perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2018-63-1-28-33perinatology-615Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSЗначение цитокинов в патогенезе атопического дерматитаThe importance of cytokines for the atopic dermatitis pathogenesishttps://orcid.org/0000-0001-5039-8473ВарламовЕ. Е.VarlamovE. E.

к.м.н., ст. научн. сотр. отдела аллергологии и клинической иммунологии Научно-исследовательского клинического института педиатрии имени академика Ю.Е.Вельтищева

ПампураА. Н.PampuraA. N.

д.м.н., зав. отделом аллергологии и клинической иммунологии Научно-исследовательского клинического института педиатрии имени академика Ю.Е.Вельтищева

https://orcid.org/0000-0002-0552-6939СухоруковВ. С.SukhorukovV. S.

д.м.н., проф., зав. научно-исследовательской лаборатории общей патологии Научно-исследовательского кли- нического института педиатрии имени академика Ю.Е.Вельтищева

ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГБОУ ВО РНИМУ им. Н.И. Пирогова, МоскваРоссияResearch Clinical Institute of Pediatry named after Academician Yu.E. Veltishchev, National Research Medical University named after N.I. Pirogov, MoscowRussian Federation2018130320186312833Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20182018Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/615

Атопический дерматит является хроническим воспалительным кожным заболеванием. Широкая распространенность заболевания, увеличение числа тяжелых форм определяют его высокую медико-социальную значимость. Развитие кожного воспали- тельного процесса у больных обусловлено сложным взаимодействием генетических механизмов, факторов окружающей среды, инфекционных агентов, дефектов кожного барьера и иммунных механизмов. В иммунопатогенезе атопического дерматита принимают участие разные популяции иммунокомпетентных клеток: Th1, Th2, Th9, Тh17, Th22, Т-регуляторные клетки и секретируемые ими цитокины. В настоящем обзоре изложены данные об участии ряда цитокинов в развитии иммунопатологического процесса при атопическом дерматите. Выявление особенностей патогенеза заболевания на основании оценки цитокинового профиля и  установление маркеров тяжести течения является крайне актуальным направлением клинической аллергологии и иммунологии для определения не только прогноза заболевания, но и терапевтических мишеней в будущем.

 

The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well.

 

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The authors declare that there are no conflicts of interest present.