<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">perinatology</journal-id><journal-title-group><journal-title xml:lang="ru">Российский вестник перинатологии и педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-4065</issn><issn pub-type="epub">2500-2228</issn><publisher><publisher-name>Ltd. “The National Academy of Pediatric Science and Innovation”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21508/1027-4065-2016-61-5-127-131</article-id><article-id custom-type="elpub" pub-id-type="custom">perinatology-394</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>XIII РОССИЙСКАЯ КОНФЕРЕНЦИЯ «ПЕДИАТРИЯ И ДЕТСКАЯ ХИРУРГИЯ В ПРИВОЛЖСКОМ ФЕДЕРАЛЬНОМ ОКРУГЕ»</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>13TH RUSSIAN CONFERENCE ON PEDIATRICS AND PEDIATRIC SURGERY IN THE VOLGA FEDERAL DISTRICT</subject></subj-group></article-categories><title-group><article-title>Инфекции, вызванные вирусами герпеса 6-го типа: современные особенности</article-title><trans-title-group xml:lang="en"><trans-title>Infections caused by herpes virus type 6: modern features</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анохин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Anokhin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра детских инфекций</p><p>д.м.н., проф., зав. кафедрой </p><p>главный детский инфекционист Минздрава Республики Татарстан </p><p>420012 Казань, ул. Бутлерова, д. 49</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сабитова</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sabitova</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра детских инфекций</p><p>к.м.н., доцент </p><p>420012 Казань, ул. Бутлерова, д. 49</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Казанский государственный медицинский университет им. С.В. Курашова» Минздрава РФ, Казань</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University, Kazan</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2016</year></pub-date><volume>61</volume><issue>5</issue><fpage>127</fpage><lpage>131</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ltd. “The National Academy of Pediatric Science and Innovation”, 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><copyright-holder xml:lang="en">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><license xlink:href="https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.ped-perinatology.ru/jour/article/view/394">https://www.ped-perinatology.ru/jour/article/view/394</self-uri><abstract><p>Представлен обзор современных сведений об этиологии, эпидемиологии, клинических проявлениях инфекции, вызванной вирусами герпеса 6-го типа у детей и взрослых, рассмотрены вопросы диагностики с использованием лабораторных методов исследования и принципы лечения данной патологии. </p></abstract><trans-abstract xml:lang="en"><p>The article presents modern data on etiology, epidemiology, clinical manifestations of infection caused by the herpes simplex viruses type 6. The problems ofthe use oflaboratory methods of research and treatment ofinfections. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>инфекция</kwd><kwd>вирусы герпеса 6-го типа</kwd><kwd>этиология</kwd><kwd>эпидемиология</kwd><kwd>клиническая картина</kwd><kwd>принципы диагностики</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>infection</kwd><kwd>herpes virus type 6</kwd><kwd>etiology</kwd><kwd>epidemiology</kwd><kwd>clinical picture</kwd><kwd>diagnosis</kwd><kwd>principles of treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Salahuddin S.Z., Ablashi D.V., Markham P.D. et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986; 234: 596.</mixed-citation><mixed-citation xml:lang="en">Salahuddin S.Z., Ablashi D.V., Markham P.D. et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986; 234: 596.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ablashi D.V., Salahuddin S.Z., Josephs S.F. et al. HBLV (or HHV-6) in human cell lines. Nature 1987; 329: 207.