perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”10.21508/1027-4065-2018-63-5-29-35perinatology-719Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSБРОНХОЭКТАТИЧЕСКАЯ БОЛЕЗНЬ У ДЕТЕЙBRONCHOECTATIC DISEASE IN CHILDRENСтепановА. А.StepanovА. А.

д.м.н., проф. кафедры педиатрии лечебного факультета.

БадалянА. Р.BadalyanA. R.

асс. кафедры педиатрии лечебного факультета.

МельниковаА. О.MelnikovaA. O.

асс. кафедры педиатрии лечебного факультета.

117997 Москва, ул. Островитянова, д. 1.

ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России.РоссияPirogov Russian National Research Medical University.Russian Federation2018171120186352935Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20182018Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/719

Бронхоэктаз характеризуется хроническим и аномальным расширением дыхательных путей и вызван нарушениями клиренса различных микроорганизмов и рецидивирующей инфекцией. В 26–53% случаев бронхоэктазы имеют неизвестную причину, а значит, вопросы этиологии и патогенеза бронхоэктазов являются весьма актуальными для изучения. В настоящем обзоре обобщены современные представления об эпидемиологии, патофизиологии, клинических особенностях и ведении детей с бронхоэктатической болезнью. В последнее время появляются новые данные, позволяющие улучшить наше понимание этого гетерогенного заболевания, например роль взаимодействия иммунной системы и микробиоты в патогенезе бронхоэктатической болезни.

Bronchiectasis is characterized by a chronic and abnormal expansion of the respiratory tract; it is caused by impaired clearance of various microorganisms and recurrent infection. The cause of 26%–53% cases of bronchiectasis is unknown, which means that their etiology and pathogenesis are to be studied. This review summarizes current knowledge of epidemiology, pathophysiology, clinical features and management of children with bronchoectatic disease. Recent data allow us to improve our understanding of this heterogeneous disease, for example, the role of the interaction of the immune system and microbiota in the pathogenesis of bronchoectatic disease.

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The authors declare that there are no conflicts of interest present.