perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2017-62-2-22-29perinatology-468Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSКисломолочные продукты в питании детей: профилактические и лечебные возможности использованияFermented dairy productsin children’ diet: Preventive and therapeutic possibilities of their useБехтереваМ. К.BekhterevaM. K.

к.м.н., ст. научн. сотр. отдела кишечных инфекций,

197022 Санкт-Петербург, ул. Профессора Попова, д. 9

Saint Petersburg

ИвановаВ. В.IvanovaV. V.

д.м.н., проф., чл.-корр. РАН, вед. научн. сотр. отдела интенсивной терапии неотложных состояний у детей,

197022 Санкт-Петербург, ул. Профессора Попова, д. 9

Saint Petersburg

МухинаН. В.MukhinaN. V.

врач-педиатр приемного отделения,

194100 Санкт-Петербург, ул. Комсомола, д. 6

Saint Petersburg

ФГБУ «Детский научно-клинический центр инфекционных болезней» Федерального медико-биологического агентства; ЛОГБУЗ «Детская клиническая больница»РоссияChildren’s Research and Clinical Center for Infectious Diseases, Federal Biomedical Agency of Russia; Children’s Clinical HospitalRussian FederationФГБУ «Детский научно-клинический центр инфекционных болезней» Федерального медико-биологического агентстваРоссияChildren’s Research and Clinical Center for Infectious Diseases, Federal Biomedical Agency of RussiaRussian FederationЛОГБУЗ «Детская клиническая больница»РоссияChildren’s Clinical HospitalRussian Federation2017010520176222229Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20172017Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/468

Проанализированы профилактические и лечебные возможности использования кисломолочных пробиотических продуктов (детские творожки, йогурты, биолакты) при различных патологических состояниях у детей. Освещено их влияние на предотвращение развития респираторных и кишечных инфекций у детей различного возраста. Показано, что включение в комплексную терапию патологических состояний, ассоциированных с Helicobacter pylori, пробиотических штаммов с доказанной эффективностью (в том числе в виде кисломолочных пробиотических продуктов) значительно повышает эффективность эрадикационной терапии и предотвращает развитие антибиотикоассоциированной диареи. Обоснована необходимость использования кисломолочных продуктов в лечении инфекционных диарей.

The article analyzes the preventive and therapeutic possibilities of using probiotic fermented dairy products (baby curds, yoghurts, biolacts) in children with various pathological conditions. It outlines their effect in preventing respiratory and intestinal infections in children of different ages. Incorporation of probiotic strains with proven efficacy (including those as probiotic fermented dairy products) into the combination treatment of pathological conditions associated with Helicobacter pylori is shown to significantly increase the efficiency of eradication therapy and to prevent the development antibiotic-associated diarrhea.

