perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2026-71-1-16-22perinatology-2353Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSМетаболомные маркеры бронхиальной астмы у детей в условиях реализации атопического марша: обзор когортных исследованийMetabolomic markers of bronchial asthma in children under the conditions of the atopic march: a review of cohort studieshttps://orcid.org/0000-0002-1085-0733СоколоваТ. С.SokolovaT. S.

Соколова Татьяна Сергеевна - к.м.н., доцент кафедры факультетской педиатрии с курсом детских болезней лечебного факультета

634050, г. Томск, Московский тракт, дом 2

634050, Tomsk

sokolova.ts@ssmu.ruКуанышеваК. А.KuanyshevaK. A.

Куанышева Кристина Алексеевна - аспирант кафедры биохимии и молекулярной биологии с курсом клинической лабораторной диагностики

634050, г. Томск, Московский тракт, дом 2

634050, Tomsk

https://orcid.org/0009-0001-3040-2647ШевелевИ. Ю.ShevelevI. Yu.

Шевелев Иван Юрьевич - аспирант кафедры факультетской педиатрии с курсом детских болезней лечебного факультета

634050, г. Томск, Московский тракт, дом 2

634050, Tomsk

https://orcid.org/0009-0003-1920-2622СобакинД. С.SobakinD. S.

Собакин Данил Сергеевич - лаборант-исследователь лаборатории трансляционной медицины

634050, г. Томск, Московский тракт, дом 2

634050, Tomsk

https://orcid.org/0000-0002-7130-9609ФедороваО. С.FedorovaO. S.

Федорова Ольга Сергеевна – д.м.н., заведующий кафедрой факультетской педиатрии с курсом детских болезней лечебного факультета

634050, г. Томск, Московский тракт, дом 2

634050, Tomsk

ФГБОУ ВО «Сибирский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical UniversityRussian Federation2026200420267111622Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20262026Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2353

В настоящее время интерес в области метаболомики аллергических болезней, в том числе бронхиальной астмы, достаточно высок. Однако недостаточно данных, направленных на раскрытие патогенетических механизмов реализации атопического марша и развития бронхиальной астмы, в том числе подтвержденных на разных популяциях детей. Метаболомные исследования позволяют выявить ранние биохимические изменения, которые могут прогнозировать развитие бронхиальной астмы.

Цель

Цель: провести анализ результатов когортных исследований, направленных на изучение метаболомных маркеров, позволяющих прогнозировать риск развития бронхиальной астмы в условиях реализации атопического марша.

Материалы и методы

Материалы и методы: поиск публикаций в базах данных Medline, Научной электронной библиотеки и КиберЛенинка в период с января 2015 года по май 2025 года. Включены когортные исследования, в которых изучали связь метаболома различных биологических сред у детей с развитием бронхиальной астмы.

Результаты

Результаты: в настоящий обзор включены 6 публикаций. Обобщены данные об изменениях метаболических профилей, ассоциированных с развитием бронхиальной астмы у детей.

Заключение

Заключение: изменения в метаболизме липидов, аминокислот, желчных кислот и энергетическом обмене, выявляемые в пуповинной крови, плазме крови и моче новорождённых и детей раннего возраста, предшествуют клиническим проявлениям атопических заболеваний и могут служить основой для прогнозирования риска развития бронхиальной астмы в старшем возрасте.

Currently, interest in the field of metabolomics of allergic diseases, including bronchial asthma, is quite high. However, there is insufficient data aimed at uncovering the mechanisms of pathogenesis of the atopic march and the development of bronchial asthma, including those confirmed in different populations of children. Metabolomic studies can reveal early biochemical changes that can predict the development of bronchial asthma.

The aim of the study is to analyze the results of cohort studies aimed at studying metabolic markers that can predict the risk of developing bronchial asthma in the context of the atopic march.

Materials and methods

Materials and methods. Search for publications in Medline databases and Scientific Electronic Library. Publication dates: January 2015 - May 2025; cohort studies aimed at finding metabolomic markers that can predict the risk of developing bronchial asthma in the context of the implementation of the atopic march were included.

Results

Results. This review includes 6 publications. The data on changes in metabolic profiles associated with the development of bronchial asthma in children are summarized.

Conclusion

Conclusion: Changes in the metabolism of lipids, amino acids, bile acids, and energy metabolism detected in umbilical cord blood, blood plasma, and urine of newborns and young children precede the clinical manifestations of atopic diseases and can serve as a basis for predicting the risk of developing bronchial asthma.

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The authors declare that there are no conflicts of interest present.