perinatologyРоссийский вестник перинатологии и педиатрииRossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)1027-40652500-2228Ltd. “The National Academy of Pediatric Science and Innovation”perinatology-732Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУGUIDELINES FOR THE PRACTITIONERВОЗМОЖНОСТИ РАННЕГО НАЧАЛА ЛЕЧЕНИЯ ОРВИ У ДЕТЕЙOPPORTUNITIES OF EARLY TREATMENT OF ACUTE RESPIRATORY VIRAL INFECTION IN CHILDRENhttps://orcid.org/0000-0003-0547-3686ГеппеН. А.GеppeN. A.

д.м.н., проф., зав. кафедрой детских болезней лечебного факультета.

https://orcid.org/0000-0002-6679-6385КрыловаН. А.KrylovaN. A.

к.м.н., доц. кафедры детских болезней лечебного факультета.

https://orcid.org/0000-0002-1769-3670ЕлисееваТ. И.EliseevaT. I.

д.м.н.,  проф.  кафедры  госпитальной  педиатрии.

603950, БОКС-470, Нижний Новгород, пл. Минина и Пожарского, д.10/1.

https://orcid.org/0000-0002-6305-3121ТюринаЕ. Н.TyurinaE. N.

к.м.н., ассистент кафедры детских болезней лечебного факультета.

https://orcid.org/0000-0003-3364-610XЯблоковаЕ. А.YablokovaE. A.

к.м.н., доц. кафедры детских болезней  лечебного  факультета.

119991 Москва, Большая Пироговская ул., д. 2-4.

ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава РФ.РоссияSechenov First Moscow State Medical University.Russian FederationФГБОУ ВО “Приволжский исследовательский медицинский университет” Минздрава РФ.РоссияPrivolzhsky Research Medical University.Russian Federation201819112018635103107Copyright © Ltd. “The National Academy of Pediatric Science and Innovation”, 20182018Ltd. “The National Academy of Pediatric Science and Innovation”Ltd. “The National Academy of Pediatric Science and Innovation”https://www.ped-perinatology.ru/jour/about/submissions#copyrightNoticehttps://www.ped-perinatology.ru/jour/article/view/732Цель работы

Цель работы: оценка эффективности оциллококцинума в терапии острых респираторных вирусных инфекций (ОРВИ) у де-тей в различных возрастных группах.

Наблюдались 140 детей в возрасте 1–14 лет с легким и среднетяжелым течением ОРВИ. Из них 80 детей (1-я группа) получали Оциллококцинум, 60 детей (2-я группа) – симптоматическую терапию. В 1-й группе были выделены подгруппа 1А (40 детей в возрасте 1–5 лет) и подгруппа 1Б (40 детей в возрасте 5–14 лет). Во 2-й группе были выделены подгруппа 2А (30 детей в возрасте 1–5 лет) и подгруппа 2Б (30 детей в возрасте 5–14 лет). Продолжительность наблюдения составила 7–10 дней. Клиническая эффективность оценивалась по выраженности симптомов ОРВИ в баллах от 0 до 2. Регистрировались все побочные явления терапии. Также оценивалось исчезновение симптомов ОРВИ в течение 48 ч после начала терапии.

Результаты

Результаты. Применение Оциллококцинума при ОРВИ снижало длительность заболевания у детей разных возрастных групп. Исчезновение симптомов ОРВИ в течение первых 2 сут наблюдения отмечено у 13 (16,3%) детей 1-й группы, получавших Оциллококцинум, и у 4 (6,7%) больных 2-й группы сравнения (ОШ = 2,7; 95% ДИ 0,8–8,8; p<0,001).

Выводы

Выводы. Оциллококцинум является эффективным и безопасным препаратом в лечении ОРВИ у детей разных возрастных групп.

Purpose

Purpose: to evaluate effectiveness of Oscillococcinum in the treatment of acute respiratory viral infections (ARVI) in children of different age groups.

