perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”perinatology-255Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSЦелиакия и ассоциированные заболеванияCeliac disease and associated diseasesЗахароваИ. Н.ZakharovaI. N.

д.м.н., проф., завкаф. педиатрии Российской медицинской академии последипломного образования

ДмитриеваЮ. А.DmitrievaYu. A.

к.м.н., доц. той же каф. 123480 Москва, ул. Баррикадная, 2/1

ДзебисоваФ. С.DzebisovaF. S.

к.м.н., асе. каф. Детских болезней № 1 Севе ро-Осетинской государственной медицинской академии 362019 Владикавказ, ул. Декабристов, д. 7

Российская медицинская академия последипломного образования, МоскваРоссияRussian Medical Academy of Postgraduate Education, MoscowRussian FederationСеверо-Осетинская государственная академия, ВладикавказРоссияNorth-Ossetian state Academy, VladikavkazRussian Federation2014160320165934449Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20162016Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/255

В соответствии с современным определением, предложенным Европейским обществом детских гастроэнтерологов, гепато-логов и нутрициологов (ESPGHAN, 2012), целиакию рассматривают как иммуноопосредованное системное заболевание, вызываемое глютеном и соответствующими проламинами у генетически предрасположенных лиц. Детальное изучение патогенеза глютеновой энтеропатии создало основу для исследования возможных причин частого сочетания целиакии с рядом аутоиммунных и эндокринологических заболеваний. В качестве возможных причин ассоциации рассматриваются наличие у пациентов общих генетических маркеров, перекрестная реакция образующихся при целиакии аутоантител и активированных Т-лимфоцитов с собственными антигенами организма, системное воздействие провоспалительных цитокинов. Несмотря на то что многие вопросы патофизиологии остаются предметом дискуссии, в настоящее время не вызывает сомнения, что пациенты, страдающие рядом заболеваний, формируют группу риска по развитию целиакии и нуждаются в тщательном наблюдении и обследовании для своевременной постановки диагноза и назначения безглютеновой диеты.

In accordance with the current definition proposed by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) in 2012, celiac disease is regarded as an immune-mediated systemic disease caused by gluten and respective prola-mins in genetically predisposed people. Detailed studies of the pathogenesis of gluten enteropathy provided the basis for investigating the possible causes of the common concurrence of celiac disease with a number of autoimmune and endocrine diseases. The possible reasons for the association are considered to be common genetic markers in the patients, a cross reaction of the autoantibodies formed in celiac disease and activated T lymphocytes with the body's intrinsic antigens, as well as the systemic action of proinflam-matory cytokines. Although many issues of pathophysiology remain a matter of debate, the fact that patients suffering from a number of diseases form a group at risk for celiac disease and require a careful follow-up and examination for timely diagnosis and use of gluten-free diet is currently beyond question.

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The authors declare that there are no conflicts of interest present.