References

perinatology

Российский вестник перинатологии и педиатрии

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)

1027-40652500-2228

Ltd. “The National Academy of Pediatric Science and Innovation”

10.21508/1027-4065-2025-70-1-18-25

perinatology-2134

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEWS

Биомаркеры для диагностики инфекционно-воспалительных заболеваний

Biomarkers for the diagnosis of infectious and inflammatory diseases

https://orcid.org/0000-0002-8165-3921

Менчиц

Я. А.

Menchits

Y. A.

Менчиц Ярослав Андреевич - стажер-исследователь кафедры педиатрии и детских инфекционных заболеваний педиатрического факультета

Москва

Moscow

https://orcid.org/0000-0002-3948-8491

Гордукова

М. А.

Gordukova

M. A.

Гордукова Мария Александровна - к.б.н., биолог

Москва

Moscow

https://orcid.org/0000-0002-6649-853X

Образцов

И. В.

Obraztsov

I. V.

Образцов Игорь Владимирович - к.м.н., врач аллерголог-иммунолог

Москва

Moscow

https://orcid.org/0000-0002-2892-4665

Еремеева

А. В.

Eremeeva

A. V.

Еремеева Алина Владимировна - д.м.н., проф. кафедры педиатрии и детских инфекционных заболеваний педиатрического факультета

Москва

Moscow

https://orcid.org/0000-0002-9087-1656

Корсунский

И. А.

Korsunsky

I. A.

Корсунский Анатолий Александрович - д.м.н., проф., зав. кафедрой педиатрии и детских инфекционных заболеваний педиатрического факультета; президент Детской городской клинической больницы № 9 им. Г.Н. Сперанского ДЗМ

119991 Москва, ул. Трубецкая, д. 8, стр. 2

Moscow

https://orcid.org/0000-0001-9154-3219

Федорова

Л. А.

Fedorova

L. A.

Федорова Людмила Анатольевна - к.м.н., доц. кафедры педиатрии и детских инфекционных заболеваний педиатрического факультета; врач аллерголог-иммунолог

123317 Москва, Шмитовский проезд, д. 29

Moscow

https://orcid.org/0000-0003-1878-4467

Кудлай

Д. А.

Kudlai

D. A.

Кудлай Дмитрий Анатольевич - член-корр. РАН, д.м.н., проф. кафедры педиатрии и детских инфекционных заболеваний педиатрического факультета; вед. науч. сотр.

Moscow

https://orcid.org/0000-0002-7822-2477

Корсунский

А. А.

Korsunsky

A. A.

Корсунский Илья Анатольевич - д.м.н., проф. кафедры педиатрии и детских инфекционных заболеваний педиатрического факультета

Москва

Moscow

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияFirst Moscow State Medical University named after I.M. Sechenov (Sechenov University);Russian Federation

ГБУЗ «Детская городская клиническая больница № 9 им. Г.Н. Сперанского ДЗМ»РоссияSperansky Children’s Hospital No. 9, Moscow Health DepartmentRussian Federation

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет); ГБУЗ «Детская городская клиническая больница № 9 им. Г.Н. Сперанского ДЗМ»РоссияFirst Moscow State Medical University named after I.M. Sechenov (Sechenov University); Speransky Children’s Hospital No. 9, Moscow Health DepartmentRussian Federation

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет); ФГБУ «Государственный научный центр Институт иммунологии» Федерального медико-биологического агентства; АО «Генериум»РоссияFirst Moscow State Medical University named after I.M. Sechenov (Sechenov University); National Research Center — Institute of Immunology Federal Medical-Biological Agency of Russia; JSC «GENERIUM»Russian Federation

2025

05032025

7011825

2025

Ltd. “The National Academy of Pediatric Science and Innovation”

https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice

https://www.ped-perinatology.ru/jour/article/view/2134

Обзор посвящен анализу биомаркеров для диагностики и прогноза инфекций у детей с иммунодефицитами, при этом особое внимание обращено на роль биомаркеров в ранней диагностике и оценке риска. В основу исследования легли научные публикации из базы данных PubMed, включая анализ иммунологических маркеров, генетических предрасположенностей и методов измерения биомаркеров. Основные результаты показывают значение таких биомаркеров, как прокальцитонин и пресепсин для ранней диагностики, IL-6 — для прогноза течения болезни, а TREC и KREC — для мониторинга иммунного статуса новорожденных. Перспективными направлениями остаются изучение генетических маркеров и оценка нейтрофильных внеклеточных ловушек для прогнозирования исходов сепсиса. Практическое применение выявленных биомаркеров может улучшить диагностику и мониторинг инфекций у детей с иммунодефицитами, снижая смертность и число осложнений, повышая эффективность терапии. Выводы работы подчеркивают значение внедрения биомаркеров для персонализированного подхода в диагностике и прогнозировании инфекционных заболеваний у детей с нарушениями иммунной системы.

This review focuses on the analysis of biomarkers for the diagnosis and prognosis of infections in immunocompromised children, with particular emphasis on their role in early diagnosis and risk assessment. The study is based on scientific publications from the PubMed database, including analyses of immunological markers, genetic predispositions, and biomarker measurement methods. The key findings highlight the importance of biomarkers such as procalcitonin and presepsin for early diagnosis, IL-6 for predicting disease progression, and TREC and KREC for monitoring neonatal immune status. Promising areas of study include genetic markers and the evaluation of neutrophil extracellular traps to predict sepsis outcomes. The practical application of these biomarkers can improve the diagnosis and monitoring of infections in immunocompromised children, reducing mortality and complications while enhancing treatment efficacy. The study’s conclusions underscore the importance of integrating biomarkers into personalized approaches to diagnosing and predicting infectious diseases in children with immune system impairments.

детибиомаркерыинфекционные заболеваниялабораторная диагностикапедиатрияпрогнозирование

childrenbiomarkersinfectious diseaseslaboratory diagnosticspediatricsprognosis

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The authors declare that there are no conflicts of interest present.