We observed 140 children from 1 to 14 years with mild to moderate-severe acute respiratory viral infection. 80 children (Group 1) were treated with Oscillococcinum, 60 children (Group 2) were treated symptomatically. Group 1 was divided into Subgroup 1А (40 children of 1–5 years old) and Subgroup 1B (40 children >5–14 years old). Group 2 was divided into Subgroup 2А (30 children of 1–5 years old) and Subgroup 2B (30 children >5–14 years old). The follow-up period was 7–10 days. Clinical efficacy was assessed by the severity of ARVI symptoms in scores from 0 to 2. All adverse events of the therapy were recorded. Also we evaluated disappearance of ARVI symptoms within 48 hours after the beginning of the therapy.

Results

Results: Oscillococcinum reduced the duration of ARVI in children of different age groups. During the first two days the symptoms of acute respiratory viral infection disappeared in 13 (16.3%) children of Group 1 receiving oscilococcinum and in 4 (6.7%) patients from Group 2 (OR = 2.7, 95 % CI 0.8–8.8, p <0.001).

Conclusion

Conclusion: Oscillococcinum is an effective and safe drug to treat ARVI in children of different age groups.

детиострые респираторные вирусные инфекциигомеопатические средстваОциллококцинумлечениеchildrenacute respiratory viral infectionshomeopathic drugsOscillococcinumtreatmentReferencesCarrat F., Avouac B., Cedraschi C., Duru G., Greppo G., Libourel V. et al. Influenza, influenza-like illness: from theory to practice. Presse Med2014; 43(3): 240-246. DOI: 10.1016/j.lpm.2013.09.004Carrat F., Avouac B., Cedraschi C., Duru G., Greppo G., Libourel V. et al. Influenza, influenza-like illness: from theory to practice. Presse Med2014; 43(3): 240-246. DOI: 10.1016/j.lpm.2013.09.004Mathie R.T., Baitson E.S., Frye J., Nayak C., Manchanda R.K., Fisher P. Homeopathic treatment of patients with influenza-like illness during the 2009 A/H1N1influenza pandemic in India. Homeopathy 2013; 102(3): 187–192. DOI: 10.1016/j.homp.2013.04.001Mathie R.T., Baitson E.S., Frye J., Nayak C., Manchanda R.K., Fisher P. Homeopathic treatment of patients with influenza-like illness during the 2009 A/H1N1influenza pandemic in India. Homeopathy 2013; 102(3): 187–192. DOI: 10.1016/j.homp.2013.04.001Marinone C., Bastard M., Bonnet P.A., Gentile G., Casanova L. Effectiveness of preventive treatment by Influenzinum in the winter period against the onset of influenza-like illnesses. Therapie2017; 72(4): 465–474. DOI: 10.1016/j.therap.2016.12.011Marinone C., Bastard M., Bonnet P.A., Gentile G., Casanova L. Effectiveness of preventive treatment by Influenzinum in the winter period against the onset of influenza-like illnesses. Therapie2017; 72(4): 465–474. DOI: 10.1016/j.therap.2016.12.011Bellavite P., Marzotto M., Chirumbolo S., Conforti A. Advances in homeopathy and immunology: a review of clinical research. Front Biosci(Schol Ed) 2011; 3: 1363–1389.Bellavite P., Marzotto M., Chirumbolo S., Conforti A. Advances in homeopathy and immunology: a review of clinical research. Front Biosci(Schol Ed) 2011; 3: 1363–1389.Marchisio P., Bianchini S., Galeone C., Baggi E., Rossi E., Albertario G. et al. Use of complementary and alternative medicine in children with recurrent acute otitis media in Italy. Int J Immunopathol Pharmacol 2011; 24(2): 441–449. DOI: 10.1177/039463201102400217Marchisio P., Bianchini S., Galeone C., Baggi E., Rossi E., Albertario G. et al. Use of complementary and alternative medicine in children with recurrent acute otitis media in Italy. Int J Immunopathol Pharmacol 2011; 24(2): 441–449. DOI: 10.1177/039463201102400217Mathie R.T., Frye J., Fisher P. Homeopathic Oscillococcinum® for preventing and treating influenza and influenzalike illness. Cochrane Database Syst Rev2015; 1: CD001957.Mathie R.T., Frye J., Fisher