</mixed-citation><mixed-citation xml:lang="en">Ablashi D.V., Salahuddin S.Z., Josephs S.F. et al. HBLV (or HHV-6) in human cell lines. Nature 1987; 329: 207.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Yamanishi K., Okuno T., Shiraki K. et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988; 1: 1065.</mixed-citation><mixed-citation xml:lang="en">Yamanishi K., Okuno T., Shiraki K. et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988; 1: 1065.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">International Committee on Taxonomy of Viruses. ICTV Master Species List 2011. http://talk.ictvonline.org/files/ ictv_documents/m/msl/4090.aspx (Accessed on June 27, 2012).</mixed-citation><mixed-citation xml:lang="en">International Committee on Taxonomy of Viruses. ICTV Master Species List 2011. http://talk.ictvonline.org/files/ ictv_documents/m/msl/4090.aspx (Accessed on June 27, 2012).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hall C.B., Long C.E., Schnabel K.C. et al. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 1994; 331: 432.</mixed-citation><mixed-citation xml:lang="en">Hall C.B., Long C.E., Schnabel K.C. et al. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 1994; 331: 432.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Tremblay C. Virology, pathogenesis, and epidemiology of human herpesvirus 6 infection. 2016; 24.168: http://www.uptodate.com</mixed-citation><mixed-citation xml:lang="en">Tremblay C. Virology, pathogenesis, and epidemiology of human herpesvirus 6 infection. 2016; 24.168: http://www.uptodate.com</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kondo K., Kondo T., Shimada K. et al. Strong interaction between human herpesvirus 6 and peripheral blood monocytes/macrophages during acute infection. J Med Virol 2002; 67: 364.</mixed-citation><mixed-citation xml:lang="en">Kondo K., Kondo T., Shimada K. et al. Strong interaction between human herpesvirus 6 and peripheral blood monocytes/macrophages during acute infection. J Med Virol 2002; 67: 364.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Di Luca D., Mirandola P., Ravaioli T. et al. Human herpesviruses 6 and 7 in salivary glands and shedding in saliva of healthy and human immunodeficiency virus positive individuals. J Med Virol 1995; 45: 462.</mixed-citation><mixed-citation xml:lang="en">Di Luca D., Mirandola P., Ravaioli T. et al. Human herpesviruses 6 and 7 in salivary glands and shedding in saliva of healthy and human immunodeficiency virus positive individuals. J Med Virol 1995; 45: 462.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dockrell D.H., Paya C.V. Human herpesvirus-6 and -7 in transplantation. Rev Med Virol 2001; 11: 1: 23.</mixed-citation><mixed-citation xml:lang="en">Dockrell D.H., Paya C.V. Human herpesvirus-6 and -7 in transplantation. Rev Med Virol 2001; 11: 1: 23.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Tremblay C. Clinical manifestations, diagnosis, and treatment of human herpesvirus 6 infection in adults, 2016; 24.159: http://www.uptodate.com 11. Ogata M., Satou T., Kadota J. et al. Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study. Clin Infect Dis 2013; 57: 671.</mixed-citation><mixed-citation xml:lang="en">Tremblay C. Clinical manifestations, diagnosis, and treatment of human herpesvirus 6 infection in adults, 2016; 24.159: http://www.uptodate.com 11. Ogata M., Satou T., Kadota J. et al. Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study. Clin Infect Dis 2013; 57: 671.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Aihara Y., Ito S.I., Kobayashi Y. et al. Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction. Br J Dermatol 2003; 149: 165.</mixed-citation><mixed-citation xml:lang="en">Aihara Y., Ito S.I., Kobayashi Y. et al. Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction. Br J Dermatol 2003; 149: 165.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Oskay T., Karademir A., Ertürk O.I. Association of anticon￾vulsant hypersensitivity syndrome with Herpesvirus 6, 7. Epilepsy Res 2006; 70: 27.