perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2025-70-5-114-117perinatology-2276Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCLINICAL CASESНеонатальный сепсис, вызванный Burkholderia cepaciaNeonatal sepsis caused by burkholderia cepaciahttps://orcid.org/0000-0002-9013-4402ХаертыновХ. С.KhaertynovKh. S.

Хаертынов Халит Саубанович — д.м.н., доцент кафедры детских инфекций.

420012, Казань, ул. Бутлерова, д. 49

420012, Kazan

khalit65@yandex.ruhttps://orcid.org/0000-0003-1050-9081АнохинВ. А.AnokhinV. A.

Анохин Владимир Алексеевич — д.м.н., проф., зав. кафедрой детских инфекций.

420012, Казань, ул. Бутлерова, д. 49

420012, Kazan

https://orcid.org/0000-0002-8563-8091ДонцоваН. В.DontsovaN. V.

Донцова Надежда Викторовна — врач-реаниматолог, зав. отделением реанимации новорожденных.

420034, Казань, ул. Декабристов, д. 125а

420034, Kazan

https://orcid.org/0009-0005-7436-2746АбдрашитоваА. И.AbdrashitovaA. I.

Абдрашитова Алия Искяндяровна — студентка 6 курса педиатрического факультета.

420012, Казань, ул. Бутлерова, д. 49

420012, Kazan

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииРоссияKazan State Medical AcademyRussian FederationГАУЗ «Городская детская больница № 1»РоссияCity Children’s Hospital № 1Russian Federation202514112025705114117Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20252025Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2276

Представлен случай неонатального сепсиса, обусловленного Burkcholderia cepacia у доношенного новорожденного. С первого дня жизни у ребенка отмечались проявления дыхательной недостаточности с необходимостью проведения искусственной вентиляции легких и кардиоваскулярные нарушения. По результатам проведенной рентгенографии органов грудной клетки была диагностирована пневмония. Отмечались признаки полиорганной недостаточности, составившей по шкале nSOFA (neonatal Sepsis-related Organ Failure Assessment) 4 балла. В крови выявлено повышение уровня С-реактивного белка до 39,3 мг/л. Из крови и эндотрахеальной трубки была выделена B.cepacia. Ребенок с рождения получал комбинированную антибактериальную терапию — ампициллин/сульбактам и амикацин. Но положительная динамика произошла на фоне терапии цефтазидимом: уменьшились признаки дыхательной недостаточности, через 3 дня ребенок был экустубирован, уровень С-реакативного белка в крови снизился до нормальных значений. Ребенок был выписан домой на 28-й день госпитализации в удовлетворительном состоянии.

A case of neonatal sepsis caused by Burkcholderia cepacia in a full-term newborn is presented. A diagnosis of sepsis caused by Burkholderia cepacia was made in a full-term newborn. Since the first day of life, the infant displayed signs of respiratory distress syndrome, necessitating mechanical ventilation of the lungs, and cardiovascular disorders. Chest X-ray results indicated pneumonia. There were signs of multi-organ failure, which scored 4 points on the neonatal Sepsis-related Organ Failure Assessment (nSOFA) scale. Blood tests revealed an elevated C-reactive protein level of 39.3 mg/L. Burkholderia cepacia was isolated from both blood and the endotracheal tube. The child received combined antibiotic therapy with ampicillin/sulbactam and amikacin from birth. But positive dynamics were observed during treatment with ceftazidime: signs of respiratory distress syndrome diminished, and the infant was extubated after three days. The C-reactive protein level in the blood decreased to normal values. The child was discharged home in satisfactory condition on the 28th day of hospitalization.