P. Homeopathic Oscillococcinum® for preventing and treating influenza and influenzalike illness. Cochrane Database Syst Rev2015; 1: CD001957.Danno K., Cognet-Dementhon B., Thevenard G., Duru G., Allaert F.A., Bordet M.F. Effectiveness of homeopathic medicine associated with allopathic medicine in the outpatient management of influenza-like illnesses or ear, nose, and throat disorders by pharmacists. J Manag Care Pharm2013; 19(8): 631–641. DOI: 10.18553/jmcp.2013.19.8.631Danno K., Cognet-Dementhon B., Thevenard G., Duru G., Allaert F.A., Bordet M.F. Effectiveness of homeopathic medicine associated with allopathic medicine in the outpatient management of influenza-like illnesses or ear, nose, and throat disorders by pharmacists. J Manag Care Pharm2013; 19(8): 631–641. DOI: 10.18553/jmcp.2013.19.8.631Danno K., Cognet-Dementhon B., Thevenard G., Duru G., Allaert F.A., Bordet M.F. Management of the early symptoms of influenza-like illnesses and ear, nose and throat(ENT) disorders by pharmacists. Homeopathy2014; 103(4): 239–249. DOI: 10.1016/j.homp.2014.04.001Danno K., Cognet-Dementhon B., Thevenard G., Duru G., Allaert F.A., Bordet M.F. Management of the early symptoms of influenza-like illnesses and ear, nose and throat(ENT) disorders by pharmacists. Homeopathy2014; 103(4): 239–249. DOI: 10.1016/j.homp.2014.04.001Siqueira C.M., Motta P.D., Cardoso T.N., de Paula Coelho C., Popi A.F., Couceiro J.N. et al. Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice. Homeopathy2016; 105(3): 257-264. DOI: 10.1016/j.homp.2016.04.002Siqueira C.M., Motta P.D., Cardoso T.N., de Paula Coelho C., Popi A.F., Couceiro J.N. et al. Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice. Homeopathy2016; 105(3): 257-264. DOI: 10.1016/j.homp.2016.04.002Селькова Е.П., Лапицкая Е.С., Оганесян А.С., Федорова И.М., Лопатина Т.К., Топтыгина А.П. и др. Изучение клинико-эпидемиологической эффективности препарата Оциллококцинум в отношении гриппа и ОРВИ. Инфекционные болезни 2012; 10(3): 83–89.Selkova E.P., Lapitskaya E.S, Oganesyan A.S., Fyodorova I.M., Lopatina T.K., Toptygina A.P. et al. A study of the clinical and epidemiologic effectiveness of a homeopathic drug with influenza and ARVI. Infectionni Bolezni 2012; 10(3): 83–89. (in Russ)Компьютерная бронхофонография респираторного цикла. Под ред. Н.А. Геппе, В.С. Малышева. М: Медиа Сфера 2016; 108.Computer bronchophonography of the respiratory cycle. N.A. Geppe, V.S. Malyshev(eds). Moscow: Media Sfera2016; 108 (in Russ)Siqueira C.M., Homsani F., da Veiga V.F., Lyrio C., Mattos H., Passos S.R. et al. Homeopathic medicines for prevention of influenza and acute respiratory tract infections in children: blind, randomized, placebo-controlled clinical trial. Homeopathy 2016; 105(1): 71–77. DOI: 10.1016/j.homp.2015.02.006Siqueira C.M., Homsani F., da Veiga V.F., Lyrio C., Mattos H., Passos S.R. et al. Homeopathic medicines for prevention of influenza and acute respiratory tract infections in children: blind, randomized, placebo-controlled clinical trial. Homeopathy 2016; 105(1): 71–77. DOI: 10.1016/j.homp.2015.02.006Van Haselen R., Thinesse-Mallwitz M., Maidannyk V., Buskin S.L., Weber S., Keller T. et al. The Effectiveness and Safety of a Homeopathic Medicinal Product in Pediatric Upper Respiratory Tract Infections With Fever: A Randomized Controlled Trial. Glob Pediatr Health 2016; 3: 2333794X16654851. DOI: 10.1177/2333794X16654851Van Haselen R., Thinesse-Mallwitz M., Maidannyk V., Buskin S.L., Weber S., Keller T. et al. The Effectiveness and Safety of a Homeopathic Medicinal Product in Pediatric Upper Respiratory Tract Infections With Fever: A Randomized Controlled Trial. Glob Pediatr Health 2016; 3: 2333794X16654851. DOI: 10.1177/2333794X16654851

The authors declare that there are no conflicts of interest present.