perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-5-45-51perinatology-2064Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОценка эффективности пробиотических бактерий Bifidobacterium BB-12 и Streptococcus thermophilus TH-4 в профилактике микроэкологических и гастроинтестинальных нарушений у детей, рожденных путем кесарева сеченияEvaluation of the effectiveness of probiotic bacteria Bifidobacterium BB-12 and Streptococcus thermophilus TH-4 in the prevention of microecological and gastrointestinal disorders in children born by cesarean sectionhttps://orcid.org/0000-0003-0104-5895НиколаеваИ. В.NikolaevaI. V.

Николаева Ирина Венидиктовна – д.м.н., проф., зав. кафедрой инфекционных болезней

420012 Казань, ул. Бутлерова, д. 49

Kazan

https://orcid.org/0000-0002-4389-4775ШайхиеваГ. С.ShaikhievaG. S.

Шайхиева Гульнара Сиреневна – к.м.н., зав. боксированным отделением №15

420110 Казань, пр. Победы, д. 83, кор. 2

Kazan

https://orcid.org/0000-0002-8124-5880ГайнатуллинаЛ. Р.GaynatullinaL. R.

Гайнатуллина Лилия Рифатовна – зав. боксированным отделением №1

420110 Казань, пр. Победы, д. 83, кор. 2

Kazan

ФГБОУ ВО «Казанский государственный медицинской университет» Минздрава РоссииРоссияKazan State Medical University of the Ministry of Health of RussiaRussian FederationГАУЗ «Республиканская клиническая инфекционная больница им. профессора А.Ф. Агафонова» Минздрава Республики ТатарстанаРоссияRepublican Clinical Hospital of Infectious DiseasesRussian Federation2024121120246954551Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2064

Изучена клинико-лабораторная эффективность биокомплекса пробиотических бактерий (Bifidobacterium BB-12, Streptococcus thermophilus TH-4) в профилактике микроэкологических и гастроинтестинальных нарушений у детей, рожденных путем кесарева сечения. Проведено проспективное открытое сравнительное исследование. Основную группу составили 16 здоровых новорожденных детей, рожденных путем кесарева сечения и получавших пробиотик (Bifidobacterium BB-12, Streptococcus thermophiles TH-4) по 1 дозе 1 раз в день. Пероральное введение пробиотика начиналось сразу после родов и продолжалось в течение 14 дней. Контрольную группу составил 21 здоровый ребенок, рожденный путем кесарева сечения и не получавший пробиотики в течение всего периода наблюдения. Бактериологическое исследование кала и оценка состояния здоровья проводилось в возрасте 4–5 дней, 1 и 3 мес. У детей, получавших пробиотик, отмечалась меньшая частота младенческих кишечных колик в возрасте 1 мес? Реже выделялась условно-патогенная микрофлора (p<0,01) и реже определялись признаки воспаления кишечника по данным копрологического исследования в течение всего периода наблюдения.

Заключение. Выявлена эффективность применения пробиотика (Bifidobacterium BB-12 и S. thermophilus TH-4) для профилактики микроэкологических и гастроинтестинальных нарушений у детей, рожденных путем кесарева сечения.

The clinical and laboratory effectiveness of a biocomplex of probiotic bacteria (Bifidobacterium BB-12, Streptococcus thermophilus TH-4) in preventing the development of microecological and gastrointestinal disorders in children born by cesarean section has been studied. A prospective open comparative study was conducted. The main group consisted of 16 healthy newborns born by cesarean section who were treated with a probiotic (Bifidobacterium BB-12, Streptococcus thermophilus TH-4) at 1 dose once a day. Oral administration of the probiotics began immediately after delivery and continued for 14 days. A control group of 21 healthy babies born by caesarian section who did not receive the probiotics during the study period was also included. Bacteriological analysis of fecal samples and assessment of the health status were performed at the ages of 4–5 days, 1 month, and 3 months. In children receiving probiotics, the incidence of infantile intestinal colic was lower at the age of 1 month, opportunistic microflora were less frequently isolated (p<0.01), and signs of inflammation in the intestines were less often detected during the follow-up period, as shown by a coprological study.

Conclusion. The effectiveness of using probiotics (Bifidobacterium BB-12 and S. thermophilus TH-4) to prevent microecological and gastrointestinal problems in children born by cesarean section has been demonstrated.