</mixed-citation><mixed-citation xml:lang="en">Oskay T., Karademir A., Ertürk O.I. Association of anticon￾vulsant hypersensitivity syndrome with Herpesvirus 6, 7. Epilepsy Res 2006; 70: 27.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Tamagawa-Mineoka R., Katoh N., Nara T. et al. DRESS syndrome caused by teicoplanin and vancomycin, associated with reactivation of human herpesvirus-6. Int J Dermatol 2007; 46: 654.</mixed-citation><mixed-citation xml:lang="en">Tamagawa-Mineoka R., Katoh N., Nara T. et al. DRESS syndrome caused by teicoplanin and vancomycin, associated with reactivation of human herpesvirus-6. Int J Dermatol 2007; 46: 654.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Morimoto T., Sato T., Matsuoka A. et al. Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6. Intern Med 2006; 45: 101.</mixed-citation><mixed-citation xml:lang="en">Morimoto T., Sato T., Matsuoka A. et al. Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6. Intern Med 2006; 45: 101.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tremblay C., Brady M. Human herpesvirus 6 infection in children: Clinical manifestations; diagnosis; and treatment. 2016; 24.168: http://www.uptodate.com</mixed-citation><mixed-citation xml:lang="en">Tremblay C., Brady M. Human herpesvirus 6 infection in children: Clinical manifestations; diagnosis; and treatment. 2016; 24.168: http://www.uptodate.com</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rotola A., Merlotti I., Caniatti L. et al. Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease. Mult Scler 2004; 10: 348.</mixed-citation><mixed-citation xml:lang="en">Rotola A., Merlotti I., Caniatti L. et al. Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease. Mult Scler 2004; 10: 348.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Luppi M., Marasca R., Barozzi P. et al. Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J Med Virol 1993; 40: 1: 44.</mixed-citation><mixed-citation xml:lang="en">Luppi M., Marasca R., Barozzi P. et al. Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J Med Virol 1993; 40: 1: 44.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Morissette G., Flamand L. Herpesviruses and chromosomal integration. J Virol 2010; 84: 23: 12100.</mixed-citation><mixed-citation xml:lang="en">Morissette G., Flamand L. Herpesviruses and chromosomal integration. J Virol 2010; 84: 23: 12100.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Никольский М.А., Голубцова В.С. Хромосомно-интегрированный вирус герпеса человека 6-го типа. Инфекция и иммунитет 2015; 5: 1: 7. (Nikolsky M.A., Golubtsova V.S. Chromosomally-integrated human herpes virus type 6. Infektsiya i immunitet 2015; 5: 1: 7. (in Russ))</mixed-citation><mixed-citation xml:lang="en">Никольский М.А., Голубцова В.С. Хромосомно-интегрированный вирус герпеса человека 6-го типа. Инфекция и иммунитет 2015; 5: 1: 7. (Nikolsky M.A., Golubtsova V.S. Chromosomally-integrated human herpes virus type 6. Infektsiya i immunitet 2015; 5: 1: 7. (in Russ))</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Jeulin H., Salmon A., Gautheret-Dejean A. et al. Contribution of human herpesvirus 6 (HHV-6) viral load in whole blood and serum to investigate integrated HHV-6 transmission after haematopoietic stem cell transplantation. J Clin Virol 2009; 45: 43.</mixed-citation><mixed-citation xml:lang="en">Jeulin H., Salmon A., Gautheret-Dejean A. et al. Contribution of human herpesvirus 6 (HHV-6) viral load in whole blood and serum to investigate integrated HHV-6 transmission after haematopoietic stem cell transplantation. J Clin Virol 2009; 45: 43.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ward K.N., Leong H.N., Nacheva E.P. et al. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J Clin Microbiol 2006; 44: 4: 1571.</mixed-citation><mixed-citation xml:lang="en">Ward K.N., Leong H.N., Nacheva E.P. et al. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J Clin Microbiol 2006; 44: 4: 1571.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Caserta M.T., Hall C.B., Canfield R.L. et al. Early developmental outcomes of children with congenital HHV-6 infection. Pediatrics 2014; 134: 1111.