perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”perinatology-72Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWSСекреция цитокинов при эозинофилии у детейCytokine secretion in children with eosinophiliaРужицкаяЕ. А.RuzhitskayaE. A.

к.м.н., в.н.с. научно-исследовательской лаборатории общей патологии

ВиноградоваТ. В.VinogradovaT. V.

к.м.н., в.н.с. научно-исследовательской лаборатории общей патологии

СеменовА. В.SemyonovA. V.

к.м.н., ст.н.с. научно-исследовательской лаборатории общей патологии

ПампураА. Н.PampuraA. N.

д.м.н., зав. отделением аллергологии и клинической иммунологии

ТреневаМ. С.TrenevaM. S.

к.м.н., в.н.с. отделения аллергологии и клинической иммунологии

СухоруковВ. С.SukhorukovV. S.

д.м.н., проф., рук. научно-исследовательской лаборатории общей патологии

Научно-исследовательский клинический институт педиатрии ГБОУ ВПО «РНИМУ им. Н.И. Пирогова», МоскваРоссияResearch Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, MoscowRussian Federation2015090320166022936Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20162016Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/72

Доказана значительная роль эозинофилов в патогенезе многих заболеваний (аллергических, гранулематозных, аутоиммунных, интерстициальных, идиопатических, паразитарных, неопластических и миелопролиферативных). Однако несмотря на длительность истории исследования эозинофилов, их биологические свойства по-прежнему малоизучены. В обзоре обобщены результаты исследований, посвященных спектру цитокинов, которые секретируются эозинофилами и обеспечивают их плейотропный эффект, в том числе иммуномодуляцию, влияние на гомеостаз и репарацию тканей. Также рассматриваются типы секреции цитокинов эозинофилами и влияние цитокинов на функции самих эозинофилов. Особое внимание уделено научным фактам, касающимся особенностей секреции цитокинов при аллергических заболеваниях у детей с эозинофилией и их патогенетической роли. 

There is evidence that eosinophils play a considerable role in the pathogenesis of many diseases (allergic, granulomatous, autoimmune, interstitial, idiopathic, parasitic, neoplastic, and myeloproliferative ones). However, despite the long history of studies of eosinophils, their biological properties were still little studied. The review summarizes the results of studies dealing with the spectrum of cytokines that are secreted by eosinophils and ensure their pleiotropic effects, including immunomodulation, an effect on tissue homeostasis and repair. It also describes the types of eosinophil secretion of cytokines and their effect on the function of eosinophils themselves. Special attention is paid to the scientific facts of cytokine secretion in allergic diseases in children with eosinophilia and to the pathogenic role of cytokines. 

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The authors declare that there are no conflicts of interest present.