<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">perinatology</journal-id><journal-title-group><journal-title xml:lang="ru">Российский вестник перинатологии и педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1027-4065</issn><issn pub-type="epub">2500-2228</issn><publisher><publisher-name>Ltd. “The National Academy of Pediatric Science and Innovation”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21508/1027-4065-2017-62-5-80-86</article-id><article-id custom-type="elpub" pub-id-type="custom">perinatology-554</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FOR THE PRACTITIONER</subject></subj-group></article-categories><title-group><article-title>Кисломолочные продукты в питании детей: пищевая и биологическая ценность</article-title><trans-title-group xml:lang="en"><trans-title>Cultured milk foods in children’s nutrition: nutritional and biological value</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комарова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Komarova</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с. отдела гастроэнтерологии НИКИ педиатрии имени академика Ю.Е. Вельтищева</p><p>125412 Москва, ул. Талдомская, д. 2</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хавкин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Havkin</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., рук. отдела гастроэнтерологии НИКИ педиатрии имени академика Ю.Е. Вельтищева</p><p>125412 Москва, ул. Талдомская, д. 2</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ОСП «Научно-исследовательский клинический институт педиатрии имени академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Research Institute of Pediatrics named after acad. Yu.E. Veltischev, N.I. Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>11</day><month>11</month><year>2017</year></pub-date><volume>62</volume><issue>5</issue><fpage>80</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ltd. “The National Academy of Pediatric Science and Innovation”, 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><copyright-holder xml:lang="en">Ltd. “The National Academy of Pediatric Science and Innovation”</copyright-holder><license xlink:href="https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://www.ped-perinatology.ru/jour/article/view/554">https://www.ped-perinatology.ru/jour/article/view/554</self-uri><abstract><p>Среди продуктов функционального питания особое внимание уделяется пробиотическим кисломолочным продуктам. При выборе этих продуктов необходимо ориентироваться на характеристики пробиотических штаммов, входящих в их состав: микроорганизмы должны быть живыми, безопасными при использовании, жизнеспособными и стабильными при хранении, а также способными к выживанию в желудочно-кишечном тракте человека. Применение пробиотических кисломолочных продуктов должно оказывать положительное влияние на здоровье человека: обладать доказанным антиинфекционным действием, иметь иммуномодулирующие свойства, способствовать нормализации моторики желудочно-кишечного тракта. Вышеперечисленные положения должны быть подтверждены контролируемыми исследованиями.</p></abstract><trans-abstract xml:lang="en"><p>Among the products of functional nutrition, special attention is paid to probiotic cultured milk foods. When selecting these products, it is necessary to focus on the characteristics of the probiotic strains that make up their composition: microorganisms must be live, safe to use, viable and stable when stored, and also capable of surviving in the human gastrointestinal tract. The use of probiotic cultured milk foods should have a positive effect on human health: to have a proven anti-infective effect, to have immune modulating properties, to promote the normalization of gastrointestinal motility. The above provisions must be confirmed by controlled studies.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>кисломолочные продукты</kwd><kwd>пробиотики</kwd><kwd>инулин</kwd><kwd>Bifidobacterium Lactis BB-12.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>cultured milk foods</kwd><kwd>probiotics</kwd><kwd>inulin</kwd><kwd>Bifidobacterium Lactis BB-12.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тутельян В.А., Конь И.Я. Руководство по детскому питанию. М: МИА, 2009; 404–420. [Tutelyan V.A, Kon’ I.Y. Guidance on baby food. Moscow: MIA 2009; 404–420. (in Russ)]</mixed-citation><mixed-citation xml:lang="en">Тутельян В.А., Конь И.