детикисломолочные продуктыпробиотикиchildrenfermented dairy productsprobioticsReferencesНациональный союз производителей молока «Союзмолоко». Ежемесячный отчет за июнь 2016 г. «Молоко и молокопродукты: спрос, производство и запасы. Динамика объемов и производства сырого молока и молочной продукции в РФ». www.milknews.ru последняя дата обращения на сайт 20.01.2017 [National union of producers of Soyuzmoloko milk. The monthly report for June, 2016. «Milk and milkprodukt: demand, production and inventories. Dynamics of amounts and production of raw milk and dairy products in the Russian Federation» www.milknews.ru. The last date of the address on the website 20.01.2017 (in Russ)]Национальный союз производителей молока «Союзмолоко». Ежемесячный отчет за июнь 2016 г. «Молоко и молокопродукты: спрос, производство и запасы. Динамика объемов и производства сырого молока и молочной продукции в РФ». www.milknews.ru последняя дата обращения на сайт 20.01.2017 [National union of producers of Soyuzmoloko milk. The monthly report for June, 2016. «Milk and milkprodukt: demand, production and inventories. Dynamics of amounts and production of raw milk and dairy products in the Russian Federation» www.milknews.ru. The last date of the address on the website 20.01.2017 (in Russ)]Клиническая диетология детского возраста. Руководство для врачей. Под ред. Т.Э. Боровик, К.С. Ладодо. М: МИА 2008; 606. [Clinical dietology of children’s age. A management for doctors. Eds T.Je. Borovik, K.S. Ladodo. Moscow: MIA 2008; 606. (in Russ)]Клиническая диетология детского возраста. Руководство для врачей. Под ред. Т.Э. Боровик, К.С. Ладодо. М: МИА 2008; 606. [Clinical dietology of children’s age. A management for doctors. Eds T.Je. Borovik, K.S. Ladodo. Moscow: MIA 2008; 606. (in Russ)]Руководство по лечебному питанию детей. Под редакцией К.С. Ладодо М: Медицина 2000; 384. [A management on clinical nutrition of children. Ed. K.S. Ladodo. Moscow: Meditsina 2000; 384. (in Russ)]Руководство по лечебному питанию детей. Под редакцией К.С. Ладодо М: Медицина 2000; 384. [A management on clinical nutrition of children. Ed. K.S. Ladodo. Moscow: Meditsina 2000; 384. (in Russ)]Ладодо К.С. Рациональное питание детей раннего возраста. М: Миклош 2007; 28. [Ladodo K.S. Balanced diet of children of early age. Moscow: Мiklosh 2007; 28. (in Russ)]Ладодо К.С. Рациональное питание детей раннего возраста. М: Миклош 2007; 28. [Ladodo K.S. Balanced diet of children of early age. Moscow: Мiklosh 2007; 28. (in Russ)]Детское питание. Руководство для врачей. Под ред. В.А. Тутельяна, И.Я. Коня. М: МИА 2009; 952. [Baby food. A management for doctors. Eds V.A. Tutel’jan, I.Ja. Kon’. Moscow: MIA 2009; 952. (in Russ)]Детское питание. Руководство для врачей. Под ред. В.А. Тутельяна, И.Я. Коня. М: МИА 2009; 952. [Baby food. A management for doctors. Eds V.A. Tutel’jan, I.Ja. Kon’. Moscow: MIA 2009; 952. (in Russ)]Kirjavainen P.V., Ouwehand A.C., Isolauri E., Salminen S.J. The ability of probiotic bacteria to bind to human intestinal mucus. FEMS Microbiology Letters 1998; 167: 185-189. DOI:10.1111/j.1574-6968.1998.tb13226.xKirjavainen P.V., Ouwehand A.C., Isolauri E., Salminen S.J. The ability of probiotic bacteria to bind to human intestinal mucus. FEMS Microbiology Letters 1998; 167: 185-189. DOI:10.1111/j.1574-6968.1998.tb13226.xJuntunen M., Kirjavainen P.V., Ouwehand A.C., Salminen S.J., Isolauri E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol 2001; 8(2): 293–296. DOI:10.1128 %2FCDLI.8.2.293-296.2001Juntunen M., Kirjavainen P.V., Ouwehand A.C., Salminen S.J., Isolauri E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol 2001; 8(2): 293–296. DOI:10.1128 %2FCDLI.8.2.293-296.2001Захарова И.Н., Дмитриева Ю.А. Штамм-специфические свойства Bifidobacterium animalis subsp. lactis BB-12. Эффективная фармакотерапия Педиатрия 2 2013; 4: 8–12. [Zaharova I.N., Dmitrieva Yu.A. Strain-specific Bifidobacterium animalis subsp properties. lactis BB-12. Jeffektivnaja farmakoterapiya Pediatrija 2 2013; 4: 8–12. (in Russ)]Захарова И.Н., Дмитриева Ю.