet R. All-cause gastroenteritis hospitalizations of children decreased after the introduction of rotavirus vaccine in Stockholm. Infect Dis 2022; 54(2): 120–127. DOI: 10.1080/23744235.2021.1982142Olsson-Åkefeldt S., Rotzén-Östlund M., Hammas B., Eriksson M., Bennet R. All-cause gastroenteritis hospitalizations of children decreased after the introduction of rotavirus vaccine in Stockholm. Infect Dis 2022; 54(2): 120–127. DOI: 10.1080/23744235.2021.1982142Perez-Ortin R., Santiso-Bellon C., Vila-Vicent S., Carmona-Vicente N., Rodriguez-Diaz J., Buesa J. Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain. BMC Infect Dis 2019; 19(1): 998. DOI: 10.1186/s12879–019–4550-xPerez-Ortin R., Santiso-Bellon C., Vila-Vicent S., Carmona-Vicente N., Rodriguez-Diaz J., Buesa J. Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain. BMC Infect Dis 2019; 19(1): 998. DOI: 10.1186/s12879–019–4550-xPerez-Ortin R., Vila-Vicent S., Carmona-Vicente N., Santiso-Bellon C., Rodriguez-Diaz J., Buesa J. Histo-blood group antigens in children with symptomatic rotavirus infection. Viruses 2019; 11(4): 339. DOI: 10.3390/v11040339Perez-Ortin R., Vila-Vicent S., Carmona-Vicente N., Santiso-Bellon C., Rodriguez-Diaz J., Buesa J. Histo-blood group antigens in children with symptomatic rotavirus infection. Viruses 2019; 11(4): 339. DOI: 10.3390/v11040339Stojkovska S., Kondova-Topuzovska I., Milenkovikj Z., Bosilkovski M., Grozdanovski K., Cvetanovska M. et al. Prevalence of rotaviruses in the etiology of acure diarrhea in young children, clinical forms, extraintestinal manifestations and complications. Makedon Akad Nauk Umet Odd Med Nauki 2020; 41(3): 23–30. DOI: 10.2478/prilozi-2020–0042Stojkovska S., Kondova-Topuzovska I., Milenkovikj Z., Bosilkovski M., Grozdanovski K., Cvetanovska M. et al. Prevalence of rotaviruses in the etiology of acure diarrhea in young children, clinical forms, extraintestinal manifestations and complications. Makedon Akad Nauk Umet Odd Med Nauki 2020; 41(3): 23–30. DOI: 10.2478/prilozi-2020–0042Подколзин А.Т., Фенске Е.Б., Абрамычева Н.Ю., Шипулин Г.А., Сагалова О.И., Мазепа В.Н. и др. Надзор за ротавирусной инфекцией по данным госпитализации в отдельных городах РФ за 2005–2007 гг. Инфекционные болезни 2008; 6(4): 28–31.Podkolzin A.T., Fenske E.B., Abramycheva N.Yu., Shipulin G.A., Sagalova O.I., Mazepa V.N. et al. Surveillance of rotavirus infection according to hospitalization data in selected cities of the Russian Federation for 2005–2007. Infektsionnye bolezni 2008; 6(4): 28–31. (in Russ.)Баранов А.А., Намазова-Баранова Л.С., Таточенко В.К., Вишнева Е.А., Федосеенко М.В., Селимзянова Л.Р. и др. Ротавирусная инфекция у детей — нерешенная проблема. Обзор рекомендаций по вакцинопрофилактике. Педиатрическая фармакология 2017; 14(4): 248–257.Baranov A.A., Namazova-Baranova L.S., Tatochenko V.K., Vishnyova E.A., Fedoseyenko M.V., Selimzyanova L.R. et al. Rotavirus infection in children is an unsolved problem. Review of recommendations on vaccine prophylaxis. Pediatricheskaya farmakologiya 2017; 14(4): 248–257. (in Russ.) DOI: 10.15690/pf.v14i4.1756Мартынова Г.П., Южакова А.Г., Соловьева И.А., Третьяков А.