Я. Руководство по детскому питанию. М: МИА, 2009; 404–420. [Tutelyan V.A, Kon’ I.Y. Guidance on baby food. Moscow: MIA 2009; 404–420. (in Russ)]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральный закон от 12.06.2008 №88-ФЗ (ред. от 22.07.2010) «Технический регламент на молоко и молочную продукцию». https://legalacts.ru (ссылка активна на 3.08.2017). [Federal Law of 12.06.2008 № 88-FZ (red. by 22.07.2010) «Technical Regulations for Milk and Dairy Products». https://legalacts.ru, the link is active on 3.08.2017. (in Russ)]</mixed-citation><mixed-citation xml:lang="en">Федеральный закон от 12.06.2008 №88-ФЗ (ред. от 22.07.2010) «Технический регламент на молоко и молочную продукцию». https://legalacts.ru (ссылка активна на 3.08.2017). [Federal Law of 12.06.2008 № 88-FZ (red. by 22.07.2010) «Technical Regulations for Milk and Dairy Products». https://legalacts.ru, the link is active on 3.08.2017. (in Russ)]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Terpend K., Blaton M.A., Candalh C., Wal J.M., Pochart F. Intestinal barrier function and cows milk sensitization in guinea pigs fed milk or fermented milk. JPJN 1999; 28: 191–198.</mixed-citation><mixed-citation xml:lang="en">Terpend K., Blaton M.A., Candalh C., Wal J.M., Pochart F. Intestinal barrier function and cows milk sensitization in guinea pigs fed milk or fermented milk. JPJN 1999; 28: 191–198.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Black F.T. Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. Scand J Infect Dis 1991; 23: 247–254.</mixed-citation><mixed-citation xml:lang="en">Black F.T. Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. Scand J Infect Dis 1991; 23: 247–254.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">FAO/WHO. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food. 2002; ftp://ftp.fao.org/es/esn/food/wgreport2.pdf</mixed-citation><mixed-citation xml:lang="en">FAO/WHO. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food. 2002; ftp://ftp.fao.org/es/esn/food/wgreport2.pdf</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Commentary by the Scientific Committee on Animal Nutrition on Data Relating to Toxin Production. Scientific Opinion. European Commission, Health &amp; Consumer Protection Directorate-General. December 2001. Retrieved 5 June 2016. http://ec.europa.eu/commission/index_en</mixed-citation><mixed-citation xml:lang="en">Commentary by the Scientific Committee on Animal Nutrition on Data Relating to Toxin Production. Scientific Opinion. European Commission, Health &amp; Consumer Protection Directorate-General. December 2001. Retrieved 5 June 2016. http://ec.europa.eu/commission/index_en</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">FDA, Food and Drug Administration. GRAS Notice Inventory. Agency Response Letter GRAS Notice No. GRN 000049. 2002. http://www.fda.gov</mixed-citation><mixed-citation xml:lang="en">FDA, Food and Drug Administration. GRAS Notice Inventory. Agency Response Letter GRAS Notice No. GRN 000049. 2002. http://www.fda.gov</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B., Morelli L. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014; 11 (8): 506–514. DOI: 10.1038/nrgastro.2014.66</mixed-citation><mixed-citation xml:lang="en">Hill C., Guarner F., Reid G., Gibson G.R., Merenstein D.J., Pot B., Morelli L. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014; 11 (8): 506–514. DOI: 10.1038/nrgastro.2014.66</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Black F.T. Placebo-contolled double-blind trial of 4 lactobacilli strains (HIP) used as prophylactic agent against traveller’s diarrhea (2 trials). Report by G.Nirnberger, Bioconsult, GmbH 1987. Vienna, Austria, 1996. http://www.efsa.europa.eu</mixed-citation><mixed-citation xml:lang="en">Black F.T. Placebo-contolled double-blind trial of 4 lactobacilli strains (HIP) used as prophylactic agent against traveller’s diarrhea (2 trials). Report by G.Nirnberger, Bioconsult, GmbH 1987. Vienna, Austria, 1996. http://www.efsa.europa.eu</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Palaria A., Johnson-Kanda I., O’Sullivan D.J. Effect Of A Synbiotic Yogurt On Levels of Fecal Bifidobacteria, Clostridia And Enterobacteria. Appl Environ Microbiol 2012; 78: 933-940. DOI: 10.1128/AEM.05848-11</mixed-citation><mixed-citation xml:lang="en">Palaria A., Johnson-Kanda I., O’Sullivan D.J. Effect Of A Synbiotic Yogurt On Levels of Fecal Bifidobacteria, Clostridia And Enterobacteria. Appl Environ Microbiol 2012; 78: 933-940. DOI: 10.1128/AEM.05848-11</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Matto J., Fonden R., Tolvanen T., Vonwright A., Vilpponensalmela T., Satokari R. et al. Intestinal survival and persistence of probiotic Lactobacillus and Bifidobacterium strains administered in tri plestrain yoghurt. Int Dairy J 2006; 16: 