perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-5-22-28perinatology-2061Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSВлияние вейп-курения на здоровье детей и подростковThe impact of vaping on the health of children and adolescentshttps://orcid.org/0000-0002-7533-3489ИшбулдинаА. В.IshbuldinaA. V.

Ишбулдина Анастасия Владимировна – к.м.н., асс. кафедры госпитальной педиатрии

420012 Казань, ул. Бутлерова, д. 49

Kazan

ishbuldinakgmu@mail.ruhttps://orcid.org/0000-0001-9339-2354ВахитовХ. М.VakhitovKh. М.

Вахитов Хаким Муратович – д.м.н., проф. кафедры госпитальной педиатрии

420012 Казань, ул. Бутлерова, д. 49

Kazan

https://orcid.org/0009-0005-9071-9100ГайчикЕ. А.GaichikЕ. А.

Гайчик Елена Алексеевна – ординатор 1-го года обучения кафедры госпитальной педиатрии

420012 Казань, ул. Бутлерова, д. 49

Kazan

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииРоссияKazan State Medical UniversityRussian Federation2024111120246952228Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2061

В статье освещается актуальная проблема употребления вейпов и электронных сигарет, особенно среди детей и подростков. Авторы проводят анализ 58 источников литературы, в которых обсуждаются вопросы повреждения легких вследствие курения электронных устройств, в целях выявления особенностей симптоматики и патологических изменений. В результате исследования подчеркивается разнообразие клинических проявлений повреждения легких, ассоциированного с вейпингом и курением электронных сигарет (EVALI, e-cigarette or vaping use-associated lung injury), и необходимость проведения дифференциальной диагностики с другими заболеваниями органов дыхания, включая COVID-19. Необходима санитарно-просветительская работа в обществе для распространения информации о вреде курения электронных устройств. Требуются дальнейшие исследования, направленные на выявление долгосрочных последствий употребления вейпов и электронных сигарет для здоровья человека.

The article discusses the issue of the use of vape pens and electronic cigarettes, particularly among children and teenagers. The authors analyzed 58 scientific articles that discuss the damage to the lungs caused by smoking electronic devices, in order to identify symptoms and pathological changes. The study highlights the various clinical manifestations of lung damage associated with vaping and using electronic cigarettes (EVALI, e-cigarettes or vaping-associated lung injuries), and the need for a differential diagnosis with other respiratory illnesses, including COVID-19. It is essential to conduct educational and awareness campaigns in society to spread information about the risks of using electronic devices. Further research is needed to understand the long-term effects of vape pens and e-cigarettes on human health.