П. Ротавирусная инфекция у детей в Красноярском крае: первые шаги к снижению заболеваемости. Фарматека 2016; 11: 45–50.Martynova G.P., Yuzhakova A.G., Solovyeva I.A., Tretyakov A.P. Rotavirus infection in children in the Krasnoyarsk region: the first steps towards reducing morbidity. Farmateka 2016; 11: 45–50. (in Russ.)Денисюк Н.Б. Генетическая характеристика ротавирусов группы А, циркулирующих в Оренбургском регионе в сезон 2016–2017 гг. Детские инфекции 2017; 16(4): 42–45.Denisyuk N.B. Genetic characteristics of rotaviruses group A circulating in the Orenburg region in season 2016–2017. Detskiye infektsii 2017; 16(4): 42–45. DOI: 10.22627/2072–8107–2017–16–4–42–45. (in Russ.)Shen S., Ren S., Chen L. et al. Rotavirus infection in children <5 years of age in Suzhou, China, 2013–2019. Pediatr Infect Dis J 2022; 41(5):375–380. DOI: 10.1097/INF.0000000000003463Shen S., Ren S., Chen L. et al. Rotavirus infection in children <5 years of age in Suzhou, China, 2013–2019. Pediatr Infect Dis J 2022; 41(5):375–380. DOI: 10.1097/INF.0000000000003463Dong S., Huang D., Wang Z., Zhang G., Zhang F., Sai L. Clinical and molecular epidemiological characterization of rotavirus infections in children under five years old in Shandong province, China. Arch Virol 2021; 166(9): 2479–2486. DOI: 10.1007/s00705–021–05161–4Dong S., Huang D., Wang Z., Zhang G., Zhang F., Sai L. Clinical and molecular epidemiological characterization of rotavirus infections in children under five years old in Shandong province, China. Arch Virol 2021; 166(9): 2479–2486. DOI: 10.1007/s00705–021–05161–4Yu W.-J., Chen S.-Y., Tsai C.-N., Chao H.-C., Kong M.-S., Chang Y.-J., Chiu C.-H. Long-term impact of suboptimal rotavirus vaccines on acute gastroenteritis in hospitalized children in Northern Taiwan. J Formos Med Assoc 2018; 117(8): 720–726. DOI: 10.1016/j.jfma.2017.09.009Yu W.-J., Chen S.-Y., Tsai C.-N., Chao H.-C., Kong M.-S., Chang Y.-J., Chiu C.-H. Long-term impact of suboptimal rotavirus vaccines on acute gastroenteritis in hospitalized children in Northern Taiwan. J Formos Med Assoc 2018; 117(8): 720–726. DOI: 10.1016/j.jfma.2017.09.009Li W., Zhu Y., Lou J., Chen J., Xie X., Mao J. Rotavirus and adenovirus infections in children during COVID-19 outbreak in Hangzhou, China. Transl Pediatr 2021; 10(9): 2281–2282. DOI: 10.21037/tp-21–150Li W., Zhu Y., Lou J., Chen J., Xie X., Mao J. Rotavirus and adenovirus infections in children during COVID-19 outbreak in Hangzhou, China. Transl Pediatr 2021; 10(9): 2281–2282. DOI: 10.21037/tp-21–150Dass S.M., Pattnaik S., Amulya K. A study on prevalence of rotavirus infection in children below 5 years with acute gastroenteritis. Intern. J Commun Med Pub Health 2018; 5(8): 3358–3361. DOI: 10.18203/2394–6040.ijcmph20183061Dass S.M., Pattnaik S., Amulya K. A study on prevalence of rotavirus infection in children below 5 years with acute gastroenteritis. Intern. J Commun Med Pub Health 2018; 5(8): 3358–3361. DOI: 10.18203/2394–6040.ijcmph20183061Shetty R.S., Kamath V.G., Nayak D.M., Hegde A., Saluja T. Rotavirus associated acute gastroenteritis among under-five children admitted in two secondary care hospitals in southem Kamataka, India. Clin Epidemiol Global