perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2024-69-6-21-26perinatology-2086Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSСаркопения у детейSarcopenia in childrenhttps://orcid.org/0000-0001-9966-6686МатвееваМ. В.MatveevaM. V.

Матвеева Мария Владимировна — д.м.н., доц., проф. кафедры педиатрии с курсом эндокринологии

634050 Томск, Московский тракт, д. 4

Tomsk

https://orcid.org/0000-0002-2667-4842СамойловаЮ. Г.SamoilovaYu. G.

Самойлова Юлия Геннадьевна — д.м.н., проф., зав. кафедрой кафедры педиатрии с курсом эндокринологии, зав. центром клинических исследований; главный специалист департамента здравоохранения Томской области по медицинской профилактике

634050 Томск, Московский тракт, д. 4

Tomsk

ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава РоссииРоссияSiberian State Medical UniversityRussian Federation2024020120256962126Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20242024Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2086

Саркопения характеризуется снижением массы скелетных мышц и мышечной функции. Скелетные мышцы играют важную роль в обмене веществ и общем состоянии здоровья на протяжении всего жизненного цикла. Новые данные указывают на то, что пренатальные (диета матери во время беременности и генетические дефекты) и постнатальные (физическая активность, гормоны, питание и ряд заболеваний, например ожирение) факторы влияют на набор мышечной массы и силы в раннем возрасте. Наличие саркопении связано с неблагоприятными исходами (кардиометаболическими нарушениями, неалкогольной жировой болезнью печени, когнитивной дисфункцией, падениями и переломами, снижением физической работоспособности и качества жизни, а также инвалидизацией и смертностью) у детей и затем у взрослых. Несмотря на растущий исследовательский интерес к саркопении в различные возрастные периоды, четкой концепции в педиатрии и клинических рекомендаций в настоящее время не существует.

Цель обзора — изучение текущих данных о саркопении в педиатрии с прицельным интересом на миокины и их роль. Обзор включает данные за последние 5 лет в базах Elibrary, Pubmed. Поиск источников осуществлялся по ключевым словам: саркопения в педиатрии, саркопения у детей, скелетная мускулатура в детском возрасте, миокины у детей.

Sarcopenia is characterized by a decline in skeletal muscle mass and muscle function. Skeletal muscle plays a crucial role in metabolism and overall health throughout the lifespan. Emerging evidence indicates that both prenatal (such as maternal diet during pregnancy and genetic factors) and postnatal factors (including physical activity, hormonal levels, nutrition, and various diseases, such as obesity) influence the development of muscle mass and strength early in life. The presence of sarcopenia is associated with adverse outcomes (such as cardiometabolic disorders, non-alcoholic fatty liver disease, cognitive dysfunction, falls and fractures, reduced physical performance and quality of life, as well as disability and mortality) in both children and later in adults. Despite growing research interest in sarcopenia across different ages, a clear pediatric concept and clinical guidelines are currently lacking. The objective of this review is to examine the latest data on sarcopenia in pediatrics, with a specific focus on myokines and their role. The review includes data from the past 5 years sourced from the Elibrary and PubMed databases. The literature search was conducted using keywords: pediatric sarcopenia, sarcopenia in children, skeletal muscle in childhood, myokines in children.

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The authors declare that there are no conflicts of interest present.