подросткиEVALIвейпингэлектронные сигаретывейпыteenagersEVALIvapinge-cigarettesvape pensReferencesICD-10-CM Official Guidelines for Coding and Reporting, FY 2021, (October 1, 2020 — September 30, 2021). https://www.cdc.gov/nchs/data/icd/10cmguidelines-FY2021.pdf / Ссылка активна на 09.06.2024.ICD-10-CM Official Guidelines for Coding and Reporting, FY 2021, (October 1, 2020 — September 30, 2021). https://www.cdc.gov/nchs/data/icd/10cmguidelines-FY2021.pdf / Ссылка активна на 09.06.2024.Cullen K.A., Ambrose B.K., Gentzke A.S., Apelberg B.J., Jamal A., King B.A. Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students — United States, 2011–2018. MMWR Morb Mortal Wkly Rep 2018; 67(45): 1276–1277. DOI: 10.15585/mmwr.mm6745a5Cullen K.A., Ambrose B.K., Gentzke A.S., Apelberg B.J., Jamal A., King B.A. Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students — United States, 2011–2018. MMWR Morb Mortal Wkly Rep 2018; 67(45): 1276–1277. DOI: 10.15585/mmwr.mm6745a5Public health consequences of E-cigarettes. Editors D.L. Eaton, L.Y. Kwan, K. Stratton Washington DC: The National Academies Press; 2018; 774.Public health consequences of E-cigarettes. Editors D.L. Eaton, L.Y. Kwan, K. Stratton Washington DC: The National Academies Press; 2018; 774.Centers for Disease Control and Prevention. (n.d.). E-Cigarette or Vaping Products Visual Dictionary. https://www.cdc.gov/tobacco/basic_information/e-cigarettes/pdfs/ecigarette-or-vaping-products-visual-dictionary-508.pdf / Ссылка активна на 09.06.2024.Centers for Disease Control and Prevention. (n.d.). E-Cigarette or Vaping Products Visual Dictionary. https://www.cdc.gov/tobacco/basic_information/e-cigarettes/pdfs/ecigarette-or-vaping-products-visual-dictionary-508.pdf / Ссылка активна на 09.06.2024.Cao D.J., Aldy K., Hsu S., McGetrick M., Verbeck G., De Silva I., Feng S.Y. Review of Health Consequences of ElectronicCigarettes and the Outbreak of Electronic Cigarette, or Vaping, Product Use-Associated Lung Injury. J Med Toxicol 2020; 16(3): 295–310. DOI: 10.1007/s13181–020–00772-wCao D.J., Aldy K., Hsu S., McGetrick M., Verbeck G., De Silva I., Feng S.Y. Review of Health Consequences of ElectronicCigarettes and the Outbreak of Electronic Cigarette, or Vaping, Product Use-Associated Lung Injury. J Med Toxicol 2020; 16(3): 295–310. DOI: 10.1007/s13181–020–00772-wCenters for Disease Control and Prevention. (n.d.). Quick Facts on the Risks of E-cigarettes for Kids, Teens, and Young Adults. https://www.cdc.gov/tobacco/e-cigarettes/youth.html?CDC_AAref_Val=https://www.cdc.gov/tobacco/basic_information/e-cigarettes/Quick-Facts-on-the-Risks-of-E-cigarettes-for-Kids-Teens-and-Young-Adults.html / Ссылка активна на 09.06.2024.Centers for Disease Control and Prevention. (n.d.). Quick Facts on the Risks of E-cigarettes for Kids, Teens, and Young Adults. https://www.cdc.gov/tobacco/e-cigarettes/youth.html?CDC_AAref_Val=https://www.cdc.gov/tobacco/basic_information/e-cigarettes/Quick-Facts-on-the-Risks-of-E-cigarettes-for-Kids-Teens-and-Young-Adults.html / Ссылка активна на 09.06.2024.Gilman G. Analytical Testing of E-cigarette Aerosol. In Analytical Assessment of E-cigarettes: From Contents to Chemical and Particle Exposure Profiles. Editors K.E. Farsalinos, I.G. Gillman, J.W. Thornburg, S.S. Hecht, R. Polosa, Amsterdam: Elsevier 2017; 9–35.Gilman G. Analytical Testing of E-cigarette Aerosol. In Analytical Assessment of E-cigarettes: From Contents to Chemical and Particle Exposure Profiles. Editors K.E. Farsalinos, I.G. Gillman, J.W. Thornburg, S.S. Hecht, R. Polosa, Amsterdam: Elsevier 2017; 9–35.Blount B.C., Karwowski M.P., Shields P.G., Morel-Espinosa M., Valentin-Blasini L., Gardner M. et al.; Lung Injury Response Laboratory Working Group. Vitamin E acetate in bronchoalveolar-lavage fluid associated with EVALI. N Engl J Med 2020; 382: 697–705. DOI: 10.1056/NEJMoa1916433Blount B.C., Karwowski M.P., Shields P.G., Morel-Espinosa M., Valentin-Blasini L., Gardner M. et al.; Lung Injury Response Laboratory Working Group. Vitamin E acetate in bronchoalveolar-lavage fluid associated with EVALI. N Engl J Med 2020; 382: 697–705. DOI: 10.1056/NEJMoa1916433Chun L.F., Moazed F., Calfee C.S., Matthay M.A., Gotts J.E. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol 2017; 313(2): L193–L206. DOI: 10.1152/ajplung.00071.2017Chun L.F., Moazed F., Calfee C.S., Matthay M.A., Gotts J.E. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol 2017; 313(2): L193–L206. DOI: 10.1152/ajplung.00071.2017Banks E., Yazidjoglou A., Brown S., Nguyen M., Martin M., Beckwith K. et al. Electronic cigarettes and health outcomes: umbrella and systematic review of the global evidence. Med J Aust 2023; 218(6): 267–275. DOI: 10.5694/mja2.51890Banks E., Yazidjoglou A., Brown S., Nguyen M., Martin M., Beckwith K. et al. Electronic cigarettes and health outcomes: umbrella and systematic review of the global evidence. Med J Aust 2023; 218(6): 267–275. DOI: 10.5694/mja2.51890Visser W.F., Klerx W.N., Cremers H.W.J.M., Ramlal R., Schwillens P.L., Talhout R. The Health Risks of Electronic Cigarette Use to Bystanders. Int J Environ Res Public Health 2019; 16(9): 1525. DOI: 10.3390/ijerph16091525Visser W.F., Klerx W.N., Cremers H.W.J.M., Ramlal R., Schwillens P.L., Talhout R. The Health Risks of Electronic Cigarette Use to Bystanders. Int J Environ Res Public Health 2019; 16(9): 1525. DOI: 10.3390/ijerph16091525Pisinger C., Døssing M. A systematic review of health effects of electronic cigarettes. Prev Med 2014; 69: 248–260. DOI: 10.1016/j.ypmed.2014.10.009Pisinger C., Døssing M. A systematic review of health effects of electronic cigarettes. Prev Med 2014; 69: 248–260. DOI: 10.1016/j.ypmed.2014.10.009Visser W.F., Klerx W.N., Cremers H.W.J.M., Ramlal R., Schwillens P.L., Talhout R. The Health Risks of Electronic Cigarette Use to Bystanders. Int J Environment Res Public Health 2019; 16(9): 1525. DOI: 10.3390/ijerph16091525Visser W.F., Klerx W.N., Cremers H.W.J.M., Ramlal R., Schwillens P.L., Talhout R. The Health Risks of Electronic Cigarette Use to Bystanders. Int J Environment Res Public Health 2019; 16(9): 1525. DOI: 10.3390/ijerph16091525Li L., Lin Y., Xia T., Zhu Y. Effects of electronic cigarettes on indoor air quality and health. Ann Rev Public Health 2020; 41: 363–380. DOI: org/10.1146/annurev-publhealth-040119–094043Li L., Lin Y., Xia T., Zhu Y. Effects of electronic cigarettes on indoor air quality and health. Ann Rev Public Health 2020; 41: 363–380. DOI: org/10.1146/annurev-publhealth-040119–094043Su W.C., Lin Y.H., Wong S.W., Chen J.Y., Lee J., Buu A. Estimation of the dose of electronic cigarette chemicals deposited in human airways through passive vaping. J Exposure Scie Environment Epidemiol 2021; 31(6): 1008–1016. DOI: 10.1038/s41370–021–00362–0Su W.C., Lin Y.H., Wong S.W., Chen J.Y., Lee J., Buu A. Estimation of the dose of electronic cigarette chemicals deposited in human airways through passive vaping. J Exposure Scie Environment Epidemiol 2021; 31(6): 1008–1016. DOI: 10.1038/s41370–021–00362–0Lee H.W., Park S.H., Weng M.W., Wang H.T., Huang W.C., Lepor H. et al. E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and blad der cells. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(7): 1560–1569. DOI: 10.1073/pnas.1718185115Lee H.W., Park S.H., Weng M.W., Wang H.T., Huang W.C., Lepor H. et al. E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and blad der cells. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(7): 1560–1569. DOI: 10.1073/pnas.1718185115Keith R., Bhatnagar A. Cardiorespiratory and Immunologic Effects of Electronic Cigarettes. Curr Add Reports 2021; 8(2): 336–346. DOI: 10.1007/S40429–021–00359–7Keith R., Bhatnagar A. Cardiorespiratory and Immunologic Effects of Electronic Cigarettes. Curr Add Reports 2021; 8(2): 336–346. DOI: 10.1007/S40429–021–00359–7Cullen K.A., Gentzke A.S., Sawdey M.D., Chang J.T., Anic G.M., Wang T.W. et al. E-cigarette use among youth in the United States, 2019. JAMA 2019; 322(21): 2095–2103. DOI: 10.1001/jama.2019.18387Cullen K.A., Gentzke A.S., Sawdey M.D., Chang J.T., Anic G.M., Wang T.W. et al. E-cigarette use among youth in the United States, 2019. JAMA 2019; 322(21): 2095–2103. DOI: 10.1001/jama.2019.18387Боярчук О.