1174–1180</mixed-citation><mixed-citation xml:lang="en">Matto J., Fonden R., Tolvanen T., Vonwright A., Vilpponensalmela T., Satokari R. et al. Intestinal survival and persistence of probiotic Lactobacillus and Bifidobacterium strains administered in tri plestrain yoghurt. Int Dairy J 2006; 16: 1174–1180</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Matsumoto M., Ohishi H., Benno Y. H+-ATPase activity in Bifidobacterium with special reference to acid tolerance. Int J Food Microbiol 2004; 93: 109–113. DOI:10.1016/j.ijfoodmicro.2003.10.009</mixed-citation><mixed-citation xml:lang="en">Matsumoto M., Ohishi H., Benno Y. H+-ATPase activity in Bifidobacterium with special reference to acid tolerance. Int J Food Microbiol 2004; 93: 109–113. DOI:10.1016/j.ijfoodmicro.2003.10.009</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lin M.Y., Savaiano D., Harlander S. Influence of nonfermented dairy products containing bacterial starter cultures on lactose maldigestion in humans. J Dairy Sci 1991; 74: 87–95. DOI: 10.3168/jds.S0022-0302(91)78147-2</mixed-citation><mixed-citation xml:lang="en">Lin M.Y., Savaiano D., Harlander S. Influence of nonfermented dairy products containing bacterial starter cultures on lactose maldigestion in humans. J Dairy Sci 1991; 74: 87–95. DOI: 10.3168/jds.S0022-0302(91)78147-2</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Picard C., Fioramonti J., Francois A., Robinson T., Neant F., Matuchansky C. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther 2005; 22: 495–512. DOI:10.1111/j.1365-2036.2005.02615.x</mixed-citation><mixed-citation xml:lang="en">Picard C., Fioramonti J., Francois A., Robinson T., Neant F., Matuchansky C. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther 2005; 22: 495–512. DOI:10.1111/j.1365-2036.2005.02615.x</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Collado M.C., Meriluoto J., Salminen S. Role of commercial probiotic strains against human path-ogen adhesion to intestinal mucus. Lett Appl Microbiol 2007; 45: 454–460. DOI: 10.1111/j.1472-765X.2007.02212.x</mixed-citation><mixed-citation xml:lang="en">Collado M.C., Meriluoto J., Salminen S. Role of commercial probiotic strains against human path-ogen adhesion to intestinal mucus. Lett Appl Microbiol 2007; 45: 454–460. DOI: 10.1111/j.1472-765X.2007.02212.x</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Martins F.S., Silva A.A., Vieira A.T., Barbosa F.H., Arantes R.M., Teixeira M.M. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces bou-lardii probiotic properties. Arch Microbiol 2009; 191: 623–630. DOI: 10.1007/s00203-009-0491-x</mixed-citation><mixed-citation xml:lang="en">Martins F.S., Silva A.A., Vieira A.T., Barbosa F.H., Arantes R.M., Teixeira M.M. Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces bou-lardii probiotic properties. Arch Microbiol 2009; 191: 623–630. DOI: 10.1007/s00203-009-0491-x</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Juntunen M., Kirjavainen P.V., Ouwehand A.C., Salminen S.J., Isolauri E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol 2001; 8 (2): 293–296. DOI: 10.1128/CDLI.8.2.293-296.2001</mixed-citation><mixed-citation xml:lang="en">Juntunen M., Kirjavainen P.V., Ouwehand A.C., Salminen S.J., Isolauri E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol 2001; 8 (2): 293–296. DOI: 10.1128/CDLI.8.2.293-296.2001</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Saavedra J.M., Bauman N.A., Oung I., Perman J.A., Yolken R.H. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hos-pital for prevention of diarrhoea and shedding of rotavirus. Lancet 1994; 344: 1046–1049.</mixed-citation><mixed-citation xml:lang="en">Saavedra J.M., Bauman N.A., Oung I., Perman J.A., Yolken R.H. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hos-pital for prevention of diarrhoea and shedding of rotavirus. Lancet 1994; 344: 1046–1049.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bhalla A. Randomized placebo-controlled, double blind, multicentric trial on efficacy and safety of providac techsules (lactobacillus acidophilus LA-5 and bifidobacterium BB-12) for prevention of antibioticassociated diarrhea in Indian patients. 40th Annual Meeting of the American College of Clinical Pharmacology, September 11-13, 2011. J Clin Pharmacol 2011; 51 (9): 1327. DOI: 10.1177/0091270010418046</mixed-citation><mixed-citation xml:lang="en">Bhalla A. Randomized placebo-controlled, double blind, multicentric trial on efficacy and safety of providac techsules (lactobacillus acidophilus LA-5 and bifidobacterium BB-12) for prevention of antibioticassociated diarrhea in Indian patients. 