perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2026-71-3-16-25perinatology-2418Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSВрожденная инфекция, обусловленная вирусом лимфоцитарного хориоменингита: малоизвестная проблема современной перинатальной медициныCongenital infection caused by lymphocytic choriomeningitis virus: little-known problem in modern perinatal medicinehttps://orcid.org/0000-0001-7305-9036СаркисянЕ. А.SarkisyanH. A.

Саркисян Егине Альбертовна к.м.н., доц. кафедры госпитальной педиатрии им. академика В.А. Таболина Института материнства и детства

117997, г. Москва, ул. Островитянова, д.1

117997, Moscow

heghinesarg@gmail.comhttps://orcid.org/0000-0003-0336-5761ВоронаЛ. Д.VoronaL. D.

Ворона Любовь Дмитриевна к.м.н., доц. кафедры госпитальной педиатрии им. академика В.А. Таболина Института материнства и детства; в.н.с. научного отдела

117997, г. Москва, ул. Островитянова, д.1

117997, Moscow

119620, Moscow

https://orcid.org/0009-0003-8625-7199МущероваД. М.MuscherovaD. M.

Мущерова Диана Максимовна ординатор 1 года кафедры госпитальной педиатрии им. академика В.А. Таболина

117997, г. Москва, ул. Островитянова, д.1

117997, Moscow

https://orcid.org/0009-0006-1151-2564ВавиловаА. И.VavilovaA. I.

Вавилова Александра Ильинична ординатор 1 года кафедры госпитальной педиатрии им. академика В.А. Таболина

117997, г. Москва, ул. Островитянова, д.1

117997, Moscow

https://orcid.org/0009-0005-9466-1081ЗизюкинаК. С.ZizyukinaK. S.

Зизюкина Карина Сергеевна студентка 6 курса Института материнства и детства

117997, г. Москва, ул. Островитянова, д.1

117997, Moscow

https://orcid.org/0000-0002-4653-9867КрапивкинА. И.KrapivkinA. I.

Крапивкин Алексей Игорьевич д.м.н., профессор, директор; профессор кафедры госпитальной педиатрии имени академика В.А. Таболина Института материнства и детства Российского национального исследовательского медицинского университета имени Н.И. Пирогова

119620, г. Москва, ул. Авиаторов, д. 38

119620, Moscow

https://orcid.org/0000-0002-9567-6761ШумиловП. В.ShumilovP. V.

Шумилов Петр Валентинович д.м.н., проф., заведующий кафедрой госпитальной педиатрии им. академика В.А. Таболина

117997, г. Москва, ул. Островитянова, д.1

117997, Moscow

peter_shumilov@mail.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияPirogov Russian National Research Medical UniversityRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; ГБУЗ «Научно-практический центр специализированной медицинской помощи детям имени В.Ф. Войно-Ясенецкого» ДЗМРоссияPirogov Russian National Research Medical University; V.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for ChildrenRussian FederationГБУЗ «Научно-практический центр специализированной медицинской помощи детям имени В.Ф. Войно-Ясенецкого» ДЗМРоссияV.F. Voyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for ChildrenRussian Federation2026210720267131625Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20262026Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/2418

Врожденные инфекции занимают значимое место в структуре перинатальной патологии. Особый интерес представляет вирус лимфоцитарного хориоменингита (Лимфоцитарный хориоменингит, МКБ-10: A87.2), обладающий выраженным нейротропным и тератогенным действием. Для врожденной инфекции, обусловленной вирусом лимфоцитарного хориоменингита, характерны микроцефалия, гидроцефалия, перивентрикулярные кальцификаты, а также поражения органа зрения и слуха. Диагностика основана на выявлении характерных структурных аномалий при проведении пренатального скринингового ультразвукового исследования и подтверждении вирусной этиологии заболевания. Специфические противовирусные препараты и вакцины против вируса лимфоцитарного хориоменингита в настоящее время отсутствуют, в связи с чем лечение носит поддерживающий характер. При этом около трети новорожденных погибают в раннем возрасте, а у выживших формируются стойкие неврологические и офтальмологические нарушения. Учитывая недооцененную распространенность описываемого вируса, настоящая работа посвящена систематизации современных данных о патогенезе, клинических особенностях, диагностике и прогнозе врожденной инфекции, вызванной вирусом лимфоцитарного хориоменингита.

Congenital infections play a significant role in perinatal pathology. Of particular interest is the lymphocytic choriomeningitis virus (Lymphocytic choriomeningitis, ICD-10: A87.2), which has pronounced neurotropic and teratogenic effects. Congenital infection caused by the lymphocytic choriomeningitis virus is characterized by microcephaly, hydrocephalus, periventricular calcifications, and visual and auditory lesions. Diagnosis is based on the identification of characteristic structural abnormalities during prenatal screening ultrasound and confirmation of the viral etiology of the disease. Specific antiviral drugs and vaccines against the lymphocytic choriomeningitis virus are currently unavailable, so treatment is supportive. Approximately one-third of newborns die in infancy, and survivors develop persistent neurological and ophthalmological disorders. Given the underestimated prevalence of this virus, this work aims to systematize current data on the pathogenesis, clinical features, diagnosis, and prognosis of congenital infection caused by the lymphocytic choriomeningitis virus.

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The authors declare that there are no conflicts of interest present.