perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-2-117-126perinatology-1979Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУGUIDELINES FOR THE PRACTITIONERСовременные представления о синдроме циклической рвоты у детейModern concepts about cyclic vomiting syndrome in childrenhttps://orcid.org/0009-0009-3037-0524ВарисоваА. Х.VarisovaA. Kh.

Варисова Анжела Хаджимурадовна - студент VI курса

344022 Ростов-на-Дону, переулок Нахичеванский, д. 29

Rostov-on-Don

https://orcid.org/0009-0005-4804-5368СвираваА. М.SviravaA. M.

Свирава Александра Мерабовна - студент VI курса

344022 Ростов-на-Дону, переулок Нахичеванский, д. 29

Rostov-on-Don

https://orcid.org/0000-0003-3205-5148ДудниковаЭ. В.DudnikovaE. V.

Дудникова Элеонора Васильевна - д.м.н., проф., зав. кафедрой детских болезней №1

344022 Ростов-на-Дону, переулок Нахичеванский, д. 29

Rostov-on-Don

https://orcid.org/0000-0003-4754-8156БадьянА. С.BadyanA. S.

Бадьян Александра Сергеевна - к.м.н., доц. кафедры детских болезней №1

344022 Ростов-на-Дону, переулок Нахичеванский, д. 29

Rostov-on-Don

alex.badyan@yandex.ruhttps://orcid.org/0000-0003-1595-7561БесединаЕ. А.BesedinaE. A.

Беседина Елена Алексеевна - к.м.н., доц., доц. кафедры детских болезней №1

344022 Ростов-на-Дону, переулок Нахичеванский, д. 29

Rostov-on-Don

ЧерноваМ. С.ChernovaM. S.

Чернова Мария Сергеевна - к.м.н., асс. кафедры детских болезней №1

344022 Ростов-на-Дону, переулок Нахичеванский, д. 29

Rostov-on-Don

ФГБОУ «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical UniversityRussian Federation202410052024692117126Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/1979

Несмотря на относительно невысокую распространенность в мире и в России в частности, такой патологии, как синдром циклической рвоты, актуальность проблемы обусловлена отсутствием исследований и достаточной информации об этиологии, патогенезе, а главное, о методах лечения и профилактики заболевания. Этот синдром характерен для детей в возрасте от 3 до 7 лет и проявляется повторяющимися стереотипными эпизодами рвоты, чередующимися с периодами полного благополучия. Синдром циклической рвоты ухудшает качество жизни ребенка и серьезно влияет на его дальнейшее развитие и социализацию. В статье представлен обзор научных исследований, посвященных синдрому циклической рвоты у детей.

Despite the relatively low prevalence in the world and in Russia, in particular, of such a pathology as cyclic vomiting syndrome, the relevance of the problem is due to the lack of research and sufficient information about the etiology, pathogenesis, and most importantly about methods of treatment and prevention of the disease. This syndrome is typical for children aged 3 to 7 years and is manifested by repeated stereotypical episodes of vomiting, alternating with periods of complete well-being. Cyclic vomiting syndrome worsens the child’s quality of life and seriously affects their further development and socialization. The article provides an overview of scientific research on cyclic vomiting syndrome in children.