40th Annual Meeting of the American College of Clinical Pharmacology, September 11-13, 2011. J Clin Pharmacol 2011; 51 (9): 1327. DOI: 10.1177/0091270010418046</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sheu B.S., Cheng H.C., Kao A.W., Wang S.T., Yang Y.J., Yang H.B. Pretreatment with Lactobacillus- and Bifidobacterium- containing yogurt can im-prove the efficacy of quadruple therapy in eradi-cating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr 2006; 83: 864–869.</mixed-citation><mixed-citation xml:lang="en">Sheu B.S., Cheng H.C., Kao A.W., Wang S.T., Yang Y.J., Yang H.B. Pretreatment with Lactobacillus- and Bifidobacterium- containing yogurt can im-prove the efficacy of quadruple therapy in eradi-cating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr 2006; 83: 864–869.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wang K.Y., Li S.N., Liu C.S., Perng D.S., Su Y.C., Wu D.C. et al. Effects of ingesting Lactobacillus- and Bifidobacteriumcontaining yogurt in subjects with colonized Helicobacter pylori. Am J Clin Nutr 2004; 80: 737–741.</mixed-citation><mixed-citation xml:lang="en">Wang K.Y., Li S.N., Liu C.S., Perng D.S., Su Y.C., Wu D.C. et al. Effects of ingesting Lactobacillus- and Bifidobacteriumcontaining yogurt in subjects with colonized Helicobacter pylori. Am J Clin Nutr 2004; 80: 737–741.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">de Vrese M., Kristen H., Rautenberg P., Laue C., Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associ-ated diarrhea and Helicobacter pylori activity. J Dairy Res 2011; 78: 396–403. DOI: 10.1017/S002202991100063X</mixed-citation><mixed-citation xml:lang="en">de Vrese M., Kristen H., Rautenberg P., Laue C., Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associ-ated diarrhea and Helicobacter pylori activity. J Dairy Res 2011; 78: 396–403. DOI: 10.1017/S002202991100063X</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sheu B.S., Wu J.J., Lo C.Y., Wu H.W., Chen J.H., Lin Y.S. et al. Impact of supplement with Lactobacillus- and Bifidobacterium- containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther 2002; 16: 1669–1675.</mixed-citation><mixed-citation xml:lang="en">Sheu B.S., Wu J.J., Lo C.Y., Wu H.W., Chen J.H., Lin Y.S. et al. Impact of supplement with Lactobacillus- and Bifidobacterium- containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther 2002; 16: 1669–1675.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez P., Gueimonde M., Margolles A., Suarez A. Distinct Bifidobacterium strains drive different immune responses in vitro. Int J Food Microbiol 2010; 138: 157–165. DOI: 10.1016/j.ijfoodmicro.2009.12.023</mixed-citation><mixed-citation xml:lang="en">Lopez P., Gueimonde M., Margolles A., Suarez A. Distinct Bifidobacterium strains drive different immune responses in vitro. Int J Food Microbiol 2010; 138: 157–165. DOI: 10.1016/j.ijfoodmicro.2009.12.023</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Latvala S., Pietila T.E., Veckman V., Kekkonen R.A., Tynkkynen S., Korpela R. et al. Potentially probi-otic bacteria induce efficient maturation but dif-ferential cytokine production in human mono-cyte-derived dendritic cells. World J Gastroenterol 2008; 14: 5570–5581.</mixed-citation><mixed-citation xml:lang="en">Latvala S., Pietila T.E., Veckman V., Kekkonen R.A., Tynkkynen S., Korpela R. et al. Potentially probi-otic bacteria induce efficient maturation but dif-ferential cytokine production in human mono-cyte-derived dendritic cells. World J Gastroenterol 2008; 14: 5570–5581.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Campeotto F., Waligora-Dupriet A.J., Doucet-Populaire F., Kalach N., Dupont C., Butel M.J. Mise en place de la flore intestinale du nouveau né. Gastroenterol Clin Biol 2007; 31: 533–542.</mixed-citation><mixed-citation xml:lang="en">Campeotto F., Waligora-Dupriet A.J., Doucet-Populaire F., Kalach N., Dupont C., Butel M.J. Mise en place de la flore intestinale du nouveau né. Gastroenterol Clin Biol 2007; 31: 533–542.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Taipale T., Pienihakkinen K., Isolauri E., Larsen C., Brockmann E., Alanen P. et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr 2011; 105: 409–416. DOI: 10.1017/S0007114510003685</mixed-citation><mixed-citation xml:lang="en">Taipale T., Pienihakkinen K., Isolauri E., Larsen C., Brockmann E., Alanen P. et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr 2011; 105: 409–416. DOI: 10.1017/S0007114510003685</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Rautava S., Salminen S., Isolauri E. Specific probi-otics in reducing the risk of acute infections in infancy--a randomised, double-blind, placebo-controlled study. Br J Nutr 2009; 101: 1722–1726. DOI: 10.1017/S0007114508116282</mixed-citation><mixed-citation xml:lang="en">Rautava S., Salminen S., Isolauri E. Specific probi-otics in reducing the risk of acute infections in infancy--a randomised, double-blind, placebo-controlled study. Br J Nutr 2009; 101: 1722–1726. DOI: 10.1017/S0007114508116282</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Хавкин А.