</mixed-citation><mixed-citation xml:lang="en">Caserta M.T., Hall C.B., Canfield R.L. et al. Early developmental outcomes of children with congenital HHV-6 infection. Pediatrics 2014; 134: 1111.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ashshi A.M., Cooper R.J., Klapper P.E. et al. Detection of human herpes virus 6 DNA in fetal hydrops. Lancet 2000; 355: 1519.</mixed-citation><mixed-citation xml:lang="en">Ashshi A.M., Cooper R.J., Klapper P.E. et al. Detection of human herpes virus 6 DNA in fetal hydrops. Lancet 2000; 355: 1519.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Asano Y., Yoshikawa T., Suga S. et al. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet 1990; 335: 862.</mixed-citation><mixed-citation xml:lang="en">Asano Y., Yoshikawa T., Suga S. et al. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet 1990; 335: 862.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Muramatsu H., Watanabe N., Matsumoto K. et al. Primary infection of human herpesvirus-6 in an infant who received cord blood SCT. Bone Marrow Transplant 2009; 43: 83.</mixed-citation><mixed-citation xml:lang="en">Muramatsu H., Watanabe N., Matsumoto K. et al. Primary infection of human herpesvirus-6 in an infant who received cord blood SCT. Bone Marrow Transplant 2009; 43: 83.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hall C.B., Caserta M.T., Schnabel K.C. et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr 2004; 145: 472.</mixed-citation><mixed-citation xml:lang="en">Hall C.B., Caserta M.T., Schnabel K.C. et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr 2004; 145: 472.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Кускова Т.К., Белова Е.Г. Семейство герпесвирусов на современном этапе. Лечащий врач 2004; 5: 611. (Kuskova T.K., Belova E.G. The family of herpes viruses at the present stage. Lechashhij vrach 2004; 5: 611. (in Russ))</mixed-citation><mixed-citation xml:lang="en">Кускова Т.К., Белова Е.Г. Семейство герпесвирусов на современном этапе. Лечащий врач 2004; 5: 611. (Kuskova T.K., Belova E.G. The family of herpes viruses at the present stage. Lechashhij vrach 2004; 5: 611. (in Russ))</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Freitas R.B., Monteiro T.A., Linhares A.C. Outbreaks of humanherpes virus 6 (HHV-6) infection in day-care centers in Belém, Pará, Brazil. Rev Inst Med Trop Sao Paulo 2000; 42: 305.</mixed-citation><mixed-citation xml:lang="en">Freitas R.B., Monteiro T.A., Linhares A.C. Outbreaks of humanherpes virus 6 (HHV-6) infection in day-care centers in Belém, Pará, Brazil. Rev Inst Med Trop Sao Paulo 2000; 42: 305.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zerr D.M., Meier A.S., Selke S.S. et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med 2005; 352: 768.</mixed-citation><mixed-citation xml:lang="en">Zerr D.M., Meier A.S., Selke S.S. et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med 2005; 352: 768.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">American Academy of Pediatrics. Human herpesvirus 6 (including roseola) and 7. In: Red Book: 2015 Report of the Committee on Infectious Diseases. D.W. Kimberlin, M.T. Brady, M.A. Jackson, S.S. Long (Eds). American Academy of Pediatrics, Elk Grove Village, IL, 2015; 449.</mixed-citation><mixed-citation xml:lang="en">American Academy of Pediatrics. Human herpesvirus 6 (including roseola) and 7. In: Red Book: 2015 Report of the Committee on Infectious Diseases. D.W. Kimberlin, M.T. Brady, M.A. Jackson, S.S. Long (Eds). American Academy of Pediatrics, Elk Grove Village, IL, 2015; 449.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Tremblay C., Brady M. Roseola infantum (exanthem subi￾tum). 2016; 24.168 (http://www.uptodate.com).</mixed-citation><mixed-citation xml:lang="en">Tremblay C., Brady M. Roseola infantum (exanthem subi￾tum). 2016; 24.168 (http://www.uptodate.com).