perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-4-109-115perinatology-2037Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУFOR THE PRACTITIONERОсобенности обеспеченности и подходы к применению витамина D у детей в постковидном периодеFeatures of supply and approaches to the use of vitamin D in children in the post-COVID periodhttps://orcid.org/0000-0003-4668-6071БогомоловаИ. К.BogomolovaI. K.

Ирина Кимовна Богомолова, д. м. н., проф., проректор по учебно-воспитательной работе, зав. кафедрой

лечебный и стоматологический факультеты; кафедра педиатрии

672000;  ул. Горького, д. 39 А; Чита

Chita

https://orcid.org/0000-0002-9684-2864ПерегоедоваВ. Н.PeregoedovaV. N.

Валентина Николаевна Перегоедова, к. м. н., доц.

лечебный и стоматологический факультеты; кафедра педиатрии 

672000;  ул. Горького, д. 39 А; Чита

Chita

ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава РоссииРоссияChita State Medical AcademyRussian Federation202401092024694109115Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2037

   Витамин D — важный компонент иммунной функции, а его дефицит в детском возрасте связан с повышенным риском острых респираторных вирусных инфекций.

   Цель исследования

   Цель исследования. Оценка динамики обеспеченности витамином D у детей после новой коронавирусной инфекции на фоне применения холекальциферола.

   Материалы и методы

   Материалы и методы. Обследованы 55 детей в возрасте 0–17 лет (10,0 [9,2; 10,6] года), 52,7 % мальчиков с COVID-19, которые получали холекальциферол в дозе от 1000 до 3000 МЕ в течение 30 дней в зависимости от исходной концентрации 25(ОН)D. Через 30 дней приема витамина D3 повторно определены уровни общего витамина D в сыворотке крови.

   Результаты

   Результаты. Медиана уровня 25(ОН)D у детей с COVID-19 составила 24,5 [23,9; 26,7] нг/мл. У 34,5 % детей имелся статус дефицита витамина D (≤ 20 нг/мл), у 32,7 % — недостаточность (21–30 нг/мл), у 30 % пациентов имелась нормальная обеспеченность витамином D (≥ 30 нг/мл). В результате лечения холекальциферолом число детей с гиповитаминозом D уменьшилось в 2 раза (35,4 %; p< 0,05), с адекватным уровнем — увеличилось в 2 раза (65,5 %; p < 0,05). В зависимости от уровня 25(ОН D не установлено статистически значимых различий от степени тяжести коронавирусной инфекции (χ2 = 0,872; p = 0,929).

   Заключение

   Заключение. В 2/3 случаев у детей, инфицированных SARS-CoV-2, отмечался гиповитаминоз D. У детей младше 6 лет чаще выявляли недостаточность витамина D, тогда как у пациентов в возрасте 7–17 лет — дефицит витамина D. Распределение уровня витамина D не различалось в зависимости от формы тяжести коронавирусной инфекции. Принимаемых доз холекальциферола в течение 30 дней сказалось положительно для повышения концентрации витамина D в сыворотке крови у детей с недостаточностью, но не обеспечило достижения нормального уровня у пациентов с дефицитом витамина D.

   Vitamin D is an important component of immune function, and deficiency in childhood is associated with an increased risk of acute respiratory viral infections.   Purpose. To assess the dynamics of vitamin D supply in children after a new coronavirus infection with the use of cholecalciferol.

   Material and methods

   Material and methods. We examined 55 children aged 0–17 years (10.0 [9.2; 10.6] years), 52.7 % boys with COVID-19, who received cholecalciferol in a dose of 1000 to 3000 IU for 30 days in depending on the concentration of 25(OH)D. After 30 days of taking vitamin D3, the levels of total vitamin D in the blood serum were re-determined.

   Results

   Results. The median 25(OH)D level in children with COVID-19 was 24.5 [23.9; 26.7] ng/ml. 34.5 % of children had vitamin D deficiency status (≤ 20 ng/ml), 32.7 % had insufficiency (21–30 ng/ml), a third of patients had normal vitamin D status (≥ 30 ng/ml). As a result of treatment with cholecalciferol, the number of children with hypovitaminosis D decreased by 2 times (35.4 %, p < 0.05), with an adequate level — doubled (65.5 %, p < 0.05). Depending on the level of 25(OH)D, no statistically significant differences were found in the severity of coronavirus infection (χ² = 0.872, p = 0.929).

   Conclusion

   Conclusion. In 2/3 of cases, children infected with SARS-CoV-2 had hypovitaminosis D. Children under 6 years of age were more likely to have vitamin D insufficiency, while patients 7–17 years of age had a deficiency. The distribution of vitamin D levels did not differ depending on the severity of coronavirus infection. Doses of cholecalciferol taken for 30 days were sufficient to increase the concentration of vitamin D in the blood serum of children with deficiency but did not reach standard values in patients with vitamin D deficiency.

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The authors declare that there are no conflicts of interest present.