References

perinatology

Российский вестник перинатологии и педиатрии

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)

1027-40652500-2228

Ltd. “The National Academy of Pediatric Science and Innovation”

10.21508/1027-4065-2018-63-1-14-21

perinatology-613

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEWS

Влияние социальных, медицинских и экологических факторов на формирование спорадических врожденных пороков сердца

Influence of the social, medicinal and environmental factors upon the development of sporadic congenital heart diseases

https://orcid.org/0000-0002-8785-7896

Шабалдин

А. В.

Shabaldin

A. V.

д.м.н., вед. научн. сотр. лаборатории клеточных технологий Научно-исследовательского института комплексных проблем сердечно-сосудистых заболеваний

https://orcid.org/0000-0002-4467-8732

Цепокина

А. В.

Tsepokina

A. V.

мл.н.с. лаборатории геномной медицины Научно-исследовательского института комплексных проблем сердечно- сосудистых заболеваний

Шмулевич

С. А.

Shmulevich

S. A.

зав. отделением детской кардиологии Кемеровского кардиологического диспансера

https://orcid.org/0000-0002-1966-3985

Табакаев

М. Ю.

Tabakaev

M. Yu.

мл.н.с. лаборатории управленческих технологий Научно-исследовательского института комплексных проблем сердечно-сосудистых заболеваний

Шабалдина

Е. В.

Shabaldina

E. V.

д.м.н., зав. кафедрой оториноларингологии и клинической иммунологии Кемеровского государственного медицинского университета

ФГБНУ «Научно–исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», КемеровоРоссияResearch Institute for Complex Issues of Cardiovascular Diseases, KemerovoRussian Federation

ГБУЗ «Кемеровский областной клинический кардиологический диспансер имени академика Л.С. Барбараша», КемеровоРоссияKemerovo Regional Clinical Cardiology Dispensary named after Academician L.A. Barabash, KemerovoRussian Federation

ГБОУ ВПО «Кемеровский государственный медицинский университет» Минздрава РФ, КемеровоРоссияKemerovo State Medical University, KemerovoRussian Federation

2018

13032018

6311421

2018

Ltd. “The National Academy of Pediatric Science and Innovation”

https://www.ped-perinatology.ru/jour/about/submissions#copyrightNotice

https://www.ped-perinatology.ru/jour/article/view/613

Эпидемиологические исследования показали рост врожденных пороков сердца в промышленных регионах Российской Федерации. Несмотря на высокие достижения в кардиологии и кардиохирургии, этиология и патогенез большинства врожденных пороков сердца до сих пор неизвестны. Цель настоящего обзора: анализ данных литературы, посвященной влиянию комплекса экзогенных и эндогенных, в том числе генетических факторов, на развитие спорадических врожденных пороков сердца, не сочетающихся с хромосомными аномалиями. Показано, что спорадические врожденные пороки сердца ассоциированы с женскими социальными факторами, такими как низкий социальный статус и уровень образования, табакокурение, алкоголизм. Загрязнение атмосферного воздуха наночастицами размером менее 10 мкм является фактором риска формирования пороков сердца и другой патологии сердечно-сосудистой системы. Доказаны ассоциативные связи между аллелями и генотипами полиморфных вариантов генов GATA6, NPPB (rs198388 и rs198389), CYP1A1, CYP1B1, NAT2 и врожденными пороками сердца у детей.

The epidemiological studies have shown an increase of congenital heart diseases in the industrial regions of the Russian Federation. The etiology and pathogenesis of most congenital heart defects are still unknown despite high achievements in cardiology and cardiac surgery. The purpose of this review is to analyze the literature data devoted to the influence of a complex of exogenous and endogenous factors, including the genetic ones, upon the development of the sporadic congenital heart diseases, which are not associated with the chromosomal abnormalities. It isshown that the sporadic congenital heart diseases associate with the women's social factors such as a low social status and level of education, smoking, and alcohol. The air pollution with nanoparticles smaller than 10 µm is a risk factor for the development of the congenital heart diseases and other pathological conditions of the cardiovascular system. It has been proven that the alleles and genotypes of polymorphic variants of genes GATA6, NPPB (rs198388 and rs198389), CYP1A1, CYP1B1, and NAT2 have the associative links with the congenital heart disease in the children.

детиврожденные пороки сердцафакторы окружающей средымедицинские и социальные факторыполиморфные варианты геновGATA6NPPBCYP1A1CYP1B1NAT2

childrencongenital heart diseasesenvironmental factorsmedical and social factorspolymorphic variants of genesGATA6NPPBCYP1A1CYP1B1NAT2

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The authors declare that there are no conflicts of interest present.