</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Vianna R.A., de Oliveira S.A., Camacho L.A. et al. Role of human herpesvirus 6 infection in young Brazilian children with rash illnesses. Pediatr Infect Dis J 2008; 27: 533.</mixed-citation><mixed-citation xml:lang="en">Vianna R.A., de Oliveira S.A., Camacho L.A. et al. Role of human herpesvirus 6 infection in young Brazilian children with rash illnesses. Pediatr Infect Dis J 2008; 27: 533.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Laina I., Syriopoulou V.P., Daikos G.L. et al. Febrile seizures and primary human herpesvirus 6 infection. Pediatr Neurol 2010; 42: 28.</mixed-citation><mixed-citation xml:lang="en">Laina I., Syriopoulou V.P., Daikos G.L. et al. Febrile seizures and primary human herpesvirus 6 infection. Pediatr Neurol 2010; 42: 28.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Никольский М.А., Радыш М.В. Роль вирусов герпеса человека 6-го и 7-го типов в возникновении фебрильных судорог у детей. Вопросы диагностики в педиатрии 2012; 4: 4: 46. (Nikolsky M.A., Radysh M.V. The role of human herpes virus 6 and the seventh type occurs in febrile convulsions in children. Voprosy diagnostiki v pediatrii 2012; 4: 4: 46. (in Russ))</mixed-citation><mixed-citation xml:lang="en">Никольский М.А., Радыш М.В. Роль вирусов герпеса человека 6-го и 7-го типов в возникновении фебрильных судорог у детей. Вопросы диагностики в педиатрии 2012; 4: 4: 46. (Nikolsky M.A., Radysh M.V. The role of human herpes virus 6 and the seventh type occurs in febrile convulsions in children. Voprosy diagnostiki v pediatrii 2012; 4: 4: 46. (in Russ))</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C.T., Lin L.H. Differentiating roseola infantum with pyuria from urinary tract infection. Pediatr Int 2013; 55: 214.</mixed-citation><mixed-citation xml:lang="en">Huang C.T., Lin L.H. Differentiating roseola infantum with pyuria from urinary tract infection. Pediatr Int 2013; 55: 214.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Rohayem J., Dinger J., Fischer R. et al. Fatal myocarditis associated with acute parvovirus B19 and human herpesvirus 6 coinfection. J Clin Microbiol 2001; 39: 4585.</mixed-citation><mixed-citation xml:lang="en">Rohayem J., Dinger J., Fischer R. et al. Fatal myocarditis associated with acute parvovirus B19 and human herpesvirus 6 coinfection. J Clin Microbiol 2001; 39: 4585.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Mannonen L., Herrgård E., Valmari P. et al. Primary human herpesvirus-6 infection in the central nervous system can cause severe disease. Pediatr Neurol 2007; 37: 186.</mixed-citation><mixed-citation xml:lang="en">Mannonen L., Herrgård E., Valmari P. et al. Primary human herpesvirus-6 infection in the central nervous system can cause severe disease. Pediatr Neurol 2007; 37: 186.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Crawford J.R., Kadom N., Santi M.R. et al. Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol 2007; 22: 1260.</mixed-citation><mixed-citation xml:lang="en">Crawford J.R., Kadom N., Santi M.R. et al. Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol 2007; 22: 1260.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ohsaka M., Houkin K., Takigami M., Koyanagi I. Acute necrotizing encephalopathy associated with human herpesvirus-6 infection. Pediatr Neurol 2006; 34: 160.</mixed-citation><mixed-citation xml:lang="en">Ohsaka M., Houkin K., Takigami M., Koyanagi I. Acute necrotizing encephalopathy associated with human herpesvirus-6 infection. Pediatr Neurol 2006; 34: 160.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Fotheringham J., Donati D., Akhyani N. et al. Association of human herpesvirus-6B with mesial temporal lobe epilepsy. PLoS Med 2007; 4: e180.</mixed-citation><mixed-citation xml:lang="en">Fotheringham J., Donati D., Akhyani N. et al. Association of human herpesvirus-6B with mesial temporal lobe epilepsy. PLoS Med 2007; 4: e180.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kawabe S., Ito Y., Ohta R. et al. Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy. J Med Virol 2010; 82: 1410.