Р., Косовская В.А., Косовская Т.М., Гариян Т.В., Добровольская Л.И. Результаты опроса школьников-подростков о вейпинге. Профилактическая медицина 2021; 24(4): 30-36.Boyarchuk O.R., Kosovskaya V.A., Kosovskaya T.M., Garian T.V., Dobrovolskaya L.I. Survey results of teenage-pupils about vaping. Profilakticheskaya meditsina 2021; 24(4): 30-36. (In Russ.) DOI: 10.17116/profmed20212404130Gilley M., Beno S. Vaping implications for children and youth. Curr Opin Pediatr 2020; 32(3): 343–348. DOI: 10.1097/MOP.0000000000000889Gilley M., Beno S. Vaping implications for children and youth. Curr Opin Pediatr 2020; 32(3): 343–348. DOI: 10.1097/MOP.0000000000000889Yoong S.L., Hall A., Leonard A., McCrabb S., Wiggers J., Tursan d’Espaignet E. et al. Prevalence of electronic nicotine delivery systems and electronic non-nicotine delivery systems in children and adolescents: a systematic review and meta-analysis. Lancet Public Health 2021; 6(9): e661–e673. DOI: 10.1016/S2468–2667(21)00106–7Yoong S.L., Hall A., Leonard A., McCrabb S., Wiggers J., Tursan d’Espaignet E. et al. Prevalence of electronic nicotine delivery systems and electronic non-nicotine delivery systems in children and adolescents: a systematic review and meta-analysis. Lancet Public Health 2021; 6(9): e661–e673. DOI: 10.1016/S2468–2667(21)00106–7Surgeon General’s Advisory on E-cigarette Use Among Youth. Atlanta, GA; Centers for Disease Control; 2018 https://stacks.cdc.gov/view/cdc/153187 / Ссылка активна на 09.06.2024.Surgeon General’s Advisory on E-cigarette Use Among Youth. Atlanta, GA; Centers for Disease Control; 2018 https://stacks.cdc.gov/view/cdc/153187 / Ссылка активна на 09.06.2024.Winnicka L., Shenoy M.A. EVALI and the Pulmonary Toxicity of Electronic Cigarettes: A Review. J Gen Intern Med 2020; 35(7): 2130–2135. DOI: 10.1007/s11606–020–05813–2Winnicka L., Shenoy M.A. EVALI and the Pulmonary Toxicity of Electronic Cigarettes: A Review. J Gen Intern Med 2020; 35(7): 2130–2135. DOI: 10.1007/s11606–020–05813–2Cecchini M.J., Mukhopadhyay S., Arrossi A.V., Beasley M.B., Butt Y.M., Jones K.D. et al. E-Cigarette or Vaping Product Use-Associated Lung Injury: A Review for Pathologists. Arch Pathol Lab Med 2020; 144(12): 1490–1500. DOI: 10.5858/arpa.2020–0024-RACecchini M.J., Mukhopadhyay S., Arrossi A.V., Beasley M.B., Butt Y.M., Jones K.D. et al. E-Cigarette or Vaping Product Use-Associated Lung Injury: A Review for Pathologists. Arch Pathol Lab Med 2020; 144(12): 1490–1500. DOI: 10.5858/arpa.2020–0024-RAPark H.R., O’Sullivan M., Vallarino J., Shumyatcher M., Himes B.E., Park J.A. et al. Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes. Sci Rep 2019; 9: 1400. DOI: 10.1038/s41598–018–37913–9Park H.R., O’Sullivan M., Vallarino J., Shumyatcher M., Himes B.E., Park J.A. et al. Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes. Sci Rep 2019; 9: 1400. DOI: 10.1038/s41598–018–37913–9Abdallah B., Lee H., Weerakoon S.M., Messiah S.E., Harrell M.B., Rao D.R. Clinical manifestations of EVALI in adolescents before and during the COVID-19 pandemic. Pediatr Pulmonol 2023; 58(3): 949–958. DOI: 10.1002/ppul.26283Abdallah B., Lee H., Weerakoon S.M., Messiah S.E., Harrell M.B., Rao D.R. Clinical manifestations of EVALI in adolescents before and during the COVID-19 pandemic. Pediatr Pulmonol 2023; 58(3): 949–958. DOI: 10.1002/ppul.26283Reddy A., Jenssen B.P., Chidambaram A., Yehya N., Lindell R.B. Characterizing e-cigarette vaping-associated lung injury in the pediatric intensive care unit. Pediatr Pulmonol 2021; 56(1): 