И. Микрофлора пищеварительного тракта. М.: Фонд социальной педиатрии 2006; 414. [Khavkin A.I. Microflora of the digestive tract. Moscow: Fond sotsial’noj pediatrii 2006; 414. (in Russ)]</mixed-citation><mixed-citation xml:lang="en">Хавкин А.И. Микрофлора пищеварительного тракта. М.: Фонд социальной педиатрии 2006; 414. [Khavkin A.I. Microflora of the digestive tract. Moscow: Fond sotsial’noj pediatrii 2006; 414. (in Russ)]</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Pitkala K.H., Strandberg T.E., Finne Soveri U.H., Ouwehand A.C., Poussa T., Salminen S. Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home resi-dents. A randomized, controlled trial. J Nutr Health Aging 2007; 11: 305– 311.</mixed-citation><mixed-citation xml:lang="en">Pitkala K.H., Strandberg T.E., Finne Soveri U.H., Ouwehand A.C., Poussa T., Salminen S. Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home resi-dents. A randomized, controlled trial. J Nutr Health Aging 2007; 11: 305– 311.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Griffin I.J., Davila P.M., Abrams S.A. Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes. Br J Nutr 2002; 87 (2): 187–191. DOI: 10.1079/BJNBJN/2002536</mixed-citation><mixed-citation xml:lang="en">Griffin I.J., Davila P.M., Abrams S.A. Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes. Br J Nutr 2002; 87 (2): 187–191. DOI: 10.1079/BJNBJN/2002536</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Langlands S.J., Hopkins M.J., Coleman N., Cummings J.H. Prebiotic carbogydrates modify the mucosa associated microflora of the human large bowel. Gut 2004; 53: 1610– 1616. DOI: 10.1136/gut.2003.037580</mixed-citation><mixed-citation xml:lang="en">Langlands S.J., Hopkins M.J., Coleman N., Cummings J.H. Prebiotic carbogydrates modify the mucosa associated microflora of the human large bowel. Gut 2004; 53: 1610– 1616. DOI: 10.1136/gut.2003.037580</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Waligora-Dupriet A.J., Campeotto F., Nicolis I., Bonet A. Effect of oligofructose supplementation on gut microflora and welldeing in young children attending a day care center. Int J Food Microbiol 2007; 113: 108-113. DOI: 10.1016/j.ijfoodmicro.2006.07.009</mixed-citation><mixed-citation xml:lang="en">Waligora-Dupriet A.J., Campeotto F., Nicolis I., Bonet A. Effect of oligofructose supplementation on gut microflora and welldeing in young children attending a day care center. Int J Food Microbiol 2007; 113: 108-113. DOI: 10.1016/j.ijfoodmicro.2006.07.009</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Letexier D., Diraison F., Baylot M. Addition of inulin to moderately highcarbogydrates diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans. Am J Clin Nutr 2003; 77: 559–564.</mixed-citation><mixed-citation xml:lang="en">Letexier D., Diraison F., Baylot M. Addition of inulin to moderately highcarbogydrates diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans. Am J Clin Nutr 2003; 77: 559–564.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">EFSA (European Food Safety Authority). Scientific Opinion on the maintenance of the list of QPS biological agents intentionally addede to food and feed (2010 update). EFSA J 2010; 8: 1–56.</mixed-citation><mixed-citation xml:lang="en">EFSA (European Food Safety Authority). Scientific Opinion on the maintenance of the list of QPS biological agents intentionally addede to food and feed (2010 update). EFSA J 2010; 8: 1–56.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Uchida K., Akashi K., Kusunoki I., Ikeda T., Katano N., Motoshima H. et al. Effect of fermented milk containing Bifidobacterium lactis Bb-12 on stool frequency, defecation, fecal microbiota and safety of excessive ingestion in healthy female students – 2nd report. J Nutr Food 2005; 8 (1): 39–51.</mixed-citation><mixed-citation xml:lang="en">Uchida K., Akashi K., Kusunoki I., Ikeda T., Katano N., Motoshima H. et al. Effect of fermented milk containing Bifidobacterium lactis Bb-12 on stool frequency, defecation, fecal microbiota and safety of excessive ingestion in healthy female students – 2nd report. J Nutr Food 2005; 8 (1): 39–51.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
