References

perinatology

Российский вестник перинатологии и педиатрии

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)

1027-40652500-2228

Ltd. “The National Academy of Pediatric Science and Innovation”

10.21508/1027-4065-2017-62-1-33-39

perinatology-449

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEWS

Перинатальное программирование и старение кардиомиоцитов

Perinatal programming and cardiomyocyte aging

Ковтун

О. П.

Kovtun

O. P.

д.м.н., проф., член корр. РАН, первый проректор Уральского государственного медицинского университета 620028 Екатеринбург, ул. Репина, д.3

Цывьян

П. Б.

Tsyvian

P. B.

д.м.н., проф., зав.кафедрой нормальной физиологии Уральского государственного медицинского университета, вед.н.с. Уральского НИИ охраны материнства и младенчества 620028 Екатеринбург, ул. Репина, д.1

Соловьева

О. Э.

Solovyeva

O. E.

д.ф-м.н., проф., зав. лабораторией математической физиологии Института иммунологии и физиологии 620137 Екатеринбург, ул. Первомайская, д. 30

ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава РоссииРоссияUral State Medical University, Ministry of Health of RussiaRussian Federation

ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России ФГБУ «Уральский НИИ охраны материнства и младенчества» Минздрава РоссииРоссияUral State Medical University, Ministry of Health of Russia Ural Research Institute of Maternity and Infancy Care, Ministry of Health of RussiaRussian Federation

ФГБУН Институт иммунологии и физиологии УрО РАНРоссияInstitute of Immunology and Physiology, Ural Branch, Russian Academy of SciencesRussian Federation

2017

06042017

6213339

2017

Ltd. “The National Academy of Pediatric Science and Innovation”

https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice

https://www.ped-perinatology.ru/jour/article/view/449

Гипотеза «программирования состояний здоровья и болезней, связанных с развитием» предполагает, что условия развития организма во внутриутробном и раннем постнатальном периодах таким образом влияют на экспрессию генов, что «программируют» раннее появление сердечно-сосудистых и метаболических заболеваний. Экспериментальные исследования демонстрируют большую роль эпигенетических механизмов (метилирование генов) в реализации такого сценария. В обзоре приводятся данные, показывающие, что перинатальное программирование может ускорять процессы старения, следствием чего является ранний дебют указанных заболеваний. Рассматривается значение гипоксии плода как фактора, ведущего к рождению детей с увеличенным риском формирования патологии мозга, сердца, печени, почек, развития артериальной гипертензии и метаболических нарушений в последующей жизни. Обсуждается роль оксидативного стресса и активных соединений кислорода в процессах перинатального программирования.

The developmental origins of health and disease hypothesis suggests that the conditions for the development of the organism in the prenatal and early postnatal periods thus affect the expression of genes that program the early onset of cardiovascular and metabolic diseases. Experimental studies demonstrate the major role of epigenetic mechanisms (gene methylation) in this scenario. The review provides data showing that perinatal programming can accelerate aging processes, resulting in early onset of these diseases. It considers the importance of fetal hypoxia as a factor leading to the birth of babies at increased risk for abnormalities of the brain, heart, liver, and kidney, as well as for hypertension and metabolic disorders in later life. The role of oxidative stress and reactive oxygen species in the processes of perinatal programming is discussed.

детиперинатальное программированиемасса при рождениистарениекардиомиоцитыоксидативный стресс

infantsperinatal programmingbirth weightagingcardiomyocytesoxidative stress

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The authors declare that there are no conflicts of interest present.