новорожденныенеонатальный сепсисBurkcholderia cepacianewbornsneonatal sepsisBurkcholderia cepaciaReferencesCamacho-Gonzales A., Spearman P.W., Stoll B.J. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am 2013; 60: 367–389. DOI: 10.1016/j.pcl.2012.12.003Camacho-Gonzales A., Spearman P.W., Stoll B.J. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am 2013; 60: 367–389. DOI: 10.1016/j.pcl.2012.12.003Fleischmann C., Reichert F., Cassini A., Horner R., Harder T., Markwart R. et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Arch Dis Child. 2021; 106(8): 745–752. DOI: 10.1136/archdis-child-2020-320217Fleischmann C., Reichert F., Cassini A., Horner R., Harder T., Markwart R. et al. Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Arch Dis Child. 2021; 106(8): 745–752. DOI: 10.1136/archdis-child-2020-320217Glaser M.A., Hughes L.M., Jnah A., Newberry D. Neonatal Sepsis: A Review of Pathophysiology and Current Management Strategies. Adv Neonatal Care. 2021; 21(1): 49–60. DOI: 10.1097/ANC.0000000000000769Glaser M.A., Hughes L.M., Jnah A., Newberry D. Neonatal Sepsis: A Review of Pathophysiology and Current Management Strategies. Adv Neonatal Care. 2021; 21(1): 49–60. DOI: 10.1097/ANC.0000000000000769Самсыгина Г.А. Неонатальный сепсис. М., ПедиатрЪ 2014; 173.Самсыгина Г.А. Неонатальный сепсис. М., ПедиатрЪ 2014; 173. [Samsygina G.A. Neonatal sepsis. Moscow, Pediatr 2014; 173. (in Russ)]Островский А.Д., Воробьев А.С. Сепсис у детей раннего возраста. Л., 1979; 125.Ostrovskij A.D., Vorob’ev A.S. Sepsis in young children. Leningrad, 1979; 125. (in Russ)Borghesi A., Stronati M. Superbugs and antibiotics in the newborn. J Pediatr Neonat Indiv Med 2015; 4(2): e040253. DOI: 10.7363/040253Borghesi A., Stronati M. Superbugs and antibiotics in the newborn. J Pediatr Neonat Indiv Med 2015; 4(2): e040253. DOI: 10.7363/040253Drevinek P., Mahenthiralingam E. Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence. Clin Microbiol Infect. 2010; 16(7): 821–830. DOI: 10.1111/j.1469-0691.2010.03237.xDrevinek P., Mahenthiralingam E. Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence. Clin Microbiol Infect. 2010; 16(7): 821–830. DOI: 10.1111/j.1469-0691.2010.03237.xMann T., Ben-David D., Zlotkin A., Shachar D., Keller N., Toren A. et al. An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patients. Infection. 2010; 38: 187–194. DOI: 10.1007/s15010-010-0017-0Mann T., Ben-David D., Zlotkin A., Shachar D., Keller N., Toren A. et al. An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patients. Infection. 2010; 38: 187–194. DOI: 10.1007/s15010-010-0017-0Bennaoui F., El Idrissi Slitine N., Benbahia A., Soraa N., Maoulainine F.M.R. Burkholderia Cepacia Sepsis: A Neonatal Case. Frontiers in Medical Case Reports. 2020; 1(2): 1208. DOI: org/10.47746Bennaoui F., El Idrissi Slitine N., Benbahia A., Soraa N., Maoulainine F.M.R. Burkholderia Cepacia Sepsis: A Neonatal Case. Frontiers in Medical Case Reports. 2020; 1(2): 1208. DOI: org/10.47746Frank T., Gil-Cuesta J., Robert Mbecko J., Sanke H., Lakis C., Le Flèche-Matéos A., Berlioz-Arthaud A. First cases of Burkholderia cenocepacia IIIA neonatal sepsis in Central African Republic. Pan African Medical Journal. 2020; 36: 330. DOI: 10.11604/pamj.2020.36.330.24512Frank T., Gil-Cuesta J., Robert Mbecko J., Sanke H., Lakis C., Le Flèche-Matéos A., Berlioz-Arthaud A. First cases of Burkholderia cenocepacia IIIA neonatal sepsis in Central African Republic. Pan African Medical Journal. 2020; 36: 330. DOI: 10.11604/pamj.2020.36.330.24512Leitão J.H., Sousa S.A., Ferreira A.S., Ramos C.G., Silva I.N., Moreira L.M. Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related species. Appl Microbiol Biotechnol. 2010; 87(1): 31–40. DOI: 10.1007/s00253-010-2528-0.Leitão J.H., Sousa S.A., Ferreira A.S., Ramos C.G., Silva I.N., Moreira L.M. Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related species. Appl Microbiol Biotechnol. 2010; 87(1): 31–40. DOI: 10.1007/s00253-010-2528-0.Tavares M., Kozak M., Balola A., Sá-Correia I. Burkholderia cepacia Complex Bacteria: a Feared Contamination Risk in Water-Based Pharmaceutical Products. Clin Microbiol Rev. 2020; 33(3):e00139–19. DOI: 10.1128/CMR.00139-19Tavares M., Kozak M., Balola A., Sá-Correia I. Burkholderia cepacia Complex Bacteria: a Feared Contamination Risk in Water-Based Pharmaceutical Products. Clin Microbiol Rev. 2020; 33(3):e00139–19. DOI: 10.1128/CMR.00139-19Burkholder W. Sour skin, a bacterial rot of onion bulbs. Phytopathol. 