Health 2017; 5: 28–32. DOI: 10.1016/j.cegh.2016.06.002Shetty R.S., Kamath V.G., Nayak D.M., Hegde A., Saluja T. Rotavirus associated acute gastroenteritis among under-five children admitted in two secondary care hospitals in southem Kamataka, India. Clin Epidemiol Global Health 2017; 5: 28–32. DOI: 10.1016/j.cegh.2016.06.002Ali S., Khan S., Khan S.N., Rauf M., Khan M.F., Majid A. et al. Molecular detection and prevalence of rotavirus with acute gastroenteritis among the children of rural and urban areas. Braz J Biol 2021; 83: e244365. DOI: 10.1590/1519–6984.244365Ali S., Khan S., Khan S.N., Rauf M., Khan M.F., Majid A. et al. Molecular detection and prevalence of rotavirus with acute gastroenteritis among the children of rural and urban areas. Braz J Biol 2021; 83: e244365. DOI: 10.1590/1519–6984.244365Bhattarai V., Sharma S., Rijal K.R., Banjara M.R. Co-infection with campylobacter and rotavirus in less than 5 year old children with acute gastroenteritis in Nepal during 2017–2018. BMC Pediatr 2020; 20(1): 68. DOI: 10.1186/s12887–020–1966–9Bhattarai V., Sharma S., Rijal K.R., Banjara M.R. Co-infection with campylobacter and rotavirus in less than 5 year old children with acute gastroenteritis in Nepal during 2017–2018. BMC Pediatr 2020; 20(1): 68. DOI: 10.1186/s12887–020–1966–9Dey S.K., Sharif N., Sarkar O.S., Sarkar M.K., Talukder A.A., Phan T., Ushijima H. Molecular epidemiology and surveillance of circulating rotavirus among children with gastroenteritis in Bangladesh during 2014–2019. PLoS ONE 2020; 15(11): e0242813. DOI: 10.1371/journal.pone.0242813Dey S.K., Sharif N., Sarkar O.S., Sarkar M.K., Talukder A.A., Phan T., Ushijima H. Molecular epidemiology and surveillance of circulating rotavirus among children with gastroenteritis in Bangladesh during 2014–2019. PLoS ONE 2020; 15(11): e0242813. DOI: 10.1371/journal.pone.0242813Myat T.W., Thu H.M., Tate J.E., Burnett E., Cates J.E., Parashar U.D. et al. Rotavirus infection among children under five years of age hospitalized with acute gastroenteritis in Myanmar during 2018–2020 — Multicentre surveillance before rotavirus vaccine introduction. Vaccine 2021; 39(47): 6907–6912. DOI: 10.1016/j.vaccine.2021.10.014Myat T.W., Thu H.M., Tate J.E., Burnett E., Cates J.E., Parashar U.D. et al. Rotavirus infection among children under five years of age hospitalized with acute gastroenteritis in Myanmar during 2018–2020 — Multicentre surveillance before rotavirus vaccine introduction. Vaccine 2021; 39(47): 6907–6912. DOI: 10.1016/j.vaccine.2021.10.014Wahyuni R.M., Utsumi T., Dinana Z., Yamani L.N., Juniastuti, Wuwuti I.S. et al. Prevalence and distribution of rotavirus genotypes among children with acute gastroenteritis in areas other than Java island, Indonesia, 2016–2018. Front Microbiol 2021; 12: 672837. DOI: 10.3389/fmicb.2021.672837Wahyuni R.M., Utsumi T., Dinana Z., Yamani L.N., Juniastuti, Wuwuti I.S. et al. Prevalence and distribution of rotavirus genotypes among children with acute gastroenteritis in areas other than Java island, Indonesia, 2016–2018. Front Microbiol 2021; 12: 672837. DOI: 10.3389/fmicb.2021.672837Lestari F.B., Vongpunsawad S., Wanlapakorn N., Poovorawan