perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2017-62-6-45-50perinatology-589Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSО ВОЗМОЖНОСТЯХ ЛАБОРАТОРНОЙ ВЕРИФИКАЦИИ ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИИ У ДЕТЕЙON THE POSSIBILITIES OF LABORATORY VERIFICATION OF CYTOMEGALOVIRUS INFECTION IN CHILDRENhttps://orcid.org/0000-0001-5189-0347ПермяковаА. В.PermyakovaA. V.

Пермякова Анна  Владимировна  – кандидат медицинских наук, доцент  кафедры  детских  инфекционных болезней.

Пермь

Perm

https://orcid.org/0000-0002-0599-7845ЛьвоваИ. И.LvovaI. I.

Львова Ирина  Иосифовна – доктор медицинских наук, профессор,  зав. кафедрой  детских инфекционных болезней.

Пермь

Perm

ПоспеловаН. С.PospelovaN. S.

Поспелова Наталья Сергеевна – асcистент кафедры детских инфекционных болезней.

Perm

ФГБОУ ВО «Пермский государственный медицинский университет им. академика Е.А. Вагнера» Минздрава РФРоссияE.A. Wagner Medical State UniversityRussian Federation2017110120186264550Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20182018Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/589

В обзоре рассматриваются исследования, посвященные вопросам лабораторной диагностики приобретенной цитомегаловирусной инфекции у детей раннего возраста. Учитывая сложность диагностики заболевания по клиническим признакам, основными методами лабораторной диагностики являются твердофазный иммуноферментный анализ (ИФА) и полимеразная цепная реакция (ПЦР),  позволяющая оценивать количество ДНК вируса (вирусную нагрузку), определять «отсекающие» (cut-off) значения.

The review considers research on issues of laboratory diagnosis of acquired cytomegalovirus (CMV) infection in early aged children. Because of the complexity of diagnosis of disease according to clinical signs, the main methods of laboratory diagnosis of CMV are enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), which allows to estimate the amount of virus DNA (viral load), to determine “cut-off” values which makes monitoring of the infectious process accessible.

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The authors declare that there are no conflicts of interest present.