perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2018-63-2-16-21perinatology-639Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSПротективные факторы слизистой оболочки мочевого пузыря – ключ к новым подходам к терапии инфекции мочевых путейProtective factors of the urinary bladder mucous membrane – the key to new approaches of urinary tract infection therapyЗахароваИ. Н.ZakharovaI. N.

д.м.н., проф., зав. кафедрой педиатрии им. Г.Н. Сперанского

ОсмановИ. М.OsmanovI. M.

д.м.н., проф., гл. врач

КасьяноваА. Н.KasyanovaA. N.

ординатор кафедры педиатрии им. Г.Н. Сперанского

МумладзеЭ. Б.MumladzeE. B.

к.м.н., доцент кафедры педиатрии им. Г.Н. Сперанского

МачневаЕ. Б.MachnevaE. B.

к.м.н., асс. кафедры педиатрии им. Г.Н. Сперанского

ЛупанИ. Н.LupanI. N.

к.м.н., доц. кафедры педиатрии и неонатологии

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, МоскваРоссияRussian medical Academy of continuing professional education of the Ministry of Health of Russia, MoscowRussian FederationГБУЗ «Детская городская клиническая больница им. З.А. Башляевой», МоскваРоссияBashlyayeva Children’s City Clinical Hospital, MoscowRussian FederationФГБОУ ВО Южно-Уральский государственный медицинский университет Минздрава России, ЧелябинскРоссияSouth Ural State Medical University of the Ministry of Health of the Russian Federation, ChelyabinskRussian Federation2018270420186321621Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20182018Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/639

Мочевой пузырь является уникальным органом, который подвержен воздействию различных агрессивных факторов  – от механического растяжения до воздействия токсинов, солей и микроорганизмов. Для защиты эпителия слизистой мочевого пузыря в процессе эволюции сформировался ряд протективных механизмов. Нарушение или отсутствие этих механизмов может привести к патологическим состояниям, в том числе к развитию инфекции мочевых путей. Изучение и глубокое понимание данных механизмов может способствовать появлению и совершенствованию новых перспективных методов профилактики и лечения инфекции мочевых путей. В представленной статье подробно освещены особенности строения слизистой оболочки мочевого пузыря и основные механизмы и факторы ее защиты от уропатогенов.

 

The bladder is a unique organ that is exposed to various aggressive factors – from mechanical stretching to exposure to toxins, salts and microorganisms. To protect the epithelium of the bladder mucosa, a number of protective mechanisms have evolved in the course of evolution. The violation or absence of these mechanisms can lead to pathological conditions, including the development of urinary tract infection. The study and deep understanding of these mechanisms can contribute to the emergence and improvement of new promising methods of prevention and treatment of urinary tract infections. The presented article details the features of the structure of the urinary bladder mucous membrane and the main mechanisms and factors of its protection against uropathogens.

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The authors declare that there are no conflicts of interest present.