новорожденныепробиотикигастроинтестинальные нарушениямикроэкологические нарушениякесарево сечениеnewbornsprobioticsgastrointestinal problemsmicroecological problemscesarean deliveryReferencesDerrien M., Alvarez A.S., de Vos W.M. The gut microbiota in the first decade of life. Trends Microbiol 2019; 27(12): 997–1010. DOI: 10.1016/j.tim.2019.08.001Derrien M., Alvarez A.S., de Vos W.M. The gut microbiota in the first decade of life. Trends Microbiol 2019; 27(12): 997–1010. DOI: 10.1016/j.tim.2019.08.001Papathoma E., Triga M., Fouzas S., Dimitriou G. Cesarean section delivery and development of food allergy and atopic dermatitis in early childhood. Pediatr Allergy Immunol 2016; 27(4): 419–424. DOI: 10.1111/pai.12552Papathoma E., Triga M., Fouzas S., Dimitriou G. Cesarean section delivery and development of food allergy and atopic dermatitis in early childhood. Pediatr Allergy Immunol 2016; 27(4): 419–424. DOI: 10.1111/pai.12552Francino M.P. Birth mode-related differences in gut microbiota colonization and immune system development. Ann Nutr Metab 2018; 73(Suppl 3): 12–16. DOI: 10.1159/000490842Francino M.P. Birth mode-related differences in gut microbiota colonization and immune system development. Ann Nutr Metab 2018; 73(Suppl 3): 12–16. DOI: 10.1159/000490842Li N., Liang S., Chen Q., Zhao L., Li B., Huo G. Distinct gut microbiota and metabolite profiles induced by delivery mode in healthy Chinese infants. J Proteomics 2021; 232: 104071. DOI: 10.1016/j.jprot.2020.104071Li N., Liang S., Chen Q., Zhao L., Li B., Huo G. Distinct gut microbiota and metabolite profiles induced by delivery mode in healthy Chinese infants. J Proteomics 2021; 232: 104071. DOI: 10.1016/j.jprot.2020.104071Dogra S., Sakwinska O., Soh S. E., Ngom-Bru C., Brück W.M., Berger B. et al. Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. MBio 2015; 6 (1): E02419–14. DOI: 10.1128/mBio.02419–14Dogra S., Sakwinska O., Soh S. E., Ngom-Bru C., Brück W.M., Berger B. et al. Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. MBio 2015; 6 (1): E02419–14. DOI: 10.1128/mBio.02419–14Николаева И.В. Формирование кишечной микрофлоры и факторы, влияющие на этот процесс. Детские инфекции 2011; 10 (3): 39–42.Nikolaeva I.V. Formation of intestinal microflora and factors influencing this process. Detskie infektsii 2011; 10 (3): 39–42. (in Russ.)Navarro-Tapia E., Sebastiani G., Sailer S., Toledano LA., Serra-Delgado M., García-Algar Ó. et al. Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease. Nutrients 2020;12(8):2243. DOI: 10.3390/nu12082243Navarro-Tapia E., Sebastiani G., Sailer S., Toledano LA., Serra-Delgado M., García-Algar Ó. et al. Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease. Nutrients 2020;12(8):2243. DOI: 10.3390/nu12082243Николаева И.В., Анохин В.А., Купчихина Л.А., Халиуллина С.В. Риск развития инфекционных и соматических заболеваний у детей раннего возраста, рожденных кесаревым сечением. Практическая медицина 2013; 6 (75): 93–96.Nikolaeva I.V., Anohin V.A., Kupchihina L.A., Haliullina S.V. Risk of infectious and somatic diseases in infants born by cesarean section. Prakticheskaya meditsina 2013; 6 (75): 93–96. (in Russ.)Николаева И.В., Шайхиева Г.С., Хаертынов Х.С., Гатауллин М.Р., Урманчеева Ю.