perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2016-61-5-14-18perinatology-373Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSСостояние сердечно-сосудистой системы у детей, зачатых при помощи вспомогательных репродуктивных технологийThe cardiovascular system in children conceived by assisted reproductive technologiesБашмаковаН. В.BashmakovaN. V.

д.м.н., проф., засл. врач РФ, директор

ЦывьянП. Б.TsyvianP. B.

отделение биофизических и лучевых методов исследования института

кафедра нормальной физиологии

д.м.н., проф., вед. н. сотр.

зав. кафедрой

620028 Екатеринбург, ул. Репина, д. 1 

pavel.tsyvian@gmail.comЧистяковаГ. Н.ChistyakovaG. N.

отдел иммунологии и клинической микробиологии 

д.м.н., проф., рук. научного отдела 

ДаньковаИ. В.DankovaI. V.

к.м.н., ст. н. сотрудник

ТрапезниковаЮ. М.TrapeznikovaYu. M.

к.м.н., н. сотрудник

БычковаС. В.BychkovaS. V.

к.м.н., ст. н. сотрудник 

РемизоваИ. И.RemizovaI. I.

биохимическая лаборатория

к.м.н., ст. н. сотр. 

ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФРоссияUral Research Institute of Maternal and Infant Care, Ministry of Health of the Russian FederationRussian FederationФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РФ; Уральский государственный медицинский университет Минздрава РФ, ЕкатеринбургРоссияUral Research Institute of Maternal and Infant Care, Ministry of Health of the Russian Federation; Ural State Medical University, Ministry of Health of the Russian Federation, YekaterinburgRussian Federation2016191120166151418Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20162016Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/373

Представлены данные о влиянии особенностей проведения вспомогательных репродуктивных технологий на состояние сердечно-сосудистой системы и метаболизма у детей и взрослых, зачатых с применением указанных технологий. Предполагается, что эпигенетические воздействия могут быть основным механизмом программирования сердечно-сосудистой и метаболической патологии в последующей жизни у таких детей. 

The paper gives data on the impact of assisted reproductive technologies (ART) on the cardiovascular system and metabolism in children and adults conceived by the above technologies. It issuggested that epigenetic exposures may be a main mechanism for programming cardiovascular and metabolic abnormalities in the later life of these children. 

детивспомогательные репродуктивные технологииэкстракорпоральное оплодотворениевнутриутробное программированиесердечно-сосудистая и метаболическая патологияэндотелиальная дисфункцияchildrenassisted reproductive technologiesin vitro fertilizationintrauterine programmingcardiovascular and metabolic abnormalitiesendothelial dysfunctionReferencesBarker D.J. The fetal and infant origins of disease. Eur J Clin Invest 1995; 25: 7: 457–463.Barker D.J. The fetal and infant origins of disease. Eur J Clin Invest 1995; 25: 7: 457–463.Barker D.J. Fetal origins of cardiovascular disease. Ann Med 1999; 31: Suppl 1: 3–6.Barker D.J. Fetal origins of cardiovascular disease. Ann Med 1999; 31: Suppl 1: 3–6.Barker D.J., Osmond C., Golding J. et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 1989; 298: 6673: 564–567.Barker D.J., Osmond C., Golding J. et al. 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The authors declare that there are no conflicts of interest present.