162–170. DOI: 10.1002/ppul.25086Reddy A., Jenssen B.P., Chidambaram A., Yehya N., Lindell R.B. Characterizing e-cigarette vaping-associated lung injury in the pediatric intensive care unit. Pediatr Pulmonol 2021; 56(1): 162–170. DOI: 10.1002/ppul.25086Layden J.E., Ghinai I., Pray I., Kimball A., Layer M., Tenforde M.W. et al. Pulmonary illness related to e-cigarette use in illinois and wisconsin — final report. N Engl J Med 2020; 382(10): 903–916. DOI: 10.1056/NEJMoa1911614Layden J.E., Ghinai I., Pray I., Kimball A., Layer M., Tenforde M.W. et al. Pulmonary illness related to e-cigarette use in illinois and wisconsin — final report. N Engl J Med 2020; 382(10): 903–916. DOI: 10.1056/NEJMoa1911614Vardavas C.I., Anagnostopoulos N., Kougias M., Evangelopoulou V., Connolly G.N., Behrakis P.K. Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impendence, and exhaled nitric oxide. Chest 2012; 141(6): 1400–1406. DOI: 10.1378/chest.11–2443Vardavas C.I., Anagnostopoulos N., Kougias M., Evangelopoulou V., Connolly G.N., Behrakis P.K. Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impendence, and exhaled nitric oxide. Chest 2012; 141(6): 1400–1406. DOI: 10.1378/chest.11–2443Siegel D.A., Jatlaoui T.C., Koumans E.H., Kiernan E.A., Layer M., Cates J.E. et al. Update: interim guidance for health care providers evaluating and caring for patients with suspected e-cigarette, or vaping, product use associated lung injury — United States. Morbidity and Mortality Weekly Report. 2019; 19 (12): 3420–3428. DOI: 10.15585/mmwr.mm6841e3Siegel D.A., Jatlaoui T.C., Koumans E.H., Kiernan E.A., Layer M., Cates J.E. et al. Update: interim guidance for health care providers evaluating and caring for patients with suspected e-cigarette, or vaping, product use associated lung injury — United States. Morbidity and Mortality Weekly Report. 2019; 19 (12): 3420–3428. DOI: 10.15585/mmwr.mm6841e3Rao D.R., Maple K.L., Dettori A., Afolabi F., Francis J.K.R., Artunduaga M. et al. Clinical Features of E-cigarette, or Vaping, Product Use-Associated Lung Injury in Teenagers. Pediatrics 2020; 146(1): e20194104. DOI: 10.1542/peds.2019–4104Rao D.R., Maple K.L., Dettori A., Afolabi F., Francis J.K.R., Artunduaga M. et al. Clinical Features of E-cigarette, or Vaping, Product Use-Associated Lung Injury in Teenagers. Pediatrics 2020; 146(1): e20194104. DOI: 10.1542/peds.2019–4104Mado H., Reichman-Warmusz E., Wojnicz R. The vaping product use associated lung injury: is this a new pulmonary disease entity? Rev Environ Health 2020; 36(2): 145–157. DOI: 10.1515/reveh-2020–0076Mado H., Reichman-Warmusz E., Wojnicz R. The vaping product use associated lung injury: is this a new pulmonary disease entity? Rev Environ Health 2020; 36(2): 145–157. DOI: 10.1515/reveh-2020–0076Belok S.H., Parikh R., Bernardo J., Kathuria H.E. E-cigarette, or vaping, product use-associated lung injury: a review. Pneumonia 2020; 33(6): 657–663. DOI: 10.1186/s41479–020–00075–2Belok S.H., Parikh R., Bernardo J., Kathuria H.E. E-cigarette, or vaping, product use-associated lung injury: a review. Pneumonia 2020; 33(6): 657–663. DOI: 10.1186/s41479–020–00075–2Werner A.K., Koumans E.H., Chatham-Stephens K., Salvatore P.P., Armatas C., Byers P. et al. Hospitalizations and deaths associated with EVALI. The New Engl J Med 2020; 382(17): 1589–1598. DOI: 10.1056/NEJMoa1915314Werner A.K., Koumans E.H., Chatham-Stephens K., Salvatore P.P., Armatas C., Byers P. et al. Hospitalizations and deaths associated with EVALI. The New Engl J Med 2020; 382(17): 1589–1598. DOI: 10.1056/NEJMoa1915314Kazachkov M., Pirzada M. Diagnosis of EVALI in the COVID-19 era. Lancet Respir Med 2020; 8(12): 1169–1170. DOI: 10.1016/S2213–2600(20)30450–1Kazachkov M., Pirzada M. Diagnosis of EVALI in the COVID-19 era. Lancet Respir Med 2020; 8(12): 1169–1170. DOI: 10.1016/S2213–2600(20)30450–1

The authors declare that there are no conflicts of interest present.