Y. Rotavirus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seassonality, and vaccination. J Biomed Sci 2020; 27(1): 66. DOI: 10.1186/s12929–020–00649–8Lestari F.B., Vongpunsawad S., Wanlapakorn N., Poovorawan Y. Rotavirus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seassonality, and vaccination. J Biomed Sci 2020; 27(1): 66. DOI: 10.1186/s12929–020–00649–8Kawata K., Hikita T., Takanashi S., Hikita H., Ogita K., Okitsu S. et al. Diagnosis of acute gastroenteritis with immunochromatography and effectiveness of rotavirus vaccine in a japanese clinic. Access Microbiol 2020; 2: 1–6. DOI: 10.1099/acmi.0.000085Kawata K., Hikita T., Takanashi S., Hikita H., Ogita K., Okitsu S. et al. Diagnosis of acute gastroenteritis with immunochromatography and effectiveness of rotavirus vaccine in a japanese clinic. Access Microbiol 2020; 2: 1–6. DOI: 10.1099/acmi.0.000085Habash S.H., Habeeb S.I. Rotavirus diarrhea in children under five in Basrah: hospital based study. Pediatr Infect Dis 2018; 3: 6. DOI: 10.21767/2573–0282.100062Habash S.H., Habeeb S.I. Rotavirus diarrhea in children under five in Basrah: hospital based study. Pediatr Infect Dis 2018; 3: 6. DOI: 10.21767/2573–0282.100062Gündeşlioğlu Ö.Ö., Kocabaş E., Haytoğlu Z., Dayar G.T., Çil M.K., Durmaz R. Rotavirus prevalence and genotype distribution in children with acute gastroenteritis in Adana province. Mikrobiyol Bul 2018; 52(2): 156–165. DOI: 10.5578/mb.66648Gündeşlioğlu Ö.Ö., Kocabaş E., Haytoğlu Z., Dayar G.T., Çil M.K., Durmaz R. Rotavirus prevalence and genotype distribution in children with acute gastroenteritis in Adana province. Mikrobiyol Bul 2018; 52(2): 156–165. DOI: 10.5578/mb.66648Gönüllü E., Soysal A., Yıldız İ., Karaböcüoğlu M. Impact of self-financed rotavirus vaccination on acute gastroenteritis in young children in Turkey. Hum Vaccin Immunother 2021; 17(2): 510–516. DOI: 10.1080/21645515.2020.1776043Gönüllü E., Soysal A., Yıldız İ., Karaböcüoğlu M. Impact of self-financed rotavirus vaccination on acute gastroenteritis in young children in Turkey. Hum Vaccin Immunother 2021; 17(2): 510–516. DOI: 10.1080/21645515.2020.1776043Zaitoon H., Hanna S., Bamberger E. Impact of rotavirus vaccine implementation on israeli children: a comparison between pre- and post-vaccination era. World J Pediatr 2022; 18(6): 417–425. DOI: 10.1007/s12519–022–00547-zZaitoon H., Hanna S., Bamberger E. Impact of rotavirus vaccine implementation on israeli children: a comparison between pre- and post-vaccination era. World J Pediatr 2022; 18(6): 417–425. DOI: 10.1007/s12519–022–00547-zDamtie D., Melku M., Tessema B., Vlasova A.N. Prevalence and genetic diversity of rotaviruses among under-five children in Ethiopia: a systematic review and meta-analysis. Viruses 2020; 12(1): 62. DOI: 10.3390/v12010062Damtie D., Melku M., Tessema B., Vlasova A.N. Prevalence and genetic diversity of rotaviruses among under-five children in Ethiopia: a systematic review and meta-analysis. Viruses 2020; 12(1): 62. DOI: 10.3390/v12010062Chissaque A., Cassocera M., Gasparinho C., Langa J.S., Bauhofer A.F.L., Chilaule J.J. et al. Rotavirus A infection in children under five years old with a double health