детисиндром циклической рвотынаследственностьдетимигреньстрессchildrencyclic vomiting syndromehereditymigrainestressReferencesАндрей Г.Щ. Синдром циклической рвоты у детей. Краткий обзор литературы. Детская медицина Северо-Запада 2022; 2(10): 38–46.Andrei G. Sch. Cyclic vomiting syndrome in children. A brief review of the literature. Detskaya meditsina Severo-Zapada 2022; 2(10): 38–46. (in Russ.)Новоселя Н.В., Кокуева О.В., Герц В.Р., Карчин О.В. Сложная диагностика повторяющейся рвоты. МНИЖ 2019; 12(90): 208–209.Novoselya N.V., Kokueva O.V., Hertz V.R., Karchin O.V. Complex diagnosis of recurrent vomiting. MNIZh 2019; 12(90): 208–209. (in Russ.) DOI: 10.23670/IRJ.2019.90.12.044Жмылева П.В., Табеева Г.Р., Сергеев А.В. Детские эквиваленты мигрени. Неврология, нейропсихиатрия, психосоматика 2021; 13(1): 94–100.Zhmylyova P.V., Tabeeva G.R., Sergeev A.V. Pediatric equivalents of migraine. Nevrologiya, neyropsikhiatriya, psikhosomatika 2021; 13(1): 94–100. (in Russ.) DOI: 10.14412/2074–2711–2021–1–94–100Donnet A., Redon S. Cyclic Vomiting Syndrome in Children. Curr Pain. Headache Rep 2018; 22: 1–30. DOI: 10.1007/s11916–018–0684–6Donnet A., Redon S. Cyclic Vomiting Syndrome in Children. Curr Pain. Headache Rep 2018; 22: 1–30. DOI: 10.1007/s11916–018–0684–6Литвинова Н.А., Сухоруков В.С., Ардаширова Н.С., Ахмадуллина Д.Р., Баранич Т.И. Анализ митохондриальной ДНК в нескольких поколениях одной семьи: значение для дифференциальной диагностики митохондриального заболевания. Российский вестник перинатологии и педиатрии 2022; 67(1): 108–111.Litvinova N.A., Sukhorukov V.S., Ardashirova N.S., Akhmadullina D.R., Baranich T.I. Analysis of mitochondrial DNA in several generations of the same family: significance for differential diagnosis of mitochondrial disease. Rossiyskiy vestnik perinatologii i pediatrii 2022; 67(1): 108–111. (in Russ.) DOI: 10.21508/1027–4065–2022–67–1–108–111Hasler W.L., Levinthal D.J., Tarbell S.E., Adams K.A.,Li B.U.K., Issenman R.M. Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions. Neurogastroenterol Motil 2019; 31 Suppl 2(Suppl 2): e13607 DOI: 10.1111/nmo.13607Li B.U., Lefevre F., Chelimsky G.G., Boles R.G., Nelson S.P., Lewis D.W. et al. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2008; 47(3): 379–393. DOI: 10.1097/MPG.0b013e318173ed39Li B.U., Lefevre F., Chelimsky G.G., Boles R.G., Nelson S.P., Lewis D.W. et al. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2008; 47(3): 379–393. DOI: 10.1097/MPG.0b013e318173ed39Kovacic K., Li B.U. Cyclic vomiting syndrome: A narrative review and guide to management. Headache 2021; 61(2): 231–243. DOI: 10.1111/head.14073Kovacic K., Li B.U. Cyclic vomiting syndrome: A narrative review and guide to management. Headache 2021; 61(2): 231–243. DOI: 10.1111/head.14073Bar O., Ebenau L., Weiner K., Mintz M., Boles R.G. Whole exome/genome sequencing in cyclic vomiting syndrome reveals multiple candidate genes, suggesting a model of elevated intracellular cations and mitochondrial dysfunction. Front Neurol 2023; 14: 1–17. DOI: 10.3389/fneur.2023.1151835Bar O., Ebenau L., Weiner K., Mintz M., Boles R.G. Whole exome/genome sequencing in cyclic vomiting syndrome reveals multiple candidate genes, suggesting a model of elevated intracellular cations and mitochondrial dysfunction. Front Neurol 2023; 14: 1–17. DOI: 10.3389/fneur.2023.1151835Sticht M.A., Limebeer C.L., Rafla B.R., Abdullah R.A., Poklis J.L., Niphakis M.J. et al. Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. Neuropharmacology 2016; 102: 92–102. DOI: 10.1016/j.neuropharm.2015.10.039Sticht M.A., Limebeer C.L., Rafla B.R., Abdullah R.A., Poklis J.L., Niphakis M.J. et al. Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. Neuropharmacology 2016; 102: 92–102. DOI: 10.1016/j.neuropharm.2015.10.039Зиганшина А.А. Гастроинтестинальные проявления митохондриальной дисфункции. Российский вестник педиатрии 2016; 61(6): 38–42.Ziganshina A.A. Gastrointestinal manifestations of mitochondrial dysfunction. Rossiyskiy vestnik pediatrii 2016; 61(6): 38–42. (in Russ.) DOI: 10.21508/1027–4065–2016–61–6–38–42Venkatesan T., Zaki E.A., Kumar N., Sengupta J., Ali M., Malik B. et al. Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome. BMC Gastroenterol 2014; 14: 181. DOI: 10.1186/1471–230X-14–181Venkatesan T., Zaki E.A., Kumar N., Sengupta J., Ali M., Malik B. et al. Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome. BMC Gastroenterol 2014; 14: 181. DOI: 10.1186/1471–230X-14–181Gordan N. Recurrent vomiting in childhood, especially of neurological origin. Dev Med Child Neurol 1994; 36(5): 463–470. DOI: 10.1111/j.1469–8749.1994.tb11873.xGordan N. Recurrent vomiting in childhood, especially of neurological origin. Dev Med Child Neurol 1994; 36(5): 463–470. DOI: 10.1111/j.1469–8749.1994.tb11873.xRashed H., Abell T.L., Familoni B.O., Cardoso S. Autonomic function in cyclic vomiting syndrome and classic migraine. Dig Dis Sci 1999; 44: 74–78.Rashed H., Abell T.L., Familoni B.O., Cardoso S. Autonomic function in cyclic vomiting syndrome and classic migraine. Dig Dis Sci 1999; 44: 74–78.Chelimsky G., Madan S., Alshekhlee A., Heller E., McNeeley K., Chelimsky T. A comparison of dysautonomias comorbid with cyclic vomiting syndrome and with migraine. Gastroenterol Res Pract 2009; 2009: 701019. DOI: 10.1155/2009/701019Chelimsky G., Madan S., Alshekhlee A., Heller E., McNeeley K., Chelimsky T. A comparison of dysautonomias comorbid with cyclic vomiting syndrome and with migraine. Gastroenterol Res Pract 2009; 2009: 701019. DOI: 10.1155/2009/701019Khasawinah T.A., Ramirez A., Berkenbosch J.W., Tobias J.D. Preliminary experience with dexmedetomidine in the treatment of cyclic vomiting syndrome. Am J Ther 2003; 10(4): 303–307. DOI: 10.1097/00045391–200307000–00012Khasawinah T.A., Ramirez A., Berkenbosch J.W., Tobias J.D. Preliminary experience with dexmedetomidine in the treatment of cyclic vomiting syndrome. Am J Ther 2003; 10(4): 303–307. DOI: 10.1097/00045391–200307000–00012Sato T. Prevalence of Syndrome of ACTH-ADH Discharge in Japan. Clin Pediatr Endocrinol 1993; 2(1): 7–12. DOI:10.1297/cpe.2.7Sato T. Prevalence of Syndrome of ACTH-ADH Discharge in Japan. Clin Pediatr Endocrinol 1993; 2(1): 7–12. DOI:10.1297/cpe.2.7Chow S., Goldman R.D. Treating children’s cyclic vomiting. Can Fam Physician 2007; 53(3): 417–419.Chow S., Goldman R.D. Treating children’s cyclic vomiting. Can Fam Physician 2007; 53(3): 417–419.Li B., Balint J. Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder. Adv Pediatr 2000; 47: 117–160.Li B., Balint J. Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder. Adv Pediatr 2000; 47: 117–160.Lucia-Casadonte C.J., Whaley K.G., Chogle A.S. Yield and Costs of Evaluating Children with Cyclic Vomiting Syndrome. J Pediatr Gastroenterol Nutrition 2018; 67(1): 13–17. DOI: 10.1097/MPG.0000000000001901Lucia-Casadonte C.J., Whaley K.G., Chogle A.S. Yield and Costs of Evaluating Children with Cyclic Vomiting Syndrome. J Pediatr Gastroenterol Nutrition 2018; 67(1): 13–17. DOI: 10.1097/MPG.0000000000001901Gelfand A.A., Gallagher R.C. Cyclic vomiting syndrome versus inborn errors of metabolism: a review with clinical recommendations. Headache 2016; 56: 215–221. DOI: 10.1111/head.12749Gelfand A.A., Gallagher R.C. Cyclic vomiting syndrome versus inborn errors of metabolism: a review with clinical recommendations. Headache 2016; 56: 215–221. DOI: 10.1111/head.12749Shields T.M., Lightdale J.R. Vomiting in Children. Pediatr Rev 2018; 39(7): 342–358. DOI: 10.1542/pir.2017–0053Shields T.M., Lightdale J.R. Vomiting in Children. Pediatr Rev 2018; 39(7): 342–358. DOI: 10.1542/pir.2017–0053Forbes D., Withers G. Prophylactic therapy in cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 1995; 21(1): 57–59. DOI: 10.1097/00005176–199501001–00016Forbes D., Withers G. Prophylactic therapy in cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 1995; 21(1): 57–59. DOI: 10.1097/00005176–199501001–00016Lee L.Y., Abbott L., Mahlangu B., Moodie S.J., Anderson S. The management of cyclic vomiting syndrome: a systematic review. Eur J Gastroenterol Hepatol 2012; 24(9): 1001–1006. DOI: 10.1097/MEG.0b013e328355638fLee L.Y., Abbott L., Mahlangu B., Moodie S.J., Anderson S. The management of cyclic vomiting syndrome: a systematic review. Eur J Gastroenterol Hepatol 2012; 24(9): 1001–1006. DOI: 10.1097/MEG.0b013e328355638fSagar R.C., Ford A.C. Cyclic Vomiting Syndrome: Randomized Controlled Trials Are Also Needed in Adults. Am J Gastroenterol 2017; 112(11): 1752–1753. DOI: 10.1038/ajg.2017.293Sagar R.C., Ford A.C. Cyclic Vomiting Syndrome: Randomized Controlled Trials Are Also Needed in Adults. Am J Gastroenterol 2017; 112(11): 1752–1753. DOI: 10.1038/ajg.2017.293Ozdemir H., Bulut S., Berilgen M., Kapan O., Balduz M., Demir C.F. et al. Resistant cyclic vomiting syndrome successfully responding to chlorpromazine. Acta Medica (Hradec Kralove) 2014; 57(1): 28–29. DOI: 10.14712/18059694.2014.5Ozdemir H., Bulut S., Berilgen M., Kapan O., Balduz M., Demir C.F. et al. Resistant cyclic vomiting syndrome successfully responding to chlorpromazine. Acta Medica (Hradec Kralove) 2014; 57(1): 28–29. DOI: 10.14712/18059694.2014.5Hejazi R., McCallum R. Cyclic vomiting syndrome: treatment options. Exp Brain Res 2014; 232(8): 2549–2552. DOI: 10.14712/18059694.2014.5Hejazi R., McCallum R. Cyclic vomiting syndrome: treatment options. Exp Brain Res 2014; 232(8): 2549–2552. DOI: 10.14712/18059694.2014.5Moses J., Keilman A., Worley S., Radhakrishnan K., Rothner A.D., Parikh S. Approach to the diagnosis and treatment of cyclic vomiting syndrome: a large single-center experience with 106 patients. Pediatr Neurol 2014; 50(6): 569–573. DOI: 10.1016/j.pediatrneurol.2014.02.009Moses J., Keilman A., Worley S., Radhakrishnan K., Rothner A.D., Parikh S. Approach to the diagnosis and treatment of cyclic vomiting syndrome: a large single-center experience with 106 patients. Pediatr Neurol 2014; 50(6): 569–573. DOI: 10.1016/j.pediatrneurol.2014.02.009Li B. Cyclic vomiting syndrome: a pediatric Rorschach test. J Pediatr Gastroenterol Nutr 1993; 17(4): 351– 353. DOI: 