1950; 64: 468–475Burkholder W. Sour skin, a bacterial rot of onion bulbs. Phytopathol. 1950; 64: 468–475Singhal T., Shah S., Naik R. Outbreak of Burkholderia cepacia complex bacteremia in a chemotherapy day care unit due to intrinsic contamination of an antiemetic drug. Indian J Med Microbiol. 2015; 33: 117–119. DOI: 10.4103/0255-0857.148405Singhal T., Shah S., Naik R. Outbreak of Burkholderia cepacia complex bacteremia in a chemotherapy day care unit due to intrinsic contamination of an antiemetic drug. Indian J Med Microbiol. 2015; 33: 117–119. DOI: 10.4103/0255-0857.148405Sousa S.A., Ramos C.G., Leitão J.H., Sousa S.A., Ramos C.G., Leitão J.H. Burkholderia cepacia complex: emerging multihost pathogens equipped with a wide range of virulence factors and determinants. Int J Microbiol. 2011: 1–9. DOI: 10.1155/2011/607575Sousa S.A., Ramos C.G., Leitão J.H., Sousa S.A., Ramos C.G., Leitão J.H. Burkholderia cepacia complex: emerging multihost pathogens equipped with a wide range of virulence factors and determinants. Int J Microbiol. 2011: 1–9. DOI: 10.1155/2011/607575Isles A., Macluski I., Corey M., Gold R., Prober C., Fleming P., Levison H. Pseudomonas cepacia infection in cystic fibrosis: an emerging problem. J Pediatr 1984; 104: 206–210Isles A., Macluski I., Corey M., Gold R., Prober C., Fleming P., Levison H. Pseudomonas cepacia infection in cystic fibrosis: an emerging problem. J Pediatr 1984; 104: 206–210Чипигина Н.С., Карпова Н.Ю., Леонтьева Н.П., Евдокимов В.И., Дубинин Н.М., Дубровина А.С. Инфекционный эндокардит, вызванный редким возбудителем Burkholderia cepacia. Архивъ внутренней медицины. 2018; 8(4): 317–322. DOI: 10.20514/2226-6704-2018-8-4-317-322Chipigina N.S., Karpova N.Yu., Leontieva N.P., Evdokimov V.I., Dubinin N.M., Dubrovina A.S. Infectious endocarditis caused by a rare agent Burkholderia cepacia. Arhiv# vnutrennej mediciny. 2018; 8(4): 317–322. DOI: 10.20514/2226-6704-2018-8-4-317-322 (in Russ)Antony B., Cherian E.V., Boloor R., Shenoy K.V. A sporadic outbreak of Burkholderia cepacia complex bacteremia in pediatric intensive care unit of a tertiary care hospital in coastal Karnataka. South India. Indian J Pathol Microbiol. 2016; 59: 197–199. DOI: 10.4103/0377-4929.182010Antony B., Cherian E.V., Boloor R., Shenoy K.V. A sporadic outbreak of Burkholderia cepacia complex bacteremia in pediatric intensive care unit of a tertiary care hospital in coastal Karnataka. South India. Indian J Pathol Microbiol. 2016; 59: 197–199. DOI: 10.4103/0377-4929.182010Zaidi A.K., Huskins W.C., Thaver D., Bhutta Z.A., Abbas Z., Goldmann D.A. Hospital-acquired neonatal infections in developing countries. Lancet. 2005; 1; 365(9465):1175–1188. DOI: 10.1016/S0140-6736(05)71881-XZaidi A.K., Huskins W.C., Thaver D., Bhutta Z.A., Abbas Z., Goldmann D.A. Hospital-acquired neonatal infections in developing countries. Lancet. 2005; 1; 365(9465):1175–1188. DOI: 10.1016/S0140-6736(05)71881-XCarmona C.A., Marante A., Levent F., Marsicek S. Burkholderia cepacia Sepsis in a Previously Healthy Full-Term Infant. Case Rep Pediatr. 2020: 8852847. DOI: 10.1155/2020/8852847.Carmona C.A., Marante A., Levent F., Marsicek S. Burkholderia cepacia Sepsis in a Previously Healthy Full-Term Infant. Case Rep Pediatr. 2020: 8852847. DOI: 10.1155/2020/8852847.Shaban R.Z., Sotomayor-Castillo C., Nahidi S., Li C., Macbeth D., Mitchell B.G., Russo P.L. Global burden, point sources, and outbreak management of healthcare-associated Burkholderia cepacia infections: An integrative review. Infect Control Hosp Epidemiol. 2020; 41(7): 777–783. DOI: 10.1017/ice.2020.184Shaban R.Z., Sotomayor-Castillo C., Nahidi S., Li C., Macbeth D., Mitchell B.G., Russo P.L. Global burden, point sources, and outbreak management of healthcare-associated Burkholderia cepacia infections: An integrative review. Infect Control Hosp Epidemiol. 2020; 41(7): 777–783. DOI: 10.1017/ice.2020.184Patra S., Bhat Y.R., Lewis L.E., Purakayastha J., Sivaramaraju V.V., Kalwaje E.V., Mishra S. Burkholderia cepacia sepsis among neonates. Indian J Pediatr. 2014; 81(11): 1233–1236. DOI: 10.1007/s12098-014-1473-9Patra S., Bhat Y.R., Lewis L.E., Purakayastha J., Sivaramaraju V.V., Kalwaje E.V., Mishra S. Burkholderia cepacia sepsis among neonates. Indian J Pediatr. 2014; 81(11): 1233–1236. DOI: 10.1007/s12098-014-1473-9

The authors declare that there are no conflicts of interest present.