problem: undernutrition and diarrhoea — a cross-sectional study in four provinces of Mozambique. BMC Infect Dis 2021; 21: 18. DOI: 10.1186/s12879–020–05718–9Chissaque A., Cassocera M., Gasparinho C., Langa J.S., Bauhofer A.F.L., Chilaule J.J. et al. Rotavirus A infection in children under five years old with a double health problem: undernutrition and diarrhoea — a cross-sectional study in four provinces of Mozambique. BMC Infect Dis 2021; 21: 18. DOI: 10.1186/s12879–020–05718–9Mahamba D., Hokororo A., Mashuda F., Msanga D.R., Bendera E.C., Kwiyolecha E.N. et al. Prevalence and factors associated with rotavirus infection among vaccinated children hospitalized for acute diarrhea in Mwanza city, Tanzania: a cross sectional study. Open J Pediatr 2020; 10: 392–403. DOI: 10.4236/ojped.2020.103040Mahamba D., Hokororo A., Mashuda F., Msanga D.R., Bendera E.C., Kwiyolecha E.N. et al. Prevalence and factors associated with rotavirus infection among vaccinated children hospitalized for acute diarrhea in Mwanza city, Tanzania: a cross sectional study. Open J Pediatr 2020; 10: 392–403. DOI: 10.4236/ojped.2020.103040Nalitolela N., Kisenge R., Mkopi N.P., Manji K. Rotavirus diarrhoea among children aged <5 years in hospital setting in Dar Es Salaam, Tanzania. J Trop Pediatr 2021; 67(2): fmab035. DOI: 10.1093/tropej/fmab035Nalitolela N., Kisenge R., Mkopi N.P., Manji K. Rotavirus diarrhoea among children aged <5 years in hospital setting in Dar Es Salaam, Tanzania. J Trop Pediatr 2021; 67(2): fmab035. DOI: 10.1093/tropej/fmab035Bennett A., Pollock L., Bar-Zeev N., Lewnard J.A., Jere K.C., Lopman B. et al. Community transmission of rotavirus infection in a vaccinated population in Blantyre, Malawi: a prospective household cohort study. Lancet Infect Dis 2021; 21(5): 731–740. DOI: 10.1016/S1473–3099(20)30597–1Bennett A., Pollock L., Bar-Zeev N., Lewnard J.A., Jere K.C., Lopman B. et al. Community transmission of rotavirus infection in a vaccinated population in Blantyre, Malawi: a prospective household cohort study. Lancet Infect Dis 2021; 21(5): 731–740. DOI: 10.1016/S1473–3099(20)30597–1Rönnelid Y., Bonkoungou I.J.O., Ouedraogo N., Barro N., Svensson L., Nordgren J. Norovirus and rotavirus in children hospitalized with diarrhoea after rotavirus vaccine introduction in Burkina Faso. Epidemiol Infection 2020; 148(e245): 1–9. DOI: 10.1017/S0950268820002320Rönnelid Y., Bonkoungou I.J.O., Ouedraogo N., Barro N., Svensson L., Nordgren J. Norovirus and rotavirus in children hospitalized with diarrhoea after rotavirus vaccine introduction in Burkina Faso. Epidemiol Infection 2020; 148(e245): 1–9. DOI: 10.1017/S0950268820002320Akinola M.T., Uba A., Umar A.F., Agbo E.B. Asymptomatic rotavirus infections among children in Maiduguri, Borno state, Northeast, Nigeria. Ann Afr Med 2020; 19(3):198–202. DOI: 10.4103/aam.aam_55_19Akinola M.T., Uba A., Umar A.F., Agbo E.B. Asymptomatic rotavirus infections among children in Maiduguri, Borno state, Northeast, Nigeria. Ann Afr Med 2020; 19(3):198–202. DOI: 10.4103/aam.aam_55_19Alkali B.R., Daneji A.I., Magaji A.A., Bilbis L.S. Clinical symptoms of human rotavirus infection observed in children in Sokoto, Nigeria. Advanc Virol 2015; 890957: 6. DOI: 10.1155/2015/890957Alkali B.R., Daneji A.I., Magaji A.A., Bilbis L.S. Clinical symptoms of human rotavirus infection observed in children in Sokoto, Nigeria. Advanc Virol 2015; 890957: 6. DOI: 10.1155/2015/890957Troeger C., Khalil I.A., Rao P.C., Cao S., Blacker B.F., Ahmed T. et al. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr 2018; 172(10): 958–965. DOI: 10.1001/jamapediatrics. 2018.1960Troeger C., Khalil I.A., Rao P.C., Cao S., Blacker B.F., Ahmed T. et al. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr 2018; 172(10): 958–965. DOI: 10.1001/jamapediatrics. 2018.1960Hallowell B.D., Parashar U.D., Curns A., DeGroote N.P., Tate J.E. Trends in the laboratory detection of rotavirus before and after implementation of routine rotavirus vaccination — United States, 2000–2018. Morb Mortal Wkly Rep 2019; 68(24): 539–543. DOI: 10.15585/mmwr.mm6824a2Hallowell B.D., Parashar U.D., Curns A., DeGroote N.P., Tate J.E. Trends in the laboratory detection of rotavirus before and after implementation of routine rotavirus vaccination — United States, 2000–2018. Morb Mortal Wkly Rep 2019; 68(24): 539–543. DOI: 10.15585/mmwr.mm6824a2Dennehy P.H. Treatment and prevention of rotavirus infection in children. Curr Inf Dis Rep 2013; 15: 242–250. DOI: 10.1007/s11908–013–0333–5Dennehy P.H. Treatment and prevention of rotavirus infection in children. Curr Inf Dis Rep 2013; 15: 242–250. DOI: 10.1007/s11908–013–0333–5Kraay A.N.M., Ionides E.L., Lee G.O., Cevallos Trujillo W.F., Eisenberg J.N.S. Effect of childhood rotavirus vaccination on community rotavirus prevalence in rural Ecuador, 2008–2013. Int J Epidemiol 2020; 49(5): 1691–1701. DOI: 10.1093/ije/dyaa124Kraay A.N.M., Ionides E.L., Lee G.O., Cevallos Trujillo W.F., Eisenberg J.N.S. Effect of childhood rotavirus vaccination on community rotavirus prevalence in rural Ecuador, 2008–2013. Int J Epidemiol 2020; 49(5): 1691–1701. DOI: 10.1093/ije/dyaa124Carraro E., Perosa A.H.S., Siqueira I., Pasternak J., Dalla Vale Martino M. Rotavirus infection in children and adult patients attending in a tertiary Hospital of São Paolo, Brazil. Braz J Infect Dis 2008; 12(1): 44–46. DOI: 10.1590/s1413–86702008000100010Carraro E., Perosa A.H.S., Siqueira I., Pasternak J., Dalla Vale Martino M. Rotavirus infection in children and adult patients attending in a tertiary Hospital of São Paolo, Brazil. Braz J Infect Dis 2008; 12(1): 44–46. DOI: 10.1590/s1413–86702008000100010McAuliffe G.N., Taylor S.L., Drinković D., Roberts S.A., Wilson E.M., Best E.J. Rotavirus infection in the Auckland region after the implementation of universal infant rotavirus vaccination: impact on hospitalizations and laboratory implications. Pediatr Infect Dis J 2018; 37(1): e1–e5. DOI: 10.1097/INF.0000000000001706McAuliffe G.N., Taylor S.L., Drinković D., Roberts S.A., Wilson E.M., Best E.J. Rotavirus infection in the Auckland region after the implementation of universal infant rotavirus vaccination: impact on hospitalizations and laboratory implications. Pediatr Infect Dis J 2018; 37(1): e1–e5. DOI: 10.1097/INF.0000000000001706

The authors declare that there are no conflicts of interest present.