А. Штамм-специфические свойства Bifidobacterium animalis subsp. lactis BB-12. Эффективная фармакотерапия Педиатрия 2 2013; 4: 8–12. [Zaharova I.N., Dmitrieva Yu.A. Strain-specific Bifidobacterium animalis subsp properties. lactis BB-12. Jeffektivnaja farmakoterapiya Pediatrija 2 2013; 4: 8–12. (in Russ)]Marteau P.R., de Vrese M., Cellier C.J., Schrezenmeir J. Protection from gastrointestinal diseases with the use of probiotics Am J Clin Nutr 2001; 73 (2): 430–436.Marteau P.R., de Vrese M., Cellier C.J., Schrezenmeir J. Protection from gastrointestinal diseases with the use of probiotics Am J Clin Nutr 2001; 73 (2): 430–436.Romond M.B., Haddou Z., Mielcareck C., Romond C. Bifidobacteria and human health: regulatory effect of indigenous bifidobacteria on Escherichia coli intestinal colonization. Anaerobe 1997; 3: 131–136. DOI: 10.1006/anae.1997.0089Romond M.B., Haddou Z., Mielcareck C., Romond C. Bifidobacteria and human health: regulatory effect of indigenous bifidobacteria on Escherichia coli intestinal colonization. Anaerobe 1997; 3: 131–136. DOI: 10.1006/anae.1997.0089Cheikhyoussef A.N., Cheikhyoussef N., Haiqin C., Zhang H. Bifidin I–a new bacteriocin produced by Bifidobacterium infantis BCRC 14602: purification and partial amino acid sequence. Food Control 2010; 21: 746–753. DOI: 10.1016/j.foodcont.2009.11.003Cheikhyoussef A.N., Cheikhyoussef N., Haiqin C., Zhang H. Bifidin I–a new bacteriocin produced by Bifidobacterium infantis BCRC 14602: purification and partial amino acid sequence. Food Control 2010; 21: 746–753. DOI: 10.1016/j.foodcont.2009.11.003Ishibashi N., Yaeshima T., Hayasawa H. Bifidobacteria: their significance in human intestinal health. Mal J Nutr 1997; 3: 149–159.Ishibashi N., Yaeshima T., Hayasawa H. Bifidobacteria: their significance in human intestinal health. Mal J Nutr 1997; 3: 149–159.Martins F.S., Silva A.A., Vieira A.T., Barbosa F.H., Arantes, R.M., Teixeira M.M., Nicoli J.R. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol 2009; 191: 623–630. DOI:10.1007/s00203-009-0491-xMartins F.S., Silva A.A., Vieira A.T., Barbosa F.H., Arantes, R.M., Teixeira M.M., Nicoli J.R. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol 2009; 191: 623–630. DOI:10.1007/s00203-009-0491-xCollado M.C., Meriluoto J., Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Arch Microbiol 2007; 45: 454–460. DOI:10.1111/j.1472-765X.2007.02212.xCollado M.C., Meriluoto J., Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Arch Microbiol 2007; 45: 454–460. DOI:10.1111/j.1472-765X.2007.02212.xJacobsen C.N., Rosenfeldt Nielsen V., Hayford A.E., Moller P.L., Michaelsen K.F., Paer-regaard A., Sandstrom B., Tvede M., Jakobsen M. Screening of probiotic activities of forty-seven strains of Lactobacillus spp. by in vitro techniques and evaluation of the colonization ability of five selected strains in humans. Appl Environ Microbiol 1999; 65: 4949–4956.Jacobsen C.N., Rosenfeldt Nielsen V., Hayford A.E., Moller P.L., Michaelsen K.F., Paer-regaard A., Sandstrom B., Tvede M., Jakobsen M. Screening of probiotic activities of forty-seven strains of Lactobacillus spp. by in vitro techniques and evaluation of the colonization ability of five selected strains in humans. Appl Environ Microbiol 1999; 65: 4949–4956.Saavedra J.M., Bauman N.A., Perman J.A., Yolken R.H., Oung I. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. 1994; 344(8929): 1046–1049.Saavedra J.M., Bauman N.A., Perman J.A., Yolken R.H., Oung I. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. 1994; 344(8929): 1046–1049.D’Aimmo M.R., Modesto M., Biavati B. Antibiotic resistance of lactic acid bacteria and Bifidobacterium spp. isolated from dairy and pharmaceutical products. Int J Food Microbiol 2007; 115(1): 35–42. DOI:10.1016/j.ijfoodmicro.2006.10.003.D’Aimmo M.R., Modesto M., Biavati B. Antibiotic resistance of lactic acid bacteria and Bifidobacterium spp. isolated from dairy and pharmaceutical products. Int J Food Microbiol 2007; 115(1): 35–42. DOI:10.1016/j.ijfoodmicro.2006.10.003.Chatterjee S., Kar P., Das T., Ray S., Gangulyt S., Rajendiran C., Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibioticassociated diarrhoea. J Ass Physic India 2013; 61: 708–712.Chatterjee S., Kar P., Das T., Ray S., Gangulyt S., Rajendiran C., Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibioticassociated diarrhoea. J Ass Physic India 2013; 61: 708–712.Forssten S.D., Ro¨ytio H., Hibberd A.A., Ouwehand A.C. The effect of polydextrose and probiotic lactobacilli in a infected human colonic model. Microbial Ecology in Health & Disease 2015; 26: 27988. DOI: 10.3402/mehd.v26.27988.Forssten S.D., Ro¨ytio H., Hibberd A.A., Ouwehand A.C. The effect of polydextrose and probiotic lactobacilli in a infected human colonic model. Microbial Ecology in Health & Disease 2015; 26: 27988. DOI: 10.3402/mehd.v26.27988.de Vrese M., Kristen H., Rautenberg P., Laue C., Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res 2011; 78, 4: 396-403. DOI: 10.1017/S002202991100063хde Vrese M., Kristen H., Rautenberg P., Laue C., Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res 2011; 78, 4: 396-403. DOI: 10.1017/S002202991100063хWang K.Y., Li S.N., Liu C.S., Perng D.S., Su Y.C., Wu D.C., Jan C.M., Lai C.H., Wang T.N., Wang W.M. Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori. Am J Clin Nutr 2004; 80: 737–741.Wang K.Y., Li S.N., Liu C.S., Perng D.S., Su Y.C., Wu D.C., Jan C.M., Lai C.H., Wang T.N., Wang W.M. Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori. Am J Clin Nutr 2004; 80: 737–741.SheuB.S.,WuJ.J.,LoC.Y.,WuH.W.,ChenJ.H.,LinY.S.,LinM.D. Impact of supplement with Lactobacillus- and Bifidobacteriumcontaining yogurt on triple therapy for Helicobacter pylori eradication. AlimentPharmacolTher 2002; 16: 1669–1675.SheuB.S.,WuJ.J.,LoC.Y.,WuH.W.,ChenJ.H.,LinY.S.,LinM.D. Impact of supplement with Lactobacillus- and Bifidobacteriumcontaining yogurt on triple therapy for Helicobacter pylori eradication. AlimentPharmacolTher 2002; 16: 1669–1675.Cooper P., Hager C., Vant Hof M. Growth and metabolism of infants born to HIV positive mothers fed whey adapted biologically acidified infant formula with and without probiotics. South African J Clin Nutr 2007; 34: 234–242.Cooper P., Hager C., Vant Hof M. Growth and metabolism of infants born to HIV positive mothers fed whey adapted biologically acidified infant formula with and without probiotics. South African J Clin Nutr 2007; 34: 234–242.Chouraqui J., Van Egroo L., Fichot M.С. Acidified milk formula supplemented with B. lactis: impact on infant diarrhea in residential care settings. JPGN 2004; 38: 288–292.Chouraqui J., Van Egroo L., Fichot M.С. Acidified milk formula supplemented with B. lactis: impact on infant diarrhea in residential care settings. JPGN 2004; 38: 288–292.Gerasimov S.V., Ivantsiv V.A., Bobryk L.M., Tsitsura O.O. Guta N.V., Yandyo B.V. Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial. Eur J Clin Nutr 2016; 70(4): 463–469. DOI:10.1038/ejcn.2015.171.Gerasimov S.V., Ivantsiv V.A., Bobryk L.M., Tsitsura O.O. Guta N.V., Yandyo B.V. Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial. Eur J Clin Nutr 2016; 70(4): 463–469. DOI:10.1038/ejcn.2015.171.Rizzardini G., Eskesen D., Calder P.C. Capetti A., Jespersen L., Clerici M. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br J Nutr 2012; 107(6): 876–884. DOI: 10.1017/S000711451100420хRizzardini G., Eskesen D., Calder P.C. Capetti A., Jespersen L., Clerici M. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br J Nutr 2012; 107(6): 876–884. DOI: 10.1017/S000711451100420хClancy R.L., Gleeson M., Cox A., Callister R., Dorrington A., D’Este C. et al. Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus. Br J Sports Med 2006; 40(4): 351–354. DOI: 10.1136/bjsm.2005.024364Clancy R.L., Gleeson M., Cox A., Callister R., Dorrington A., D’Este C. et al. Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus. Br J Sports Med 2006; 40(4): 351–354. DOI: 10.1136/bjsm.2005.024364Диетотерапия острых кишечных инфекций у детей. Под ред. М.К. Бехтеревой, Н.В. Скрипченко. Санкт-Петербург, 2014; 36. [Dietotherapy of gastrointestinal infections at children. Eds M.K. Bekhtereva, N.V. Skripchenko. SanktPeterburg, 2014; 36. (in Russ)]Диетотерапия острых кишечных инфекций у детей. Под ред. М.К. Бехтеревой, Н.В. Скрипченко. Санкт-Петербург, 2014; 36. [Dietotherapy of gastrointestinal infections at children. Eds M.K. Bekhtereva, N.V. Skripchenko. SanktPeterburg, 2014; 36. (in Russ)]Плоскирева А.А., Горелов А.В. Ступенчатая диетотерапия острых кишечных инфекций у детей. Медицинский совет 2013; 2: 64-68. [Ploskireva A.A., Gorelov A.V. Step dietotherapy of gastrointestinal infections at children. Medicinskij sovet 2013; 2: 64–68. (in Russ)]Плоскирева А.А., Горелов А.В. Ступенчатая диетотерапия острых кишечных инфекций у детей. Медицинский совет 2013; 2: 64-68. [Ploskireva A.A., Gorelov A.V. Step dietotherapy of gastrointestinal infections at children. Medicinskij sovet 2013; 2: 64–68. (in Russ)]

The authors declare that there are no conflicts of interest present.