</mixed-citation><mixed-citation xml:lang="en">Kawabe S., Ito Y., Ohta R. et al. Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy. J Med Virol 2010; 82: 1410.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hammerling J.A., Lambrecht R.S., Kehl K.S., Carrigan D.R. Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis. J Clin Pathol 1996; 49: 802.</mixed-citation><mixed-citation xml:lang="en">Hammerling J.A., Lambrecht R.S., Kehl K.S., Carrigan D.R. Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis. J Clin Pathol 1996; 49: 802.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Kanegane C., Katayama K., Kyoutani S. et al. Mononucleosislike illness in an infant associated with human herpesvirus 6 infection. Acta Paediatr Jpn 1995; 37: 227.</mixed-citation><mixed-citation xml:lang="en">Kanegane C., Katayama K., Kyoutani S. et al. Mononucleosislike illness in an infant associated with human herpesvirus 6 infection. Acta Paediatr Jpn 1995; 37: 227.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Fretzayas A., Douros K., Moustaki M., Nicolaidou P. Papularpurpuric gloves and socks syndrome in children and adoles￾cents. Pediatr Infect Dis J 2009; 28: 250.</mixed-citation><mixed-citation xml:lang="en">Fretzayas A., Douros K., Moustaki M., Nicolaidou P. Papularpurpuric gloves and socks syndrome in children and adoles￾cents. Pediatr Infect Dis J 2009; 28: 250.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Chuh A.A., Chan H.H., Chiu S.S. et al. A prospective case control study of the association of Gianotti-Crosti syndrome with human herpesvirus 6 and human herpesvirus 7 infections. Pediatr Dermatol 2002; 19: 492.</mixed-citation><mixed-citation xml:lang="en">Chuh A.A., Chan H.H., Chiu S.S. et al. A prospective case control study of the association of Gianotti-Crosti syndrome with human herpesvirus 6 and human herpesvirus 7 infections. Pediatr Dermatol 2002; 19: 492.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Boccara O., Lesage F., Regnault V. et al. Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication. Br J Dermatol 2009; 161: 181.</mixed-citation><mixed-citation xml:lang="en">Boccara O., Lesage F., Regnault V. et al. Nonbacterial purpura fulminans and severe autoimmune acquired protein S deficiency associated with human herpesvirus-6 active replication. Br J Dermatol 2009; 161: 181.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Miyake F., Yoshikawa T., Suzuki K. et al. Guillain-Barré syndrome after exanthem subitum. Pediatr Infect Dis J 2002; 21: 569.</mixed-citation><mixed-citation xml:lang="en">Miyake F., Yoshikawa T., Suzuki K. et al. Guillain-Barré syndrome after exanthem subitum. Pediatr Infect Dis J 2002; 21: 569.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Pitkäranta A., Lahdenne P., Piiparinen H. Facial nerve palsy after human herpesvirus 6 infection. Pediatr Infect Dis J 2004; 23: 688.</mixed-citation><mixed-citation xml:lang="en">Pitkäranta A., Lahdenne P., Piiparinen H. Facial nerve palsy after human herpesvirus 6 infection. Pediatr Infect Dis J 2004; 23: 688.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Nishimura N., Yoshikawa T., Ozaki T. et al. In vitro and in vivo analysis of human herpesvirus-6 U90 protein expression. J Med Virol 2005; 75: 86.</mixed-citation><mixed-citation xml:lang="en">Nishimura N., Yoshikawa T., Ozaki T. et al. In vitro and in vivo analysis of human herpesvirus-6 U90 protein expression. J Med Virol 2005; 75: 86.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Никольский М.А., Мессорош В.Г., Минченко С.И. Сероконверсия и нарастание концентрации IgG-антител при инфекции, вызванной вирусом герпеса 6-го типа у детей. Эпидемиология и инфекционные болезни 2008; 4: 22. (Nikolsky M.A., Messorosh V.G., Minchenko S.I. Seroconversion and increase in the concentration of IgG antibodies against infections caused by the herpes virus type 6 children. EHpidemiologiya i infektsionnye bolezni 2008; 4: 22. (in Russ))</mixed-citation><mixed-citation xml:lang="en">Никольский М.