10.1097/00005176–199311000–00001Li B. Cyclic vomiting syndrome: a pediatric Rorschach test. J Pediatr Gastroenterol Nutr 1993; 17(4): 351– 353. DOI: 10.1097/00005176–199311000–00001Hejazi R.A., Reddymasu S.C., Namin F., Lavenbarg T., Foran P., McCallum R.W. Efficacy of tricyclic antidepressant therapy in adults with cyclic vomiting syndrome: a two-year follow-up study. J Clin Gastroenterol 2010; 44(1): 18–21. DOI: 10.1097/MCG.0b013e3181ac6489Hejazi R.A., Reddymasu S.C., Namin F., Lavenbarg T., Foran P., McCallum R.W. Efficacy of tricyclic antidepressant therapy in adults with cyclic vomiting syndrome: a two-year follow-up study. J Clin Gastroenterol 2010; 44(1): 18–21. DOI: 10.1097/MCG.0b013e3181ac6489Li B. Cyclic vomiting: new understanding of an old disorder. Contemp Pediatr 1996; 8(1): 48–62. DOI: 10.1053/spen.2001.23456Li B. Cyclic vomiting: new understanding of an old disorder. Contemp Pediatr 1996; 8(1): 48–62. DOI: 10.1053/spen.2001.23456Benson J.M., Zorn S.L., Book L.S. Sumatriptan in the treatment of cyclic vomiting. Ann Pharmacother 1995; 29(10): 997–999. DOI: 10.1177/106002809502901008Benson J.M., Zorn S.L., Book L.S. Sumatriptan in the treatment of cyclic vomiting. Ann Pharmacother 1995; 29(10): 997–999. DOI: 10.1177/106002809502901008Камалова А.А., Шакирова А.В. Синдром циклической рвоты. Современная медицина 2017; 4(8): 59–61. [Kamalova A.A., Shakirova A.V. Syndrome of cyclic vomiting. Sovremennaya meditsina 2017; 4: 59–61. (in Russ.)Камалова А.А., Шакирова А.В. Синдром циклической рвоты. Современная медицина 2017; 4(8): 59–61. [Kamalova A.A., Shakirova A.V. Syndrome of cyclic vomiting. Sovremennaya meditsina 2017; 4: 59–61. (in Russ.)Raucci U., Borrelli O., Di Nardo G., Tambucci R., Pavone P., Salvatore S. et al. Cyclic Vomiting Syndrome in Children. Front Neurol 2020; 2(11): 1–22. DOI: 10.3389/fneur.2020.583425Raucci U., Borrelli O., Di Nardo G., Tambucci R., Pavone P., Salvatore S. et al. Cyclic Vomiting Syndrome in Children. Front Neurol 2020; 2(11): 1–22. DOI: 10.3389/fneur.2020.583425Boles R.G., Lovett-Barr M.R., Preston A., Li B.U., Adams K. Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. BMC Neurol 2010; 10: 1–5. DOI: 10.1186/1471–2377–10–10Boles R.G., Lovett-Barr M.R., Preston A., Li B.U., Adams K. Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. BMC Neurol 2010; 10: 1–5. DOI: 10.1186/1471–2377–10–10Paul S.P., Barnard P., Soondrum K., Candy D.C. Antimigraine (Low-Amine) Diet May Be Helpful in Children With Cyclic Vomiting Syndrome. J Pediatr Gastroenterol 2012; 54(5): 698–699. DOI: 10.1097/MPG.0b013e3182Paul S.P., Barnard P., Soondrum K., Candy D.C. Antimigraine (Low-Amine) Diet May Be Helpful in Children With Cyclic Vomiting Syndrome. J Pediatr Gastroenterol 2012; 54(5): 698–699. DOI: 10.1097/MPG.0b013e3182Karrento K., Venkatesan T., Zhang L., Pawela L., Simpson P., Li B.U.K. Percutaneous Electrical Nerve Field Stimulation for Drug-Refractory Pediatric Cyclic Vomiting Syndrome. J Pediatr Gastroenterol Nutrition 2023; 77(3): 347–353. DOI: 10.1097/MPG.0000000000003876Karrento K., Venkatesan T., Zhang L., Pawela L., Simpson P., Li B.U.K. Percutaneous Electrical Nerve Field Stimulation for Drug-Refractory Pediatric Cyclic Vomiting Syndrome. J Pediatr Gastroenterol Nutrition 2023; 77(3): 347–353. DOI: 10.1097/MPG.0000000000003876

The authors declare that there are no conflicts of interest present.