perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”perinatology-39Research ArticleАЛЛЕРГОЛОГИЯALLERGOLOGYДобровольное согласие родителей на участие в научном исследовании: смещение выборки относительно популяции?Parents’ voluntary consent to participate in research: biased sampling in relation to the population?ТреневаМ. С.ТrenevaM. S.

к.м.н., в.н.с. отделения аллергологии и клинической иммунологии

МунблитД. Б.МunblitD. B.

MD, MSc, асп. (research postgraduate) отделения педиатрии

ПампураА. Н.PampuraA. N.

д.м.н., зав. отделения аллергологии и клинической иммунологии

Научно-исследовательский клинический институт педиатрии, МоскваРоссияResearch Clinical Institute of Pediatric, MoscowRussian FederationИмперский колледж Лондона, ВеликобританияВеликобританияImperial College London, United KingdomUnited Kingdom2014030320165918287Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20162016Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/39

Московский НИИ педиатрии и детской хирургии участвует в международном исследовании “MecMilk Study”. Необходимо выявить и оценить возможные различия между согласившимися на участие в “MecMilk Study” и отказавшимися от участия в нём. В 2011 г. в Москве была набрана когорта из 393 детей, матери 200 из них согласились на участие в «MecMilk Study». Собраны сведения о проявлении аллергии у родственников этих новорожденных. Через 1 год по критериям «The UK Atopic Dermatitis Diagnostic Criteria Working Party» опрошены 363 (92,4%) матери. Частота проявлений аллергии среди родственников была в 2 раза выше в группе согласившихся на участие в “MecMilk Study”. В годовалом возрасте проявления атопического дерматита зафиксированы у 8 из 200 детей в группе согласившихся, в то время как у 193 детей из группы отказавшихся не установлено ни одного случая заболевания (р=0,0074). Таким образом, согласившиеся на участие в «MecMilk Study» отличались от отказавшихся по частоте проявлений аллергии среди детей и их родственников. При планировании исследования и интерпретации результатов необходимо учитывать вероятность смещения выборки по отношению к популяции. В противном случае сопоставлять полученные результаты будет не только сложно, но и некорректно. 

The Moscow Research Institute of Pediatrics and Pediatric Surgery is taking part in the international MecMilk study. Its purpose is to reveal and estimate possible differences between those who have consented to participate in the MecMilk study and those who have refused. A Moscow cohort of 393 infants, the mothers of 200 babies of them agreed to take part in the MecMilk study, was recruited in 2011. Familial allergy history data in these neonatal infants were collected. A year later, 363 (92,4%) mothers were interviewed using the United Kingdom Working Party criteria for atopic dermatitis. The incidence of allergic manifestations was two-fold higher in the families who had agreed to participate in the MecMilk study. The manifestations of atopical dermatitis were recorded in 8 of the 200 babies aged one year whose mothers had consented to participate in the study while 193 infants whose mothers had refused presented with no symptoms of atopic dermatitis (р=0,0074). Thus, those who had agreed to participate in the MecMilk study differed from those who had refused in the incidence of allergic manifestations among the babies and their relatives. The probability of biased sampling in relation to the population should be taken in consideration when planning a study and interpreting its results. Otherwise it will be not difficult, but also incorrect to compare obtained results. 

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The authors declare that there are no conflicts of interest present.