А., Мессорош В.Г., Минченко С.И. Сероконверсия и нарастание концентрации IgG-антител при инфекции, вызванной вирусом герпеса 6-го типа у детей. Эпидемиология и инфекционные болезни 2008; 4: 22. (Nikolsky M.A., Messorosh V.G., Minchenko S.I. Seroconversion and increase in the concentration of IgG antibodies against infections caused by the herpes virus type 6 children. EHpidemiologiya i infektsionnye bolezni 2008; 4: 22. (in Russ))</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Fujiwara N., Namba H., Ohuchi R. et al. Monitoring of human herpesvirus-6 and -7 genomes in saliva samples of healthy adults by competitive quantitative PCR. J Med Virol 2000; 61: 208.</mixed-citation><mixed-citation xml:lang="en">Fujiwara N., Namba H., Ohuchi R. et al. Monitoring of human herpesvirus-6 and -7 genomes in saliva samples of healthy adults by competitive quantitative PCR. J Med Virol 2000; 61: 208.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Caserta M.T., McDermott M. P., Dewhurst S. et al. Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. J Pediatr 2004; 145: 478.</mixed-citation><mixed-citation xml:lang="en">Caserta M.T., McDermott M. P., Dewhurst S. et al. Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. J Pediatr 2004; 145: 478.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Flamand L., Gravel A., Boutolleau D. et al. Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum. J Clin Microbiol 2008; 46: 2700.</mixed-citation><mixed-citation xml:lang="en">Flamand L., Gravel A., Boutolleau D. et al. Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum. J Clin Microbiol 2008; 46: 2700.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy S., Manna P. Quantitative detection and differentiation of human herpesvirus 6 subtypes in bone marrow transplant patients by using a single real-time polymerase chain reaction assay. Biol Blood Marrow Transplant 2005; 11: 530.</mixed-citation><mixed-citation xml:lang="en">Reddy S., Manna P. Quantitative detection and differentiation of human herpesvirus 6 subtypes in bone marrow transplant patients by using a single real-time polymerase chain reaction assay. Biol Blood Marrow Transplant 2005; 11: 530.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Zerr D.M., Boeckh M., Delaney C. et al. HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation. Biol Blood Marrow Transplant 2012; 18: 1700.</mixed-citation><mixed-citation xml:lang="en">Zerr D.M., Boeckh M., Delaney C. et al. HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation. Biol Blood Marrow Transplant 2012; 18: 1700.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Caserta M.T., Hall C.B., Schnabel K. et al. Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). J Clin Virol 2010; 48: 55.</mixed-citation><mixed-citation xml:lang="en">Caserta M.T., Hall C.B., Schnabel K. et al. Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). J Clin Virol 2010; 48: 55.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">De Bolle L., Naesens L., De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 2005; 18: 217.</mixed-citation><mixed-citation xml:lang="en">De Bolle L., Naesens L., De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 2005; 18: 217.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Zerr D.M., Gupta D., Huang M.L. et al. Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clin Infect Dis 2002; 34: 309.</mixed-citation><mixed-citation xml:lang="en">Zerr D.M., Gupta D., Huang M.L. et al. Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clin Infect Dis 2002; 34: 309.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Denes E., Magy L., Pradeau K. et al. Successful treatment of human herpesvirus 6 encephalomyelitis in immunocompetent patient. Emerg Infect Dis 2004; 10: 729.</mixed-citation><mixed-citation xml:lang="en">Denes E., Magy L., Pradeau K. et al. Successful treatment of human herpesvirus 6 encephalomyelitis in immunocompetent patient. Emerg Infect Dis 2004; 10: 729.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
