perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-4-11-15perinatology-2023Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSПерспективы оценки уровня тканевого IgE и применения биологической терапии у детей с полипозным риносинуситомProspects for assessing the level of tissue IgE and the use of biological therapy in children with polypous rhinosinusitishttps://orcid.org/0009-0001-1938-8346ШабельниковаЕ. И.ShabelnikovaE. I.

Екатерина Игоревна Шабельникова, к. м. н., ст. науч. сотр.

отдел острой и хронической патологии уха, горла и носа

125412; ул. Талдомская, д. 2; Москва

Moscow

https://orcid.org/0000-0001-5039-8473ПампураА. Н.PampuraA. N.

Александр Николаевич Пампура, д. м. н., зав. отделом

отдел аллергологии и клинической иммунологии

125412; ул. Талдомская, д. 2; Москва

Moscow

https://orcid.org/0000-0002-3116-6447АсмановА. И.AsmanovA. I.

Алан Исмаилович Асманов, к. м. н., рук. отдела

отдел острой и хронической патологии уха, горла и носа

125412; ул. Талдомская, д. 2; Москва

Moscow

https://orcid.org/0000-0003-3673-9272ПивневаН. Д.PivnevaN. D.

Наталья Дмитриевна Пивнева, к. м. н., ст. науч. сотр.

отдел острой и хронической патологии уха, горла и носа

125412; ул. Талдомская, д. 2; Москва

Moscow

ОСП «Научно-исследовательский клинический институт педиатрии и детской хирургии им. академика Ю.Е. Вельтищева» (Институт Вельтищева) ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияVeltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical UniversityRussian Federation2024310820246941115Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2023

   В обзоре описан механизм Т2-воспаления и его взаимосвязь с хроническим полипозным риносинуситом. Авторами проведены поиск и систематизация данных о лечении пациентов, больных риносинуситом, с использованием моноклональных антител, которые воздействуют на различные биомаркеры, затронута проблема локального IgE-воспаления в слизистой оболочке носа.

   The review describes the mechanism of T2 inflammation and its relationship with chronic polypous rhinosinusitis. The authors conducted a search and systematization of data on the treatment of polypous rhinosinusitis using monoclonal antibodies that act on various biomarkers, and touched upon the problem of local IgE inflammation in the nasal mucosa.

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The authors declare that there are no conflicts of interest present.