Р. Этиологическая структура и особенности клинических проявлений неонатальных инфекций у детей, рожденных путем кесарева сечения. Российский вестник перинатологии и педиатрии 2017; 62(5): 88–92.Nikolaeva I.V., Shajhieva G.S., Haertynov H.S., Gataullin M.R., Urmancheeva Yu.R. Etiological structure and features of clinical manifestations of neonatal infections in children born by cesarean section. Rossiyskiy vestnik perinatologii i pediatrii 2017; 62(5): 88–92. (in Russ.) DOI:10.21508/1027–4065–2017–62–5–88–92Gong Y., Zhong H., Wang J., Wang X., Huang L., Zou Y. et al. Effect of probiotic supplementation on the gut microbiota composition of infants delivered by cesarean section: an exploratory, randomized, open-label, parallel-controlled Trial. Curr Microbiol 2023; 80 (11): 341. DOI: 10.1007/s00284–023–03444–4Gong Y., Zhong H., Wang J., Wang X., Huang L., Zou Y. et al. Effect of probiotic supplementation on the gut microbiota composition of infants delivered by cesarean section: an exploratory, randomized, open-label, parallel-controlled Trial. Curr Microbiol 2023; 80 (11): 341. DOI: 10.1007/s00284–023–03444–4Korpela K., Salonen A., Vepsäläinen O., Suomalainen M., Kolmeder C., Varjosalo M. et al. Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants. Microbiome 2018; 6(1): 182. DOI: 10.1186/s40168–018–0567–4Korpela K., Salonen A., Vepsäläinen O., Suomalainen M., Kolmeder C., Varjosalo M. et al. Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants. Microbiome 2018; 6(1): 182. DOI: 10.1186/s40168–018–0567–4Ahmadi E., Alizadeh-Navaei R., Sadegh Rezai M. Efficacy of probiotic use in acute rotavirus diarrhea in children: A systematic review and meta-analysis. Caspian J Intern Med 2015; 6(4): 187–195.Ahmadi E., Alizadeh-Navaei R., Sadegh Rezai M. Efficacy of probiotic use in acute rotavirus diarrhea in children: A systematic review and meta-analysis. Caspian J Intern Med 2015; 6(4): 187–195.Guandalini S., Cernat E., Moscoso D. Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children. Benef Microbes 2015; 6(2): 209–217. DOI: 10.3920/BM2014.0067Guandalini S., Cernat E., Moscoso D. Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children. Benef Microbes 2015; 6(2): 209–217. DOI: 10.3920/BM2014.0067Blaabjerg S., Artzi D.M., Aabenhus R. Probiotics for the prevention of antibiotic-associated diarrhea in outpatients — a systematic review and meta-analysis. Antibiotics (Basel) 2017; 6(4): 21. DOI: 10.3390/antibiotics6040021Blaabjerg S., Artzi D.M., Aabenhus R. Probiotics for the prevention of antibiotic-associated diarrhea in outpatients — a systematic review and meta-analysis. Antibiotics (Basel) 2017; 6(4): 21. DOI: 10.3390/antibiotics6040021Руженцова Т.А., Хавкина Д.А., Плоскирева А.А., Мешкова Н.А. Рациональные подходы к терапии нарушений функции желудочно-кишечного тракта у детей. Медицинский Совет 2020; 1: 106–112.Ruzhencova T.A., Havkina D.A., Ploskireva A.A., Meshkova N.A. Childhood functional gastrointestinal disorders: rational therapy. Medicinskij Sovet 2020; 1: 106–112. (in Russ.) DOI: 10.21518/2079–701X-2020–1–106–112Robertson C., Savva G.M., Clapuci R., Jones J., Maimouni H., Brown E. et al. Incidence of necrotising enterocolitis before and after introducing routine prophylactic Lactobacillus and Bifidobacterium probiotics. Arch Dis Child Fetal Neonatal Ed 2020; 105: 380–386. DOI: 10.1136/archdis-child-2019–317346Robertson C., Savva G.M., Clapuci R., Jones J., Maimouni H., Brown E. et al. Incidence of necrotising enterocolitis before and after introducing routine prophylactic Lactobacillus and Bifidobacterium probiotics. Arch Dis Child Fetal Neonatal Ed 2020; 105: 380–386. DOI: 10.1136/archdis-child-2019–317346Shirazinia R., Golabchifar A.A., Fazeli M.R. Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review. Clin Exp Pediatr 2021; 64(12): 642–651. DOI: 10.3345/cep.2020.01676Shirazinia R., Golabchifar A.A., Fazeli M.R. Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review. Clin Exp Pediatr 2021; 64(12): 642–651. DOI: 10.3345/cep.2020.01676Мазанкова Л.Н., Рыбальченко О.В., Корниенко Е.А., Перловская С.Г. Пробиотики в педиатрии: за и против с позиции доказательной медицины. Российский вестник перинатологии и педиатрии 2016; 1: 16–26.Mazankova L.N., Rybal’chenko O.V., Kornienko E.A., Perlovskaja S.G. Probiotics in pediatrics: pros and cons in the context of evidence-based medicine. Rossiyskiy vestnik perinatologii i pediatrii 2016; 1: 16–26. (in Russ.) DOI: 10.21508/1027–4065–2016–61–1–17–23Андреева И.В., Стецюк О.У. Эффективность и безопасность комбинации Lactobacillus acidophilus LA 5 и Bifido-bacterium lactis ВB 12 в гастроэнтерологии, педиатрии и аллергологии. Клиническая микробиология и антимикробная химиотерапия 2016; 2(18): 113–124.Andreeva I.V., Stecjuk O.U. Efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12 combination in gastroenterology, pediatrics and allergology. Klinicheskaya mikrobiologiya i antimikrobnaya himioterapiya 2016; 2(18): 113–124. (in Russ.)Jungersen M., Wind A., Johansen E., Christensen J.E., Stuer-Lauridsen B., Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. Lactis BB-12. Microorganisms 2014; 2: 92–110. DOI: 10.3390/microor-ganisms2020092Jungersen M., Wind A., Johansen E., Christensen J.E., Stuer-Lauridsen B., Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. Lactis BB-12. Microorganisms 2014; 2: 92–110. DOI: 10.3390/microor-ganisms2020092Sharma R., Bhaskar B., Sanodiya B.S., Thakur G.S., Jaiswal P., Yadav N. et al. Probiotic Efficacy and Potential of Streptococcus thermophilus modulating human health: A synoptic review. J Pharm Biol Scie 2014; 9(3): 52–58. DOI: 10.9790/3008–09325258Sharma R., Bhaskar B., Sanodiya B.S., Thakur G.S., Jaiswal P., Yadav N. et al. Probiotic Efficacy and Potential of Streptococcus thermophilus modulating human health: A synoptic review. J Pharm Biol Scie 2014; 9(3): 52–58. DOI: 10.9790/3008–09325258Patel S., Chaudhari M., Kadam S., Rao S., Patole S. Standardized feeding and probiotic supplementation for reducing necrotizing enterocolitis in preterm infants in a resource limited set up. Eur J Clin Nutr 2018; 72: 281–287. DOI: 10.1038/s41430–017–0040–7Patel S., Chaudhari M., Kadam S., Rao S., Patole S. Standardized feeding and probiotic supplementation for reducing necrotizing enterocolitis in preterm infants in a resource limited set up. Eur J Clin Nutr 2018; 72: 281–287. DOI: 10.1038/s41430–017–0040–7Plummer E.L., Bulach D.M., Murray G.L., Jacobs S.E., Tabrizi S.N., Garland S.M. Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial. BMC Microbiol 2018; 18(1): 184. DOI: 10.1186/s12866–018–1326–1Plummer E.L., Bulach D.M., Murray G.L., Jacobs S.E., Tabrizi S.N., Garland S.M. Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial. BMC Microbiol 2018; 18(1): 184. DOI: 10.1186/s12866–018–1326–1Пахомовская Н.Л., Венедиктова М.М. Влияние микробиоты ребенка первого года жизни на его развитие. Медицинский совет 2018; 2: 200–205.Pahomovskaja N.L., Venediktova M.M. Impact of early-life microbiota on the development of infants. Meditsinskii sovet 2018; 2: 200–205. (in Russ.) DOI: 10.21518/2079–701X-2018–2–200–205Мазанкова Л.Н., Яковлева Г.Ю., Ардатская М.Д. Ротавирусная инфекция у детей раннего возраста: обоснование пробиотической терапии. Детские инфекции 2011; 2: 52–56.Mazankova L.N., Jakovleva G.Yu., Ardatskaja M.D. Rotavirus infection in infant: rationale of probiotics therapy. Detskie infektsii 2011; 2: 52–56. (in Russ.)

The authors declare that there are no conflicts of interest present.